Robot companion cats for people at home with dementia: A qualitative case study on companotics

Pike J., Picking R., & Cunningham S. (2021). Robot companion cats for people at home with dementia: A qualitative case study on companotics. Dementia, 20(4), 1300-1318. Copyright © [2021] (The Authors). Reprinted by permission of SAGE Publications.The use of robot companion pets for people in care homes has been extensively studied. The results are largely positive and suggest that they are valuable in enhancing wellbeing, communication and behavioural aspects. However, there has been little research in people’s own homes, possibly due to the cost and complexity of some of the robot pets currently available. As dementia affects people in different ways, this study explores the effects of a robot cat for people in their own homes, without specifically investigating the effects on a particular symptom. We utilised a case study design to investigate the proposition that various factors influence the impact of a robot cat on the person living with dementia and their carer, including acceptability of the robot pet and acceptance of dementia and its symptoms. The qualitative analysis explores the similarities and differences within the data which were gathered during interviews with people with dementia and their families. This analysis revealed four themes: Distraction, Communication, Acceptance and rejection, and Connecting with the cat and connecting with others. These themes were synthesised into two overarching themes: the effect of the cat on mood and behaviour, and The interaction with the cat. We present the acceptability and impact of the robot cat on symptoms of dementia, with data presented across and within the group of participants. Our analysis suggests that benefits of the robot pet were evident, and although this was a small-scale study, where they were accepted, robot pets provided positive outcomes for the participants and their families

Enhancing film sound design using audio features, regression models and artificial neural networks

This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of New Music Research on 21/09/2021, available online: https://doi.org/10.1080/09298215.2021.1977336Making the link between human emotion and music is challenging. Our aim was to produce an efficient system that emotionally rates songs from multiple genres. To achieve this, we employed a series of online self-report studies, utilising Russell's circumplex model. The first study (n = 44) identified audio features that map to arousal and valence for 20 songs. From this, we constructed a set of linear regressors. The second study (n = 158) measured the efficacy of our system, utilising 40 new songs to create a ground truth. Results show our approach may be effective at emotionally rating music, particularly in the prediction of valence

A multi-genre model for music emotion recognition using linear regressors

Making the link between human emotion and music is challenging. Our aim was to produce an efficient system that emotionally rates songs from multiple genres. To achieve this, we employed a series of online self-report studies, utilising Russell's circumplex model. The first study (n = 44) identified audio features that map to arousal and valence for 20 songs. From this, we constructed a set of linear regressors. The second study (n = 158) measured the efficacy of our system, utilising 40 new songs to create a ground truth. Results show our approach may be effective at emotionally rating music, particularly in the prediction of valence

Characterization of a Novel Fusion Protein from IpaB and IpaD of Shigella spp. and Its Potential as a Pan-Shigella Vaccine

Shigellosis is an important disease in the developing world, where about 90 million people become infected with Shigella spp. each year. We previously demonstrated that the type three secretion apparatus (T3SA) proteins IpaB and IpaD are protective antigens in the mouse lethal pulmonary model. In order to simplify vaccine formulation and process development, we have evaluated a vaccine design that incorporates both of these previously tested Shigella antigens into a single polypeptide chain. To determine if this fusion protein (DB fusion) retains the antigenic and protective capacities of IpaB and IpaD, we immunized mice with the DB fusion and compared the immune response to that elicited by the IpaB/IpaD combination vaccine. Purification of the DB fusion required coexpression with IpgC, the IpaB chaperone, and after purification it maintained the highly α-helical characteristics of IpaB and IpaD. The DB fusion also induced comparable immune responses and retained the ability to protect mice against Shigella flexneri and S. sonnei in the lethal pulmonary challenge. It also offered limited protection against S. dysenteriae challenge. Our results show the feasibility of generating a protective Shigella vaccine comprised of the DB fusion

eHealth Eurocampus Project: preparing innovative ICT professionals

The eHealth Eurocampus project, an EU-funded project, aims at preparing innovative professionals able to cope with the challenge of fostering a spirit of innovation in eHealth in Europe as the way forward to ensure better health and better and safer care. The main objectives of the eHealth Eurocampus are improving the relevance and quality of higher education in the field of ICT applications for health, and fostering employability through curricula adaptation to labour market needs and the development of entrepreneurship skills. In the frame of this project we are developing course materials, and implementing new and innovative teaching methods that are tested through joint learning activities (summer schools), which will be used later on in different master courses. The project includes the organization of training seminars to exchange good practices and knowledge among teachers and researchers. The eHealth Eurocampus consortium includes 8 higher education institutions, a regional centre of technological development and entrepreneurship promotion, and a European Grouping of Territorial Cooperation. The partnership represents different European health management systems, from 5 European countries.Postprint (author's final draft

eHealth Eurocampus: An innovative educational framework to train qualified professionals in the emerging ehealth sector

The aim of this paper is to present the results of an initiative called the eHealth Eurocampus (http://ehealtheurocampus.eu), whose main goal is to define a framework to prepare professionals for the eHealth work environment. To do so, three main activities have been organized: develop eHealth learning materials, international intensive study programs for both health science and IT students and international training seminars for researches and professors. The eHealth Eurocampus project is an EU-funded Erasmus+ Strategic Partnership for higher education (September-2016 / August-2019) which aims at preparing qualified professionals able to cope with the challenge of “fostering a spirit of innovation in eHealth in Europe as the way forward to ensure better health and better and safer care for EU citizens, a more skilled workforce, more efficient and sustainable health and care systems, new business opportunities” (EC eHealth Action Plan 2012-2020). The consortium of the eHealth Eurocampus project along with the participants of the designed activities have created an original eHealth teaching-learning framework where university professors, students, researchers, and clinicians are able to share their experiences and knowledge with the aim of improving the skills of graduates in order to improve their employability. These are the organized activities and the topics that have been covered: - eHealth learning materials. Five courses of 6 ECTS each have been developed in the following topics: innovation and entrepreneurship, IT for a longer independent life, robotics for health care, graphics and medical imaging and eHealth applications and tools. - Intensive study programs. Three international summer schools for both health and IT students have been organized with an interdisciplinary approach. The first one deal with innovation and entrepreneurship in eHealth. The second one is focused on applications and tools for longer independent life. And robotics, graphics and medical imaging are covered in the third one. The summer schools have proven to be the best testbed for the learning materials and for innovative teaching methodologies in interdisciplinary context. - Training seminars. When you face the training of qualified eHealth professionals it is critical to have good educators. Two training seminars have been organized with the goal of share experiences and knowledge among practitioners, university teachers and researches of the health and IT fields. The topics covered in the seminars are eHealth Teaching Challenges and Accessibility, Inclusion, and Rehabilitation using IT, respectively. In this paper, we will introduce in detail the different activities carried out, the results and conclusions of this teaching-learning framework and how the different stakeholders would take advantage of it.Postprint (author's final draft

Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodeling

Nucleosomes, the fundamental units of chromatin structure, are regulators and barriers to transcription, replication and repair. Post-translational modifications (PTMs) of the histone proteins within nucleosomes regulate these DNA processes. Histone H3(T118) is a site of phosphorylation [H3(T118ph)] and is implicated in regulation of transcription and DNA repair. We prepared H3(T118ph) by expressed protein ligation and determined its influence on nucleosome dynamics. We find H3(T118ph) reduces DNA–histone binding by 2 kcal/mol, increases nucleosome mobility by 28-fold and increases DNA accessibility near the dyad region by 6-fold. Moreover, H3(T118ph) increases the rate of hMSH2–hMSH6 nucleosome disassembly and enables nucleosome disassembly by the SWI/SNF chromatin remodeler. These studies suggest that H3(T118ph) directly enhances and may reprogram chromatin remodeling reactions

Internet of Nano-Things, Things and Everything: Future Growth Trends

The current statuses and future promises of the Internet of Things (IoT), Internet of Everything (IoE) and Internet of Nano-Things (IoNT) are extensively reviewed and a summarized survey is presented. The analysis clearly distinguishes between IoT and IoE, which are wrongly considered to be the same by many commentators. After evaluating the current trends of advancement in the fields of IoT, IoE and IoNT, this paper identifies the 21 most significant current and future challenges as well as scenarios for the possible future expansion of their applications. Despite possible negative aspects of these developments, there are grounds for general optimism about the coming technologies. Certainly, many tedious tasks can be taken over by IoT devices. However, the dangers of criminal and other nefarious activities, plus those of hardware and software errors, pose major challenges that are a priority for further research. Major specific priority issues for research are identified