94 research outputs found
A new paleoecological look at the Dinwoody Formation (Lower Triassic, western USA): intrinsic versus extrinsic controls on ecosystem recovery after the end-Permian mass extinction
The Dinwoody Formation of the western United States represents an important archive of Early Triassic ecosystems in the immediate aftermath of the end-Permian mass extinction. We present a systematic description and a quantitative paleoecological analysis of its benthic faunas in order to reconstruct benthic associations and to explore the temporal and spatial variations of diversity, ecological structure and taxonomic composition throughout the earliest Triassic of the western United States. A total of 15 bivalve species, two gastropod species, and two brachiopod species are recognized in the study area. The paleoecological analysis shows that the oldest Dinwoody communities are characterized by low diversity, low ecological complexity and high dominance of few species. We suggest that this low diversity most likely reflects the consequences of the mass extinction in the first place and not necessarily the persistence of environmental stress. Whereas this diversity pattern persists into younger strata of the Dinwoody Formation in outer shelf environments, an increase in richness, evenness and guild diversity occurred around the Griesbachian-Dienerian boundary in more shallow marine habitats. This incipient recovery towards the end of the Griesbachian is in accordance with observations from other regions and thus probably represents an interregional signal. In contrast to increasing richness within communities (alpha-diversity), beta-diversity remained low during the Griesbachian and Dienerian in the study area. This low beta-diversity reflects a wide environmental and geographical range of taxa during the earliest Triassic, indicating that the increase of within-habitat diversity has not yet led to significant competitive exclusion. We hypothesize that the well-known prevalence of generalized taxa in post-extinction faunas is primarily an effect of reduced competition that allows species to exist through the full range of their fundamental niches, rather than being caused by unusual and uniform environmental stres
Determination of alpha_s from F_2^p at HERA
We compute the proton structure function F_2^p at small x and large Q^2 at
next-to-leading order in alpha_s(Q^2), including summations of all leading and
subleading logarithms of Q^2 and 1/x in a way consistent with momentum
conservation. We perform a detailed comparison to the 1993 HERA data, and show
that they may be used to determine alpha_s(M_Z^2)=0.120 pm 0.005(exp) pm
0.009(th). The theoretical error is dominated by the renormalization and
factorization scheme ambiguities.Comment: 24 pages, TeX with harvmac and epsf, 10 figures in compressed
postscript. Final (published) versio
Finite-top-mass effects in NNLO Higgs production
We construct an accurate approximation to the exact NNLO cross section for
Higgs production in gluon-gluon fusion by matching the dominant finite top mass
corrections recently computed by us to the known result in the infinite mass
limit. The ensuing corrections to the partonic cross section are very large
when the center of mass energy of the partonic collision is much larger than
the Higgs mass, but lead to a moderate correction at the percent level to the
total Higgs production cross section at the LHC. Our computation thus reduces
the uncertainty related to these corrections at the LHC from the percent to the
per mille level.Comment: 4 pages, 4 figures; to be published in the proceedings of QCD2008.
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Geodetic surveying is a core volcano monitoring technique. Measurements of how the crust deforms can give valuable insight into the mechanisms and processes that drive an eruption, and the way in which they change. Various geodetic observables, including ground deformation and gravity changes, have been recorded on Montserrat throughout the eruption. Instrumentation and surveying networks used to make such measurements have evolved significantly since 1995, providing increasingly accurate and robust observations. The detailed research that has been facilitated by these rich geodetic datasets has illuminated many aspects of the Soufrière Hills Volcano (SHV) and demonstrated eruptive mechanisms that are relevant to the study of other volcanoes. We have compiled a history of the geodetic study of the eruption on Montserrat, detailing the development of surveying techniques, network design and data processing since 1995. We then underline some of the key geodetic observations and review some of the most significant research that has contributed to our understanding of this volcanic system. Finally, we apply a series of typical deformation inversion models to deformation observations, and discuss the parameter sensitivity of such modelling approaches and how confidently they can be applied to identify the characteristics of the mechanisms feeding the eruption
Influence of Pharyngeal Anaesthesia on Post-Bronchoscopic Coughing: A Prospective, Single Blinded, Multicentre Trial
Background: Local anaesthesia of the pharynx (LAP) was introduced in the era of rigid bronchoscopy (which was initially a conscious procedure under local anaesthetic), and continued into the era of flexible bronchoscopy (FB) in order to facilitate introduction of the FB. LAP reduces cough and gagging reflex, but its post-procedural effect is unclear. This prospective multicentre trial evaluated the effect of LAP on coughing intensity/time and patient comfort after FB, and the feasibility of FB under propofol sedation alone, without LAP. Material and methods: FB was performed in 74 consecutive patients under sedation with propofol, either alone (35 patients, 47.3%) or with additional LAP (39 patients, 52.7%). A primary endpoint of post-procedural coughing duration in the first 10 min after awakening was evaluated. A secondary endpoint was the cough frequency, quality and development of coughing in the same period during the 10 min post-procedure. Finally, the ease of undertaking the FB and the patient’s tolerance and safety were evaluated from the point of view of the investigator, the assistant technician and the patient. Results: We observed a trend to a shorter cumulative coughing time of 48.6 s in the group without LAP compared to 82.8 s in the group receiving LAP within the first 10 min after the procedure, although this difference was not significant (p = 0.24). There was no significant difference in the cough frequency, quality, peri-procedural complication rate, nor patient tolerance or safety. FB, including any additional procedure, could be performed equally well with or without LAP in both groups. Conclusions: Our study suggests that undertaking FB under deep sedation without LAP does to affect post-procedural cough duration and frequency. However, further prospective randomised controlled trials are needed to further support this finding
Resummation of Hadroproduction Cross-sections at High Energy
We reconsider the high energy resummation of photoproduction,
electroproduction and hadroproduction cross-sections, in the light of recent
progress in the resummation of perturbative parton evolution to NLO in
logarithms of Q^2 and x. We show in particular that the when the coupling runs
the dramatic enhancements seen at fixed coupling, due to infrared singularities
in the partonic cross-sections, are substantially reduced, to the extent that
they are largely accounted for by the usual NLO and NNLO perturbative
corrections. This leads to a novel explanation of the large K-factors commonly
found in perturbative calculations of hadroproduction cross-sections. We give
numerical estimates of high energy resummation effects for inclusive
B-production, inclusive jets, Drell-Yan and vector boson production, along with
their rapidity distributions. We find that resummation modifies the
B-production cross-section at the LHC by at most 15%, but that the enhancement
of gluonic W-production may be as large as 50% at large rapidities.Comment: 49 pages, 25 figures, version to be published in Nucl Phys
Summation of Leading Logarithms at Small x
We show how perturbation theory may be reorganized to give splitting
functions which include order by order convergent sums of all leading
logarithms of . This gives a leading twist evolution equation for parton
distributions which sums all leading logarithms of and , allowing
stable perturbative evolution down to arbitrarily small values of .
Perturbative evolution then generates the double scaling rise of observed
at HERA, while in the formal limit at fixed the Lipatov
behaviour is eventually reproduced. We are thus able to explain
why leading order perturbation theory works so well in the HERA region.Comment: 21 pages, TeX with harvmac, 3 figures in compressed postscript. Final
published version (several minor corrections
Functional diversity of marine ecosystems after the Late Permian mass extinction event
Article can be accessed from http://www.nature.com/ngeo/journal/v7/n3/full/ngeo2079.htmlThe Late Permian mass extinction event was the most severe such crisis of the past 500 million years and occurred during an episode of global warming. It is assumed to have had significant ecological impact, but its effects on marine ecosystem functioning are unknown and the patterns of marine recovery are debated. We analysed the fossil occurrences of all known Permian-Triassic benthic marine genera and assigned each to a functional group based on their inferred life habit. We show that despite the selective extinction of 62-74% of marine genera there was no significant loss of functional diversity at the global scale, and only one novel mode of life originated in the extinction aftermath. Early Triassic marine ecosystems were not as ecologically depauperate as widely assumed, which explains the absence of a Cambrian-style Triassic radiation in higher taxa. Functional diversity was, however, significantly reduced in particular regions and habitats, such as tropical reefs, and at these scales recovery varied spatially and temporally, probably driven by migration of surviving groups. Marine ecosystems did not return to their pre-extinction state, however, and radiation of previously subordinate groups such as motile, epifaunal grazers led to greater functional evenness by the Middle Triassic
Higgs production via gluon-gluon fusion with finite top mass beyond next-to-leading order
We present a computation of the cross section for inclusive Higgs production
in gluon-gluon fusion for finite values of the top mass in perturbative QCD to
all orders in the limit of high partonic center-of-mass energy. We show that at
NLO the high energy contribution accounts for most of the difference between
the result found with finite top mass and that obtained in the limit of
infinite top mass. We use our result to improve the known NNLO order result
obtained with infinite top mass. We estimate the effect of the high energy NNLO
top mass dependence on the K factor to be of the order of a few per cent.Comment: 20 pages, 5 figures, latex with epsfi
Increased PD-L1 expression in radioresistant HNSCC cell lines after irradiation affects cell proliferation due to inactivation of GSK-3beta
At present, targeting PD-1/PD-L1 axis for immune checkpoint inhibition has improved treatment of various tumor entities, including head and neck squamous cell carcinoma (HNSCC). However, one part of the patient cohort still shows little improvement or even hyperprogression. We established three radioresistant (RR) and three radiosensitive (RS) HNSCC cell lines. RR cells showed prolonged survival as well as delayed and diminished apoptosis after irradiation with vimentin expression but no E-cadherin expression, whereas RS cell lines died early and exhibited early apoptosis after irradiation and high vimentin expression. Here, we present results demonstrating differential basal PD-L1 gene and protein expression in RR and RS HNSCC cell lines. Moreover, we observed a radiation dose dependent increase of total PD-L1 protein expression in RR cell lines up to 96h after irradiation compared to non-irradiated (non-IRR) cells. We found a significant GSK-3beta phosphorylation, resulting in an inactivation, after irradiation of RR cell lines. Co-immunoprecipitation experiments revealed decreased interaction of GSK-3beta with PD-L1 in non-IRR compared to irradiated (IRR) RR cells leading to PD-L1 stabilization in RR cells. PD-L1 knockdown in RR cells showed a strong decrease in cell survival. In summary, our results suggest an irradiation dependent increase in basal PD-L1 expression in RR HNSCC cell lines via GSK-3beta inactivation
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