Goiter and Multiple Food Allergies

Severe iodine deficiency results in impaired thyroid hormone synthesis and thyroid enlargement. In the United States, adequate iodine intake is a concern for women of childbearing age and pregnant women. Beyond this high risk group iodine deficiency is not considered to be a significant problem. This case report describes a 12-year-old male with severe iodine deficiency disorder (IDD) resulting from restricted dietary intake due to multiple food allergies. We describe iodine replacement for this patient and continued monitoring for iodine sufficiency. Children with multiple food allergies, in particular those with restrictions to iodized salt and seafood, should be considered high risk for severe iodine deficiency

SILCC-ZOOM: The early impact of ionizing radiation on forming molecular clouds

As part of the SILCC-ZOOM project we present our first sub-parsec resolution radiation-hydrodynamic simulations of two molecular clouds self-consistently forming from a turbulent, multi-phase ISM. The clouds have similar initial masses of few 10$^4$ M$_{\odot}$, escape velocities of ~5 km s$^{-1}$, and a similar initial energy budget. We follow the formation of star clusters with a sink based model and the impact of radiation from individual massive stars with the tree-based radiation transfer module TreeRay. Photo-ionizing radiation is coupled to a chemical network to follow gas heating, cooling and molecule formation and dissociation. For the first 3 Myr of cloud evolution we find that the overall star formation effciency is considerably reduced by a factor of ~4 to global cloud values of < 10 % as the mass accretion of sinks that host massive stars is terminated after <1 Myr. Despite the low effciency, star formation is triggered across the clouds. Therefore, a much larger region of the cloud is affected by radiation and the clouds begin to disperse. The time scale on which the clouds are dispersed sensitively depends on the cloud substructure and in particular on the amount of gas at high visual extinction. The damage of radiation done to the highly shielded cloud (MC1) is delayed. We also show that the radiation input can sustain the thermal and kinetic energy of the clouds at a constant level. Our results strongly support the importance of ionizing radiation from massive stars for explaining the low observed star formation effciency of molecular cloud

Animal derived antibodies should be considered alongside convalescent human plasma to deliver treatments for COVID-19

Published data on the first 5,000 coronavirus patients to receive plasma shows promise in the United States. However, delivering convalescent plasma therapies in low- and even middle-income countries is both difficult and costly. Here we discuss the advantages and disadvantages of antisera raised in animals that ma

Super-solar N/C in the NLS1 Galaxy Markarian 1044

Narrow-Line Seyfert 1s (NLS1s) are known to have extreme values of a number of properties compared to Active Galactic Nuclei (AGN) as a class. In particular, previous emission-line studies have suggested that NLS1s are unusually metal rich compared to broad-line AGN of comparable luminosity. We present low- and medium-resolution spectroscopic observations of the NLS1 Markarian 1044 with the Hubble Space Telescope Imaging Spectrometer (STIS). We identify two blueshifted intrinsic absorption systems at -1145 and -295 km/s relative to the systemic velocity of the galaxy. Using a simple photoionization model of the absorbing gas, we find that the strongest and best-measured of the absorption systems has N/C approximately 6.96 times the solar value. We also report on the discovery of three new Ly-alpha forest lines with neutral Hydrogen column density log greater than 12.77 in the log. This number is consistent with the 2.6 expected in the path length to the source redshift of Mrk 1044.Comment: Submitted to ApJ. 21 pages including 4 figures & 5 table

Tree-based solvers for adaptive mesh refinement code flash - IV. An X-ray radiation scheme to couple discrete and diffuse X-ray emission sources to the thermochemistry of the interstellar medium

X-ray radiation, in particular radiation between 0.1 and 10 keV, is evident from both point-like sources, such as compact objects and T-Tauri young stellar objects, and extended emission from hot, cooling gas, such as in supernova remnants. The X-ray radiation is absorbed by nearby gas, providing a source of both heating and ionization. While protoplanetary chemistry models now often include X-ray emission from the central young stellar object, simulations of star-forming regions have yet to include X-ray emission coupled to the chemo-dynamical evolution of the gas. We present an extension of the treeray reverse ray trace algorithm implemented in the flash magnetohydrodynamic code which enables the inclusion of X-ray radiation from 0.1 keV &lt; Eγ &lt; 100 keV, dubbed xraythespot. xraythespot allows for the use of an arbitrary number of bins, minimum and maximum energies, and both temperature-independent and temperature-dependent user-defined cross-sections, along with the ability to include both point and extended diffuse emission and is coupled to the thermochemical evolution. We demonstrate the method with several multibin benchmarks testing the radiation transfer solution and coupling to the thermochemistry. Finally, we show two example star formation science cases for this module: X-ray emission from protostellar accretion irradiating an accretion disc and simulations of molecular clouds with active chemistry, radiation pressure, and protostellar radiation feedback from infrared to X-ray radiation

Hydration effects turn a highly stretched polymer from an entropic into an energetic spring

Polyethylene glycol (PEG) is a structurally simple and nontoxic water-soluble polymer that is widely used in medical and pharmaceutical applications as molecular linker and spacer. In such applications, PEG’s elastic response against conformational deformations is key to its function. According to text-book knowledge, a polymer reacts to the stretching of its end-to-end separation by a decrease in entropy that is due to the reduction of available conformations, which is why polymers are commonly called entropic springs. By a combination of single-molecule force spectroscopy experiments with molecular dynamics simulations in explicit water, we show that entropic hydration effects almost exactly compensate the chain conformational entropy loss at high stretching. Our simulations reveal that this entropic compensation is due to the stretching-induced release of water molecules that in the relaxed state form double hydrogen bonds with PEG. As a consequence, the stretching response of PEG is predominantly of energetic, not of entropic, origin at high forces and caused by hydration effects, while PEG backbone deformations only play a minor role. These findings demonstrate the importance of hydration for the mechanics of macromolecules and constitute a case example that sheds light on the antagonistic interplay of conformational and hydration degrees of freedom

The Time Evolution of the Social Cost Of Carbon: An Application of FUND. ESRI WP405. August 2011

We estimate the growth rate of the social cost of carbon. This is an indication of the optimal rate of acceleration of greenhouse gas emission reduction policy over time. We find that the social cost of carbon increases by 1.3% to 3.9% per year, with a central estimate of 2.2%. Previous studies found an average rate of 2.3% and a range of 0.9‐4.1%. The rate of increase of the social carbon depends on a range of factors, including the pure rate of time preference, the rate of risk aversion, equity weighting, the socio‐economic and emission scenarios, the climate sensitivity, dynamic vulnerability, and the curvature of the impact functions