Asking Better Questions: Small-Scale Assessment Measures That Inform Ongoing Work

The authors explore readily available ways to assess library services such as inter-library loan fill rates, student satisfaction surveys, circulation rates of newly acquired material, and assessment of the bibliographies of student papers. They also discuss their experience with administrating the LibQual+ survey

Heirs of Vision, Devotion, and Sacrifice

Professor Edwin Kagin\u27s 1961 Founders Day speech, Heirs of Vision, Devotion, and Sacrifice. Reel #14

Janet Wallace Fine Arts Center Dedication

Dedication of the Janet Wallace Fine Arts Center on 10/27/1965. Speakers and featured guests include: Dr. J. Maxwell Adams, President Harvey M. Rice, Robert Dean, George Dayton, II, and DeWitt and Lila Wallace. Reel #34

Improving Biomethanation of Chicken Manure by Co-Digestion with Ethanol Plant Effluent

As the global production of chicken manure has steadily increased, its proper management has become a challenging issue. This study examined process effluent from a bioethanol plant as a co-substrate for efficient anaerobic digestion of chicken manure. An anaerobic continuous reactor was operated in mono- and co-digestion modes by adding increasing amounts of the ethanol plant effluent (0%, 10%, and 20% (v/v) of chicken manure). Methanogenic performance improved significantly in terms of both methane production rate and yield (by up to 66% and 36%, respectively), with an increase in organic loading rate over the experimental phases. Correspondingly, the specific methanogenic activity was significantly higher in the co-digestion sludge than in the mono-digestion sludge. The reactor did not suffer any apparent process imbalance, ammonia inhibition, or nutrient limitation throughout the experiment, with the removal of volatile solids being stably maintained (56.3???58.9%). The amount of ethanol plant effluent appears to directly affect the rate of acidification, and its addition at ???20% (v/v) to chicken manure needs to be avoided to maintain a stable pH. The overall results suggest that anerobic co-digestion with ethanol plant effluent may provide a practical means for the stable treatment and valorization of chicken manure

Science Building Announcement 11/13/1962

President Harvey Rice introduces Charles Horn, President of the Olin Foundation, who spoke and announced the plans to build the new science building, on 11/13/1962. Reel #15

UNIVERSITY OF OREGON : MUSEUM OF NATURAL HISTORY : ITS OWN STORY

24 pagesThrough the doorway of the Museum of Natural History come many visitors. Inside are displays which contain materials arranged to interpret various aspects of nature. Each display tells its own story. Displays range from the phenomena of vulcanism to the ways of life of the earliest known residents of Oregon, each designed by an expert on the subject. Here is an opportunity to learn by seeing

Founders\u27 Day 1960

Founders\u27 Day 1960 with speakers President Harvey Rice, Professor O.T. Walter, as well as Edmund Wood, Kay Lorans, Fred Koch, and George Bonniwell. Reel #3

Have proto-planetary discs formed planets?

It has recently been noted that many discs around T Tauri stars appear to comprise only a few Jupiter-masses of gas and dust. Using millimetre surveys of discs within six local star-formation regions, we confirm this result, and find that only a few percent of young stars have enough circumstellar material to build gas giant planets, in standard core accretion models. Since the frequency of observed exo-planets is greater than this, there is a `missing mass' problem. As alternatives to simply adjusting the conversion of dust-flux to disc mass, we investigate three other classes of solution. Migration of planets could hypothetically sweep up the disc mass reservoir more efficiently, but trends in multi-planet systems do not support such a model, and theoretical models suggest that the gas accretion timescale is too short for migration to sweep the disc. Enhanced inner-disc mass reservoirs are possible, agreeing with predictions of disc evolution through self-gravity, but not adding to millimetre dust-flux as the inner disc is optically thick. Finally, the incidence of massive discs is shown to be higher at the {\it proto}stellar stages, Classes 0 and I, where discs substantial enough to form planets via core accretion are abundant enough to match the frequency of exo-planets. Gravitational instability may also operate in the Class 0 epoch, where half the objects have potentially unstable discs of \ga30 % of the stellar mass. However, recent calculations indicate that forming gas giants inside 50 AU by instability is unlikely, even in such massive discs. Overall, the results presented suggest that the canonically 'proto-planetary' discs of Class II T Tauri stars {\bf have globally low masses in dust observable at millimetre wavelengths, and conversion to larger bodies (anywhere from small rocks up to planetary cores) must already have occurred.}Comment: Accepted for publication in MNRAS (main journal

The chromospherically active binary star EI Eridani II. Long-term Doppler imaging

Data from 11 years of continuous spectroscopic observations of the active RS CVn-type binary star EI Eridani - gained at NSO/McMath-Pierce, KPNO/Coude Feed and during the MUSICOS 98 campaign - were used to obtain 34 Doppler maps in three spectroscopic lines for 32 epochs, 28 of which are independent of each other. Various parameters are extracted from our Doppler maps: average temperature, fractional spottedness, and longitudinal and latitudinal spot-occurrence functions. We find that none of these parameters show a distinct variation nor a correlation with the proposed activity cycle as seen from photometric long-term observations. This suggests that the photometric brightness cycle may not necessarily be due to just a cool spot cycle. The general morphology of the spot pattern remains persistent over the whole period of 11 years. A large cap-like polar spot was recovered from all our images. A high degree of variable activity was noticed near latitudes of approx. 60-70 degrees where the appendages of the polar spot emerged and dissolved

Mutations in hepatitis C virus E2 located outside the CD81 binding sites lead to escape from broadly neutralizing antibodies but compromise virus infectivity.

Broadly neutralizing antibodies are commonly present in the sera of patients with chronic hepatitis C virus (HCV) infection. To elucidate possible mechanisms of virus escape from these antibodies, retrovirus particles pseudotyped with HCV glycoproteins (HCVpp) isolated from sequential samples collected over a 26-year period from a chronically infected patient, H, were used to characterize the neutralization potential and binding affinity of a panel of anti-HCV E2 human monoclonal antibodies (HMAbs). Moreover, AP33, a neutralizing murine monoclonal antibody (MAb) to a linear epitope in E2, was also tested against selected variants. The HMAbs used were previously shown to broadly neutralize HCV and to recognize a cluster of highly immunogenic overlapping epitopes, designated domain B, containing residues that are also critical for binding of viral E2 glycoprotein to CD81, a receptor essential for virus entry. Escape variants were observed at different time points with some of the HMAbs. Other HMAbs neutralized all variants except for the isolate 02.E10, obtained in 2002, which was also resistant to MAb AP33. The 02.E10 HCVpp that have reduced binding affinities for all antibodies and for CD81 also showed reduced infectivity. Comparison of the 02.E10 nucleotide sequence with that of the strain H-derived consensus variant, H77c, revealed the former to have two mutations in E2, S501N and V506A, located outside the known CD81 binding sites. Substitution A506V in 02.E10 HCVpp restored binding to CD81, but its antibody neutralization sensitivity was only partially restored. Double substitutions comprising N501S and A506V synergistically restored 02.E10 HCVpp infectivity. Other mutations that are not part of the antibody binding epitope in the context of N501S and A506V were able to completely restore neutralization sensitivity. These findings showed that some nonlinear overlapping epitopes are more essential than others for viral fitness and consequently are more invariant during earlier years of chronic infection. Further, the ability of the 02.E10 consensus variant to escape neutralization by the tested antibodies could be a new mechanism of virus escape from immune containment. Mutations that are outside receptor binding sites resulted in structural changes leading to complete escape from domain B neutralizing antibodies, while simultaneously compromising viral fitness by reducing binding to CD81