Privacy and data protection in elderly healthcare: threats and legal warranties

The progressive aging of the population requires new kinds of social and medical intervention and the availability of different services provided to the elder population. New applications have been developed and some services are now provided at home, allowing the older people to stay home instead of having to stay in hospitals. But an adequate response to the needs of the users will imply a high percentage of use of personal data and information, including the building up and maintenance of user profiles, feeding the systems with the data and information needed for a proactive intervention in scheduling of events in which the user may be involved. Fundamental Rights may be at stake, so a legal analysis must also be considered

Supporting elimination of lymphatic filariasis in Samoa by predicting locations of residual infection using machine learning and geostatistics

The global elimination of lymphatic filariasis (LF) is a major focus of the World Health Organization. One key challenge is locating residual infections that can perpetuate the transmission cycle. We show how a targeted sampling strategy using predictions from a geospatial model, combining random forests and geostatistics, can improve the sampling efficiency for identifying locations with high infection prevalence. Predictions were made based on the household locations of infected persons identified from previous surveys, and environmental variables relevant to mosquito density. Results show that targeting sampling using model predictions would have allowed 52% of infections to be identified by sampling just 17.7% of households. The odds ratio for identifying an infected individual in a household at a predicted high risk compared to a predicted low risk location was 10.2 (95% CI 4.2–22.8). This study provides evidence that a ‘one size fits all’ approach is unlikely to yield optimal results when making programmatic decisions based on model predictions. Instead, model assumptions and definitions should be tailored to each situation based on the objective of the surveillance program. When predictions are used in the context of the program objectives, they can result in a dramatic improvement in the efficiency of locating infected individuals

The relative contribution of climate variability and vector control coverage to changes in malaria parasite prevalence in Zambia 2006-2012

BACKGROUND: Four malaria indicator surveys (MIS) were conducted in Zambia between 2006 and 2012 to evaluate malaria control scale-up. Nationally, coverage of insecticide-treated nets (ITNs) and indoor residual spraying (IRS) increased over this period, while parasite prevalence in children 1-59 months decreased dramatically between 2006 and 2008, but then increased from 2008 to 2010. We assessed the relative effects of vector control coverage and climate variability on malaria parasite prevalence over this period. METHODS: Nationally-representative MISs were conducted in April-June of 2006, 2008, 2010 and 2012 to collect household-level information on malaria control interventions such as IRS, ITN ownership and use, and child parasite prevalence by microscopic examination of blood smears. We fitted Bayesian geostatistical models to assess the association between IRS and ITN coverage and climate variability and malaria parasite prevalence. We created predictions of the spatial distribution of malaria prevalence at each time point and compared results of varying IRS, ITN, and climate inputs to assess their relative contributions to changes in prevalence. RESULTS: Nationally, the proportion of households owning an ITN increased from 37.8 % in 2006 to 64.3 % in 2010 and 68.1 % in 2012, with substantial heterogeneity sub-nationally. The population-adjusted predicted child malaria parasite prevalence decreased from 19.6 % in 2006 to 10.4 % in 2008, but rose to 15.3 % in 2010 and 13.5 % in 2012. We estimated that the majority of this prevalence increase at the national level between 2008 and 2010 was due to climate effects on transmission, although there was substantial heterogeneity at the provincial level in the relative contribution of changing climate and ITN availability. We predict that if climate factors preceding the 2010 survey were the same as in 2008, the population-adjusted prevalence would have fallen to 9.9 % nationally. CONCLUSIONS: These results suggest that a combination of climate factors and reduced intervention coverage in parts of the country contributed to both the reduction and rebound in malaria parasite prevalence. Unusual rainfall patterns, perhaps related to moderate El Niño conditions, may have contributed to this variation. Zambia has demonstrated considerable success in scaling up vector control. This analysis highlights the importance of accounting for climate variability when using cross-sectional data for evaluation of malaria control efforts

Post-harvesting longevity of bird of paradise (Strelitzia spp.) treated with carnauba wax

  Strelitzias are tropical plants that have shown great interest in the market and can be used in landscaping in tropical floral arrangements. Aiming to extend its postharvest life, the objective of the work was to evaluate different concentrations of the commercial product based on carnauba wax in the postharvest longevity of Strelitzia juncea and Strelitzia reginae leaves. The experiment was conducted in a completely randomized design with five treatments and six repetitions, with one leaf per repetition for each species. The concentrations used were: 0% (control), 2%, 20%, 40% and 100%. The loss of leaf mass (%) and the visual quality of the leaves were evaluated through the criterion of notes, in addition to making use of anatomical analyzes of the stomatal structures of the leaves through scanning microscopy. The loss of mass was reduced with the increase of the wax concentration, however, high doses provided increased loss. The use of carnauba wax proved efficient at concentrations of 20 and 40%, maintaining the commercial quality of the leaves of S. reginae and S. juncea until the 24th day, while in the control treatment, the leaves maintained a commercial pattern until the 16th for S. reginae and 18th day for S. juncea. The deposition of wax in the stomatal structures may have influenced the loss of mass of both species as observed by scanning microscopy.As Strelitzias são plantas tropicais que têm despontado grande interesse do mercado, podendo ser utilizadas no paisagismo em arranjos florais tropicais. Visando ampliar sua vida pós-colheita, o objetivo do trabalho foi avaliar diferentes concentrações do produto comercial a base de cera de carnaúba na longevidade pós-colheita de folhas de Strelitzia juncea e Strelitzia reginae. O experimento foi conduzido em delineamento inteiramente casualizado com cinco tratamentos e seis repetições, com uma folha por repetição para cada espécie. As concentrações utilizadas foram: 0% (controle), 2%, 20%, 40% e 100%. Avaliaram-se a perda de massa foliar (%) e a qualidade visual das folhas por meio do critério de notas, além de se fazer uso de análises anatômicas das estruturas estomáticas das folhas através de microscopia de varredura. A perda de massa foi reduzida com o aumento da concentração de cera, no entanto, altas doses proporcionaram aumento da perda. O uso de cera de carnaúba se mostrou eficiente nas concentrações de 20 e 40%, mantendo a qualidade comercial das folhas de S. reginae e S. juncea até o 24º dia, enquanto no tratamento controle, as folhas mantiveram padrão comercial até o 16° para S. reginae e 18° dia para S. juncea. A deposição de cera nas estruturas estomáticas pode ter influenciado na perda de massa de ambas as espécies conforme foi observado por meio da microscopia de varredura

Pós-colheita de folhas de espécies de Strelitizia spp

A floricultura constitui um dos segmentos mais dinâmicos do agronegócio e a utilização de arranjos florais exige alto padrão de qualidade de seus produtos e uma maior longevidade pós-colheita das flores. A quitosana é um polissacarídeo biodegradável capaz de formar um filme natural e permeável às trocas gasosas realizadas pelo vegetal, permitindo a redução do metabolismo da planta favorecendo o prolongamento de sua vida útil. Este estudo teve como objetivo avaliar a durabilidade pós-colheita de folhas de Strelitizia reginae e Strelitizia juncea utilizando produto comercial a base de quitosana (FishFertil®). O experimento foi conduzido inteiramente casualisado de 6 tratamentos com 5 repetições (onde cada folha foi considerada como uma repetição). Foram utilizadas 6 doses ( 0 ; 10 ; 20 ; 40 ; 80 e 160 mg L-1 do produto comercial). Realizaram-se avaliações visuais da longevidade das folhas através de notas e o acompanhamento da perda de água nos tecidos foliares. Observou-se que FishFertil® retardou a perda de massa fresca das folhas de S. juncea e S. reginae. Para ambas as espécies o tratamento controle permaneceu até o 22° dia com notas aceitáveis comercialmente (nota 4). O produto retardou a perda de massa fresca das folhas de S. juncea e S. reginae e as mantiveram até o 34° dia notas dentro do padrão comercial, contudo não foi possível determinar a dose de máxima eficiência do produto para as duas espécies de Strelitzia

Context-dependence of race self-classification : results from a highly mixed and unequal middle-income country

Ethnic-racial classification criteria are widely recognized to vary according to historical, cultural and political contexts. In Brazil, the strong influence of individual socio-economic factors on race/colour self-classification is well known. With the expansion of genomic technologies, the use of genomic ancestry has been suggested as a substitute for classification procedures such as self-declaring race, as if they represented the same concept. We investigated the association between genomic ancestry, the racial composition of census tracts and individual socioeconomic factors and self-declared race/colour in a cohort of 15,105 Brazilians. Results show that the probability of self-declaring as black or brown increases according to the proportion of African ancestry and varies widely among cities. In Porto Alegre, where most of the population is white, with every 10% increase in the proportion of African ancestry, the odds of self-declaring as black increased 14 times (95%CI 6.08–32.81). In Salvador, where most of the population is black or brown, that increase was of 3.98 times (95%CI 2.96–5.35). The racial composition of the area of residence was also associated with the probability of selfdeclaring as black or brown. Every 10% increase in the proportion of black and brown inhabitants in the residential census tract increased the odds of self-declaring as black by 1.33 times (95%CI 1.24–1.42). Ancestry alone does not explain self-declared race/colour. An emphasis on multiple situational contexts (both individual and collective) provides a more comprehensive framework for the study of the predictors of self-declared race/colour, a highly relevant construct in many different scenarios, such as public policy, sociology and medicine

Differences in the immune response elicited by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trial

BACKGROUND: The development of vaccines to control the COVID-19 pandemic progression is a worldwide priority. CoronaVac® is an inactivated SARS-CoV-2 vaccine approved for emergency use with robust efficacy and immunogenicity data reported in trials in China, Brazil, Indonesia, Turkey, and Chile. METHODS: This study is a randomized, multicenter, and controlled phase 3 trial in healthy Chilean adults aged ≥18 years. Volunteers received two doses of CoronaVac® separated by two (0-14 schedule) or four weeks (0-28 schedule). 2,302 volunteers were enrolled, 440 were part of the immunogenicity arm, and blood samples were obtained at different times. Samples from a single center are reported. Humoral immune responses were evaluated by measuring the neutralizing capacities of circulating antibodies. Cellular immune responses were assessed by ELISPOT and flow cytometry. Correlation matrixes were performed to evaluate correlations in the data measured. RESULTS: Both schedules exhibited robust neutralizing capacities with the response induced by the 0-28 schedule being better. No differences were found in the concentration of antibodies against the virus and different variants of concern between schedules. Stimulation of PBMCs with MPs induced the secretion of IFN-g and the expression of activation induced markers for both schedules. Correlation matrixes showed strong correlations between neutralizing antibodies and IFN-g secretion. CONCLUSIONS: Immunization with CoronaVac® in Chilean adults promotes robust cellular and humoral immune responses. The 0-28 schedule induced a stronger humoral immune response than the 0-14 schedule. FUNDING: Ministry of Health, Government of Chile, Confederation of Production and Commerce & Millennium Institute on Immunology and Immunotherapy, Chile. CLINICAL TRIAL NUMBER: NCT04651790

Eco-bio-social determinants for house infestation by non-domiciliated Triatoma dimidiata in the Yucatan peninsula, Mexico

Background Chagas disease is a vector-borne disease of major importance in the Americas. Disease prevention is mostly limited to vector control. Integrated interventions targeting ecological, biological and social determinants of vector-borne diseases are increasingly used for improved control. Methodology/principal findings We investigated key factors associated with transient house infestation by T. dimidiata in rural villages in Yucatan, Mexico, using a mixed modeling approach based on initial null-hypothesis testing followed by multimodel inference and averaging on data from 308 houses from three villages. We found that the presence of dogs, chickens and potential refuges, such as rock piles, in the peridomicile as well as the proximity of houses to vegetation at the periphery of the village and to public light sources are major risk factors for infestation. These factors explain most of the intra-village variations in infestation. Conclusions/significance These results underline a process of infestation distinct from that of domiciliated triatomines and may be used for risk stratification of houses for both vector surveillance and control. Combined integrated vector interventions, informed by an Ecohealth perspective, should aim at targeting several of these factors to effectively reduce infestation and provide sustainable vector control