9 research outputs found
Fatty Acid Profile and Bioactivity from Annona hypoglauca Seeds Oil
- Author
- Publication venue
- 'African Journals Online (AJOL)'
- Publication date
- 28/08/2015
- Field of study
Plants from Annona (Annonaceae) genus are present in tropical regions, where they have economic and medicinal potential. Information on the fatty acids profile and bioactivity from seed oil of Annona species are incipient. The objective of this work was to investigate Annona hypoglauca seeds oil in terms of its yield, composition and biological activity (acetylcholinesterase enzyme inhibition, bactericidal and fungicidal activity). Fatty acids profiles were determined by Gas Chromatography equipped with Flame Ionization Detector. Oil yield reached about 15% and the major constituents detected were ω-9 oleic acid (42.65%) and ω-6 linoleic acid (29.63%). A. hypoglauca oil was potent for acetylcholinesterase inhibition (79.55%), and presented high and selective bioactivity against Candida albicans.Keywords: Annona hypoglauca, ω-9 Oleic Acid, ω-6 Linoleic Acid, Acetylcholinesterase, Candida albican
A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease
- Author
- Adelman
- Anderson
- Bindea
- Brand
- Cosnes
- du Pre MF
- Du Pré
- Fan
- Fu
- Geem
- Green
- Hadjivassiliou
- Heikkilä
- Hindryckx
- Hobeika
- Kaukinen
- Kaukinen
- Kim
- Korpimäki
- Korponay-Szabó
- Kuitunen
- Kurppa
- Kurppa
- Lahdeaho
- Lanzavecchia
- Leffler
- Leffler
- Leffler
- Lohi
- Lähdeaho
- Menon
- Mesin
- Mishima
- Miyagaki
- Mäki
- Mäki
- Mäki
- Nepom
- Newman
- Pabst
- Paparo
- Ribeiro
- Rosser
- Ráki
- Salmi
- Sollid
- Stamnaes
- Taavela
- Thorsby
- Tollefsen
- Tosco
- van Leeuwen
- Vilppula
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background & Aims: Celiac disease (CeD) provides an opportunity to study autoimmunity and the transition in immune cells as dietary gluten induces small intestinal lesions. Methods: Seventy-three celiac disease patients on a long-term, gluten-free diet ingested a known amount of gluten daily for 6 weeks. A peripheral blood sample and intestinal biopsy specimens were taken before and 6 weeks after initiating the gluten challenge. Biopsy results were reported on a continuous numeric scale that measured the villus-heightâtoâcrypt-depth ratio to quantify gluten-induced intestinal injury. Pooled B and T cells were isolated from whole blood, and RNA was analyzed by DNA microarray looking for changes in peripheral B- and T-cell gene expression that correlated with changes in villus height to crypt depth, as patients maintained a relatively healthy intestinal mucosa or deteriorated in the face of a gluten challenge. Results: Gluten-dependent intestinal damage from baseline to 6 weeks varied widely across all patients, ranging from no change to extensive damage. Genes differentially expressed in B cells correlated strongly with the extent of intestinal damage. AÂ relative increase in B-cell gene expression correlated with a lack of sensitivity to gluten whereas their relative decrease correlated with gluten-induced mucosal injury. A core B-cell gene module, representing a subset of B-cell genes analyzed, accounted for the correlation with intestinal injury. Conclusions: Genes comprising the core B-cell module showed a net increase in expression from baseline to 6 weeks in patients with little to no intestinal damage, suggesting that these individuals may have mounted a B-cell immune response to maintain mucosal homeostasis and circumvent inflammation. DNA microarray data were deposited at the GEO repository (accession number: GSE87629; available: https://www.ncbi.nlm.nih.gov/geo/). Keywords: Oral Tolerance, Mucosal Immunity, Autoimmunity, Regulatory B Cel
Déficits de autocuidado em crianças e adolescentes com doença renal crônica
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Thermal decomposition of selected chlorinated hydrocarbons during gas combustion in fluidized bed
- Author
- A Fadli
- AN Hayhurst
- B Higgins
- C Mueller
- CP Fenimore
- DR van der Vaart
- EM Bulewicz
- EM Bulewicz
- EM Bulewicz
- J Baron
- J Baron
- J Baron
- Jerzy Baron
- JF Roesler
- JS Dennis
- L Ribeiro
- LA Sgro
- Malgorzata Olek
- P Gokulakrishnan
- P Pre
- PH Taylor
- PW Atkins
- S Julien
- SC Saxena
- W Ho
- W Vitovec
- W Żukowski
- W Żukowski
- W Żukowski
- WC Gardiner Jr
- WD Chang
- Witold Zukowski
- X Wei
- Y Chi
- YB Zeldovich
- Publication venue
- BMC
- Publication date
- 01/01/2013
- Field of study
<p>Abstract</p> <p>Background</p> <p>The process of thermal decomposition of dichloromethane (DCM) and chlorobenzene (MCB) during the combustion in an inert, bubbling fluidized bed, supported by LPG as auxiliary fuel, have been studied. The concentration profiles of C<sub>6</sub>H<sub>5</sub>CI, CH<sub>2</sub>Cl<sub>2</sub>, CO<sub>2</sub>, CO, NO<sub>x</sub>, COCl<sub>2</sub>, CHCl<sub>3</sub>, CH<sub>3</sub>Cl, C<sub>2</sub>H<sub>2</sub>, C<sub>6</sub>H<sub>6</sub>, CH<sub>4</sub> in the flue gases were specified versus mean bed temperature.</p> <p>Results</p> <p>The role of preheating of gaseous mixture in fluidized bed prior to its ignition inside bubbles was identified as important factor for increase the degree of conversion of DCM and MCB in low bed temperature, in comparison to similar process in the tubular reactor.</p> <p>Conclusions</p> <p>Taking into account possible combustion mechanisms, it was identified that autoignition in bubbles rather than flame propagation between bubbles is needed to achieve complete destruction of DCM and MCB. These condition occurs above 900°C causing the degree of conversion of chlorine compounds of 92-100%.</p
Validade e reprodutibilidade de um questionário para medida de atividade física em adolescentes: uma adaptação do Self-Administered Physical Activity Checklist
- Author
- Adair da Silva Lopes
- Adamo KB
- Allor KM
- Baranowski T
- Bastos JP
- Biddle S
- Bland JM
- Bland JM
- Bouchard C
- Bratteby L-E
- Brown TD
- Byrt T
- Corder K
- Crocker PRE
- Dollman J
- Dumith SC
- Ekelund U
- Farias Júnior JC
- Florindo AA
- Guedes DP
- Guedes DP
- Joanne SH
- Jorge Mota
- José Carlos Ribeiro
- José Cazuza de Farias Júnior
- Landis JR
- Maria Paula Santos
- Monteiro CA
- Nahas MVN
- Patterson P
- Pedro Curi Hallal
- Ridley K
- Sallis JF
- Sallis JF
- Shephard R
- Sirard J
- Weston AT
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Human health risk and potential environmental damage of organic and conventional Nicotiana tobaccum production
- Author
- Adriane Lawisch Rodriguez
- Afubra
- Ahlgren
- Alyaseri
- Ana Letícia Zappe
- Anderson
- Ashmore
- Barosi
- Boettcher
- Bos
- Brentrup
- Budavari
- Butt
- Calvo
- de Oliveira
- Diosnel Antonio Rodriguez Lopez
- Drope
- Foteinis
- Fraval
- Geist
- Gerosa
- Goglio
- Hakala
- Hanserud
- Hasler
- Hauschild
- He
- Hesampour
- Huijbregts
- Hussain
- Hussain
- Jesus
- Lægreid
- Makhlouf
- Manuel Arlindo Amador de Matos
- Mohamad
- Nemecek
- Nikkhah
- Notarnicola
- Oguzcan
- Pierobon
- PRe-Consultants
- Priscila Fernandes de Oliveira
- Pâmela Andréa Mantey dos Santos
- Regina
- Ribeiro
- Ricardo Boettcher
- Ritchie
- Rivera
- Rocchi
- Rosenbaum
- Roy
- Sinditabaco
- Skowronska
- Solli
- Susca
- Taki
- Toffolatti
- Tubiello
- Tuomisto
- Vicente
- WHO
- Wiedmann
- Zafeiridou
- Ênio Leandro Machado
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The impact of Action Schools! BC on the health of Aboriginal children and youth living in rural and remote communities in British Columbia
- Author
- Baranowski T
- Barlow SE
- Bernard L
- Blair SN
- Bélanger M
- Caballero B
- Crocker PRE
- Day ME
- DiPietro L
- Downs SM
- Ebbeling C
- Esliger DW
- Fernández JR
- Field AE
- Foerster S
- Freedson P
- Janssen I
- Jimenez MM
- Katzmarzyk PT
- Kriemler S
- Leger L
- Lohman TG
- Luepker RV
- Macauley AC
- Macdonald H
- Manios Y
- McKenzie TL
- Mitchell M
- Mullenbach V
- National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents
- Naylor PJ
- Naylor PJ
- Naylor PJ
- Nelson M
- Ogden CL
- Ortega FB
- Panagiotopoulos C
- Paradis G
- Reed KE
- Ribeiro JC
- Ritenbaugh C
- Saksvig BI
- Savva SC
- St Leger L
- van Sluijs E
- Vandongen R
- Zorzi A
- Publication venue
- 'Co-Action Publishing'
- Publication date
- Field of study
Delayed colorectal cancer care during covid-19 pandemic (decor-19). Global perspective from an international survey
- Author
- Abary Ryan Rainiel A
- Abdelwahab Khaled M Egypt
- Abellán Antonio M Spain
- Abraham Ned Australia
- Achkasov Sergey I Russia
- Adamina Michel Switzerland
- Adamo Vincenzo Italy
- Agapov Mikhail Russia
- Agarwal Amit USA
- Aguado López Héctor Spain
- Aguilar Werner Chile
- AguilarMartínez María Del Mar AM Spain
- Aguilera Asuncion Spain
- Ahmed Jamil UK
- Aiello Domenico Italy
- Akagi Tomonori Japan
- Akcakaya Adem Turkey
- Akhtar Khalid I Pakistan
- Akiba Ricardo Brazil
- Akrami Majid Iran
- Akyol Cihangir Turkey
- Al-Radjid Jamiri Philippines
- Alaamer Ohood H Saudi Arabia
- Alapati Kishore India
- Alasari Sami Saudi Arabia
- Albastaki Sara UAE
- Albergaria Diogo Portugal
- Alconchel Felipe Spain
- Alerta-Torre Andrea J Philippines
- Alex Ochsner Switzerland
- Alexander Herold Germany
- Alfaro Samuel El Salvador
- Ali Jehangir F Pakistan
- Aliyazicioglu Tolga Turkey
- Almgla Naser South Africa
- Alonsopoza Alfredo Spain
- Alselaim Nahar A Saudi Arabia
- Altaf Kiran K UK
- Althebaity Rasha Saudi Arabia
- Altinel Yuksel Turkey
- Altiparmak Basak Turkey
- Altomare Donato F Italy
- Alvandipour Mina Iran
- Alvarez-Gallego Mario Spain
- Alyami Mohammad Saudi Arabia
- Amado Sandra Portugal
- Amato Antonio Italy
- Amodio Pietro M Italy
- Ana-Maria Mușină Romania
- Andrade Luis Chile
- Andreas Kohler Switzerland
- Angelini Giulio Italy
- Angenete Eva Sweden
- Annicchiarico Alfredo Italy
- Antelo Galarza Renan Bolivia
- Anwer Mariyah Pakistan
- Aparício David J Portugal
- Arciniega Jose A Mexico
- Arenas Mara Belgium
- Arezzo Alberto Italy
- Argenio Giulio Italy
- Arnaud Alves AA France
- Arredondo Jorge Spain
- Arslan Baha Turkey
- Arya Shobhit UK
- Aselmann Heiko Germany
- Aumann Georg Germany
- Avanzolini Andrea Italy
- Avendano Rodolfo Chile
- Awedew Atalel F Ethiopia
- Ayantunde Abraham UK
- Aycan Ilker Turkey
- Aytac Erman Turkey
- Azevedo Constança TM Portugal
- Ba Am Iraq
- Bader Fg Germany
- Baehrle Markus Germany
- Bagaglini Giulia Italy
- Balaban Vladimir Russia
- Balciscueta Izaskun Spain
- Balciscueta Zutoia Spain
- Baldazzi Gianandrea Italy
- Balik Emre Turkey
- Bandolon Robert Philippines
- Barberis Andrea Italy
- Barisic Goran I Serbia
- Barrera Alejandro Chile
- Barros Inês MSF Portugal
- Basaran Betul Turkey
- Basilio Pedro C Brazil
- Bech Flemming Denmark
- Behboo Roubik Iran
- Behboudi Behnam Iran
- Beitia Ivan E Panama
- Bellato Vittoria Italy
- Bellolio Felipe Chile
- Benli Sami Turkey
- Bernal Jc Spain
- Bernante Paolo Italy
- Berrospi Francisco E Peru
- Bertelson Noelle USA
- Bevan Katharine UK
- Bhama Anuradha USA
- Bianco Francesco Italy
- Bievel Radulescu Raluca Romania
- Bintraiki Thamer Saudi Arabia
- Bisgin Tayfun Turkey
- Bislenghi Gabriele Belgium
- Blaslaina Juanluis Spain
- Bloom Itm UK
- Boehm Gabriele Germany
- Bogoni Selene Italy
- Bohlooli Mehrdad Iran
- Bondurri Andrea Italy
- Boni Luigi Italy
- Bonomi Alessandro Michele Italy
- Booning Nitikun Thailand
- Boonpipattanapong Teeranut Thailand
- Bordeianou Liliana USA
- Bossard Kerrie USA
- Botelho Maria Portugal
- Boto Carlos Portugal
- Bottini Corrado Italy
- Bouchagier Konstantinos Greece
- Boutall Adam South Africa
- Bowers Dan USA
- Bozbiyik Osman Turkey
- Brambilla Eduardo Brazil
- Brisinda Giuseppe Italy
- Brizzi Maria Pia Italy
- Brizzolari Marco Italy
- Brusciano Luigi Italy
- Bucci Luigi Italy
- Buchwald Pam Sweden
- Bugra Dursun Turkey
- Bui Andrew Australia
- Buldanlı Mehmet Zeki Turkey
- Bulut Orhan Denmark
- Cagigas Fernandez Carmen Spain
- Cai Yuankun China
- Calcerrada Alises Enrique Spain
- Caldes Pedro Portugal
- Calussi Marco Italy
- Calvo Espino Pablo Spain
- Campanelli Michela Italy
- Campbell Ken UK
- Campennì Paola Italy
- Canda Arasemre Turkey
- Capolupo Gabriella T Italy
- Caravana Jorge Portugal
- Carballo Federico HE Argentina
- Carbone Fabio Italy
- Carcamo Leonardo C Chile
- Cardoso Paulo Portugal
- Cariati Maria Italy
- Caricato Marco Italy
- Carmona Maria Spain
- Carpelan Holmstrom Monika Finland
- Carrino Francesco Italy
- Carrié Augusto J Argentina
- Cartucho Daniel DF Portugal
- Carvalho Marcia Portugal
- Carvas João M Portugal
- Casagranda Biagio Italy
- Casimiro Carlos Portugal
- Castro Anyely Dominican Republic
- Catiwala-An Michael T Philippines
- Caushaj Philip F USA
- Cavallo Debora Italy
- Cedermas Mariela Argentina
- Celayir Fevzi Turkey
- Celentano Valerio UK
- Cengiz Fevzi Turkey
- Chaisomboon Nopdanai Thailand
- Chenghua Luo China
- Cherepenin Mikhail Russia
- Chessa Antonella Italy
- Chierici Andrea France
- Chile
- Chok Aikyong Singapore
- Chouliaras Christos Greece
- Chowchankit Irin Thailand
- Christou Niki France
- Chun Hokyung South Korea
- Cillara Nicola Italy
- Cinza Margarida Portugal
- Cione Gianpiero Italy
- Cipe Gokhan Turkey
- Ciprian Duta Romania
- Cirocco William USA
- Citgez Bulent Turkey
- Clark Jill E USA
- Clementi Ilaria IC Italy
- Clerc Daniel Switzerland
- Clermonts Journal Pre-proof 39 Stefan HEM Netherlands
- Cobellis Luigi Italy
- Colak Tahsin Turkey
- Colao Garcia Laura Spain
- Colombo Francesco Italy
- Comba Andrea Italy
- Coret Franco Alba CFA Spain
- Correa Bonito Alba Spain
- Cosman Bard USA
- Costa Marta RP Portugal
- Costa Pereira Joaquim Portugal
- Costa Susana GS Portugal
- Cravero Francesca Italy
- Creavin Ben Ireland
- Cross Katie LR UK
- Cruz Arturo Spain
- Cui Junhui China
- Cunha Miguel F Portugal
- Curado Antonio Portugal
- Cózar Lozano Coral Spain
- D'Ugo Stefano Italy
- Dajti Irida Albania
- Dal Monte Giorgio Italy
- Dalessandro Antonio France
- Danelli Piergiorgio Italy
- Daniels Ian R UK
- Dar Asif M India
- Davies Richard J UK
- De Andrés Beatriz Spain
- De Angelis Marsilio Italy
- De Falco Nadia Italy
- De Luca Maurizio Italy
- De Luca Raffaele Italy
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- De Nardi Paola Italy
- De Rosa Michele Italy
- De Santis Mariangela France
- De Silva Kaluthanthiri Patabanadi VR Sri Lanka
- De Simone Veronica Italy
- De Wilt Johannes HW Netherlands
- De-León-Rendón Jorge Luis Mexico
- Dean Phillip USA
- Deangelis Nicola France
- Dedemadi Georgia Greece
- Del Rio Paolo Italy
- Delgadillo Edgar Switzerland
- Delgadillo Xavier Switzerland
- Delibegovic Samir Bosnia and Herzegovina
- Delis S Greece
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- Demey Karel Belgium
- Demirli Atıcı Semra Turkey
- Denoya Paula I USA
- Derebey Murat Turkey
- Devezas Vítor BS Portugal
- Dhaif Ali Bahrain
- Di Candido Francesca Italy
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- Diaconescu Bogdan Romania
- Die Javier Spain
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- Dieter Hahnloser Switzerland
- Diez Alonso Manuel Spain
- Dimaren Ishmael Philippines
- Disimone Massimo Italy
- Doerner Johannes Germany
- Domingos Hugo VG Portugal
- Dominguez Rubén RD Paraguay
- Dorenbusch Michael USA
- Doulias Triantafyllos A UK
- Duff Sarah UK
- Dulskas Audrius Lithuania
- Dunn Gary USA
- Duque-Mallén Victoria Spain
- Dusek Tomas Czech Republic
- Dusitanond Navara Thailand
- Dworkin Michael United Kingdom
- Dybau Aleh Belarus
- Dziakova Jana Spain
- Dziki Adam Poland
- Dziki Lukasz Poland
- Dzulkarnaen Zakaria Andee Malaysia
- D’Elia Antonio Italy
- Efetov Sergey K Russia
- Eisa Mohamed Egypt
- Eisenstat Ted USA
- El Sorogy Mohamed Egypt
- El-Hussuna Alaa Denmark
- Elfeki Hossam Egypt
- Elhussuna Alaa Denmark
- Eliasrabelo Fernanda Brazil
- Ellis Tyler USA
- Elzalabany Tamer Egypt
- Emile Sameh H Egypt
- Emiroglu Mustafa Turkey
- Emmanuel Odet France
- Enomoto Masanobu Japan
- Epifani Angelo Gabriele Italy
- Erenler Ilknur Turkey
- Erkan Arman USA
- Erol Timuçin Turkey
- Erturk Suphan Turkey
- Escalante Ricardo Venezuela
- Escartin Jorg Spain
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- Espin-Basany Eloy Spain
- Estaire-Gomez Mercedes Spain
- Falaschi Federica Italy
- Falken Ylva Sweden
- Fantini Corrado Italy
- Fantozzi Mauricio Argentina
- Farid Asim USA
- Farina Pablo Argentina
- Farmer Martin UK
- Farmer Russ USA
- Faul Eleanor M Ireland
- Favara Andrea Italy
- Febra Pedro Portugal
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- Fermani Claudio Argentina
- Fernandes Fábio FN Portugal
- Fernandes Miguel Portugal
- Ferracci Federica Italy
- Ferrara Francesco Italy
- Ferrari Giovanni Italy
- Ferrario Luca Italy
- Ferreira Carlos Portugal
- Ferreira Rita Portugal
- Ferris Jeff USA
- Ferronetti Antonio Italy
- Fialho Guilherme L Portugal
- Fichera Alessandro USA
- Figueiredo Odete Portugal
- Filipe Vieira Pedro JG Portugal
- Fiore Felicia Italy
- Folliero Cristina Italy
- Folstad Torbjorn Norway
- Forerotorres Alexander Spain
- Forgan Timothy R South Africa
- Franceschilli Marzia Italy
- Frizelle Frank New Zealand
- Froehner Junior Ilario Brazil
- Frois Miguel Portugal
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- Fu Chuangang China
- Fulginiti Serena Italy
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- Gallagher Hugh J UK
- Gallardo Cristian Chile
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- Gama Barbara Portugal
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- Garcia Walter Argentina
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- García Sánchez Felipe Spain
- Garmanova Tatiana N Russia
- Garofalo Thomas USA
- Garoufalia Zoe Greece
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- Ghignone Federico Italy
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- Gianfrancisco James A USA
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- Guerra Daniel Mexico
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- Gurjar Shashank UK
- Hainsworth Alison J UK
- Hall Nigel UK
- Hamed Hosam H Egypt
- Hammer Clare UK
- Hannon Rob Ireland
- Harmston Christopher New Zealand
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- Hartendorp Paul USA
- Hassan Imran USA
- Hassan Iyad UAE
- Hawkins Alexander T USA
- Hayssen Theresa USA
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- Hul Rene Netherlands
- Hunt Louise E UK
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- Italy
- Italy
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- Journal Pre-proof 42 Selemane Carlos Mozambique
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- Juwid Abdallah E Libya
- Kanjanasilp Prapon Thailand
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- Kazachenko Ekaterina A Russia
- Kazemi Nava Andrea Italy
- Kelkar Ashish UK
- Kelly Michael E Ireland
- Keramati Mohammad Reza Iran
- Kerawala Asad Pakistan
- Khalil Mohammad I Bangladesh
- Khan Jim S UK
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- Khitaryan Alexander Russia
- Kinjo Tatsuya Japan
- Kirilova Tanya N Bulgaria
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- Knapp Jens Norway
- Koc Mehmet A Turkey
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- Konishi Tsuyoshi Japan
- Konstantoudakis Georgios Cyprus
- Konsten Joop Netherlands
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- Krdzic Igor D
- Krivokapic Zoran Serbia
- Kumar Sandip Malaysia
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- Kushtrim Shala Germany
- Kynaston James UK
- Kørner Hartwig
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- Lal Roshan UK
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- Langmayr Johannes Austria
- Langone Antonio Italy
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- Leao Pedro Portugal
- Lee Pamela C USA
- Lee Suk-Hwan South Korea
- Lee Wooyong South Korea
- Lefevre Jeremie H France
- Leite Julio Portugal
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- Lemma Maria Italy
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- Lenna Giovanni Italy
- Leo Cosimo Alex UK
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- Lienert Mark Germany
- Lima Sergio Brazil
- Limbert Manuel CSB Portugal
- Lisi Giorgio Italy
- Litta Francesco Italy
- Littaua Dennis Philippines
- Liu Fanlong China
- Liyanage Chris New Zealand
- Llovera Antony Cuba
- Lo Dico Rea France
- Lo Oswens China
- Lobascio Pierluigi Italy
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- Lorber Julie USA
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- Madbouly Khaled Egypt
- Madhoun Nisreen
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- Magbojos Christian Raymond S Philippines
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- Makhoul Rami USA
- Mallmann Karen DP Brazil
- Manatakis Dimitrios K Greece
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- Manfredelli Simone France
- Mangione John USA
- Manso Antonio Portugal
- Marakutsa Eugen V Moldova
- Marano Alessandra Italy
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- Marfan Michael Australia
- Marianelli Raphael Brazil
- Mariani Nicolò M Italy
- Marimuthu Kalimuthu UK
- Marinello Franco Spain
- Marinis Athanasios Greece
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- Markides Georgios Cyprus
- Marquez Lucila Spain
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- Martin-Martin Gonzalo P Spain
- Martinez Javier Spain
- Martinez-Iglesias Marta A UK
- Martins Ana RG Portugal
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- Mascali Davide DM Italy
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- Maun Dipen USA
- Maurus Christine F Switzerland
- McCormick Jim USA
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- McKinley Aileen UK
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- Mellgren Anders
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- Zucchella Martino Italy
- Zuhdy Mohammad
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background
The widespread nature of coronavirus disease 2019 (COVID-19) has been unprecedented. We sought to analyze its global impact with a survey on colorectal cancer (CRC) care during the pandemic.
Methods
The impact of COVID-19 on preoperative assessment, elective surgery, and postoperative management of CRC patients was explored by a 35-item survey, which was distributed worldwide to members of surgical societies with an interest in CRC care. Respondents were divided into two comparator groups: 1) ‘delay’ group: CRC care affected by the pandemic; 2) ‘no delay’ group: unaltered CRC practice.
Results
A total of 1,051 respondents from 84 countries completed the survey. No substantial differences in demographics were found between the ‘delay’ (745, 70.9%) and ‘no delay’ (306, 29.1%) groups. Suspension of multidisciplinary team meetings, staff members quarantined or relocated to COVID-19 units, units fully dedicated to COVID-19 care, personal protective equipment not readily available were factors significantly associated to delays in endoscopy, radiology, surgery, histopathology and prolonged chemoradiation therapy-to-surgery intervals. In the ‘delay’ group, 48.9% of respondents reported a change in the initial surgical plan and 26.3% reported a shift from elective to urgent operations. Recovery of CRC care was associated with the status of the outbreak. Practicing in COVID-free units, no change in operative slots and staff members not relocated to COVID-19 units were statistically associated with unaltered CRC care in the ‘no delay’ group, while the geographical distribution was not.
Conclusions
Global changes in diagnostic and therapeutic CRC practices were evident. Changes were associated with differences in health-care delivery systems, hospital’s preparedness, resources availability, and local COVID-19 prevalence rather than geographical factors. Strategic planning is required to optimize CRC care
Cardiovascular Activity
- Author
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- Wienen W Hauel N, van Meel JCA, Narr B, Ries U, Entzeroth M (1993) Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. Br J Pharmacol 110:245–252 Wong PC, Quan ML, Saye JAM, Bernard R, Crain EJ Jr, Nc- Call DE, Watson CA, Zaspel AM, Smith RD, Wexler RR, Timmermans PBMWM, Chiu AT
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study