Pantoprazole-related Symptomatic Hyponatremia

Hyponatremia is the most common electrolyte balance disorder, especially in the elderly and polymedicated population. The authors report the case of an 83-year-old man with symptomatic severe hyponatremia due to Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) related to pantoprazole. Pantoprazole was discontinued and serum sodium levels reached normal values in two months. To the authors’ knowledge, this is the second reported case of pantoprazole-related hyponatremia and, while most patients with hyponatremia related to proton pump inhibitors have mild symptoms, this patient had severe manifestations

Eucalyptus citriodora and Azadirachta indica oil activity in the control of Colletotrichum acutatum, in strawberry crop

A flor-preta é uma das doenças mais importantes do morangueiro e a busca por alternativas de controle tem sido uma constante, principalmente em áreas de cultivo orgânico. Assim, objetivou-se avaliar a eficiência, in vitro e in vivo, dos óleos de Eucalyptus citriodora e Azadirachta indica no controle de Colletotrichum acutatum em morangueiro. No experimento in vitro determinou-se a inibição do crescimento micelial quando o fungo foi submetido aos extratos nas concentrações de 0; 0,25; 0,5; 1,0 e 1,5%. No campo, avaliou-se o controle da doença com a aplicação dos óleos nas concentrações de 0, 0,5 e 1,0%, pulverizados em intervalos de 7, 15 e 30 dias, em plantas inoculadas com suspensão de 10(6) conídios/mL. As avaliações foram realizadas semanalmente, observando-se a ocorrência e tamanho de lesões no pedúnculo e nos frutos, abortamento floral, produtividade, e ocorrência natural da doença. In vitro todos os tratamentos apresentaram redução significativa do crescimento micelial do fungo quando comparados ao controle. No campo, apenas o óleo de nim apresentou efeito significativo, reduzindo o abortamento floral e a ocorrência de frutos doentes advindos de flores inoculadas. Porém, maior ocorrência natural de doença foi observada quando a dosagem de 1,0% foi aplicada semanalmente.Anthracnose is one of the most important diseases in strawberry crop, and the search for control alternatives has been frequent, especially in organic cultivation areas. Thus, the present study aimed to evaluate the in vitro and in vivo efficiency of Eucaliptus citriodora and Azadirachta indica oil on the control of Colletotrichum acutatum in strawberry. In the in vitro experiment, mycelial growth inhibition was determined when the fungus was subjected to extracts at the following concentrations: 0; 0.25; 0.5; 1.0; and 1.5%. In the field, the disease control was evaluated through oil spraying at 0, 0.5 and 1.0% concentrations at intervals of seven, fifteen and thirty days, in plants inoculated with 10(6) conidia/mL suspension. Evaluations were weekly performed, and parameters such as occurrences and size of lesions in the peduncle and in the fruits, flower abortion, productivity, and natural disease occurrences were observed. In vitro, all treatments showed significant reduction in the mycelial growth relative to control. In the field, only neem oil had a significant effect decreasing flower abortion and the occurrences of sick fruits originated from inoculated flowers. However, natural disease occurrence was higher when 1.0% was weekly sprayed

Etiologia do estridor laríngeo congênito no recém-nascido: uma revisão integrativa / Etiology of congenital laryngeal stridor in the newborn: an integrative review

Diversas são as causas de estridor na infância. A revisão integrativa realizada buscou identificar as principais etiologias do estridor laríngeo no recém-nascido de forma científica. A laringomalácia foi a etiologia mais prevalente encontrada. Foi possível constatar a importância do exame endoscópico em crianças que apresentam estridor. Também foi plausível perceber a escassez de estudos recentes e dados sobre o tema

Transthyretin Amyloidosis: Chaperone Concentration Changes and Increased Proteolysis in the Pathway to Disease

Transthyretin amyloidosis is a conformational pathology characterized by the extracellular formation of amyloid deposits and the progressive impairment of the peripheral nervous system. Point mutations in this tetrameric plasma protein decrease its stability and are linked to disease onset and progression. Since non-mutated transthyretin also forms amyloid in systemic senile amyloidosis and some mutation bearers are asymptomatic throughout their lives, non-genetic factors must also be involved in transthyretin amyloidosis. We discovered, using a differential proteomics approach, that extracellular chaperones such as fibrinogen, clusterin, haptoglobin, alpha-1-anti-trypsin and 2-macroglobulin are overrepresented in transthyretin amyloidosis. Our data shows that a complex network of extracellular chaperones are over represented in human plasma and we speculate that they act synergistically to cope with amyloid prone proteins. Proteostasis may thus be as important as point mutations in transthyretin amyloidosis

Gastric and Peritoneal Involvement of Human Herpes Virus 8 Related Kaposi Sarcoma in a Patient with Acquired Immunodeficiency Syndrome

Kaposi's sarcoma (KS) is one of the most frequent neoplastic diseases in patients infected with human immunodeficiency virus (HIV). The authors report the case of a 40-year-old male with ascites, peripheral edema and peritoneal carcinomatosis secondary to a gastric KS related to human herpes virus type 8 (HHV-8). The patient had severe immunodeficiency, with a TCD4+ count of 86 cells/µl and newly diagnosed acquired immunodeficiency syndrome. His clinical condition rapidly deteriorated, with multiorgan failure, and he died without the possibility of initiating antiretroviral therapy or chemotherapy. To the authors’ knowledge, carcinomatosis is a rare feature in KS

Produção de vídeo aulas como ferramenta educacional no processo de ensino e aprendizagem de física no ensino médio

Atualmente no ensino médio, a Física é vista por muitos alunos como uma disciplina de difícil acesso e pouco atraente. Sem apoio do professor, a relação entre a disciplina de física e o aluno pode se tornar obsoleta, gerando assim, dificuldades no processo de ensino e de aprendizagem, fazendo com que a física não seja compreendida em sua totalidade. Outro fator que pode influenciar nesse cenário, é o fato de que algumas vezes, as metodologias usadas para o ensino de Física não são inovadoras, predominando um ensino descontextualizado e sem significado para o aluno. Este trabalho traz como suporte a teoria da aprendizagem significativa, que foi enunciada inicialmente pelo psicólogo e pesquisador norte americano David Paul Ausubel (1918-2008). Essa teoria é baseada em uma abordagem cognitivista da construção do conhecimento, onde resulta no armazenamento organizado de informações na mente daquele que aprende. De acordo com David Ausubel (apud MOREIRA, 2006, p. 14), “É um processo pelo qual uma nova informação se relaciona, de maneira substantiva (não literal) e não arbitrária, a um aspecto relevante da estrutura cognitiva do indivíduo”, ou seja, se a intenção do professor é ensinar de maneira significativamente, é necessário que o mesmo avalie aquilo que o aluno já sabe e então ensinar conforme com esses conhecimentos. Neste sentido, as possibilidades da produção e uso do vídeo em sala de aula proporcionam a inovação no processo ensino e aprendizagem, pois o vídeo pode estimular a construção do conhecimento de forma ativa, atrativa, criativa e significativa. Dessa forma, o professor pode proporcionar ao aluno uma aprendizagem mais significativa e próxima ao seu cotidiano, além de permitir que ele saia do papel de ouvinte, tornando-se o principal agente na formação do próprio conhecimento e apto a sugerir soluções e condições que proporcionem a própria aprendizagem

Peixes

Os peixes sao organismos aquaticos que associamosde imediato aos rios, mas sobre os quais existe aindamuito desconhecimento. Neste capitulo damos a conhecer asespecies que existem em Portugal, como estao distribuidasno nosso territorio, que fatores ambientais determinam a suaocorrencia, que comportamentos exibem, que ameacas pairamsobre as suas populacoes, ou como podem ser utilizadoscomo sentinelas para monitorizar o estado ecologico dos rios.Sao ainda descritas as principais caracteristicas dos habitatsdulciaquicolas portugueses e das associacoes piscicolas que neles ocorrem, e discutidos quais os principais fatores ambientaisque terao contribuido para a distribuicao das especiesno nosso territorio. Face as pressoes de natureza antropica aque estao sujeitos, e dado destaque aos principais fatores deameaca a conservacao dos peixes dulciaquicolas e migradores,e as medidas de mitigacao mais adequadas a sua proteção

Fish larval performance fed with copepods (Acartia grani) and the dinoflagellate (Oxyrrhis marina) as supplement: the case of dusky grouper (Epinephelus marginatus)

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Electrodialytic recovery of rare earth elements from coal ashes

Fundação para a Ciência e a Tecnologia, I.P., Portugal, UIDB/04085/2020 (Research unit CENSE “Center for Environmental and Sustainability Research”). Fundação para a Ciência e a Tecnologia is also acknowledged for N. Couto Contract established under Individual Call to Scientific Employment Stimulus (CEECIND/04210/2017).Rare earth elements (REE) are critical raw materials crucial for modern technologies and used in a variety of industries. There is a need of investment in REE recovery from secondary sources. The present work was designed to assess the potential of the electrodialytic process to recover REE from coal ash. The content of REE was evaluated in bituminous and anthracite ash. Anthracite presented higher REE concentration (447 ppm vs. 138 ppm) and a triple concentration of critical REE compared with bituminous ash. Anthracite ash was treated aiming to test the REE recover potential, including differences between light REE (LREE) and heavy REE (HREE) fractions as well as the specific recovery of REE with high criticality. A two-compartment electrodialytic cell was tested with the matrix placed in the anode compartment and a cation-exchange membrane separating the compartments. Experiments lasted a maximum of 7 days applying different current intensities and pH adjustment in the catholyte (≈ 2). Three main steps are observed in the removal process 1) REE solubilization - from the solid to the liquid phase (anolyte); 2) REE mobilization - movement from the anolyte towards the cathode end; 3) REE removal - presence in the catholyte. The extent of each step observed for the REE depends on their individual position in the periodic table with HREE removal being more regulated by step 1 and LREE by step 2. At the best tested conditions (50 mA, 3 days, pH adjustment), more than 70% of REE were extracted from the ash with the catholyte enclosing up to ≈ 50% of LREE and HREE. Combining the high criticality of neodymium with its high concentration in anthracite coal ash (65 ppm), the electrodialytic treatment is highly recommended to concentrate this REE in the catholyte. The results demonstrated the proof-of-concept for electro-assisted extraction of REE from anthracite coal ash, opening perspectives to a selective recovery of these elements from secondary sources.authorsversionpublishe

Assessment of combined electro–nanoremediation of molinate contaminated soil

Molinate is a pesticide widely used, both in space and time, for weed control in rice paddies. Due to its water solubility and affinity to organic matter, it is a contaminant of concern in ground and surface waters, soils and sediments. Previous works have showed that molinate can be removed from soils through electrokinetic (EK) remediation. In this work, molinate degradation by zero valent iron nanoparticles (nZVI) was tested in soils for the first time. Soil is a highly complex matrix, and pollutant partitioning between soil and water and its degradation rates in different matrices is quite challenging. A system combining nZVI and EK was also set up in order to study the nanoparticles and molinate transport, as well as molinate degradation. Results showed that molinate could be degraded by nZVI in soils, even though the process is more time demanding and degradation percentages are lower than in an aqueous solution. This shows the importance of testing contaminant degradation, not only in aqueous solutions, but also in the soil-sorbed fraction. It was also found that soil type was the most significant factor influencing iron and molinate transport. The main advantage of the simultaneous use of both methods is the molinate degradation instead of its accumulation in the catholyte.info:eu-repo/semantics/publishedVersio