Nur etwas im Auge: 35 Tage Sport

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Followership styles scrutinized: temporal consistency and relationships with job attitudes and self-efficacy

While followership has been repeatedly acknowledged as an important part of leadership, key questions are still awaiting empirical testing. In our two studies, we test Kelley’s prominent concept of followership styles for the first time in a longitudinal design. Specifically, we use a latent-state trait approach to examine the degree to which followership behaviors (i.e., active engagement [AE] and independent, critical thinking [ICT]) reflect rather stable or rather dynamic behaviors. Furthermore, we examine the relationships of followership behaviors with job attitudes (i.e., job satisfaction and organizational commitment) and self-efficacy in latent states cross-lagged models. We first test our hypotheses in a sample of N = 184 employees from eleven German service organizations, which were surveyed twice with a time lag of nine to 12 months. To replicate and extend our findings from Study 1, we conducted Study 2 with a sample of N = 570 participants from a German open-access panel, which were surveyed twice with a time lag of four months. In Study 2, we additionally test leader humility and perceived organizational support (POS) as potential moderators of the relationships between followership and job attitudes. While our findings support Kelley’s conceptualization of followership styles as rather consistent behavior patterns, mixed results were found for the relationships with the other variables. We discuss the theoretical and practical implications of our findings as well as the relevance of time in followership research

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Toxic DrivingAmerican Photography and the "Oil Epiphany"

The essay explores the American road trip as a central element of photography's history. It investigates the close connection between driving and camera work – and particularly the artistic and personal enthusiasm produced by this combination. Canonical photographic oeuvres of the twentieth century have emerged from extensive driving. Dorothea Lange, Walker Evans, the Bechers, and others come to mind. Based on these examples and observations, the essay opens ecocritical perspectives on the Age of the Automobile. These readings emphasize the toxic nature of car travel and processes of standardization that complicate the legends of the road. Photographer Edward Burtynsky's twenty-first century mediations on the "oil epiphany" prove particularly interesting in this context. As this essays shows, however, the relationship between photography and the automobile was transformed much earlier. 1970s artists such as Stephen Shore and Ed Ruscha and the exhibition New Topographics developed new interpretations of mobility and more nuanced versions of the Great American Road Trip, concepts more concerned with the act of standing still