Molecular cloning of the human rad gene: gene structure and complete nucleotide sequence

AbstractWe have isolated and sequenced human genomic DNA clones encoding the Ras-related GTP-binding protein, Rad. The gene spans 3.75 kb and consists of five exons and four introns. Translation initiates from the first of two in-frame methionine residues in the second exon. Several potential transcription cis-elements were revealed throughout the 1.7 kb 5′-flanking region, including ‘E box’ and CArG binding sites for regulators of transcription in muscle

ESS Spoke Cryomodule and Test Valve Box

International audienceESS project aims being the world’s most powerful neutron source feeding multidisplinary researches. The superconducting part of the ESS linear accelerator includes 28 b=0.5 352.2 MHz SRF niobium double Spoke cavities. Paired in 13 cryomodules and held at 2K in a saturated helium bath those cavities will generate of an accelerating field of 9MV/m. The prototype Spoke cryomodule holds two cavities and their RF power couplers and integrates all the interfaces necessary to be operational within the linac machine. It is now being fabricated and its assembly will be performed with dedicated tooling and procedures in and out of the clean room. This prototype will be tested by the end of 2015 at IPNO site and then at full power at FREIA (Uppsala university) test stand. A valve box has thus been designed to take into account the specific features of this prototype cryomodule and of the cryogenic environments of both test sites. This valve box is also considered as a prototype of the cryogenic distribution of the linac Spoke section. This element will then be used for the tests of the series cryomodules. We propose to present this prototype Spoke cryomodule for ESS and the test valve box

ESS SRF Linear Accelerator Components Preliminary Results and Integration

International audienceThe European Spallation Source (ESS) is a pan-European project and one of world's largest research infrastructures based on neutron sources. This collaborative project is funded by a collaboration of 17 European countries and is under construction in Lund, Sweden. The 5 MW, 2.86 ms long pulse proton accelerator has a repetition frequency of 14 Hz (4 % duty cycle), and a beam current of 62.5 mA. The Superconducting Radio-Frequency (SRF) linac is composed of three families of Superconducting Radio-Frequency (SRF) cavities, which are being prototyped, counting the spoke resonators with a geometric beta of 0.5, medium-beta elliptical cavities (beta_{g}=0.67) and high-beta elliptical cavities (beta_{g}=0.86). After a description of the ESS linear accelerator layout, this article will focus on the recent progress towards integration of the first test results of the main critical components to be assembled in cryomodules, then in the ESS tunnel

The Superconducting Radio-Frequency Linear Accelerator Components for the European Spallation Source: First Test Results

International audienceThe European Spallation Source requires a pulsed Linac with an average beam power on the target of 5MW which is about five times higher than the most powerful spallation source in operation today. Over 97% of the acceleration occurs in superconducting cavities. ESS will be the first accelerator to employ double spoke cavities to accelerate beam. Accelerating gradients of 9MV/meter is required in the spoke section. The spoke section will be followed by 36 elliptical 704 MHz cavities with a geometrical beta of 0.67 and elliptical 704 MHz cavities with a geometrical beta of 0.86. Accelerating gradients of 20MV/m is required in the elliptical section. Initial gradient test results will be presented in which results exceed expected requirements