397 research outputs found
Edificio de archivos en Los Angeles
The 80th birthday of Richard Neutra coincides with the completion of this building, a special feature of which is that it has 13 half-floor levels, thus saving space and making it easier to reach the documents.
Besides housing the Territorial Archives Office, it accommodates the Territorial Testing Dept., Regional Planning Committee and Territorial Library.
40 ms high rotary sun shields are fitted, made of aluminium. They are controlled automatically by electronic devices, motivated by the solar action, and are thus correctly orientated at any time to provide protection against sun glare. They close altogether when the wind speed is such that they might be damaged.
On the main facade looking towards Temple Street, the plastic arts organisation has contributed a large mosaic by Joseph Young, showing a map of the district.
This archives building in Los Angeles is a fine exponent of what technology can do for man, and it is a characteristic example of contemporary organic architecture at its best.El principio de la octava década de Neutra coincide con la terminación del edificio, cuya sección nos ofrece trece medias plantas, para economizar espacio y facilitar el alcance de los documentos. Aloja, además de la Oficina Territorial de Archivos, otras varias: Departamento Territorial de Pruebas, Comisión de Planificación Regional y Biblioteca Territorial. Unos «brise-soleils» giratorios, de aluminio, de 40 m de altura, que funcionan automáticamente —controlados por un cerebro electrónico— bajo la acción solar, proporcionan la orientación «adecuada» en cada momento y protegen del brillo lateral, cerrándose cuando el viento sopla con una velocidad que puede serles perjudicial. Como aportación de las Artes Plásticas aparece en la fachada principal, que da a la calle Temple, un gran mosaico, de Joseph Young, del mapa del territorio. Este edificio de archivos en Los Angeles constituye un claro exponente en el que la, técnica está puesta al servicio del hombre, y un ejemplo característico de arquitectura orgánica
Cost-effectiveness analysis of 3-D computerized tomography colonography versus optical colonoscopy for imaging symptomatic gastroenterology patients.
BACKGROUND: When symptomatic gastroenterology patients have an indication for colonic imaging, clinicians have a choice between optical colonoscopy (OC) and computerized tomography colonography with three-dimensional reconstruction (3-D CTC). 3-D CTC provides a minimally invasive and rapid evaluation of the entire colon, and it can be an efficient modality for diagnosing symptoms. It allows for a more targeted use of OC, which is associated with a higher risk of major adverse events and higher procedural costs. A case can be made for 3-D CTC as a primary test for colonic imaging followed if necessary by targeted therapeutic OC; however, the relative long-term costs and benefits of introducing 3-D CTC as a first-line investigation are unknown. AIM: The aim of this study was to assess the cost effectiveness of 3-D CTC versus OC for colonic imaging of symptomatic gastroenterology patients in the UK NHS. METHODS: We used a Markov model to follow a cohort of 100,000 symptomatic gastroenterology patients, aged 50 years or older, and estimate the expected lifetime outcomes, life years (LYs) and quality-adjusted life years (QALYs), and costs (£, 2010-2011) associated with 3-D CTC and OC. Sensitivity analyses were performed to assess the robustness of the base-case cost-effectiveness results to variation in input parameters and methodological assumptions. RESULTS: 3D-CTC provided a similar number of LYs (7.737 vs 7.739) and QALYs (7.013 vs 7.018) per individual compared with OC, and it was associated with substantially lower mean costs per patient (£467 vs £583), leading to a positive incremental net benefit. After accounting for the overall uncertainty, the probability of 3-D CTC being cost effective was around 60 %, at typical willingness-to-pay values of £20,000-£30,000 per QALY gained. CONCLUSION: 3-D CTC is a cost-saving and cost-effective option for colonic imaging of symptomatic gastroenterology patients compared with OC
Phenoscape: Identifying Candidate Genes for Evolutionary Phenotypes
Phenotypes resulting from mutations in genetic model organisms can help reveal candidate genes for evolutionarily important phenotypic changes in related taxa. Although testing candidate gene hypotheses experimentally in nonmodel organisms is typically difficult, ontology-driven information systems can help generate testable hypotheses about developmental processes in experimentally tractable organisms. Here, we tested candidate gene hypotheses suggested by expert use of the Phenoscape Knowledgebase, specifically looking for genes that are candidates responsible for evolutionarily interesting phenotypes in the ostariophysan fishes that bear resemblance to mutant phenotypes in zebrafish. For this, we searched ZFIN for genetic perturbations that result in either loss of basihyal element or loss of scales phenotypes, because these are the ancestral phenotypes observed in catfishes (Siluriformes). We tested the identified candidate genes by examining their endogenous expression patterns in the channel catfish, Ictalurus punctatus. The experimental results were consistent with the hypotheses that these features evolved through disruption in developmental pathways at, or upstream of, brpf1 and eda/edar for the ancestral losses of basihyal element and scales, respectively. These results demonstrate that ontological annotations of the phenotypic effects of genetic alterations in model organisms, when aggregated within a knowledgebase, can be used effectively to generate testable, and useful, hypotheses about evolutionary changes in morphology
A Comprehensive Spectroscopic Analysis of DB White Dwarfs
We present a detailed analysis of 108 helium-line (DB) white dwarfs based on
model atmosphere fits to high signal-to-noise optical spectroscopy. We derive a
mean mass of 0.67 Mo for our sample, with a dispersion of only 0.09 Mo. White
dwarfs also showing hydrogen lines, the DBA stars, comprise 44% of our sample,
and their mass distribution appears similar to that of DB stars. As in our
previous investigation, we find no evidence for the existence of low-mass (M <
0.5 Mo) DB white dwarfs. We derive a luminosity function based on a subset of
DB white dwarfs identified in the Palomar-Green survey. We show that 20% of all
white dwarfs in the temperature range of interest are DB stars, although the
fraction drops to half this value above Teff ~ 20,000 K. We also show that the
persistence of DB stars with no hydrogen features at low temperatures is
difficult to reconcile with a scenario involving accretion from the
interstellar medium, often invoked to account for the observed hydrogen
abundances in DBA stars. We present evidence for the existence of two different
evolutionary channels that produce DB white dwarfs: the standard model where DA
stars are transformed into DB stars through the convective dilution of a thin
hydrogen layer, and a second channel where DB stars retain a helium-atmosphere
throughout their evolution. We finally demonstrate that the instability strip
of pulsating V777 Her white dwarfs contains no nonvariables, if the hydrogen
content of these stars is properly accounted for.Comment: 74 pages including 30 figures, accepted for publication in the
Astrophysical Journa
A Bright Submillimeter Source in the Bullet Cluster (1E0657--56) Field Detected with BLAST
We present the 250, 350, and 500 micron detection of bright submillimeter
emission in the direction of the Bullet Cluster measured by the Balloon-borne
Large Aperture Submillimeter Telescope (BLAST). The 500 micron centroid is
coincident with an AzTEC 1.1 mm point-source detection at a position close to
the peak lensing magnification produced by the cluster. However, the 250 micron
and 350 micron centroids are elongated and shifted toward the south with a
differential shift between bands that cannot be explained by pointing
uncertainties. We therefore conclude that the BLAST detection is likely
contaminated by emission from foreground galaxies associated with the Bullet
Cluster. The submillimeter redshift estimate based on 250-1100 micron
photometry at the position of the AzTEC source is z_phot = 2.9 (+0.6 -0.3),
consistent with the infrared color redshift estimation of the most likely IRAC
counterpart. These flux densities indicate an apparent far-infrared luminosity
of L_FIR = 2E13 Lsun. When the amplification due to the gravitational lensing
of the cluster is removed, the intrinsic far-infrared luminosity of the source
is found to be L_FIR <= 10^12 Lsun, consistent with typical luminous infrared
galaxies.Comment: Accepted for publication in the Astrophysical Journal. Maps are
available at http://blastexperiment.info
Over half of the far-infrared background light comes from galaxies at z >= 1.2
Submillimetre surveys during the past decade have discovered a population of
luminous, high-redshift, dusty starburst galaxies. In the redshift range 1 <= z
<= 4, these massive submillimetre galaxies go through a phase characterized by
optically obscured star formation at rates several hundred times that in the
local Universe. Half of the starlight from this highly energetic process is
absorbed and thermally re-radiated by clouds of dust at temperatures near 30 K
with spectral energy distributions peaking at 100 microns in the rest frame. At
1 <= z <= 4, the peak is redshifted to wavelengths between 200 and 500 microns.
The cumulative effect of these galaxies is to yield extragalactic optical and
far-infrared backgrounds with approximately equal energy densities. Since the
initial detection of the far-infrared background (FIRB), higher-resolution
experiments have sought to decompose this integrated radiation into the
contributions from individual galaxies. Here we report the results of an
extragalactic survey at 250, 350 and 500 microns. Combining our results at 500
microns with those at 24 microns, we determine that all of the FIRB comes from
individual galaxies, with galaxies at z >= 1.2 accounting for 70 per cent of
it. As expected, at the longest wavelengths the signal is dominated by
ultraluminous galaxies at z > 1.Comment: Accepted to Nature. Maps available at http://blastexperiment.info
BLAST Observations of the South Ecliptic Pole field: Number Counts and Source Catalogs
We present results from a survey carried out by the Balloon-borne Large
Aperture Submillimeter Telescope (BLAST) on a 9 deg^2 field near the South
Ecliptic Pole at 250, 350 and 500 {\mu}m. The median 1{\sigma} depths of the
maps are 36.0, 26.4 and 18.4 mJy, respectively. We apply a statistical method
to estimate submillimeter galaxy number counts and find that they are in
agreement with other measurements made with the same instrument and with the
more recent results from Herschel/SPIRE. Thanks to the large field observed,
the new measurements give additional constraints on the bright end of the
counts. We identify 132, 89 and 61 sources with S/N>4 at 250, 350, 500 {\mu}m,
respectively and provide a multi-wavelength combined catalog of 232 sources
with a significance >4{\sigma} in at least one BLAST band. The new BLAST maps
and catalogs are available publicly at http://blastexperiment.info.Comment: 25 pages, 6 figures, 4 tables, Accepted by ApJS. Maps and catalogs
available at http://blastexperiment.info
BLAST05: Power Spectra of Bright Galactic Cirrus at Submillimeter Wavelengths
We report multi-wavelength power spectra of diffuse Galactic dust emission
from BLAST observations at 250, 350, and 500 microns in Galactic Plane fields
in Cygnus X and Aquila. These submillimeter power spectra statistically
quantify the self-similar structure observable over a broad range of scales and
can be used to assess the cirrus noise which limits the detection of faint
point sources. The advent of submillimeter surveys with the Herschel Space
Observatory makes the wavelength dependence a matter of interest. We show that
the observed relative amplitudes of the power spectra can be related through a
spectral energy distribution (SED). Fitting a simple modified black body to
this SED, we find the dust temperature in Cygnus X to be 19.9 +/- 1.3 K and in
the Aquila region 16.9 +/- 0.7 K. Our empirical estimates provide important new
insight into the substantial cirrus noise that will be encountered in
forthcoming observations.Comment: Submitted to the Astrophysical Journal. Maps and other data are
available at http://blastexperiment.info
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