Bioactive ceramic-reinforced composites for bone augmentation

Biomaterials have been used to repair the human body for millennia, but it is only since the 1970s that man-made composites have been used. Hydroxyapatite (HA)-reinforced polyethylene (PE) is the first of the ‘second-generation’ biomaterials that have been developed to be bioactive rather than bioinert. The mechanical properties have been characterized using quasi-static, fatigue, creep and fracture toughness testing, and these studies have allowed optimization of the production method. The in vitro and in vivo biological properties have been investigated with a range of filler content and have shown that the presence of sufficient bioactive filler leads to a bioactive composite. Finally, the material has been applied clinically, initially in the orbital floor and later in the middle ear. From this initial combination of HA in PE other bioactive ceramic polymer composites have been developed

Noroviruses as a Cause of Diarrhea in Immunocompromised Pediatric Hematopoietic Stem Cell and Solid Organ Transplant Recipients

Case reports describe significant norovirus gastroenteritis morbidity in immunocompromised patients. We evaluated norovirus pathogenesis in prospectively enrolled solid organ (SOT) and hematopoietic stem cell transplant (HSCT) patients with diarrhea who presented to Texas Children\u27s Hospital and submitted stool for enteric testing. Noroviruses were detected by real-time reverse transcription polymerase chain reaction. Clinical outcomes of norovirus diarrhea and non-norovirus diarrhea patients, matched by transplanted organ type, were compared. Norovirus infection was identified in 25 (22%) of 116 patients, more frequently than other enteropathogens. Fifty percent of norovirus patients experienced diarrhea lasting ≥14 days, with median duration of 12.5 days (range 1–324 days); 29% developed diarrhea recurrence. Fifty-five percent of norovirus patients were hospitalized for diarrhea, with 27% requiring intensive care unit (ICU) admission. One HSCT recipient developed pneumatosis intestinalis. Three HSCT patients expired ≤6 months of norovirus diarrhea onset. Compared to non-norovirus diarrhea patients, norovirus patients experienced significantly more frequent ICU admission (27% vs. 0%, p = 0.02), greater serum creatinine rise (median 0.3 vs. 0.2 mg/dL, p = 0.01), and more weight loss (median 1.6 vs. 0.6 kg, p \u3c 0.01). Noroviruses are an important cause of diarrhea in pediatric transplant patients and are associated with significant clinical complications

Tedera: From a Promising Novel Species to a Commercial Pasture Option for Mediterranean Southern Australia

Tedera (Bituminaria bituminosa var. albomarginata and var. crassiuscula) is a traditional forage species used for centuries in the Canary Islands (Méndez and Fernández 1990), that has increasingly attracted interest from researchers in regions with Mediterranean-type climates from Spain, Italy, Israel, Greece, Portugal, Morocco, Turkey and Australia. In 2000, Australian pasture researchers started a large and systematic screening process that evaluated about 720 species of exotic and native legumes, grasses and herbs for adaptation and productivity in Mediterranean and temperate environments (Real et al. 2011). Tedera was one of the few novel perennial legumes to show potential for domestication (Real et al. 2008; Real et al. 2011). Now an international multidisciplinary team has come together to take tedera forward towards commercial adoption by farmers in Mediterranean-type environments. This paper provides a technical update and discussion on all research aspects conducted by the tedera research team up to February 2013

Fog type classification using a modified Richardson number for Christchurch, New Zealand

Situated on a coastal plain between the Southern Alps and Banks Peninsula, Christchurch, New Zealand, experiences around 49 fog days every year. Given its complex topography, accurate fog forecasting is difficult at Christchurch International Airport (CHA). Climatological analysis of local fog events is an important first step to gain insight into the processes involved in the fog lifecycle. In this study, fog events were identified using 12 years of meteorological observations from an automatic weather station situated at CHA. A novel fog type classification method was developed using the modified Richardson number (MRi). The MRi fog type classification method assesses the local dynamic stability of a 1.25 m shallow layer of near-surface air. Here, the MRi is used as a quantitative index to classify advection fog, advection–radiation fog, and radiation fog. Vertical gradients of air temperature and wind speed were derived for prefog and fog periods, and a number of criteria were applied to the MRi for the fog type classification. The fog type classification results were examined in correspondence with the derived fog intensity, duration, diurnal and seasonal variability of frequency of occurrences, and synoptic and local wind flows. In agreement with other fog studies across the world, fog occurs most frequently during local winter and spring. Radiation fog is the predominant type of fog identified at CHA, and its formation and development usually coincide with the local drainage northwesterlies. This study is the first to use long-term observational data to investigate the fog climatology and typology at CHA in detail. The fog climatological characteristics presented in this study will serve as the basis of future fog studies in Christchurch. The presented MRi fog type classification method can potentially be used in fog characteristic studies worldwide

Long-term survival and center volume for functionally single-ventricle congenital heart disease in England and Wales

OBJECTIVES: Long-term survival is an important metric for health care evaluation, especially in functionally single-ventricle (f-SV) congenital heart disease (CHD). This study's aim was to evaluate the relationship between center volume and long-term survival in f-SV CHD within the centralized health care service of England and Wales. METHODS: This was a retrospective cohort study of children born with f-SV CHD between 2000 and 2018, using the national CHD procedure registry, with survival ascertained in 2020. RESULTS: Of 56,039 patients, 3293 (5.9%) had f-SV CHD. Median age at first intervention was 7 days (interquartile range [IQR], 4, 27), and median follow-up time was 7.6 years (IQR, 1.0, 13.3). The largest diagnostic subcategories were hypoplastic left heart syndrome, 1276 (38.8%); tricuspid atresia, 440 (13.4%); and double-inlet left ventricle, 322 (9.8%). The survival rate at 1 year and 5 years was 76.8% (95% confidence interval [CI], 75.3%-78.2%) and 72.1% (95% CI, 70.6%-73.7%), respectively. The unadjusted hazard ratio for each 5 additional patients with f-SV starting treatment per center per year was 1.04 (95% CI, 1.02-1.06), P < .001. However, after adjustment for significant risk factors (diagnostic subcategory; antenatal diagnosis; younger age, low weight, acquired comorbidity, increased severity of illness at first procedure), the hazard ratio for f-SV center volume was 1.01 (95% CI, 0.99-1.04) P = .28. There was strong evidence that patients with more complex f-SV (hypoplastic left heart syndrome, Norwood pathway) were treated at centers with greater f-SV case volume (P < .001). CONCLUSIONS: After adjustment for case mix, there was no evidence that f-SV center volume was linked to longer-term survival in the centralized health service provided by the 10 children's cardiac centers in England and Wales

The PELskin project: part IV—control of bluff body wakes using hairy filaments

The passive control of bluff body wakes using a sparse layer of elastic hairy filaments has been investigated via a series of numerical simulations and compared to selected experiments under well-controlled boundary conditions. It has been found that a distribution of filaments spaced half of the dominant three dimensional instability and resonating with the main shedding frequency can drastically delay the three dimensional transition of the wake behind a circular cylinder. It will also be shown that when using a pair of rows of filaments symmetrically spaced by an azimuthal angle, the wake topology can be deeply affected as well as the value of the integral force coefficients of the cylinder. In the most favourable case, a coupled three dimensional transition delay and strongly reduced values of the drag and of the lift fluctuation can be simultaneously achieved. These results hold also for higher Reynolds-number flows as shown in experiments on a cylinder with hairy flaps attached to the aft part. The lock-in effect of structural vibration of the flaps with the vortex shedding is assumed to be the reason for a sudden change in the shedding cycle as soon as the motion amplitude is high enough to modify the wake. In line with this hypothesis, it has been demonstrated that a long elastic filament pinned on the centerline of a forced spatially developing mixing layer can interact with the vortex dynamics delaying the pairing process-leading to a reduced thickness of the layer. These findings show that a properly designed fluid structure interaction can indeed lead to technological benefits in terms of wake control: drag reduction, vibration control and possibly palliation of aeroacoustic emissions

Phylogenetic relationships of cone snails endemic to Cabo Verde based on mitochondrial genomes

Background: Due to their great species and ecological diversity as well as their capacity to produce hundreds of different toxins, cone snails are of interest to evolutionary biologists, pharmacologists and amateur naturalists alike. Taxonomic identification of cone snails still relies mostly on the shape, color, and banding patterns of the shell. However, these phenotypic traits are prone to homoplasy. Therefore, the consistent use of genetic data for species delimitation and phylogenetic inference in this apparently hyperdiverse group is largely wanting. Here, we reconstruct the phylogeny of the cones endemic to Cabo Verde archipelago, a well-known radiation of the group, using mitochondrial (mt) genomes. Results: The reconstructed phylogeny grouped the analyzed species into two main clades, one including Kalloconus from West Africa sister to Trovaoconus from Cabo Verde and the other with a paraphyletic Lautoconus due to the sister group relationship of Africonus from Cabo Verde and Lautoconus ventricosus from Mediterranean Sea and neighboring Atlantic Ocean to the exclusion of Lautoconus endemic to Senegal (plus Lautoconus guanche from Mauritania, Morocco, and Canary Islands). Within Trovaoconus, up to three main lineages could be distinguished. The clade of Africonus included four main lineages (named I to IV), each further subdivided into two monophyletic groups. The reconstructed phylogeny allowed inferring the evolution of the radula in the studied lineages as well as biogeographic patterns. The number of cone species endemic to Cabo Verde was revised under the light of sequence divergence data and the inferred phylogenetic relationships. Conclusions: The sequence divergence between continental members of the genus Kalloconus and island endemics ascribed to the genus Trovaoconus is low, prompting for synonymization of the latter. The genus Lautoconus is paraphyletic. Lautoconus ventricosus is the closest living sister group of genus Africonus. Diversification of Africonus was in allopatry due to the direct development nature of their larvae and mainly triggered by eustatic sea level changes during the Miocene-Pliocene. Our study confirms the diversity of cone endemic to Cabo Verde but significantly reduces the number of valid species. Applying a sequence divergence threshold, the number of valid species within the sampled Africonus is reduced to half.Spanish Ministry of Science and Innovation [CGL2013-45211-C2-2-P, CGL2016-75255-C2-1-P, BES-2011-051469, BES-2014-069575, Doctorado Nacional-567]info:eu-repo/semantics/publishedVersio