RANCANG BANGUN SISTEM INFORMASI REPOSITORY MATERI AJAR MENGGUNAKAN FRAMEWORK LARAVEL (STUDI KASUS: MAN INSAN CENDEKIA SIAK)

RANCANG BANGUN SISTEM INFORMASI REPOSITORY MATERI AJAR MENGGUNAKAN FRAMEWORK LARAVEL (STUDI KASUS: MAN INSAN CENDEKIA SIAK) MUHAMAD REVAN. S NIM: 11653100049 Tanggal Sidang: 13 Januari 2022 Periode Wisuda: Program Studi Sistem Informasi Fakultas Sains dan Teknologi Universitas Islam Negeri Sultan Syarif Kasim Riau Jl. Soebrantas, No. 155, Pekanbaru ABSTRAK Materi ajar merupakan salah satu komponen penting bagi guru atau tenaga pendidik dalam pelaksanaan aktivitas mengajar. Untuk materi ajar yang digunakan pada Madrasah Aliyah Negeri Insan Cendekia Siak sudah berbasis digital yaitu e-book dalam bentuk PDF dan materi berbasis slide. Sekolah ini memiliki dua bidang jurusan yaitu Ilmu Pengetahuan Alam dan Ilmu Pengetahuan Sosial. Pada masing-masing bidang jurusan pasti memiliki banyak mata pelajaran dan setiap mata pelajaran juga memiliki materi ajarnya tersendiri. Maka banyaknya jumlah mata pelajaran tentu membutuhkan tempat untuk penyimpanan materi ajar. Seiring berjalannya waktu dengan semakin banyaknya dokumen materi ajar dari tiap mata pelajaran, maka ruang storage yang diperlukan tentu akan semakin besar juga. Untuk tempat penyimpanan digital semacam repository materi ajar belum tersedia di sekolah, sehingga guru memiliki keterbatasan dalam menyimpan dan mendistribusikan materi ajarnya. Tujuan dari penelitian ini adalah untuk membangun sistem informasi repository materi ajar menggunakan Framework Laravel dengan Metode Waterfall. Berdasarkan hasil User Acceptance Test yang dilakukan terhadap 10 responden didapatkan tingkat penerimaan pengguna sebesar 88%, sehingga dari hasil tersebut sistem dikategorikan sangat baik. Sistem repository ini mampu memenuhi kebutuhan guru dan murid di MAN Insan Cendekia Siak. Kata Kunci: laravel, madrasah aliyah negeri, materi ajar, sistem informasi repositor

Dynamic purine signaling and metabolism during neutrophil–endothelial interactions

During episodes of hypoxia and inflammation, polymorphonuclear leukocytes (PMN) move into underlying tissues by initially passing between endothelial cells that line the inner surface of blood vessels (transendothelial migration, TEM). TEM creates the potential for disturbances in vascular barrier and concomitant loss of extravascular fluid and resultant edema. Recent studies have demonstrated a crucial role for nucleotide metabolism and nucleoside signaling during inflammation. These studies have implicated multiple adenine nucleotides as endogenous tissue protective mechanisms invivo. Here, we review the functional components of vascular barrier, identify strategies for increasing nucleotide generation and nucleoside signaling, and discuss potential therapeutic targets to regulate the vascular barrier during inflammation

Adenosine A2A receptors: localization and function

Adenosine is an endogenous purine nucleoside present in all mammalian tissues, that originates from the breakdown of ATP. By binding to its four receptor subtypes (A1, A2A, A2B, and A3), adenosine regulates several important physiological functions at both the central and peripheral levels. Therefore, ligands for the different adenosine receptors are attracting increasing attention as new potential drugs to be used in the treatment of several diseases. This chapter is aimed at providing an overview of adenosine metabolism, adenosine receptors localization and their signal transduction pathways. Particular attention will be paid to the biochemistry and pharmacology of A2A receptors, since antagonists of these receptors have emerged as promising new drugs for the treatment of Parkinson's disease. The interactions of A2A receptors with other nonadenosinergic receptors, and the effects of the pharmacological manipulation of A2A receptors on different body organs will be discussed, together with the usefulness of A2A receptor antagonists for the treatment of Parkinson's disease and the potential adverse effects of these drugs

More on the restricted ridge regression estimation

Several alternative methods for derivation of the restricted ridge regression estimator (RRRE) are provided. Theoretical comparison and relationship of RRRE with related methods for regression with the multicollinearity problem are described.We also find inter-connections among RRRE, ordinary ridge regression estimator (ORRE), restricted least squares estimator (RLSE), modified ridge regression estimator (MRRE) and restricted modified generalized ridge estimator (RMGRE). Finally, numerical comparison, in addition to theoretical derivation, is also conducted with a Monte Carlo simulation and a real data example. © 2011 Taylor & Francis

Effects of treatment with coenzyme Q10 on exercised rat aorta

In this study, the effect of long-term supplementation of coenzyme Q10 (CoQ10) on the responses of swim-trained rat aorta was investigated. Twenty-four adult male Wistar rats were divided into four groups: untrained, trained, untrained+CoQ10, and trained+CoQ10group. In the trained groups rats swam for 60 min/day, five days/week for six weeks. The CoQ10 supplements were administered by intraperitoneal injection at a daily dose of 10 mg·kg−1 of body weight five days/week for six weeks. Swimming of the rats was performed in a container containing tap water. Rats were sacrificed and thoracic aortas were removed for ex vivo analysis after the last swimming session. The aortas were cut into rings 2.5 mm in length. Concentration-response curves for phenylephrine (PHE, 10−9–3×10−4 M) and potassium chloride (KCl, 5–100 mM) were isometrically recorded. The sensitivity and maximal responses to PHE and KCl of aortic rings obtained from trained rats were lower than those of untrained rats. CoQ10 supplementation decreased the responses to both vasoconstrictors in untrained and especially in trained groups. Although neither CoQ10 nor training did affect malondialdehyde (MDA) and protein carbonyl (PC) levels, creatine kinase (CK) activity decreased and superoxide dismutase (SOD) activity increased only with exercise training. Glutathione (GSH) levels increased in CoQ10 supplemented-untrained rats. In conclusion, our results suggest that CoQ10 supplementation may have beneficial effects during exercise