Electroencephalography (EEG) as a Research Tool in the Information Systems Discipline: Foundations, Measurement, and Applications

The concept of neuro-information systems (neuroIS) has emerged in the IS discipline recently. Since the neuroIS field’s genesis, several neuroIS papers have been published. Investigating empirical papers published in scientific journals and conference proceedings reveals that electroencephalography (EEG) is a widely used tool. Thus, considering its relevance in contemporary research and the fact that it will also play a major role in future neuroIS research, we describe EEG from a layman’s perspective. Because previous EEG descriptions in the neuroIS literature have only scantily outlined theoretical and methodological aspects related to this tool, we urgently need a more thorough one. As such, we inform IS scholars about the fundamentals of EEG in a compact way and discuss EEG’s potential for IS research. Based on the knowledge base provided in this paper, IS researchers can make an informed decision about whether EEG could, or should, become part of their toolbox

Synthesis and cation-receptor properties of macrocyclic imines of anthraquinone

At the present study a series of crown-containing imines of 1-hydroxy-9,10-anthraquinone with donor and acceptor substituents at the anthraquinone nucleus were synthesized. Compounds were prepared photochemically from the corresponding photoactive 1-phenoxyanthraquinones and 4-aminobenzo-15-crown-5 ether. It was established spectrophotometrically that for crown-containing anthraquinone imines that are characterized by "imine-enamine" prototropic tautomerism, the insertion of acceptor substituents shifts the equilibrium to the "enamine" form. This shift leads to essential spectral changes in complexing chlor- and nitrocontaining macrocyclic imines of anthraquinone with alkali and alkaline-earth metal cations

Large halloween asteroid at lunar distance

The near-Earth asteroid (NEA) 2015 TB had a very close encounter with Earth at 1.3 lunar distances on October 31, 2015. We obtained 3-band mid-infrared observations of this asteroid with the ESO VLT-VISIR instrument covering approximately four hours in total. We also monitored the visual lightcurve during the close-encounter phase. The NEA has a (most likely) rotation period of 2.939 ± 0.005 h and the visual lightcurve shows a peak-to-peak amplitude of approximately 0.12 ± 0.02 mag. A second rotation period of 4.779 ± 0.012 h, with an amplitude of the Fourier fit of 0.10 ± 0.02 mag, also seems compatible with the available lightcurve measurements. We estimate a V-R colour of 0.56 ± 0.05 mag from different entries in the MPC database. A reliable determination of the object's absolute magnitude was not possible. Applying different phase relations to the available R-/V-band observations produced H = 18.6 mag (standard H-G calculations) or H = 19.2 mag and H = 19.8 mag (via the H-G procedure for sparse and low-quality data), with large uncertainties of approximately 1 mag. We performed a detailed thermophysical model analysis by using spherical and partially also ellipsoidal shape models. The thermal properties are best explained by an equator-on (± 30°) viewing geometry during our measurements with a thermal inertia in the range 250-700 J m s K (retrograde rotation) or above 500 J m s K (prograde rotation). We find that the NEA has a minimum size of approximately 625 m, a maximum size of just below 700 m, and a slightly elongated shape with a/b 1.1. The best match to all thermal measurements is found for: (i) thermal inertia Γ = 900 J m s K; D = 644 m, p = 5.5% (prograde rotation with 2.939 h); regolith grain sizes of 50-100 mm; (ii) thermal inertia Γ = 400 J m s K; D = 667 m, p = 5.1% (retrograde rotation with 2.939 h); regolith grain sizes of 10-20 mm. A near-Earth asteroid model (NEATM) confirms an object size well above 600 m (best NEATM solution at 690 m, beaming parameter η = 1.95), significantly larger than early estimates based on radar measurements. In general, a high-quality physical and thermal characterisation of a close-encounter object from two-week apparition data is not easily possible. We give recommendations for improved observing strategies for similar events in the future. © ESO, 2017.The research leading to these results has received funding from the European Union's Horizon 2020 Research and Innovation Programme, under Grant Agreement No. 687378. Funding from Spanish grant AYA-2014-56637-C2-1-P is acknowledged. Hungarian funding from the NKFIH grant GINOP-2.3.2-15-2016-00003 is also acknowledged. R.D. acknowledges the support of MINECO for his Ramon y Cajal Contract.Peer Reviewe

Recursive Definitions of Monadic Functions

Using standard domain-theoretic fixed-points, we present an approach for defining recursive functions that are formulated in monadic style. The method works both in the simple option monad and the state-exception monad of Isabelle/HOL's imperative programming extension, which results in a convenient definition principle for imperative programs, which were previously hard to define. For such monadic functions, the recursion equation can always be derived without preconditions, even if the function is partial. The construction is easy to automate, and convenient induction principles can be derived automatically.Comment: In Proceedings PAR 2010, arXiv:1012.455

Different pieces of the same puzzle : a multifaceted perspective on the complex biological basis of Parkinson’s disease

The biological basis of the neurodegenerative movement disorder, Parkinson’s disease (PD), is still unclear despite it being ‘discovered’ over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying theories as to its pathobiology. The aim of this article was to explore some of these different theories by summarizing the viewpoints of laboratory and clinician scientists in the PD field, on the biological basis of the disease. To achieve this aim, we posed this question to thirteen “PD experts” from six continents (for global representation) and collated their personal opinions into this article. The views were varied, ranging from toxin exposure as a PD trigger, to LRRK2 as a potential root cause, to toxic alpha-synuclein being the most important etiological contributor. Notably, there was also growing recognition that the definition of PD as a single disease should be reconsidered, perhaps each with its own unique pathobiology and treatment regimen

A randomized double-blind placebo-controlled trial to investigate the effects of nasal calcitonin on bone microarchitecture measured by high-resolution peripheral quantitative computerized tomography in postmenopausal women — Study protocol

<p>Abstract</p> <p>Background</p> <p>Bone microarchitecture is a significant determinant of bone strength. So far, the assessment of bone microarchitecture has required bone biopsies, limiting its utilization in clinical practice to one single skeletal site. With the advance of high-resolution imaging techniques, non-invasive in vivo measurement of bone microarchitecture has recently become possible. This provides an opportunity to efficiently assess the effects of anti-osteoporotic therapies on bone microarchitecture. We therefore designed a protocol to investigate the effects of nasal salmon calcitonin, an inhibitor of osteoclast activity, on bone microarchitecture in postmenopausal women, comparing weight bearing and non-weight bearing skeletal sites.</p> <p>Methods</p> <p>One hundred postmenopausal women will be included in a randomized, placebo-controlled, double-blind trial comparing the effect of nasal salmon calcitonin (200 UI/day) to placebo over two years. Bone microarchitecture at the distal radius and distal tibia will be determined yearly by high-resolution peripheral quantitative computerized tomography (p-QCT) with a voxel size of 82 μm and an irradiation of less than 5 μSv. Serum markers of bone resorption and bone formation will be measured every 6 months. Safety and compliance will be assessed. Primary endpoint is the change in bone microarchitecture; secondary endpoint is the change in markers of bone turnover.</p> <p>Hypothesis</p> <p>The present study should provide new information on the mode of action of nasal calcitonin. We hypothezise that - compared to placebo - calcitonin impacts on microstructural parameters, with a possible difference between weight bearing and non-weight bearing bones.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov NCT00372099</p

Assessment of eutrophication abatement scenarios for the Baltic Sea by multi-model ensemble simulations

Peer reviewe

Assessment of Uncertainties in Scenario Simulations of Biogeochemical Cycles in the Baltic Sea

Following earlier regional assessment studies, such as the Assessment of Climate Change for the Baltic Sea Basin and the North Sea Region Climate Change Assessment, knowledge acquired from available literature about future scenario simulations of biogeochemical cycles in the Baltic Sea and their uncertainties is assessed. The identification and reduction of uncertainties of scenario simulations are issues for marine management. For instance, it is important to know whether nutrient load abatement will meet its objectives of restored water quality status in future climate or whether additional measures are required. However, uncertainties are large and their sources need to be understood to draw conclusions about the effectiveness of measures. The assessment of sources of uncertainties in projections of biogeochemical cycles based on authors' own expert judgment suggests that the biggest uncertainties are caused by (1) unknown current and future bioavailable nutrient loads from land and atmosphere, (2) the experimental setup (including the spin up strategy), (3) differences between the projections of global and regional climate models, in particular, with respect to the global mean sea level rise and regional water cycle, (4) differing model-specific responses of the simulated biogeochemical cycles to long-term changes in external nutrient loads and climate of the Baltic Sea region, and (5) unknown future greenhouse gas emissions. Regular assessments of the models' skill (or quality compared to observations) for the Baltic Sea region and the spread in scenario simulations (differences among projected changes) as well as improvement of dynamical downscaling methods are recommended.Peer reviewe

Semantic text mining support for lignocellulose research

Biofuels produced from biomass are considered to be promising sustainable alternatives to fossil fuels. The conversion of lignocellulose into fermentable sugars for biofuels production requires the use of enzyme cocktails that can efficiently and economically hydrolyze lignocellulosic biomass. As many fungi naturally break down lignocellulose, the identification and characterization of the enzymes involved is a key challenge in the research and development of biomass-derived products and fuels. One approach to meeting this challenge is to mine the rapidly-expanding repertoire of microbial genomes for enzymes with the appropriate catalytic properties. Semantic technologies, including natural language processing, ontologies, semantic Web services and Web-based collaboration tools, promise to support users in handling complex data, thereby facilitating knowledge-intensive tasks. An ongoing challenge is to select the appropriate technologies and combine them in a coherent system that brings measurable improvements to the users. We present our ongoing development of a semantic infrastructure in support of genomics-based lignocellulose research. Part of this effort is the automated curation of knowledge from information on fungal enzymes that is available in the literature and genome resources. Working closely with fungal biology researchers who manually curate the existing literature, we developed ontological natural language processing pipelines integrated in a Web-based interface to assist them in two main tasks: mining the literature for relevant knowledge, and at the same time providing rich and semantically linked information