Rapid 3D dynamic rupture modeling of the February 6, 2023, Kahramanmara\c{s}, Turkey, MWM_W7.8 and MWM_W7.7 earthquake doublet

The 2023 Turkey Earthquake sequence involved unexpected ruptures across numerous fault segments, challenging data interpretation efforts. We present rapid, 3D dynamic rupture simulations to illuminate the complexities of the $M_W$7.8 and $M_W$7.7 earthquake doublet. Constrained by observations available within days of the sequence, our models deliver timely, mechanically consistent explanations for the unforeseen rupture paths, diverse rupture speeds, multiple slip episodes, locally strong shaking, and fault system interactions. We reconcile regional seismo-tectonics, rupture dynamics, and ground motions of a fault system represented by ten curved dipping segments and a heterogeneous stress field. Our simulations link both events matching geodetic and seismic observations. The $M_W$7.8 earthquake features delayed backward branching from a steeply intersecting splay fault, not requiring supershear speeds. The asymmetrical dynamics of the distinct, bilateral $M_W$7.7 event is explained by heterogeneous fault strength, prestress orientation, fracture energy, and static stress changes from the previous event. Our models explain the northward deviation of its western rupture and the minimal slip observed on the S\"urg\"u fault. Rapidly developed 3D dynamic rupture scenarios can elucidate unexpected observations shortly after major earthquakes, providing timely insights for data-driven analysis and hazard assessment toward a comprehensive, physically consistent understanding of the mechanics of multi-fault systems

Kinetic study of the selective hydrogenation of styrene over a Pd egg-shell composite catalyst

This is a study on the kinetics of the liquid-phase hydrogenation of styrene to ethylbenzene over a catalyst of palladium supported on an inorganic–organic composite. This support has a better mechanical resistance than other commercial supports, e.g. alumina, and yields catalysts with egg-shell structure and a very thin active Pd layer. Catalytic tests were carried out in a batch reactor by varying temperature, total pressure and styrene initial concentration between 353–393 K, 10–30 bar, and 0.26–0.60 mol L−1. Kinetic models were developed on the assumptions of dissociative hydrogen chemisorption and non-negligible adsorption of hydrogen and styrene. Final chemical reaction expressions useful for reactor design were obtained. The models that best fitted the experimental data were those ones that considered the surface reaction as the limiting step. In this sense, a two-step Horiuti–Polanyi working mechanism with half hydrogenation intermediates gave the best fit of the experimental data. The heats of adsorption of styrene and ethylbenzene were also estimated.The authors are gratefully indebted to CONICET, ANPCyT and Universidad Nacional del Litoral for financially sponsoring this research work

Identification of active sites on supported metal catalysts with carbon nanotube hydrogen highways

Catalysts consisting of metal particles supported on reducible oxides exhibit promising activity and selectivity for a variety of current and emerging industrial processes. Enhanced catalytic activity can arise from direct contact between the support and the metal or from metal-induced promoter effects on the oxide. Discovering the source of enhanced catalytic activity and selectivity is challenging, with conflicting arguments often presented based on indirect evidence. Here, we separate the metal from the support by a controlled distance while maintaining the ability to promote defects via the use of carbon nanotube hydrogen highways. As illustrative cases, we use this approach to show that the selective transformation of furfural to methylfuran over Pd/TiO2 occurs at the Pd-TiO2 interface while anisole conversion to phenol and cresol over Cu/TiO2 is facilitated by exposed Ti3+ cations on the support. This approach can be used to clarify many conflicting arguments in the literatureWe acknowledge financial support from the National Science Foundation, Grant CAREER1653935. Use of the Advanced Photon Source is supported by the U.S. Department of Energy, Office of Science, and Office of Basic Energy Sciences, under Contract DE-AC02-06CH11357. MRCAT operations are supported by the Department of Energy and the MRCAT member institutions. E.C.W. and J.T.M. were supported in part by Center for Innovative Transformation of Alkane Resources (CISTAR) by the National Science Foundation under Cooperative Agreement No. EEC-1647722. Open access fees fees for this article provided whole or in part by OU Libraries Open Access Fund.Ye

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Implementation of safe and reliable coverage control for multiple mobile robots

This thesis presents some results relating to an implementation of a safe and reliable coverage control algorithm. The application was focused on implementation on differential drive robots developed at the University of Illinois at Urbana-Champaign. Control laws for coverage, avoidance, and proximity were applied to a multi-agent system of robots. The control laws were merged to provide coverage using the system while guaranteeing inter-agent proximity, inter-agent collision avoidance, and agent-environment collision avoidance. Circular regions were considered for avoidance. The performance and limitation of the application are examined. Practical considerations for implementation are discussed. The experimental platform consisted of a motion capture system, three differential drive robots with multiple sensing capabilities, and two supporting computers for the motion capture system and data visualization

Multiattribute Utility Copulas for Multi-objective Coverage Control

This paper presents theoretical and experimental results related to the control and coordination of multirobot systems interested in dynamically covering a compact domain while remaining proximal, so as to promote robust inter-robot communications, and while remaining collision free with respect to each other and static obstacles. A design for a novel, gradient-based controller using nonnegative definite objective functions and an overapproximation to the maximum function is presented. By using a multiattribute utility copula to scalarize the multiobjective control problem, a control law is presented that allows for flexible tuning of the tradeofs between objectives. This procedure mitigates the controller’s dependence on objective function parameters and allows for the straightforward integration of a novel global coverage objective. Simulation and experiments demonstrate the controller’s efectiveness in promoting scenarios with collision free trajectories, robust communications, and satisfactory coverage of the entire coverage domain concurrently for a group of differential drive robots