Business as Missions: Applying Business as Missions to the Hospitality Industry

Business is a vehicle highly useful for achieving specific missions for the kingdom of God that could not otherwise be accomplished. A Business as Missions (BAM) organization is one structure of business that focuses intently on accomplishing the mission of reaching others for the kingdom of God. BAMs can be utilized in virtually any industry; however, the following thesis focuses on the unique opportunities that exist within the hospitality industry. These unique opportunities are present because of its relational components and consumer demands for community and social interaction. A hostel is one specific form of a hospitality company that has numerous distinct opportunities to be used for ministry. Due to the atmosphere, ambiance, community focus, clientele, and other characteristics associated with hostels, these businesses present many specific ways for a business to accomplish its mission of reaching others for Christ

First Record of the Deepwater Sculpin, Myoxocephalus thompsonii, from George Lake in Whiteshell Provincial Park, Manitoba

Two adult female specimens of Deepwater Sculpin, Myoxocephalus thompsonii, were collected by gillnet from George Lake near Point Du Bois, Manitoba, 36.8 km east of Lac Du Bonnet on 21 September 2000. This constitutes the first confirmed occurrence of the species in George Lake. The only other Manitoba lakes with known populations of Deepwater Sculpin are Lake Athapapuskow and West Hawk Lake. Deepwater Sculpins have also been collected from Reindeer Lake; however, these individuals were collected from the deeper Saskatchewan side of the lake

β-Deuteration of N-nitrosoethylmethylamine causes a shift in DNA methylation from rat liver to esophagus

While N-nitrosoethylmethylamine (NEMA) is carcinogenic primarily for the liver, its β-trideuterated derivative, N-nitroso([2-D3]ethyl)methylamine (NEMA-d3), also produces a high incidence of tumors in the esophagus. To determine whether this shift in organ specificity is associated with an altered pattern of DNA alkylation, [methyl-14C]- and [1-ethyl-14C]-labeled NEMA-d3 were administered to adult male Fischer 344 rats as a single i.p. dose (0.05 mmol/kg; 4 h survival). Levels of methylated and ethylated purines in the DNA of various organs were determined by radiochromatography on Sephasorb-HP columns. When compared to previous data using undeuterated NEMA, 7-niethylguanine levelswerefoundtobereducedby ∽30%inliverandkldney, but were 160% greater in esophagus. This resulted in a decrease in the 7-methylguanine ratio for liver/esophagus from 109 to 29. O6-Methlguanine was diminished in liver and kidney, but levels in lung and esophagus were too low for quantitative detection. Similarly, deuteration led to an 18% decrease of 7-ethylguanine In hepatic DNA. The observed increase in esophageal DNA methylation correlates with the increased carcinogenicity of NEMA-d3 relative to undeuterated NEMA in that organ. Since pharmacokinetic studies have shown that β-trideuteration of NEMA does not alter its bioavailability, the data suggest that the observed shift in target organ results from isotopically-induced changes in the balance among competing metabolic pathways in different rat tissue

Evidence for Non-Anadromous Behaviour of Arctic Charr (Salvelinus alpinus) from Lake Hazen, Ellesmere Island, Northwest Territories, Canada, Based on Scanning Proton Microprobe Analysis of Otolith Strontium Distribution

Scanning proton microprobe analysis was used to determine the distribution of strontium (Sr) in otoliths from arctic charr (Salvelinus alpinus) of known non-anadromous, known anadromous, and unknown life histories. Strontium concentration patterns in otoliths of known non-anadromous charr were low and relatively flat (with little variation) from the core area to the outermost edge of the otolith, while patterns for known anadromous charr were characterized by a similar low, flat region for the first several years of life, followed by marked oscillatory increases and decreases in Sr content for the duration of the fish's life. Small and large forms of Lake Hazen charr of unknown life histories exhibited Sr profiles that were similar to those of the known non-anadromous charr, which strongly suggest that Lake Hazen charr are non-anadromous. These results indicate that Lake Hazen is a "closed" system with energy cycling primarily within the system; this conclusion suggests that a conservative approach would be appropriate for the management of the Lake Hazen charr population.À l'aide d'une sonde protonique à balayage, on a procédé à une analyse afin de déterminer la répartition du strontium (Sr) dans des otolithes prélevés sur des ombles chevaliers (Salvelinus alpinus) ayant eu soit un cycle biologique non anadrome connu, soit un cycle anadrome connu ou un cycle inconnu. Les courbes de concentration en strontium dans les otolithes d'ombles reconnus comme non anadromes étaient faibles et relativement uniformes (montrant peu de fluctuations) en allant du centre de l'otolithe vers la périphérie, tandis que les courbes relatives aux ombles reconnus comme anadromes se caractérisaient par une zone de concentrations faibles et uniformes pour plusieurs des premières années de vie, suivie par des oscillations à la hausse et à la baisse très nettes quant au contenu en Sr pour la durée de vie du poisson. De gros et de petits spécimens d'ombles au cycle biologique inconnu, trouvés dans le lac Hazen, affichaient des profils de Sr semblables à ceux des ombles reconnus comme non anadromes, ce qui suggère fortement que l'omble du lac Hazen est non anadrome. Ces résultats révèlent que le lac Hazen est un système où l'énergie circule surtout en circuit «fermé». Cette conclusion suggère qu'il faudrait adopter une approche prudente quant à la gestion de la population d'ombles du lac Hazen

CAFF Monitoring Series Report No. 4 - Development of an Arctic Freshwater Biodiversity Monitoring Plan; Framework document

CAFF Monitoring Series Report No. 4 - Development of an Arctic Freshwater Biodiversity Monitoring Plan; Framework documen

Drosophila studies support a role for a presynaptic synaptotagmin mutation in a human congenital myasthenic syndrome.

During chemical transmission, the function of synaptic proteins must be coordinated to efficiently release neurotransmitter. Synaptotagmin 2, the Ca2+ sensor for fast, synchronized neurotransmitter release at the human neuromuscular junction, has recently been implicated in a dominantly inherited congenital myasthenic syndrome associated with a non-progressive motor neuropathy. In one family, a proline residue within the C2B Ca2+-binding pocket of synaptotagmin is replaced by a leucine. The functional significance of this residue has not been investigated previously. Here we show that in silico modeling predicts disruption of the C2B Ca2+-binding pocket, and we examine the in vivo effects of the homologous mutation in Drosophila. When expressed in the absence of native synaptotagmin, this mutation is lethal, demonstrating for the first time that this residue plays a critical role in synaptotagmin function. To achieve expression similar to human patients, the mutation is expressed in flies carrying one copy of the wild type synaptotagmin gene. We now show that Drosophila carrying this mutation developed neurological and behavioral manifestations similar to those of human patients and provide insight into the mechanisms underlying these deficits. Our Drosophila studies support a role for this synaptotagmin point mutation in disease etiology

Mosquito coil emissions and health implications.

Burning mosquito coils indoors generates smoke that can control mosquitoes effectively. This practice is currently used in numerous households in Asia, Africa, and South America. However, the smoke may contain pollutants of health concern. We conducted the present study to characterize the emissions from four common brands of mosquito coils from China and two common brands from Malaysia. We used mass balance equations to determine emission rates of fine particles (particulate matter < 2.5 microm in diameter; PM(2.5)), polycyclic aromatic hydrocarbons (PAHs), aldehydes, and ketones. Having applied these measured emission rates to predict indoor concentrations under realistic room conditions, we found that pollutant concentrations resulting from burning mosquito coils could substantially exceed health-based air quality standards or guidelines. Under the same combustion conditions, the tested Malaysian mosquito coils generated more measured pollutants than did the tested Chinese mosquito coils. We also identified a large suite of volatile organic compounds, including carcinogens and suspected carcinogens, in the coil smoke. In a set of experiments conducted in a room, we examined the size distribution of particulate matter contained in the coil smoke and found that the particles were ultrafine and fine. The findings from the present study suggest that exposure to the smoke of mosquito coils similar to the tested ones can pose significant acute and chronic health risks. For example, burning one mosquito coil would release the same amount of PM(2.5) mass as burning 75-137 cigarettes. The emission of formaldehyde from burning one coil can be as high as that released from burning 51 cigarettes

Search for the lepton-family-number nonconserving decay \mu -> e + \gamma

The MEGA experiment, which searched for the muon- and electron-number violating decay \mu -> e + \gamma, is described. The spectrometer system, the calibrations, the data taking procedures, the data analysis, and the sensitivity of the experiment are discussed. The most stringent upper limit on the branching ratio of \mu -> e + \gamma) < 1.2 x 10^{-11} was obtained