2,289 research outputs found
Cryo-cooled high-power window for high-frequency plasma heating. Thermodynamic study of the single-disk concept with liquid nitrogen edge cooling
Quantifying uncertainties in precipitation: a case study from Greece
The main objective of the present study was the examination and the quantification of the uncertainties in the precipitation time series over the Greek area, for a 42-year time period. The uncertainty index applied to the rainfall data is a combination (total) of the departures of the rainfall season length, of the median data of the accumulated percentages and of the total amounts of rainfall. Results of the study indicated that all the stations are characterized, on an average basis, by medium to high uncertainty. The stations that presented an increasing rainfall uncertainty were the ones located mainly to the continental parts of the study region. From the temporal analysis of the uncertainty index, it was demonstrated that the greatest percentage of the years, for all the stations time-series, was characterized by low to high uncertainty (intermediate categories of the index). Most of the results of the uncertainty index for the Greek region are similar to the corresponding results of various stations all over the European region
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FOREVER: Fault/intrusiOn REmoVal through Evolution & Recovery
The goal of the FOREVER project is to develop a service for Fault/intrusiOn REmoVal through Evolution & Recovery. In order to achieve this goal, our work addresses three main tasks: the definition of the FOREVER service architecture; the analysis of how diversity techniques can improve resilience; and the evaluation of the FOREVER service. The FOREVER service is an important contribution to intrustion-tolerant replication middleware and significantly enhances the resilience
High-power operation of a K-band second harmonic gyroklystron
Amplification studies of a two-cavity second-harmonic gyroklystron are reported. A magnetron injection gun produces a 440 kV, 200–245 A, 1 μs beam with an average perpendicular-to-parallel velocity ratio slightly less than 1. The TE011 input cavity is driven near 9.88 GHz and the TE021 output cavity resonates near 19.76 GHz. Peak powers exceeding 21 MW are achieved with an efficiency near 21% and a large signal gain above 25 dB. This performance represents the current state of the art for gyroklystrons in terms of the peak power normalized to the output wavelength squared
Chaotic Orbits in Thermal-Equilibrium Beams: Existence and Dynamical Implications
Phase mixing of chaotic orbits exponentially distributes these orbits through
their accessible phase space. This phenomenon, commonly called ``chaotic
mixing'', stands in marked contrast to phase mixing of regular orbits which
proceeds as a power law in time. It is operationally irreversible; hence, its
associated e-folding time scale sets a condition on any process envisioned for
emittance compensation. A key question is whether beams can support chaotic
orbits, and if so, under what conditions? We numerically investigate the
parameter space of three-dimensional thermal-equilibrium beams with space
charge, confined by linear external focusing forces, to determine whether the
associated potentials support chaotic orbits. We find that a large subset of
the parameter space does support chaos and, in turn, chaotic mixing. Details
and implications are enumerated.Comment: 39 pages, including 14 figure
Simplified production and concentration of HIV-1-based lentiviral vectors using HYPERFlask vessels and anion exchange membrane chromatography
<p>Abstract</p> <p>Background</p> <p>During the past twelve years, lentiviral (LV) vectors have emerged as valuable tools for transgene delivery because of their ability to transduce nondividing cells and their capacity to sustain long-term transgene expression in target cells <it>in vitro </it>and <it>in vivo</it>. However, despite significant progress, the production and concentration of high-titer, high-quality LV vector stocks is still cumbersome and costly.</p> <p>Methods</p> <p>Here we present a simplified protocol for LV vector production on a laboratory scale using HYPERFlask vessels. HYPERFlask vessels are high-yield, high-performance flasks that utilize a multilayered gas permeable growth surface for efficient gas exchange, allowing convenient production of high-titer LV vectors. For subsequent concentration of LV vector stocks produced in this way, we describe a facile protocol involving Mustang Q anion exchange membrane chromatography.</p> <p>Results</p> <p>Our results show that unconcentrated LV vector stocks with titers in excess of 10<sup>8 </sup>transduction units (TU) per ml were obtained using HYPERFlasks and that these titers were higher than those produced in parallel using regular 150-cm<sup>2 </sup>tissue culture dishes. We also show that up to 500 ml of an unconcentrated LV vector stock prepared using a HYPERFlask vessel could be concentrated using a single Mustang Q Acrodisc with a membrane volume of 0.18 ml. Up to 5.3 × 10<sup>10 </sup>TU were recovered from a single HYPERFlask vessel.</p> <p>Conclusion</p> <p>The protocol described here is easy to implement and should facilitate high-titer LV vector production for preclinical studies in animal models without the need for multiple tissue culture dishes and ultracentrifugation-based concentration protocols.</p
Efficient computation of matched solutions of the Kapchinskij-Vladimirskij envelope equations for periodic focusing lattices
A new iterative method is developed to numerically calculate the periodic,
matched beam envelope solution of the coupled Kapchinskij-Vladimirskij (KV)
equations describing the transverse evolution of a beam in a periodic, linear
focusing lattice of arbitrary complexity. Implementation of the method is
straightforward. It is highly convergent and can be applied to all usual
parameterizations of the matched envelope solutions. The method is applicable
to all classes of linear focusing lattices without skew couplings, and also
applies to all physically achievable system parameters -- including where the
matched beam envelope is strongly unstable. Example applications are presented
for periodic solenoidal and quadrupole focusing lattices. Convergence
properties are summarized over a wide range of system parameters.Comment: 20 pages, 5 figures, Mathematica source code provide
Ultrabroad-bandwidth multifrequency Raman generation
We report on the modeling of transient stimulated rotational Raman scattering in H2 gas. We predict a multifrequency output, spanning a bandwidth greater than the pump frequency, that may be generated without any significant delay with respect to the pump pulses. The roles of dispersion and transiency are quantified
Generation of Relativistic Electron Bunches with Arbitrary Current Distribution via Transverse-to-Longitudinal Phase Space Exchange
We propose a general method for tailoring the current distribution of
relativistic electron bunches. The technique relies on a recently proposed
method to exchange the longitudinal phase space emittance with one of the
transverse emittances. The method consists of transversely shaping the bunch
and then converting its transverse profile into a current profile via a
transverse-to-longitudinal phase-space-exchange beamline. We show that it is
possible to tailor the current profile to follow, in principle, any desired
distributions. We demonstrate, via computer simulations, the application of the
method to generate trains of microbunches with tunable spacing and
linearly-ramped current profiles. We also briefly explore potential
applications of the technique.Comment: 13 pages, 17 figure
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