LibriWASN: A Data Set for Meeting Separation, Diarization, and Recognition with Asynchronous Recording Devices

We present LibriWASN, a data set whose design follows closely the LibriCSS meeting recognition data set, with the marked difference that the data is recorded with devices that are randomly positioned on a meeting table and whose sampling clocks are not synchronized. Nine different devices, five smartphones with a single recording channel and four microphone arrays, are used to record a total of 29 channels. Other than that, the data set follows closely the LibriCSS design: the same LibriSpeech sentences are played back from eight loudspeakers arranged around a meeting table and the data is organized in subsets with different percentages of speech overlap. LibriWASN is meant as a test set for clock synchronization algorithms, meeting separation, diarization and transcription systems on ad-hoc wireless acoustic sensor networks. Due to its similarity to LibriCSS, meeting transcription systems developed for the former can readily be tested on LibriWASN. The data set is recorded in two different rooms and is complemented with ground-truth diarization information of who speaks when.Comment: Accepted for presentation at the ITG conference on Speech Communication 202

Spatial Diarization for Meeting Transcription with Ad-Hoc Acoustic Sensor Networks

We propose a diarization system, that estimates "who spoke when" based on spatial information, to be used as a front-end of a meeting transcription system running on the signals gathered from an acoustic sensor network (ASN). Although the spatial distribution of the microphones is advantageous, exploiting the spatial diversity for diarization and signal enhancement is challenging, because the microphones' positions are typically unknown, and the recorded signals are initially unsynchronized in general. Here, we approach these issues by first blindly synchronizing the signals and then estimating time differences of arrival (TDOAs). The TDOA information is exploited to estimate the speakers' activity, even in the presence of multiple speakers being simultaneously active. This speaker activity information serves as a guide for a spatial mixture model, on which basis the individual speaker's signals are extracted via beamforming. Finally, the extracted signals are forwarded to a speech recognizer. Additionally, a novel initialization scheme for spatial mixture models based on the TDOA estimates is proposed. Experiments conducted on real recordings from the LibriWASN data set have shown that our proposed system is advantageous compared to a system using a spatial mixture model, which does not make use of external diarization information.Comment: Accepted at Asilomar Conference on Signals, Systems, and Computers 202

Delayed Pion Spectroscopy of Hypernuclei

New possibilities of hypernuclear studies at modern electron accelerators based on recently developed radio frequency photomultiplier tubes are discussed

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries