62 research outputs found
Experimental X-ray Stress Analysis Procedures for Ultra High Strength Materials
- Publication venue
- Publication date
- Field of study
X-ray stress analysis procedures for accurate measurement of elastic strain in high strength steel
Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials
- Author
- A Gillbanks
- A R Norman
- A Rosemurgy
- AB Miller
- AD Gilliam
- B Glimelius
- B Kalindjian
- B Theis
- C Louvet
- C Russell
- C Ziske
- CM Rocha Lima
- D Cunningham
- D Cunningham
- DM Parkin
- E Van Cutsem
- EL Kaplan
- EM O' Reilly
- F Daniels
- G Middleton
- G Murray
- H Oettle
- HA Burris III
- I Chau
- J Black
- J Prendeville
- J Shapiro
- J Stemmler
- JD Berlin
- JD Evans
- JP Neoptolemos
- JP Neoptolemos
- JP Smith
- JP Smith
- M Walker
- MA Henaghan
- MC Fung
- MJ Moore
- MJ Moore
- N Maisey
- N Shankley
- NR Maisey
- O Micke
- P Cheverton
- P Clerc
- P Harper
- P Harrison
- P J Ross
- R Hull
- R Peto
- S Roberts
- SR Bramhall
- SR Bramhall
- T Hickish
- T Kurzawinski
- Publication venue
- Publication date
- 24/04/2006
- Field of study
Gastrin has been shown to be a growth stimulant in pancreatic cancer cells. Gastrazole is a potent and selective gastrin receptor antagonist. Two randomised blinded trials were conducted to assess the effect of gastrazole in advanced pancreatic cancer. Patients with biopsy-proven, inoperable pancreatic carcinoma were recruited. Trial A compared protracted venous infusion (PVI) gastrazole with PVI placebo, whereas trial B compared PVI gastrazole with PVI fluorouracil (5-FU). Eighteen patients were randomised in trial A. Gastrazole produced significantly better survival compared to placebo (median 7.9 months vs 4.5 months; 1-year survival: 33 vs 11%, respectively; log rank P=0.02). No difference in toxicity was seen between gastrazole and placebo, except central venous catheter and pump complications. Ninety-eight patients were randomised in trial B. No significant survival difference was detected between gastrazole and 5-FU (median: 3.6 vs 4.2 months; 1-year survival: 13.2 vs 26.2%, respectively; log rank P=0.42). Toxicity of gastrazole was mild with significantly less diarrhoea (P=0.03), stomatitis (P<0.001) and handâ foot syndrome (P<0.001) compared to 5-FU. Quality of life (QoL) assessment showed similar QoL between gastrazole and 5-FU at baseline and no significant differences occurred with treatment either between arms or within arms. Compared to placebo, patients with advanced pancreatic cancer treated with gastrazole appeared to live longer, albeit in a very small trial and will require confirmation with large-scale randomised data. However, it did not produce survival advantage over PVI 5-FU. Lack of toxicity for gastrazole may allow its combination with cytotoxic drugs
In Vivo Evaluation of the Presence of Bone Marrow in Cortical Porosity in Postmenopausal Osteopenic Women
- Author
- A Laib
- A Piney
- AH Burstein
- B Borah
- BC Berg Vande
- BR McCreadie
- C Studholme
- C Studholme
- C Studholme
- CD Thomas
- DC Newitt
- DG Mitchell
- DK Yeung
- DM Black
- DM Cooper
- DM Cooper
- F Aguado
- F Maes
- Galateia Kazakia
- GC Reilly
- GJ Kazakia
- GP Liney
- GR Jordan
- HK Genant
- HR Buie
- J Iwamoto
- J Power
- JA Ochoa
- Janet Goldenstein
- JB Vogler III
- JD Currey
- JE Holmes
- KA Davis
- KL Bell
- KL Bell
- KL Bell
- KL Bell
- L Vincent
- M Holden
- M Jenkinson
- M Kasra
- M Kasra
- MA Liebschner
- MB Schaffler
- MD Robson
- P Augat
- P Roschger
- P Viola
- R Krug
- RB Martin
- RW McCalden
- S Banerjee
- SA Feik
- SC Cowin
- Sharmila Majumdar
- SL Greenspan
- SR Cummings
- UA Liberman
- V Bousson
- WF Neuman
- YN Yeni
- Publication venue
- Springer US
- Publication date
- 01/01/2009
- Field of study
This is the first observational study examining cortical porosity in vivo in postmenopausal osteopenic women and to incorporate data from two different imaging modalities to further examine the nature of cortical porosity. The goal of this study was to combine high-resolution peripheral computed tomography (HR-pQCT) images, which contain high spatial resolution information of the cortical structure, and magnetic resonance (MR) images, which allow the visualization of soft tissues such as bone marrow, to observe the amount of cortical porosity that contains bone marrow in postmenopausal osteopenic women. The radius of 49 and the tibia of 51 postmenopausal osteopenic women (age 56 ± 3.7) were scanned using both HR-pQCT and MR imaging. A normalized mutual information registration algorithm was used to obtain a three-dimensional rigid transform which aligned the MR image to the HR-pQCT image. The aligned images allowed for the visualization of bone marrow in cortical pores. From the HR-pQCT image, the percent cortical porosity, the number of cortical pores, and the size of each cortical pore was determined. By overlaying the aligned MR and HR-pQCT images, the percent of cortical pores containing marrow, the number of cortical pores containing marrow, and the size of each cortical pore containing marrow were measured. While the amount of cortical porosity did not vary greatly between subjects, the type of cortical pore, containing marrow vs. not containing marrow, varied highly between subjects. The results suggest that cortical pore spaces contain components of varying composition, and that there may be more than one mechanism for the development of cortical porosity
The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs
- Author
- A. E. Nixon
- A. J. Zurita
- A. J. Zurita
- A. L. Kayushin
- A. P. Levene
- A. Rosenberg
- B. C. Ritchie
- B. K. Kay
- B. K. Kay
- B. Kuhnast
- B. L. Bray
- C. Adessi
- C. Huang
- D. C. Sullivan
- D. J. Rodi
- D. J. Rodi
- D. J. Rodi
- D. M. Eckert
- D. N. Krag
- E. Ruoslahti
- F. Nilsson
- F. Tian
- G. P. Adams
- G. P. Adams
- G. P. Miljanich
- G. P. Smith
- H. M. Azzazy
- H. M. Ellerby
- I. A. Ho
- III C. F. Barbas
- J. A. Hoffman
- J. A. Joyce
- J. A. Patch
- J. Eichler
- J. K. Scott
- J. Xie
- J.-L. Su
- K. A. Kelly
- K. Adermann
- K. Deshayes
- K. S. Lam
- K. Wiesehan
- K. Wiesehan
- L. A. Landon
- L. Castagnoli
- L. L. Nielsen
- L. Liu
- Lauren R.H. Krumpe
- M. E. Akerman
- M. Essler
- M. Ferrari
- M. Grifman
- M. Kolonin
- M. Shadidi
- M. Stern
- M. Szardenings
- M. Z. Lin
- N. Oku
- O. A. Roges
- O. H. Aina
- O. H. Aina
- P. A. Wark
- P. Holig
- P. Kemp
- P. Laakkonen
- P. Laakkonen
- R. C. Ladner
- R. Haubner
- R. J. Winquist
- R. M. Reilly
- R. Pasqualini
- R. Pasqualini
- S. E. Perea
- S. Rafii
- S. Zitzmann
- T. Clackson
- T. J. Fleming
- T. Jiang
- T. Kieber-Emmons
- T. Matthews
- T. Mori
- T. N. Schumacher
- Toshiyuki Mori
- V. A. Petrenko
- V. Cortez-Retamozo
- V. I. Romanov
- V. J. Yao
- W. Arap
- W. Arap
- W. Arap
- Publication venue
- Kluwer Academic Publishers
- Publication date
- 01/01/2005
- Field of study
Monoclonal antibodies have been successfully utilized as cancer-targeting therapeutics and diagnostics, but the efficacies of these treatments are limited in part by the size of the molecules and non-specific uptake by the reticuloendothelial system. Peptides are much smaller molecules that can specifically target cancer cells and as such may alleviate complications with antibody therapy. Although many endogenous and exogenous peptides have been developed into clinical therapeutics, only a subset of these consists of cancer-targeting peptides. Combinatorial biological libraries such as bacteriophage-displayed peptide libraries are a resource of potential ligands for various cancer-related molecular targets. Target-binding peptides can be affinity selected from complex mixtures of billions of displayed peptides on phage and further enriched through the biopanning process. Various cancer-specific ligands have been isolated by in vitro, in vivo, and ex vivo screening methods. As several peptides derived from phage-displayed peptide library screenings have been developed into therapeutics in current clinical trials, which validates peptide-targeting potential, the use of phage display to identify cancer-targeting therapeutics should be further exploited
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström PÄ
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
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- Bramlet D
- Brath H
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- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
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- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
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- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
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- Busak L
- Busic N
- Byars W
- BĂžen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
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- Cech V
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- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
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- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
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- Chattin W
- Chauhan D
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- Chaussé I
- Chavada J
- Chaverra I
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- Cheng Jj
- Cheng S
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- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
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- Collier D
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- Coloma G
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- Coman S
- Commerford P
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- Conrado Y
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- Cornel Jh
- Corona V
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- Cosgrove N
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- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
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- Crea F
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- Crocamo A
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- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
- Davidsson K
- Davies M
- Davies N
- Davis B
- Davis M
- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
- Duhan S
- Dunhurst F
- Dussan Ma
- Dutka C
- Dwenger E
- Dzupina A
- DĂ©kĂĄny Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
- Eaton C
- Eaves W
- Ebeling K
- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
- Edwards T
- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
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- Facello A
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- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
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- Feng Z
- Ferdinand K
- Ferkl R
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- Ferraz R
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- Ferreira-Jardim A
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- Fitilev S
- Fitz-Patrick D
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- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
- Flores E
- Flores Gs
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- Floro T
- Foerster A
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- Fonseca A
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- Forgon T
- Forgosh L
- Forker A
- Forster T
- Foster M
- Foucauld J
- Fowler V
- Fox B
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- Frandsen B
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- Frankenstein L
- Fratczak M
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- Fruchter G
- Fu G
- Fucak E
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- Fucili A
- Fukuike C
- Fullerton D
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- Genest J
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- Gilbert J
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- Godoy Sanchez M
- Goette A
- Goff R
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- Gordeev I
- Gorges R
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- Gotcheva N
- Goudev A
- Gould R
- Govindaraj D
- Goyal B
- Goyal S
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- Gravenhorst-Muenter U
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- Greenway F
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- Grigaraviciene I
- Grigorova V
- Gros C
- Grosse A
- Grover A
- Grundtvig M
- Gudipati Rvc
- Guerrero A
- Guillinta P
- Gundala Ak
- Gupta A
- Gupta A
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- Gupta V
- Gutmann J
- Guzman I
- Guzman P
- Gwyn M
- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
- H Hill
- Haase F
- Haege R
- Haenel T
- Hage F
- Hageman T
- Hagemann D
- Hagenow A
- Hagiwara Y
- Haidar A
- Haider K
- Hakas J
- Haldis T
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- Hall S
- Halliwell Tc
- Halpern S
- Hamer Bjb
- Hamud-Socoro A
- Han B
- Han S
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- Hanefeld M
- Hangyal T
- Hansson A
- Hanustiakova A
- Hao Y
- Hardas S
- Hardee L
- Harrell W
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- Hartleib M
- Hartwell J
- Hasan F
- Hasbani E
- Hasegawa K
- Hattler B
- Haughton G
- Haynes E
- Haywood A
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- Hecht J
- Heeren G
- Hegedus V
- Heider J
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- Henley L
- Hennig D
- Henriksson A
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- Hernandez I
- Hernandez M
- HernĂĄndez N
- Herrman Jp
- Herzog W
- Hess E
- Hettwer Magedanz E
- Hickey L
- Hiden C
- Hielscher S
- Higuchi T
- Higuchi Y
- Hilkert R
- Hilton T
- Himpel-Boenninghoff A
- Hinderaker P
- Hioki M
- Hirayama A
- Hiroma J
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- Hodnett P
- Hoffman M
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- Hollanders G
- Holmes Z
- Holoubek D
- Holscher A
- Hominal M
- Homza M
- Hong T
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- Hoogslag Pam
- Horackova K
- Horak A
- Hornig M
- Horvat P
- Hosokawa S
- Hotchkiss D
- Houra M
- Hristova K
- Hsieh Ic
- Huang A
- Huang P
- Huang Ph
- Humbert J
- Hurtig U
- Hutchens E
- Huynh T
- Hwang Jj
- Hwang Jj
- Hyun K
- HĂ€rstedt N
- HĂživik Ho
- I Ilic
- I Ivanov
- Iachini K
- Iannopollo G
- Ibarra J
- Ibarra M
- Ibañez J
- Iby M
- Ichisawa M
- Igbokidi O
- Iijima T
- Ilahi T
- Ilic S
- Ilsley M
- Imbrognio M
- Imre Bs
- Inada T
- Inagaki M
- Indolfi C
- Infusino F
- Invitti C
- Ipp E
- Isaza D
- Istratoaie O
- Istvan Kp
- Iteld B
- Ito K
- Ivan P
- Iveta H
- Izmozherova N
- J Jiang
- J Johnson
- J Johnston
- J Jose
- Jacques G
- Jafri A
- Jafry B
- Jagtap P
- Jaguszewska G
- Jain A
- Jansen M
- Jardula M
- Jayasinghe R
- Jefferson D
- Jenkins R
- Jensen Ed
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- Yim S
- Yokoyama M
- Yong H
- Yoshida M
- Yoshimoto E
- Yossen M
- Young A
- Younis L
- Youssef G
- Yuan Z
- Yunoki C
- Yupanqui H
- Z Zhai
- Z Zilahi
- Zadionchenko V
- Zadra R
- Zagozen P
- Zaidman C
- Zalazar L
- Zaman A
- Zangroniz P
- Zarate J
- Zareczky P
- Zarifis I
- Zdrenghea D
- Zebrack J
- Zena N
- Zhang J
- Zhang W
- Zhang Y
- Zhao R
- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1ÎČ, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1ÎČ innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abbott D.
- Abdalla M.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarim M.
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- Aboelkassem Ibrahim A.
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- Abubakar A.
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- Achalandabaso Boira M. Sales Mallafré R. (Hospital Universitari de Tarragona Joan XXIII)
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- Aguado H. (HellĂn Hospital)
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- COVIDSurg COllabOratIVe | 15 Violante T. (IRCCS Azienda Ospedaliero â Universitaria di Bologna
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- Thomas A. (Royal Liverpool University Hospital)
- Thompson D. (Morriston Hospital Swansea)
- Thornhill M. (Dell Seton Medical Center at the University of Texas)
- Thrumurthy S. (Epsom and St Helier University Hospitals NHS Trust)
- Thulasiraman S. V.
- Timbrell S.
- Tirloni L.
- Titu S. (Prof. Dr. Ion Chiricuta Institute of Oncology). Russia: Garmanova T.
- Tonini V. (S. Orsola-Malpighi Hospital)
- Torres A. (Hospital ClĂnico de Madrid)
- Torres Arcos C.
- Townson A.
- Trabulsi N. (King Abdulaziz University Hospital)
- Travaglio E. (Regina Montis Regalis Hospital
- Tribillon E. (Institut Mutualiste Montsouris)
- Troncoso Pereira P. (Hospital Mateu Orfila)
- Tropeano F. P. (Federico II University Hospital)
- Trujillo DĂaz J.
- Tsai L.
- Tsarkov P.
- Tsiamalou I.
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- TU Dresden)
- Tucci R. (Azienda Ospedaliera Universitaria Careggi)
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- Tuncer K.
- Turnbull A. (Victoria Hospital Kirkcaldy)
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- Tweedle E. (Addenbrookeâs Hospital)
- Ugarte-Sierra B. (Hospital Universitario de Galdakao)
- UludaÄ S. S.
- Umair M.
- Universiti Sains Malaysia)
- University of Amsterdam)
- UniversitĂ di Ferrara)
- Université Mohammed V Rabat). Netherlands: Hompes R.
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- Uslu G.
- Utkan N. Z.
- Uyanik M. S. (Samsun Training and Research Hospital)
- Uzunoglu F. G. (University Medical Center HamburgâEppendorf). Greece: Antonakis P.
- Vaccarella G. (Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello)
- Valbuena Jabares V. (Marqués de Valdecilla University Hospital)
- Valdes- Hernandez J. (Hospital Universitario Virgen Macarena)
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- Valle Rubio A. (Getafe University Hospital)
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- Van den Eynde J.
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- Vassiliu P. (Attikon University General Hospital)
- Vaz Pereira R.
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- Velchuru V.
- Velickovic D. (Clinic for Digestive Surgery
- Velidedeoglu M.
- Venn M. (Royal London Hospital)
- Venskutonis D. (Lithuanian University of Health Sciences Kaunas Clinical Hospital). Madagascar: Rasoaherinomenjanahary F.
- Vera Mansilla C. (Hospital Universitario Principe de Asturias)
- Verberne C. (John Radcliffe Hospital)
- Vergari R. (Ospedali Riuniti di Ancona)
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- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras â Centro Hospitalar do Oeste)
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- Vigorita V. (Ălvaro Cunqueiro Hospital)
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- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
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- Westwood E. (James Paget University NHS Foundation Trust Hospital)
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- Whitmore H. (Torbay and South Devon NHS Trust)
- Wilkin R. J. W. (South Warwickshire NHS Foundation Trust)
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- Yang W.
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- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- YĂĄnez C. (Royo Villanova)
- YĂŒksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Caâ Foncello Treviso â DISCOG â UniversitĂ di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- ZeliÄ M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty â CerrahpaĆa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 â Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda UnitĂ Sanitaria Locale â IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla OrtĂșzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa âKoutlimpaneio and Triantafylleioâ)
- Zubaidi A. M. (King Saud University). Serbia: AleksiÄ L.
- Ăngelo M.
- Ăelebi F.
- Ăolak E.
- Ăfner D. (Medical University of Innsbruck)
- Ăhlberger L.
- Ăzçelık M. F.
- ĂÄĂŒcĂŒ H.
- ĂberrĂŒck L.
- Äoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Development of copper based drugs, radiopharmaceuticals and medical materials
- Author
- A Chakraborty
- A Garcia-GonzĂĄlez
- A GölcĂŒ
- A Obata
- A Ruangma
- A Sreedhara
- AB Delaloye
- AB Packard
- AC GonzĂĄlez-BarĂł
- AF Prasanphanich
- AJ Guo
- AM Derfus
- AM Studer
- AP Singh
- AR Jalilian
- AS Taggar
- BA Rzigalinski
- BK Singh
- BR Jarrett
- BY Yang
- C Gunawan
- C Yoshida
- CA Boswell
- CJ Anderson
- CJ Mathias
- CL Kao
- CP Firme III
- D Chen
- D Kovala-Demertzi
- D Ma
- DG Medvedev
- DM Goldenberg
- DP Holschneider
- DW Dietz
- DW McCarthy
- E Pontiki
- E Toyota
- E Vegt
- EG Ferrer
- EL Engelhardt
- ElĆŒbieta Mikiciuk-Olasik
- F Carrel
- F Dehdashti
- F Dehdashti
- FA Sheikh
- G Borkow
- G Borkow
- G Borkow
- G Hao
- G Liu
- GE Jackson
- GL DeNardo
- GM Thurber
- GR Mirick
- H Cai
- H Heli
- H Timonen
- H Zhang
- H-Y Lee
- HA Williams
- HL Seng
- I Bertini
- I Dijkgraaf
- I Novak-Hofer
- J Bhattacharya
- J Chen
- J Emerit
- J Kofoed
- J-M Zen
- JA OâDonoghue
- JA Taraszka
- JE Sprague
- JE Sprague
- JE Weder
- JE Weder
- JJ HostĂœnek
- JLJ Dearling
- JN Zvimba
- JRJ Sorenson
- JRJ Sorenson
- K Chen
- K Fujita
- K Ghosh
- K Knogler
- K Zhang
- K Zimmermann
- K Zimmermann
- KB Male
- KM El-Azony
- KSC Chao
- KT Yong
- L Balogh
- L Franco
- L Jin
- L Nan
- L Sampath
- L Wei
- L Wei
- LA Bass
- LC Jiang
- LP Szajek
- LW Hung
- M Azenha
- M BarcelĂł-Oliver
- M Belicchi-Ferrari
- M Boopathi
- M Eiblmaier
- M Galibert
- M Grace
- M Isozaki
- M Maiti
- M Salvati
- M Shakir
- M Sylla-Iyarreta VeitĂa
- M Yang
- MA Green
- Magdalena Markowicz
- MD Bilgin
- MJF-A Tuorkey
- ML Bonardi
- ML Thakur
- MM Ibrahim
- MS Refat
- N Li
- N Mora
- N Takahashi
- NE Basken
- NF Black
- ODM Hughes
- P Burgman
- P Lemoine
- P McQuade
- P Rowshanfarzad
- PaweĆ SzymaĆski
- PD Bonnitcha
- PJ Blower
- Q Xu
- R Cini
- R Cini
- R Laforest
- R Rossin
- RC Chan
- RC Zatcoff
- RG Hopkins
- RK OâReilly
- RL Aft
- RL Sang
- RM Reilly
- RS Kumar
- S Cai
- S Dutta
- S Odisitse
- S Odisitse
- S Puig
- S Roy
- S Sakuma
- S Sakuma
- S Sreedaran
- SJ DeNardo
- SR Lane
- SS Das
- T Fukumura
- T Katabuchi
- T Suksrichavalit
- T Suksrichavalit
- TJ Hoffman
- TJ Wadas
- TM Farley
- Tomasz FrÄ czek
- TZ Wong
- V Bertrand
- VS Le
- W Cai
- W Cai
- W Zhang
- WI Choi
- WP Li
- X Chen
- X Ding
- X Gao
- X Liu
- X Ren
- X Tian
- X Zhao
- Y Han
- Y Li
- Y Minagawa
- Y Ohsumi
- Y Wu
- Y Yoshii
- Y Zhang
- Y Zhang
- YP Dong
- YS Yang
- YZ Wan
- Z Cheng
- Z Liu
- Z Liu
- Z Miao
- ZH Jin
- ZL Huang
- ZQ Tian
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Hypercarbia during tracheostomy: a comparison of percutaneous endoscopic, percutaneous Doppler, and standard surgical tracheostomy
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Recovery curves for pediatric burn survivors advances in patient-oriented outcomes
- Author
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/06/2016
- Field of study
The generation of transplasmic Drosophila simulans by cytoplasmic injection Effects of segregation and selection on the perpetuation of mitochondrial DNA heteroplasmy
- Author
- A Adoutte
- A Sainsard-Chanet
- BD Greenberg
- CA Hutchison III
- CW Birky Jr
- DC Wallace
- DM Rand
- DY Thomas
- ES Goldring
- F Baba-Aissa
- GG Brown
- H Ennafaa
- IB Dawid
- IJ Holt
- J David
- J-I Hayashi
- J-I Hayashi
- JC Avise
- JG Reilly
- LD Densmore
- M Monnerot
- M Solignac
- M Solignac
- M Solignac
- M Solignac
- M Solignac
- M Solignac
- MP King
- P Boursot
- P Santamaria
- WW Hauswirth
- Y Satta
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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