Thermal Analysis for Orbiter and ISS Plume Impingement on International Space Station

The NASA Reaction Control System (RCS) Plume Model (RPM) is an exhaust plume flow field and impingement heating code that has been updated and applied to components of the International Space Station (ISS). The objective of this study was to use this code to determine if plume environments from either Orbiter PRCS jets or ISS reboost and Attitude Control System (ACS) jets cause thermal issues on ISS component surfaces. This impingement analysis becomes increasingly important as the ISS is being assembled with its first permanent crew scheduled to arrive by the end of fall 2000. By early summer 2001 , the ISS will have a number of major components installed such as the Unity (Node 1), Destiny (Lab Module), Zarya (Functional Cargo Block), and Zvezda (Service Module) along with the P6 solar arrays and radiators and the Z-1 truss. Plume heating to these components has been analyzed with the RPM code as well as additional components for missions beyond Flight 6A such as the Propulsion Module (PM), Mobile Servicing System, Space Station Remote Manipulator System, Node 2, and the Cupola. For the past several years NASA/JSC has been developing the methodology to predict plume heating on ISS components. The RPM code is a modified source flow code with capabilities for scarfed nozzles and intersecting plumes that was developed for the 44 Orbiter RCS jets. This code has been validated by comparison with Shuttle Plume Impingement Flight Experiment (SPIFEX) heat flux and pressure data and with CFD and Method of Characteristics solutions. Previous analyses of plume heating predictions to the ISS using RPM have been reported, but did not consider thermal analysis for the components nor jet-firing histories as the Orbiter approaches the ISS docking ports. The RPM code has since been modified to analyze surface temperatures with a lumped mass approach and also uses jet-firing histories to produce pulsed heating rates. In addition, RPM was modified to include plume heating from ISS jets to ISS components where the jet coordinates are specified, together with the engine cant angle. These latter studies have been focused on the PM with plumes from its reboost and ACS jets impinging on various ISS components and also focused on the Japanese H2 Transfer Vehicle (HTV) with the plumes from its reboost engines impinging on the Cupola window. This paper will present plume heating and surface temperature results on a number of ISS components with and without jet-firing histories, evaluate post-flight data, and describe any potential thermal issue

Comparison of Orbiter PRCS Plume Flow Fields Using CFD and Modified Source Flow Codes

The Space Shuttle Orbiter will use Reaction Control System (RCS) jets for docking with the planned International Space Station (ISS). During approach and backout maneuvers, plumes from these jets could cause high pressure, heating, and thermal loads on ISS components. The object of this paper is to present comparisons of RCS plume flow fields used to calculate these ISS environments. Because of the complexities of 3-D plumes with variable scarf-angle and multi-jet combinations, NASA/JSC developed a plume flow-field methodology for all of these Orbiter jets. The RCS Plume Model (RPM), which includes effects of scarfed nozzles and dual jets, was developed as a modified source-flow engineering tool to rapidly generate plume properties and impingement environments on ISS components. This paper presents flow-field properties from four PRCS jets: F3U low scarf-angle single jet, F3F high scarf-angle single jet, DTU zero scarf-angle dual jet, and F1F/F2F high scarf-angle dual jet. The RPM results compared well with plume flow fields using four CFD programs: General Aerodynamic Simulation Program (GASP), Cartesian (CART), Unified Solution Algorithm (USA), and Reacting and Multi-phase Program (RAMP). Good comparisons of predicted pressures are shown with STS 64 Shuttle Plume Impingement Flight Experiment (SPIFEX) data

Spacecraft Orbital Debris Reentry: Aerothermal Analysis

In the past 40 years, thousands of objects have been placed in Earth orbit and are being tracked. Space hardware reentry survivability must be evaluated to assess risks to human life and property on the ground. The objective of this paper is to present results of a study to determine altitude of demise (burn-up) or survivability of reentering objects. Two NASA/JSC computer codes - Object Reentry Survival Analysis Tool (ORSAT) and Miniature ORSAT (MORSAT) were used to determine trajectories, aerodynamic aerothermal environment, and thermal response of selected spacecraft components. The methodology of the two codes is presented, along with results of a parametric study of reentering objects modeled as spheres and cylinders. Parameters varied included mass, diameter, wall thickness, ballistic coefficient, length, type of material, and mode of tumbling/spinning. Two fragments of a spent Delta second stage undergoing orbital decay, stainless steel cylindrical propellant tank and titanium pressurization sphere, were evaluated with ORSAT and found to survive entry, as did the actual objects. Also, orbital decay reentry predictions of the Japanese Advanced Earth Observing Satellite (ADEOS) aluminum and nickel box-type components and the Russian COSMOS 954 satellite beryllium cylinders were made with MORSAT. These objects were also shown to survive reentry

Comparing Cryptos - How Cryptocurrencies Fit with the Global Economy

Project Objective and Proposed Hypothesis: To assess the credibility of cryptocurrencies via using statistical methods to investigate potential relationships and correlations between select economic indicators. A currency’s credibility can be scored by how well its’ value correlates with select economic indicators. The degree of correlation can be used to determine its’ possible use case and financial strength in the global economy. This project addresses if cryptocurrency values correlate with the global economy.Ope

Complete Sequences of Multiple-Drug Resistant IncHI2 ST3 Plasmids in Escherichia coli of Porcine Origin in Australia

IncHI2 ST3 plasmids are known carriers of multiple antimicrobial resistance genes. Complete plasmid sequences from multiple drug resistant Escherichia coli circulating in Australian swine is however limited. Here we sequenced two related IncHI2 ST3 plasmids, pSDE-SvHI2, and pSDC-F2_12BHI2, from phylogenetically unrelated multiple-drug resistant Escherichia coli strains SvETEC (CC23:O157:H19) and F2_12B (ST93:O7:H4) from geographically disparate pig production operations in New South Wales, Australia. Unicycler was used to co-assemble short read (Illumina) and long read (PacBio SMRT) nucleotide sequence data. The plasmids encoded three drug-resistance loci, two of which carried class 1 integrons. One integron, hosting drfA12-orfF-aadA2, was within a hybrid Tn1721/Tn21, with the second residing within a copper/silver resistance transposon, comprising part of an atypical sul3-associated structure. The third resistance locus was flanked by IS15DI and encoded neomycin resistance (neoR). An oqx-encoding transposon (quinolone resistance), similar in structure to Tn6010, was identified only in pSDC-F2_12BHI2. Both plasmids showed high sequence identity to plasmid pSTM6-275, recently described in Salmonella enterica serotype 1,4,[5],12:i:- that has risen to prominence and become endemic in Australia. IncHI2 ST3 plasmids circulating in commensal and pathogenic E. coli from Australian swine belong to a lineage of plasmids often in association with sul3 and host multiple complex antibiotic and metal resistance structures, formed in part by IS26

Dynamic lattice distortions driven by surface trapping in semiconductor nanocrystals

Nonradiative processes limit optoelectronic functionality of nanocrystals and curb their device performance. Nevertheless, the dynamic structural origins of nonradiative relaxations in nanocrystals are not understood. Here, femtosecond electron diffraction measurements corroborated by atomistic simulations uncover transient lattice deformations accompanying radiationless electronic processes in semiconductor nanocrystals. Investigation of the excitation energy dependence shows that hot carriers created by a photon energy considerably larger than the bandgap induce structural distortions at nanocrystal surfaces on few picosecond timescales associated with the localization of trapped holes. On the other hand, carriers created by a photon energy close to the bandgap result in transient lattice heating that occurs on a much longer 200 ps timescale, governed by an Auger heating mechanism. Elucidation of the structural deformations associated with the surface trapping of hot holes provides atomic-scale insights into the mechanisms deteriorating optoelectronic performance and a pathway towards minimizing these losses in nanocrystal devices.Comment: 17 pages, 4 figure

Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy.

Despite the enormous economic importance of Neospora caninum related veterinary diseases, the number of effective therapeutic agents is relatively small. Development of new therapeutic strategies to combat the economic impact of neosporosis remains an important scientific endeavor. This study demonstrates molecular, structural and phenotypic evidence that N. caninum calcium-dependent protein kinase 1 (NcCDPK1) is a promising molecular target for neosporosis drug development. Recombinant NcCDPK1 was expressed, purified and screened against a select group of bumped kinase inhibitors (BKIs) previously shown to have low IC50s against Toxoplasma gondii CDPK1 and T. gondii tachyzoites. NcCDPK1 was inhibited by low concentrations of BKIs. The three-dimensional structure of NcCDPK1 in complex with BKIs was studied crystallographically. The BKI-NcCDPK1 structures demonstrated the structural basis for potency and selectivity. Calcium-dependent conformational changes in solution as characterized by small-angle X-ray scattering are consistent with previous structures in low Calcium-state but different in the Calcium-bound active state than predicted by X-ray crystallography. BKIs effectively inhibited N. caninum tachyzoite proliferation in vitro. Electron microscopic analysis of N. caninum cells revealed ultra-structural changes in the presence of BKI compound 1294. BKI compound 1294 interfered with an early step in Neospora tachyzoite host cell invasion and egress. Prolonged incubation in the presence of 1294 interfered produced observable interference with viability and replication. Oral dosing of BKI compound 1294 at 50 mg/kg for 5 days in established murine neosporosis resulted in a 10-fold reduced cerebral parasite burden compared to untreated control. Further experiments are needed to determine the PK, optimal dosage, and duration for effective treatment in cattle and dogs, but these data demonstrate proof-of-concept for BKIs, and 1294 specifically, for therapy of bovine and canine neosporosis

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Loneliness and social media: A qualitative investigation of young people's motivations for use and perceptions of social networking sites

The democratisation of Internet access has incrementally changed every domain of activity and has created new business and economic models. From answering work emails to learning a new language, shopping, booking medical appointments or managing one’s finances, almost everything is attainable at the click of a button. The added implications of the rapid rise of social networking websites (SNSs), such as Facebook, Twitter, Instagram or Snapchat, have further contributed to changing the way we communicate and build new friendships. Indeed most of our social relationships are now being ‘increasingly developed and maintained online’ (Nowland, Necka & Cacioppo, 2017: 1). Ostensibly, despite improved Internet access and enhanced social connectedness, modern societies are struggling to combat loneliness. It is reported to affect people of all ages, especially young adults (16-24 and 25-34 years old) who are avid Internet and social media users (see Office for National Statistics, 2018)