A shuttle development flight test vehicle study

A study is presented that identifies the potential performance capability of the production shuttle orbiter for powered flight tests using several propulsion systems following vertical takeoff and using J-2 rocket engines following air launch. Of the approaches considered, the air-launched orbiter equipped with J-2 rocket engines appeared to have the highest potential for early shuttle development flights. With this approach, mach 4 appeared attainable using 45.5K kg (100K lb) of internal propellant. Several issues were identified that require resolution to prove feasibility

Superoxide Release And Cellular Gluthatione Peroxidase Activity In Leukocytes From Children With Persistent Asthma.

Asthma is an inflammatory condition characterized by the involvement of several mediators, including reactive oxygen species. The aim of the present study was to investigate the superoxide release and cellular glutathione peroxidase (cGPx) activity in peripheral blood granulocytes and monocytes from children and adolescents with atopic asthma. Forty-four patients were selected and classified as having intermittent or persistent asthma (mild, moderate or severe). The spontaneous or phorbol myristate acetate (PMA, 30 nM)-induced superoxide release by granulocytes and monocytes was determined at 0, 5, 15, and 25 min. cGPx activity was assayed spectrophotometrically. The spontaneous superoxide release by granulocytes from patients with mild (N = 15), moderate (N = 12) or severe (N = 6) asthma was higher at 25 min compared to healthy individuals (N = 28, P 0.05 in all times of incubation, Duncan test). cGPx activity of granulocytes and monocytes from patients with persistent asthma (N = 20) was also similar to healthy individuals (N = 10, P > 0.05, Kruskal-Wallis test). We conclude that, under specific circumstances, granulocytes from children with persistent asthma present a higher respiratory burst activity compared to healthy individuals. These findings indicate a risk of oxidative stress, phagocyte auto-oxidation, and the subsequent release of intracellular toxic oxidants and enzymes, leading to additional inflammation and lung damage in asthmatic children.371607-1

Effect of vitamin-enriched bread on the vitamin status of an isolated rural community - a controlled clinical trial

No Abstract

Effects of the 2014 major Baltic inflow on methane and nitrous oxide dynamics in the water column of the Central Baltic Sea

Peer reviewe