Economic evaluation of the eradication program for bovine viral diarrhea in the Swiss dairy sector

The aim of this study was to conduct an economic evaluation of the BVD eradication program in the Swiss dairy sector. The situation before the start of the program (herd-level prevalence: 20%) served as a baseline scenario. Production models for three dairy farm types were used to estimate gross margins as well as net production losses and expenditures caused by BVD. The total economic benefit was estimated as the difference in disease costs between the baseline scenario and the implemented eradication program and was compared to the total eradication costs in a benefit-cost analysis. Data on the impact of BVD virus (BVDV) infection on animal health, fertility and production parameters were obtained empirically in a retrospective epidemiological case-control study in Swiss dairy herds and complemented by literature. Economic and additional production parameters were based on benchmarking data and published agricultural statistics. The eradication costs comprised the cumulative expenses for sampling and diagnostics. The economic model consisted of a stochastic simulation in @Risk for Excel with 20,000 iterations and was conducted for a time period of 14 years (2008–2021)

Risk attribution of Campylobacter infection by age group using exposure modelling

Knowledge on the relative importance of alternative sources of human campylobacteriosis is important in order to implement effective disease prevention measures. The objective of this study was to assess the relative importance of three key exposure pathways (travelling abroad, poultry meat, pet contact) for different patient age groups in Switzerland. With a stochastic exposure model data on Campylobacter incidence for the years 2002-2007 were linked with data for the three exposure pathways and the results of a case-control study. Mean values for the population attributable fractions (PAF) over all age groups and years were 27% (95% CI 17-39) for poultry consumption, 27% (95% CI 22-32) for travelling abroad, 8% (95% CI 6-9) for pet contact and 39% (95% CI 25-50) for other risk factors. This model provided robust results when using data available for Switzerland, but the uncertainties remained high. The output of the model could be improved if more accurate input data are available to estimate the infection rate per exposure. In particular, the relatively high proportion of cases attributed to ‘other risk factors' requires further attentio

Probabilistic Distillation of Quantum Coherence

© 2018 American Physical Society. The ability to distill quantum coherence is pivotal for optimizing the performance of quantum technologies; however, such a task cannot always be accomplished with certainty. Here we develop a general framework of probabilistic distillation of quantum coherence in a one-shot setting, establishing fundamental limitations for different classes of free operations. We first provide a geometric interpretation for the maximal success probability, showing that under maximally incoherent operations (MIO) and dephasing-covariant incoherent operations (DIO) the problem can be simplified into efficiently computable semidefinite programs. Exploiting these results, we find that DIO and its subset of strictly incoherent operations have equal power in the probabilistic distillation of coherence from pure input states, while MIO are strictly stronger. We then prove a fundamental no-go result: Distilling coherence from any full-rank state is impossible even probabilistically. We further find that in some conditions the maximal success probability can vanish suddenly beyond a certain threshold in the distillation fidelity. Finally, we consider probabilistic coherence distillation assisted by a catalyst and demonstrate, with specific examples, its superiority to the unassisted and deterministic cases

Prevalence and Correlates of Depressive Symptoms in a Community Sample of People Suffering from Heart Failure

To examine the rates and correlates of depressive symptoms and syndromal depression in people with self-reported heart failure participating in a community study of people aged 70 and older. DESIGN: Cross-sectional. SETTING: Community-based epidemiological study of older people from the continental United States. PARTICIPANTS: Six thousand one hundred twenty-five older people participating in the longitudinal study of Assets and Health Dynamics. Participants had to be born in 1923 or earlier. MEASUREMENTS: The short-form Composite International Diagnostic Interview assessed syndromal depression, and a revised version of the Center for Epidemiologic Studies—Depression scale assessed depressive symptoms. Medical illness was based on self-report. The authors compared the rates of syndromal depression and individual depressive symptoms in people with self-reported heart failure (n = 199) with those in people with other heart conditions (n = 1,856) and with no heart conditions (n = 4,070). RESULTS: Eleven percent of those with heart failure met criteria for syndromal depression, compared with 4.8% of people with other heart conditions and 3.2% of those with no heart conditions. The association between heart failure and depression held even after controlling for disability, reported fatigue and breathlessness, and number of comorbid chronic illnesses. CONCLUSION: Community-living older people with self-reported heart failure were at approximately twice the risk for syndromal depression of the rest of the community. Although fatigue and functional disability were also related to depression in this sample, these variables did not account for the association between syndromal depression and self-reported heart failure.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66305/1/j.1532-5415.2002.50612.x.pd

Memory Complaint in a Community Sample Aged 70 and Older

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111116/1/j.1532-5415.2000.tb02634.x.pd

Gaussian quantum resource theories

© 2018 American Physical Society. We develop a general framework to assess capabilities and limitations of the Gaussian toolbox in continuous-variable quantum information theory. Our framework allows us to characterize the structure and properties of quantum resource theories specialized to Gaussian states and Gaussian operations, establishing rigorous methods for their description and yielding a unified approach to their quantification. We show in particular that, under a few intuitive and physically motivated assumptions on the set of free states, no Gaussian quantum resource can be distilled with free Gaussian operations, even when an unlimited supply of the resource state is available. This places fundamental constraints on state manipulations in all such Gaussian resource theories. We discuss in particular the applications to quantum entanglement, where we extend previously known results by showing that Gaussian entanglement cannot be distilled even with Gaussian operations preserving the positivity of the partial transpose, as well as to other Gaussian resources such as steering and optical nonclassicality. A comprehensive semidefinite programming representation of all these resources is explicitly provided

IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity.

Contrary to expectations based on in vitro experiments, we previously found that pancreatic IL-10 did not inhibit autoimmune diabetes but accelerated it in an MHC-dependent manner. Therefore, the ability of IL-10 to overcome the absence of all non-MHC diabetes susceptibility (Idd) alleles was studied in transgenic mice expressing pancreatic IL-10 backcrossed to B10.H2g7 congenic mice, which have no Idd alleles other than NOD MHC (H2g7). IL-10 transgenic backcross 1 (BC1) mice with H2g7/g7 haplotype developed clear-cut insulitis and diabetes, but neither transgenic mice with the H2g/b haplotype nor nontransgenic BC1 mice did so. Further implicating IL-10 in autoimmune diabetes, anti-IL-10 antibody treatment inhibited the development of insulitis in NOD mice. These results suggest that IL-10 may be necessary and sufficient for producing autoimmune diabetes in conjunction with NOD MHC homozygosity and that some Idd genes may be related to the regulation of IL-10

Zoonotic pathogens and antimicrobial resistance in ‘animal-friendly’ pig production systems in Switzerland

In a cross-sectional study, the impact of ‘animal-friendly’ housing systems on the prevalence of Salmonella species, Campylobacter species, and Yersinia enterocolitica in finishing pigs and pork was investigated. Furthermore, antimicrobial resistance patterns of isolated campylobacter strains were analysed. In faecal samples of two out of 88 fattening pig farms salmonellae were isolated. All 865 samples of pork were found to be negative. Campylobacter was isolated on 98.9 % of the farms but only from 0.2 % of the pork samples. Yersiniae were found in samples of 63.3 % of the farms and in 15.4 % of pork samples. For all three bacteria, there was no statistically significant difference in the prevalence between conventional and ‘animal-friendly’ housing systems. In ‘animal-friendly’ farms, antimicrobial resistance of campylobacter isolates to fluoroquinolones and streptomycin was significantly less frequent than in conventional farms. Furthermore, fewer isolates had resistance to three or more antimicrobials in ‘animal-friendly’ farms

Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain.

Bispecific antibodies are considered as a promising class of future biotherapeutic molecules. They comprise binding specificities for two different antigens, which may provide additive or synergistic modes of action. There is a wide variety of design alternatives for such bispecific antibodies, including the "CrossMab" format. CrossMabs contain a domain crossover in one of the antigen-binding (Fab) parts, together with the "knobs-and-holes" approach, to enforce the correct assembly of four different polypeptide chains into an IgG-like bispecific antibody. We determined the crystal structure of a hAng-2-binding Fab in its crossed and uncrossed form and show that CH1-CL-domain crossover does not induce significant perturbations of the structure and has no detectable influence on target binding