Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry

OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc). METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers. RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group. CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies

Régression spontanée de carcinomes spinocellulaires multiples à l’arrêt d’un traitement par adalimumab et méthotrexate

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Caractéristiques cliniques et traitement du pyoderma gangrenosum dans la Marne

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The impact of atopic dermatitis on sexual health

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Patient Burden is Associated with Alterations in Quality of Life in Adult Patients with Atopic Dermatitis: Results from the ECLA Study

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Assessing the sociology of sport: On sport participation and disabilities in France

International audienceOn the 50th anniversary of the ISSA and IRSS, Stéphane Héas, a leading French scholar on sport participation and the rights and opportunities of people with disabilities and minorities to engage in sporting activity, considers the trajectory and challenges of sociology of sport in France with special reference to the needs of these populations. It is noted that while studies of sport and physical activity that engaged “a sociological gaze” were relatively late in coming to France, research engaging socio-cultural understandings of sport has accelerated in recent years. A key challenge to research in this area has been to redress the relative neglect of studying the opportunities and participation of people with disabilities and other minorities in sport and physical activity. In the future, the sociology of sport holds the promise of being able to support meaningful policy changes to enable equity and opportunity for these populations