Paediatric acute basilar thrombosis successfully treated with intravenous alteplase

Acute ischaemic stroke has significant attendant morbidity and is one of the top ten causes of childhood death. It requires prompt investigation and management, however little is known about the safety and efficacy of acute thrombolytic therapies in childhood arterial ischaemic stroke. The authors report a case of a 13-year-old girl with an acute basilar thrombosis, successfully treated with intravenous recombinant tissue plasminogen activator and discuss the management of paediatric arterial ischaemic stroke.info:eu-repo/semantics/publishedVersio

Neonatal stroke associated with de novo antiphospholipid antibody and homozygous 1298C/C methylenetetrahydrofolate reductase mutation

Antiphospholipid antibodies are a recognised prothrombotic risk factor associated with acute ischaemic infarction. Most autoimmune diseases are rare in infants, and in the neonatal period, autoimmunity is related to transplacental passage of maternal immunoglobulin G autoantibodies. Distinguishing between de novo and acquired autoimmunity has important therapeutic implications and is crucial for determining the prognosis. We present a case of a neonatal thrombotic stroke associated with de novo synthesis of antiphospholipid antibodies, a homozygous 1298C/C methylene-tetrahydrofolate reductase mutation and a double-homozygous plasminogen activator inhibitor 1 polymorphism (PAI-1 844A/A and 675 4G/4G), which may have increased the final thrombotic risk. Her mother was not positive for antiphospholipid antibodies. The authors highlight an unequivocal evidence of a de novo case of paediatric antiphospholipid antibody syndrome and emphasise the need for a thorough investigation in cases of neonatal stroke including molecular thrombophilia study.info:eu-repo/semantics/publishedVersio

Evolving conceptions of work-family boundaries: In defense of the family as stakeholder

In the management and organization studies literature, a key question to explore and explain is that of the family as an organizational stakeholder, particularly when working-from-home became the “new normal”. Departing from meta-analytic studies on the work-family relation and connecting with scholarly conversation on work-family boundary dynamics, we identify three main narratives. In the separation narrative, work and family belong to different realms, and including the family in the domain of organizational responsibility is seen as pointless. The interdependence narrative stresses that organizations and families are overlapping domains in which it is important to acknowledge that the policies and practices of the former might have an impact on family life, and vice-versa. The embeddedness narrative, brought to the fore by the COVID-19 pandemic, sees employment and family as progressively convergent and hybrid work domains. The evolution of employment relations towards increased hybridity of the work situation being embedded in the familial/household context increasingly calls for consideration of the family/household as an integral rather than a peripheral stakeholder.info:eu-repo/semantics/publishedVersio

Uso de agentes de biocontrole sobre a brusone das panículas do arroz em campo.

O objetivo foi avaliar a redução da severidade da brusone nas panículas do arroz com uso de rizobactérias Burkholderia pyrrocinia e Pseudomonas fluorensces e quatro isolados do fungo Trichoderma asperellum

Simulation Mechanism with 2 Degrees of Freedom

This article discusses the historical analysis of the development of simulators applied to aviation. From the development with the application of the first necessity, at the beginning of the 20th century, to the nowadays technology. Today the technology is used in several fields, justifying the increasing business investment destined to the sector, such as training, recycling, development and entertainment. Its advantage, compared to the real model, is the lower cost and greater security. Some simulator mechanisms were studied in order to select one that meets practical USAge demands, and, in the end, a mechanism design is presented, aiming at the future construction and study of the different systems of a simulator in practice

Heritability of motor skills: Study with monozygotic and dizygotic twins

El objetivo del estudio fue evaluar el poder relativo de contribución genética y ambiental de la variación de capacidades motoras en gemelos monocigóticos y dicigóticos. Método: participado 88 sujetos divididos en 56 monocigóticos y 32 dicigóticos de ambos sexos. Para la evaluación de la flexibilidad fue realizado el test de flexión de cadera; para la potencia de miembros inferiores fue aplicado el test contra movimiento y para la velocidad de desplazamiento, el test de carrera de 30m. Para determinar el índice de heredabilidad, utilizamos la ecuación: (h²) = (S²DZ–S²MZ)/S²DZx100. Fue utilizado tratamiento descriptivo y el test Shapiro-Wilk. Con la varianza de datos fueron calculados valores de tendencia central. Los datos fueron categorizados en percentiles de 25%. Resultados: flexibilidad 16%, velocidad de desplazamiento 83% y potencia de los miembros inferiores 70%.Conclusión: Fue evidenciado mayor heredabilidad para las variables de potencia y velocidad, y mayor influencia ambiental para la flexibilidadThe aim of the study was to assess the relative power of genetic and environmental contributions to the variation of motor skills in monozygotic and dizygotic twins. Method: For this study, participated 88 people divided in 56 monozygotic and 32 dizygotic twins of both sexes. For the assessment the flexibility, was performed hip flexion test, for assessment the lower limb power, was applied the test against movement and the speed of movement, the 30m running test. To determine the index of heritability, was used an equation: (h ²) = (S ²MZ- S²DZ) / S²DZx100. For the statistic, was used the descriptive treatment and Shapiro-Wilk test. The variance values were calculated, through the tendency central values. Data were categorized into percentiles of 25%. Results: Flexibility was 16% by heritability influence, speed of movement 83% of influence and for the lower limbs power were 70%. Conclusion: In this study was demonstrated higher heritability for the variables of lower limbs power and the speed of movement, and for the flexibility, a greater influence was linked for environmental factor

Severe Neurological Abnormalities in a Young Boy with Impaired Thyroid Hormone Sensitivity Due to a Novel Mutation in the MCT8 Gene

Monocarboxylate transporter 8 (MCT8) is an active and specific thyroid hormone transporter into neurons. MCT8 mutations cause an X-linked condition known as Allan-Herndon-Dudley syndrome and are characterized by impaired psychomotor development and typical abnormal thyroid function. We describe a 10-year-old boy with severe cognitive disability, axial hypotonia, spastic quadriplegia and sporadic dyskinetic episodes. He initially presented with thyroid dysfunction (high FT3, low rT3, low FT4 and normal TSH) and generalized retardation of the cerebral and cerebellar myelination in brain magnetic resonance imaging. The clinical and laboratory findings led to sequencing of the SLC16A2/MCT8 gene, which identified a novel missense mutation in exon 5. The study of peripheral markers of thyroid function suggests a paradoxical state of thyrotoxicosis in some peripheral tissues. Our patient had a typical clinical presentation at birth but because of the rarity of his disease his diagnosis was not made until the age of 7. The delay can also be explained by the omission of the free T3 assay in the first thyroid evaluation performed. This case therefore highlights the possible benefit of including the T3 assay in the study of patients with severe psychomotor disability of unknown etiology, thus eliminating extra costs for unnecessary complementary diagnostic tests.info:eu-repo/semantics/publishedVersio

The Caloric Necessities of Critical Care Patients During the First Week of Admission

Introduction: The nutritional needs of critically ill patients have been the subject of intense controversy. In accordance with international guidelines, it is advocated to optimize a nutritional intake based on the following recommendation: 25-30 kcal/kg body weight per day. However, there still are authors who recommend permissive underfeeding in the first week of hospitalization. Nevertheless, energy expenditure (EE) and necessity are influenced by the catabolic phase of critical illness, which may vary over time on a patient and from patient to patient. Objective: The objective of this study is to assess if the energy needs of critically ill patients admitted in our intensive care unit (ICU) in the first week of hospitalization are in line with those recommended by the European Society for Clinical Nutrition and Metabolism (ESPEN) international guidelines. Methods: A prospective cross-sectional study was carried out from September to December 2019. The energy needs were evaluated by indirect calorimetry and by the Harris-Benedict equation. Stress variables were evaluated, namely, the type of pathology, hemodynamic support, sedation, temperature, sequential organ failure assessment (SOFA) score, and state at discharge. Results: Forty-six patients were included in this study, with an average energy expenditure by indirect calorimetry of 19.22 ± 4.67 kcal/kg/day. The energy expenditure was less than 20 kcal/kg/day in 63% of the measurements. The concordance rate did not show the relationship between the Harris-Benedict equation and the values of indirect calorimetry. Stress variables were analyzed, with the SOFA score as the only variable with values close to statistical significance. Conclusion: In our ICU, the energy needs of critically ill patients in the first week of hospitalization are lower than the intake recommended by the guidelines.info:eu-repo/semantics/publishedVersio

Algorithmic thinking and creativity: a deck of cards for early childhood education

The challenges presented to educational systems and researchers about algorithmic thinking are wide and exciting. Several initiatives are working on contributions. In the framework of a European Project focused on algorithmic thinking skills through play-based learning, we undertook the development of a resource for introducing algorithmic thinking to teachers and children in Early Childhood Education. The paper presents the resource, a deck of cards, highlighting its connections to creativity and algorithmic thinking. The paper briefly introduces the research design in place to pilot together with preliminary data from the tests with future teachers and a group of 5 years-old children. The deck of cards has been well received by both future teachers and children. The simple drawings are considered attractive and allow for diverse decisions about what to represent. Conditions, in particular, were well received by children. Further analysis of existing data will provide more information regarding the potential and limitations of the deck of cards.info:eu-repo/semantics/publishedVersio