I Want to Get This off My Chest: When Perpetrators Publicly Disclose how They Raped Their Victims

Women live in a world where nearly one in four will experience sexual assault. In fact, sexual violence is now so common that the World Health Organization recently declared it a global epidemic. Despite the prevalence of such incidents, few perpetrators self-identify. In the cases where they did acknowledge their infractions, many perpetrators said they acted as they did because they misconceived a partner’s sexual intention. This current article will argue that confusion about consent serves as more than a potential risk factor; it also provides a reason for disclosing details about the assault. By using the social media website, Reddit.com, we found a connection between confusion about consent and the perpetrators’ desire to recount their actions. Researchers gathered 77 first-hand sexual assault accounts from Reddit.com and then thematically analyzed perpetrators’ statements using an inductive qualitative method, which allows researchers to start with a broad area of study and let theory emerge from the data set. Findings supported the notion that perpetrators’ emotions about consent affected their decisions to disclose. Many expressed a need for catharsis, to “get it off (their) chest.” Others described feeling guilt or remorse, expressing that they felt “sick” with themselves. Still more questioned whether they had crossed a line and wondered whether their experience constituted sexual assault. For these stated reasons, perpetrators turned to Reddit, telling fellow users that they would “like to hear (readers’) opinions.” This study demonstrates that tools such as social media can be used to gain a greater insight into a perpetrator’s mindset. Public policy, education curricula, and prevention programs can implement better language and more effective content by better understanding what confuses perpetrators about the definition and implications of consent

The rights of the child in voluntary care in Ireland: a call for reform in law, policy and practice

Voluntary care agreements form a significant part of child protection systems in many jurisdictions. From a children’s rights perspective, they enjoy numerous advantages over court-ordered removals of children. However, when loosely regulated, voluntary care agreements can give rise to significant concerns in respect of compliance with international children’s rights law. This paper will present findings from the Voluntary Care in Ireland Study, one of the first in-depth empirical examinations internationally of voluntary care agreements. It will present qualitative data on the system in operation in Ireland that indicates that voluntary care agreements are less adversarial, time-consuming and costly than court proceedings. This frees up resources for early intervention and facilitates a more collaborative relationship between parents and social services, making it more likely that children will remain at home or eventually return home from care. At the same time, the findings suggest that the voluntary care system currently operated in Ireland suffer from numerous flaws, including absence of independent oversight; unlimited duration; potential instability (since parents can withdraw consent at any time); weak mechanisms for child participation; and inferior resource allocation compared to court-ordered care placements. The paper examines legislative provisions from a number of comparable jurisdictions and makes recommendations designed to ensure that the voluntary care system in Ireland complies more strongly with principles of international children’s rights law

Multivariate analysis using high definition flow cytometry reveals distinct T cell repertoires between the fetal–maternal interface and the peripheral blood

The human T cell compartment is a complex system and while some information is known on repertoire composition and dynamics in the peripheral blood, little is known about repertoire composition at different anatomical sites. Here, we determine the T cell receptor beta variable (TRBV) repertoire at the decidua and compare it with the peripheral blood during normal pregnancy and pre-eclampsia. We found total T cell subset disparity of up to 58% between sites, including large signature TRBV expansions unique to the fetal–maternal interface. Defining the functional nature and specificity of compartment-specific T cells will be necessary if we are to understand localized immunity, tolerance, and pathogenesis

Reviews

Charles Williams: The Third Inkling. Grevel Lindop. Reviewed by Scott McLaren. The Chapel of the Thorn: A Dramatic Poem. Charles Williams. Edited and Introduced by Sørina Higgins. Reviewed by Scott McLaren. Women and C.S. Lewis: What His Life and Literature Reveal For Today’s Culture. Carolyn Curtis and Mary Pomroy Key, eds. Reviewed by Rebekah Choat. Tolkien Among the Moderns. Edited by Ralph C. Wood. Reviewed by Andrew C. Stout. Tolkien. Raymond Edwards. Reviewed by Cait Coker. Children into Swans: Fairy Tales and the Pagan Imagination. Jan Beveridge. Reviewed by Brian Roberts. Trilby/The Crumb Fairy. Charles Nodier. Translated and adapted by Ruth Berman. Reviewed by Kelly Orazi. The Prince of the Aquamarines. Louise Cavalier Levesque. Trans. and with an afterword by Ruth Berman. Reviewed by Kelly Orazi. The Lessons of Nature in Mythology. Rachel S. McCoppin. Reviewed by Kristine Larsen. Hither Shore: Jahrbuch der Deutschen Tolkien Gesellschaft. Special issue: Nature and Landscape in Tolkien. Ed. Thomas Fornet-Ponse et al. Reviewed by Janet Brennan Croft. Seven: An Anglo-American Literary Review. Ed. Marjorie Lamp Mead. Reviewed by Janet Brennan Croft. Tolkien Studies: An Annual Scholarly Review. Ed. Michael D.C. Drout, Verlyn Flieger, and David Bratman. Reviewed by Janet Brennan Croft. The Skill of a Seeker: Rowling, Religion and Gen 9/11. Marilyn R. Pukkila. Reviewed by Emily Moniz Mirova. Light: C.S. Lewis\u27s First and Final Short Story. Charlie W. Starr. Reviewed by Melody Green. The Story of Kullervo. J.R.R. Tolkien. Edited and introduced by Verlyn Flieger. Reviewed by Mike Foster. The Victorian Approach to Modernism in the Fiction of Dorothy L. Sayers. Aoife Leahy. Reviewed by Joe R. Christopher. Reading Joss Whedon. Rhonda V. Wilcox, Tanya R. Cochran, Cynthea Masson, and David Lavery, eds. Reviewed by by Janet Brennan Croft

Using technology to deliver cancer follow-up : a systematic review

Peer reviewedPublisher PD

PARC:a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults

Background: The survival for many children with relapsed/refractory cancers remains poor despite advances in therapies. Arginine metabolism plays a key role in the pathophysiology of a number of pediatric cancers. We report the first in child study of a recombinant human arginase, BCT-100, in children with relapsed/refractory hematological, solid or CNS cancers.Procedure: PARC was a single arm, Phase I/II, international, open label study. BCT-100 was given intravenously over one hour at weekly intervals. The Phase I section utilized a modified 3 + 3 design where escalation/de-escalation was based on both the safety profile and the complete depletion of arginine (defined as adequate arginine depletion; AAD <8μM arginine in the blood after 4 doses of BCT-100). The Phase II section was designed to further evaluate the clinical activity of BCT-100 at the pediatric RP2D determined in the Phase I section, by recruitment of patients with pediatric cancers into 4 individual groups. A primary evaluation of response was conducted at eight weeks with patients continuing to receive treatment until disease progression or unacceptable toxicity.Results: 49 children were recruited globally. The Phase I cohort of the trial established the Recommended Phase II Dose of 1600U/kg iv weekly in children, matching that of adults. BCT-100 was very well tolerated. No responses defined as a CR, CRi or PR were seen in any cohort within the defined 8 week primary evaluation period. However a number of these relapsed/refractory patients experienced prolonged radiological SD.Conclusion: Arginine depletion is a clinically safe and achievable strategy in children with cancer. The RP2D of BCT-100 in children with relapsed/refractory cancers is established at 1600U/kg intravenously weekly and can lead to sustained disease stability in this hard to treat population.Clinical trial registration: EudraCT, 2017-002762-44; ISRCTN, 21727048; and ClinicalTrials.gov, NCT03455140

“Blood Letting” – Self-phlebotomy in injecting anabolic-androgenic steroids within Performance and Image Enhancing Drug (PIED) culture

Background New evidence with regard to a previously undocumented practice – self phlebotomy, known as ‘bloodletting’ – incontemporary injecting performance and image enhancing drug (PIED) culture is the subject of this paper. While self phlebotomy has been evidenced in psychiatric patients previously, it was performed here in people who inject AAS as a self directed health care procedure. Methods Data was collected from five publicly accessible internet discussion forums and coded using NVivo software. For the purposes of this study, posts in relation to bloodletting were extracted from the final set of records for analysis Results Motivation to perform bloodletting or to ‘self – bleed’ was largely grounded in experiencing symptoms of high blood pressure or a high red blood cell count (RBC).Instructions on how to perform bloodletting were found within discussion threads. Conclusion This study is intended to provide the first snapshot of online communal activity around practice of self-phlebotomy or bloodletting amongst people who inject AAS. Further research in this area is warranted, and will be of benefit to healthcare workers, treatment providers and policy makers particularly as this relates to evidence informed and targeted harm reduction policies and effective public health interventions

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

Human leukocyte antigen (HLA) gene polymorphism plays a critical role in protective immunity, disease susceptibility, autoimmunity, and drug hypersensitivity, yet the basis of how HLA polymorphism influences T cell receptor (TCR) recognition is unclear. We examined how a natural micropolymorphism in HLA-B44, an important and large HLA allelic family, affected antigen recognition. T cell–mediated immunity to an Epstein-Barr virus determinant (EENLLDFVRF) is enhanced when HLA-B*4405 was the presenting allotype compared with HLA-B*4402 or HLA-B*4403, each of which differ by just one amino acid. The micropolymorphism in these HLA-B44 allotypes altered the mode of binding and dynamics of the bound viral epitope. The structure of the TCR–HLA-B*4405EENLLDFVRF complex revealed that peptide flexibility was a critical parameter in enabling preferential engagement with HLA-B*4405 in comparison to HLA-B*4402/03. Accordingly, major histocompatibility complex (MHC) polymorphism can alter the dynamics of the peptide-MHC landscape, resulting in fine-tuning of T cell responses between closely related allotypes

Allelic polymorphism in the T cell receptor and its impact on immune responses

In comparison to human leukocyte antigen (HLA) polymorphism, the impact of allelic sequence variation within T cell receptor (TCR) loci is much less understood. Particular TCR loci have been associated with autoimmunity, but the molecular basis for this phenomenon is undefined. We examined the T cell response to an HLA-B*3501-restricted epitope (HPVGEADYFEY) from Epstein-Barr virus (EBV), which is frequently dominated by a TRBV9*01 public TCR (TK3). However, the common allelic variant TRBV9*02, which differs by a single amino acid near the CDR2β loop (Gln55→His55), was never used in this response. The structure of the TK3 TCR, its allelic variant, and a nonnaturally occurring mutant (Gln55→Ala55) in complex with HLA-B*3501 revealed that the Gln55→His55 polymorphism affected the charge complementarity at the TCR-peptide-MHC interface, resulting in reduced functional recognition of the cognate and naturally occurring variants of this EBV peptide. Thus, polymorphism in the TCR loci may contribute toward variability in immune responses and the outcome of infection