Homesteading the Plains: Toward a New History.

Through hard work and thorough research, Richard Edwards, Jacob Friefeld, and Rebecca Wingo seek to dispel any false notions and set the record straight on what was one of the most influential events in the history of the United States in their book, Homesteading the Plains. Th roughout the work, the authors are able to correct false historical accounts that cast a poor light on the Homestead Act while they provide a wealth of statistical evidence to move toward a new history, as the book’s subtitle suggests. Th e Homestead Act provided opportunity for many ancestors of current Great Plains residents and helped populate the Great Plains along with making the region a major agricultural producer, cementing our roles in both national and international markets. As land was given out, communities were formed and churches and schools were soon to follow, helping to make the region and its people not only economically viable, but also culturally significant. While nothing is without its flaws, the Homestead Act was successful in its original goals, which is conclusively proven throughout the book

Tributes to Rick Edwards upon His Retirement

I understand that you will be retiring from UNL in August. I wanted to express my sadness that you will be leaving the Center for Great Plains Studies, but am glad that you will now be able to perhaps enjoy life even more without having to do the administrative tasks that go with being the director of any organization. (RFD

Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

Funding Information: This work was supported by the National Institute of Mental Health / U.S. Army Medical Research and Development Command (Grant No. R01MH106595 [to CMN, IL, MBS, KJRe, and KCK], National Institutes of Health (Grant No. 5U01MH109539 to the Psychiatric Genomics Consortium ), and Brain & Behavior Research Foundation (Young Investigator Grant [to KWC]). Genotyping of samples was provided in part through the Stanley Center for Psychiatric Genetics at the Broad Institute supported by Cohen Veterans Bioscience . Statistical analyses were carried out on the LISA/Genetic Cluster Computer ( https://userinfo.surfsara.nl/systems/lisa ) hosted by SURFsara. This research has been conducted using the UK Biobank resource (Application No. 41209). This work would have not been possible without the financial support provided by Cohen Veterans Bioscience, the Stanley Center for Psychiatric Genetics at the Broad Institute, and One Mind. Funding Information: MBS has in the past 3 years received consulting income from Actelion, Acadia Pharmaceuticals, Aptinyx, Bionomics, BioXcel Therapeutics, Clexio, EmpowerPharm, GW Pharmaceuticals, Janssen, Jazz Pharmaceuticals, and Roche/Genentech and has stock options in Oxeia Biopharmaceuticals and Epivario. In the past 3 years, NPD has held a part-time paid position at Cohen Veterans Bioscience, has been a consultant for Sunovion Pharmaceuticals, and is on the scientific advisory board for Sentio Solutions for unrelated work. In the past 3 years, KJRe has been a consultant for Datastat, Inc., RallyPoint Networks, Inc., Sage Pharmaceuticals, and Takeda. JLM-K has received funding and a speaking fee from COMPASS Pathways. MU has been a consultant for System Analytic. HRK is a member of the Dicerna scientific advisory board and a member of the American Society of Clinical Psychopharmacology Alcohol Clinical Trials Initiative, which during the past 3 years was supported by Alkermes, Amygdala Neurosciences, Arbor Pharmaceuticals, Dicerna, Ethypharm, Indivior, Lundbeck, Mitsubishi, and Otsuka. HRK and JG are named as inventors on Patent Cooperative Treaty patent application number 15/878,640, entitled “Genotype-guided dosing of opioid agonists,” filed January 24, 2018. RP and JG are paid for their editorial work on the journal Complex Psychiatry. OAA is a consultant to HealthLytix. All other authors report no biomedical financial interests or potential conflicts of interest. Funding Information: This work was supported by the National Institute of Mental Health/ U.S. Army Medical Research and Development Command (Grant No. R01MH106595 [to CMN, IL, MBS, KJRe, and KCK], National Institutes of Health (Grant No. 5U01MH109539 to the Psychiatric Genomics Consortium), and Brain & Behavior Research Foundation (Young Investigator Grant [to KWC]). Genotyping of samples was provided in part through the Stanley Center for Psychiatric Genetics at the Broad Institute supported by Cohen Veterans Bioscience. Statistical analyses were carried out on the LISA/Genetic Cluster Computer (https://userinfo.surfsara.nl/systems/lisa) hosted by SURFsara. This research has been conducted using the UK Biobank resource (Application No. 41209). This work would have not been possible without the financial support provided by Cohen Veterans Bioscience, the Stanley Center for Psychiatric Genetics at the Broad Institute, and One Mind. This material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the U.S. Department of the Army or the Department of Defense. We thank the investigators who comprise the PGC-PTSD working group and especially the more than 206,000 research participants worldwide who shared their life experiences and biological samples with PGC-PTSD investigators. We thank Mark Zervas for his critical input. Full acknowledgments are in Supplement 1. MBS has in the past 3 years received consulting income from Actelion, Acadia Pharmaceuticals, Aptinyx, Bionomics, BioXcel Therapeutics, Clexio, EmpowerPharm, GW Pharmaceuticals, Janssen, Jazz Pharmaceuticals, and Roche/Genentech and has stock options in Oxeia Biopharmaceuticals and Epivario. In the past 3 years, NPD has held a part-time paid position at Cohen Veterans Bioscience, has been a consultant for Sunovion Pharmaceuticals, and is on the scientific advisory board for Sentio Solutions for unrelated work. In the past 3 years, KJRe has been a consultant for Datastat, Inc. RallyPoint Networks, Inc. Sage Pharmaceuticals, and Takeda. JLM-K has received funding and a speaking fee from COMPASS Pathways. MU has been a consultant for System Analytic. HRK is a member of the Dicerna scientific advisory board and a member of the American Society of Clinical Psychopharmacology Alcohol Clinical Trials Initiative, which during the past 3 years was supported by Alkermes, Amygdala Neurosciences, Arbor Pharmaceuticals, Dicerna, Ethypharm, Indivior, Lundbeck, Mitsubishi, and Otsuka. HRK and JG are named as inventors on Patent Cooperative Treaty patent application number 15/878,640, entitled ?Genotype-guided dosing of opioid agonists,? filed January 24, 2018. RP and JG are paid for their editorial work on the journal Complex Psychiatry. OAA is a consultant to HealthLytix. All other authors report no biomedical financial interests or potential conflicts of interest. Publisher Copyright: © 2021 Society of Biological PsychiatryBackground: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs). Methods: A GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with linkage disequilibrium score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. Functional mapping and annotation of leading loci was performed with FUMA. Replication was evaluated using the Million Veteran Program GWAS of PTSD total symptoms. Results: GWASs of PTSD symptoms and LTE burden identified 5 and 6 independent genome-wide significant loci, respectively. There was a 72% genetic correlation between PTSD and LTE. PTSD and LTE showed largely similar patterns of genetic correlation with other traits, albeit with some distinctions. Adjusting PTSD for LTE reduced PTSD heritability by 31%. Multivariate analysis of PTSD and LTE increased the effective sample size of the PTSD GWAS by 20% and identified 4 additional loci. Four of these 9 PTSD loci were independently replicated in the Million Veteran Program. Conclusions: Through using a quantitative trait measure of PTSD, we identified novel risk loci not previously identified using prior case-control analyses. PTSD and LTE have a high genetic overlap that can be leveraged to increase discovery power through multivariate methods.publishersversionpublishe

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

We identified rare coding variants associated with Alzheimer’s disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1×10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5×10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38×10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56×10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P=1.55×10-14, OR=1.67, MAFcases=0.0143, MAFcontrols=0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development

Restructuring the Reservation: House-building policy and adult education on the Crow Reservation, 1880–1934

Using the Apsáalooke (Crow) Nation in Montana as a case study, Restructuring the Reservation examines the impact of federal house-building campaigns and adult education programs from 1880–1934 on the citizenship, domesticity, economic opportunity, environment, family structure, gender roles, health, housing infrastructure, landscape, moral authority, and motherhood. The Office of Indian Affairs (OIA) designed programs, such as the farmer and field matron field services, to supervise the promotion of white middle-class values among adult reservation communities. Missionaries implemented other programs to exercise moral control over reservation adults as well. Building upon the expansive literature about boarding school education for Native American children and the intimate domestic spaces of Indigenous women, this dissertation explores gendered adult programming within the context of citizenship, race, and settler colonialism. This research further demonstrates that administrators of housing and related policies and reformers ironically undermined both their own and each other\u27s civilizing efforts, implying a disconnect between the policy, practice, and rhetoric of federal house-building policy. While the OIA sought to control reservation adults, the Crow creatively and clandestinely worked to retain and exercise their cultural, religious, and social autonomy within their own domestic spaces. Crow men and women actively used the house as a site of negotiation to blunt the sharp edges of coercive assimilation policy. The Crow incorporated their culture and traditions into their highly supervised daily lives. The Apsáalooke met their colonizers head-on as government-sponsored domestic imperialistic programs attempted to repackage and restructure the reservation

Tributes to Rick Edwards upon His Retirement

I understand that you will be retiring from UNL in August. I wanted to express my sadness that you will be leaving the Center for Great Plains Studies, but am glad that you will now be able to perhaps enjoy life even more without having to do the administrative tasks that go with being the director of any organization. (RFD

Creating Public History Master Programs: International Guidelines

Universities create new public history Master’s programs every year. Public history university programs first emerged in the United States (the first public history program was launched at the University of California, Santa Barbara, in 1976). Public history Master’s programs are now established throughout the world (See the IFPH’s map of public history programs) and the number of programs keeps growing. At the same time, creating a new program can be overwhelming and challenging. Indeed, while Public History belongs to the overall historical discipline, it bears some crucial specificity regarding its practices and training. In 2015, the National Council on Public History in the United States published useful best practices for “Establishing and Developing a Public History Program.” However, the field has rapidly changed in the past few years and numerous programs are emerging outside the United States. Although public history programs were successfully integrated into university systems in the United States, the same practices do not necessarily translate to other countries and contexts. In response to International Federation for Public History (IFPH) members and partnering universities’ needs for a set of teaching and training guidelines to be adapted to a range of international contexts, a Curriculum and Training committee was launched in 2021. Composed of IFPH members from a variety of national contexts and public history backgrounds, the Committee was tasked with leading practitioner discussions and drafting a new set of model practices to reference when creating Master’s level public history programs. More than 40 participants from all over the world took part in our online discussions. What started as a basic forum for ideas and questions evolved into more structured collaborative writing sessions. With the range and variations of national circumstances, university requirements, departmental objectives, and available resources, there can be no one-size-fits-all set of guidelines. Rather, this reference intends to offer ideas and suggestions, which may be applied, adapted, and modified according to national, local, and university contexts. Having said that, we strongly believe that these steps can help colleagues (faculty and administrators) around the globe launch discussions on the need and demand for a Master’s in Public History program at their institution. We are aware that each process and institution is unique. As such, this document presents different components for the creation of a public history program, identifies stages and processes, and proposes general guidelines with the aim of offering guidance in the creation, implementation, and evaluation of Master’s programs in public history