Testing predictions of inclusive fitness theory in inbreeding relatives with biparental care

Data accessibility Data are deposited in Dryad https:doi.org/10.5061/dryad.1zcrdfnf. R code supporting this article has been uploaded as part of the electronic supplementary material. Acknowledgements We thank the Tsawout and Tseycum First Nation bands for allowing access to Mandarte, numerous field assistants, graduate students and postdoctoral fellows who contributed to long-term data collection, and Brad Duthie for insightful discussions regarding underlying concepts. National Sciences and Engineering Research Council (P.A., E.A.G); Izaak Walton Killam Memorial Fund for Advanced Studies (E.A.G, J.M.R.), UK Natural Environment Research Council (R.J.S.) and the European Research Council (J.M.R.) provided funding.Peer reviewedPostprin

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.

This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/ng.3448Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, mostly rare, protein-altering variants. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and rare variants (P < 5 × 10(-8)) distributed across 34 loci. Although wet and dry AMD subtypes exhibit predominantly shared genetics, we identify the first genetic association signal specific to wet AMD, near MMP9 (difference P value = 4.1 × 10(-10)). Very rare coding variants (frequency <0.1%) in CFH, CFI and TIMP3 suggest causal roles for these genes, as does a splice variant in SLC16A8. Our results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.We thank all participants of all the studies included for enabling this research by their participation in these studies. Computer resources for this project have been provided by the high-performance computing centers of the University of Michigan and the University of Regensburg. Group-specific acknowledgments can be found in the Supplementary Note. The Center for Inherited Diseases Research (CIDR) Program contract number is HHSN268201200008I. This and the main consortium work were predominantly funded by 1X01HG006934-01 to G.R.A. and R01 EY022310 to J.L.H

Gestión de financiamiento para el desarrollo de las micro y pequeñas empresas manufactureras de la región de Huánuco - 2017

TesisEl presente trabajo tuvo como objetivo general, explicar la gestión del financiamiento y su influencia en el desarrollo de las MYPES manufactureras de la región Huánuco 2017, de diseño cuasi experimental, donde la población está conformada por 1722 MYPES, y la muestra está conformada por 50 micro y pequeñas empresas de la región Huánuco, se empleó una muestra no probabilística, para la recolección de datos, se utilizó el cuestionario, mediante la técnica de la encuesta, nuestros instrumentos son altamente confiables, donde al obtener los resultados del pre test en ambos grupos de estudio, los encuestados respondieron a veces conocen sobre gestión del financiamiento; específicamente en el grupo experimental en pre test el promedio es 60.28 y si centramos en la interpretación de los resultados del post test notamos claramente el progreso y la evolución del conocimiento de los participantes, con un promedio de 73.04, se ha logrado el objetivo propuesto dentro de la investigación. Asimismo, se observa diferencia en los promedios los cuales han superado los niveles iniciales sobre todo en el grupo experimental, por ejemplo, en el promedio existe una diferencia de 12.76 a favor, la mediana con una diferencia de 13, eso significa que se rechaza la hipótesis nula, por lo tanto, se concluye que, se acepta la hipótesis general propuesta, la gestión del financiamiento influye positivamente en el desarrollo de las MYPES manufactureras de la región de Huánuco 2017

Data from: Female mating preferences and offspring survival: testing hypotheses on the genetic basis of mate choice in a wild lekking bird

Indirect benefits of mate choice result from increased offspring genetic quality and may be important drivers of female behaviour. ‘Good-genes-for-viability’ models predict that females prefer mates of high additive genetic value, such that offspring survival should correlate with male attractiveness. Mate choice may also vary with genetic diversity (e.g. heterozygosity) or compatibility (e.g. relatedness), where the female's genotype influences choice. The relative importance of these nonexclusive hypotheses remains unclear. Leks offer an excellent opportunity to test their predictions, because lekking males provide no material benefits and choice is relatively unconstrained by social limitations. Using 12 years of data on lekking lance-tailed manakins, Chiroxiphia lanceolata, we tested whether offspring survival correlated with patterns of mate choice. Offspring recruitment weakly increased with father attractiveness (measured as reproductive success, RS), suggesting attractive males provide, if anything, only minor benefits via offspring viability. Both male RS and offspring survival until fledging increased with male heterozygosity. However, despite parent–offspring correlation in heterozygosity, offspring survival was unrelated to its own or maternal heterozygosity or to parental relatedness, suggesting survival was not enhanced by heterozygosity per se. Instead, offspring survival benefits may reflect inheritance of specific alleles or nongenetic effects. Although inbreeding depression in male RS should select for inbreeding avoidance, mates were not less related than expected under random mating. Although mate heterozygosity and relatedness were correlated, selection on mate choice for heterozygosity appeared stronger than that for relatedness and may be the primary mechanism maintaining genetic variation in this system despite directional sexual selection

Data from: Offspring fitness varies with parental extra-pair status in song sparrows, Melospiza melodia

Numerous studies have tested for indirect selection on female extra-pair reproduction (EPR) by quantifying whether extra-pair young (EPY) are fitter than their within-pair young (WPY) maternal half-siblings. In contrast, the hypothesis that offspring of EPY and WPY (rather than the EPY and WPY themselves) differ in fitness has not been tested, even though inter-generational effects of parental extra-pair status on offspring fitness could alter the magnitude and direction of indirect selection on EPR. We tested whether offspring of EPY song sparrows, Melospiza melodia, were more likely to recruit or produce hatched or recruited offspring over their lifetimes than offspring of WPY. Hatchlings with one or two EPY parents were more likely to recruit and produce hatched offspring than hatchlings with two WPY parents. Furthermore, these relationships differed between maternal versus paternal extra-pair status. Hatchlings with EPY fathers were more likely to recruit and produce offspring than hatchlings with WPY fathers. In contrast, hatchlings with EPY mothers were as likely to recruit as hatchlings with WPY mothers and tended to be less likely to produce recruited offspring. Depending on the causal genetic and environmental mechanisms, such conflicting inter-generational relationships between parental extra-pair status and offspring fitness could substantially influence the evolutionary dynamics of EPR

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