Chandra observations of the interacting galaxies NGC 3395/3396 (Arp 270)

In this paper we present the results of a 20-ks high-resolution Chandra X-ray observation of the peculiar galaxy pair NGC 3395/3396, a system at a very early stage of merging, and less evolved than the famous Antennae and Mice merging systems. Previously unpublished ROSAT High-Resolution Imager data are also presented. The point-source population and the hot diffuse gas in this system are investigated and compared with other merging galaxy pairs. 16 X-ray point sources are detected in Arp 270, seven of which are classified as ultraluminous X-ray sources (ULXs, LX>= 1039 erg s-1). From spectral fits and the age of the system it seems likely that these are predominantly high-mass X-ray binaries. The diffuse gas emits at a global temperature of ~0.5 keV, consistent with temperatures observed in other interacting systems, and we see no evidence of the starburst-driven hot gaseous outflows seen in more evolved systems such as The Mice and The Antennae. It is likely that these features are absent from Arp 270 as the gas has had insufficient time to break out of the galaxy discs. 32 per cent of the luminosity of Arp 270 arises from the diffuse gas in the system, this is low when compared with later stage merging systems and gives further credence that this is an early-stage merger. Comparing the ULX population of Arp 270 to other merging systems, we derive a relationship between the star formation rate of the system, indicated by LFIR, and the number [N(ULX)] and luminosity (LULX) of its ULX population. We find N(ULX) ~L0.18FIR and LULX~L0.54FIR. These relationships, coupled with the relation of the point-source X-ray luminosity (LXP) to LK and LFIR+UV (Colbert et al. 2003), indicate that the ULX sources in an interacting system have contributions from both the old and young stellar populations.Peer reviewe

Mosquito appetite for blood is stimulated by Plasmodium chabaudi infections in themselves and their vertebrate hosts

BACKGROUND: Arthropod vectors of disease may encounter more than one infected host during the course of their lifetime. The consequences of super-infection to parasite development are rarely investigated, but may have substantial epidemiological and evolutionary consequences. METHODS: Using a rodent malaria model system, behavioural avoidance of super-infection was tested by examining whether already-infected Anopheles stephensi mosquitoes were less responsive to new vertebrate hosts if they were infected. Additionally, a second dose of parasites was given to malaria-infected mosquitoes on a biologically realistic time scale to test whether it impeded the development of a first infection. RESULTS: No effect of a second infected blood meal on either the prevalence or parasite burden arising from a first was found. Furthermore, it was found that not only were infected mosquitoes more likely to take a second blood meal than their uninfected counterparts, they were disproportionately drawn to infected hosts. CONCLUSIONS: The alterations in mosquito feeding propensity reported here would occur if parasites have been selected to make infected vertebrate hosts more attractive to mosquitoes, and infected mosquitoes are more likely to seek out new blood meals. Although such a strategy might increase the risk of super-infection, this study suggests the cost to parasite development is not high and as such would be unlikely to outweigh the potential benefits of increasing the contact rate between the parasite's two obligate hosts

XMM-Newton Reflection Grating Spectrometer Observations of the Prototypical Starburst Galaxy M82

We present results from XMM-Newton Reflection Grating Spectrometer observations of the prototypical starburst galaxy M82. These high resolution spectra represent the best X-ray spectra to date of a starburst galaxy. A complex array of lines from species over a wide range of temperatures is seen, the most prominent being due to Lyman-alpha emission from abundant low Z elements such as N, O, Ne, Mg and Si. Emission lines from Helium-like charge states of the same elements are also seen in emission, as are strong lines from the entire Fe-L series. Further, the OVII line complex is resolved and is seen to be consistent with gas in collisional ionization equilibrium. Spectral fitting indicates emission from a large mass of gas with a differential emission measure over a range of temperatures (from 0.2 keV to 1.6 keV, peaking at 0.7 keV), and evidence for super-solar abundances of several elements is indicated. Spatial analysis of the data indicates that low energy emission is more extended to the south and east of the nucleus than to the north and west. Higher energy emission is far more centrally concentrated.Comment: 5 pages, 4 figures, MNRAS accepte

GEOLOGICAL STRENGTH INDEX METHOD FOR ROCK MASS PARAMETERS ABOUT JINPING UNDERGROUND CAVERNS

工程开挖卸荷后岩体参数研究一直是工程界关注的焦点,是稳定性评价的基础性工作.本文以锦屏地下厂房开挖工程为背景,通过对上下游边墙不同桩号段开挖揭露的岩体进行工程地质岩组划分,进行了开挖后岩体质量评价并对其进行分类,通过在GSI(Geological Strength Index)评价体系中引入Jv(节理数/m3),使评价体系相对合理化,经回归分析,对不同风化程度的岩体进行了力学参数求解,发现内聚力及内摩擦角的计算值与建议值吻合较

Time-to-Contact and Collision-Detection Estimations as Measures of Driving Safety in Old and Dementia Drivers

The paper discusses the importance of Time-to-Contact (TTC) and collision occurrence (CD) estimations for safe driving. It describes a computerised testing tool that requires TTC and CD estimations while dividing attention and discusses the association between performance on this task and several measures of driving safety. We report four studies showing that the task is sensitive to age effects and dementia effects, that the accuracy of Time-to-Contact estimations differentiates between old and dementia drivers recently involved in accidents and those not involved. We also found an association between performance on this task and that on navigation and car following tasks in a driving simulator

Was the soft X-ray flare in NGC 3599 due to an AGN disc instability or a delayed tidal disruption event?

We present unpublished data from a tidal disruption candidate in NGC 3599 which show that the galaxy was already X-ray bright 18 months before the measurement which led to its classification. This removes the possibility that the flare was caused by a classical, fast-rising, short-peaked, tidal disruption event. Recent relativistic simulations indicate that the majority of disruptions will actually take months or years to rise to a peak, which will then be maintained for longer than previously thought. NGC 3599 could be one of the first identified examples of such an event. The optical spectra of NGC 3599 indicate that it is a low-luminosity Seyfert/LINER with L_bol~10^40 ergs/s The flare may alternatively be explained by a thermal instability in the accretion disc, which propagates through the inner region at the sound speed, causing an increase of the disc scale height and local accretion rate. This can explain the <9 years rise time of the flare. If this mechanism is correct then the flare may repeat on a timescale of several decades as the inner disc is emptied and refilled.Comment: Resubmitted due to typo in author nam

Chandra Observations of the Mice

Presented here are high spatial and spectral resolution Chandra X-ray observations of the famous interacting galaxy pair, the Mice, a system similar to, though less evolved than, the well-known Antennae galaxies. Previously unpublished ROSAT HRI data of the system are also presented. Starburst-driven galactic winds outflowing along the minor axis of both galaxies (but particularly the northern) are observed, and spectral and spatial properties, and energetics are presented. That such a phenomenon can occur in such a rapidly-evolving and turbulent system is surprising, and this is the first time that the very beginning - the onset, of starburst-driven hot gaseous outflow in a full-blown disk-disk merger has been seen. Point source emission is seen at the galaxy nuclei, and within the interaction-induced tidal tails. Further point source emission is associated with the galactic bar in the southern system. A comparison of the source X-ray luminosity function and of the diffuse emission properties is made with the Antennae and other galaxies, and evidence of a more rapid evolution of the source population than the diffuse component is found. No evidence for variability is found between the Chandra and previous observations.Comment: 11 pages, 8 figures, accepted by MNRAS, low-resolution figures included, high-resolution version available at http://www.sr.bham.ac.uk/~amr/publications.htm

Evolutionary History and Attenuation of Myxoma Virus on Two Continents

The attenuation of myxoma virus (MYXV) following its introduction as a biological control into the European rabbit populations of Australia and Europe is the canonical study of the evolution of virulence. However, the evolutionary genetics of this profound change in host-pathogen relationship is unknown. We describe the genome-scale evolution of MYXV covering a range of virulence grades sampled over 49 years from the parallel Australian and European epidemics, including the high-virulence progenitor strains released in the early 1950s. MYXV evolved rapidly over the sampling period, exhibiting one of the highest nucleotide substitution rates ever reported for a double-stranded DNA virus, and indicative of a relatively high mutation rate and/or a continually changing selective environment. Our comparative sequence data reveal that changes in virulence involved multiple genes, likely losses of gene function due to insertion-deletion events, and no mutations common to specific virulence grades. Hence, despite the similarity in selection pressures there are multiple genetic routes to attain either highly virulent or attenuated phenotypes in MYXV, resulting in convergence for phenotype but not genotype. © 2012 Kerr et al

A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market

In vitro pharmacokinetic studies were conducted on enantiomer pairs of twelve valinate or tert-leucinate indole and indazole-3-carboxamide synthetic cannabinoid receptor agonists (SCRAs) detected on the illicit drug market to investigate their physicochemical parameters and structure-metabolism relationships (SMRs). Experimentally derived Log D7.4 ranged from 2.81 (AB-FUBINACA) to 4.95 (MDMB-4en-PINACA) and all SCRAs tested were highly protein bound, ranging from 88.9 ± 0.49% ((R)-4F-MDMB-BINACA) to 99.5 ± 0.08% ((S)-MDMB-FUBINACA). Most tested SCRAs were cleared rapidly in vitro in pooled human liver microsomes (pHLM) and pooled cryopreserved human hepatocytes (pHHeps). Intrinsic clearance (CLint) ranged from 13.7 ± 4.06 ((R)-AB-FUBINACA) to 2944 ± 95.9 mL min−1 kg−1 ((S)-AMB-FUBINACA) in pHLM, and from 110 ± 34.5 ((S)-AB-FUBINACA) to 3216 ± 607 mL min−1 kg−1 ((S)-AMB-FUBINACA) in pHHeps. Predicted Human in vivo hepatic clearance (CLH) ranged from 0.34 ± 0.09 ((S)-AB-FUBINACA) to 17.79 ± 0.20 mL min−1 kg−1 ((S)-5F-AMB-PINACA) in pHLM and 1.39 ± 0.27 ((S)-MDMB-FUBINACA) to 18.25 ± 0.12 mL min−1 kg−1 ((S)-5F-AMB-PINACA) in pHHeps. Valinate and tert-leucinate indole and indazole-3-carboxamide SCRAs are often rapidly metabolised in vitro but are highly protein bound in vivo and therefore predicted in vivo CLH is much slower than CLint. This is likely to give rise to longer detection windows of these substances and their metabolites in urine, possibly as a result of accumulation of parent drug in lipid-rich tissues, with redistribution into the circulatory system and subsequent metabolism