Ceres' opposition effect observed by the Dawn framing camera

The surface reflectance of planetary regoliths may increase dramatically towards zero phase angle, a phenomenon known as the opposition effect (OE). Two physical processes that are thought to be the dominant contributors to the brightness surge are shadow hiding (SH) and coherent backscatter (CB). The occurrence of shadow hiding in planetary regoliths is self-evident, but it has proved difficult to unambiguously demonstrate CB from remote sensing observations. One prediction of CB theory is the wavelength dependence of the OE angular width. The Dawn spacecraft observed the OE on the surface of dwarf planet Ceres. We characterize the OE over the resolved surface, including the bright Cerealia Facula, and to find evidence for SH and/or CB. We analyze images of the Dawn framing camera by means of photometric modeling of the phase curve. We find that the OE of most of the investigated surface has very similar characteristics, with an enhancement factor of 1.4 and a FWHM of 3{\deg} (broad OE). A notable exception are the fresh ejecta of the Azacca crater, which display a very narrow brightness enhancement that is restricted to phase angles $< 0.5${\deg} (narrow OE); suggestively, this is in the range in which CB is thought to dominate. We do not find a wavelength dependence for the width of the broad OE, and lack the data to investigate the dependence for the narrow OE. The prediction of a wavelength-dependent CB width is rather ambiguous. The zero-phase observations allow us to determine Ceres' visible geometric albedo as $p_V = 0.094 \pm 0.005$. A comparison with other asteroids suggests that Ceres' broad OE is typical for an asteroid of its spectral type, with characteristics that are primarily linked to surface albedo. Our analysis suggests that CB may occur on the dark surface of Ceres in a highly localized fashion.Comment: Credit: Schr\"oder et al, A&A in press, 2018, reproduced with permission, \copyright ES

Variations in the amount of water ice on Ceres' surface suggest a seasonal water cycle.

The dwarf planet Ceres is known to host a considerable amount of water in its interior, and areas of water ice were detected by the Dawn spacecraft on its surface. Moreover, sporadic water and hydroxyl emissions have been observed from space telescopes. We report the detection of water ice in a mid-latitude crater and its unexpected variation with time. The Dawn spectrometer data show a change of water ice signatures over a period of 6 months, which is well modeled as ~2-km2 increase of water ice. The observed increase, coupled with Ceres' orbital parameters, points to an ongoing process that seems correlated with solar flux. The reported variation on Ceres' surface indicates that this body is chemically and physically active at the present time

A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings

BackgroundA composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful for assisting with basic clinical interpretation of CGM data.MethodsWe assembled a data set of 14-day CGM tracings from 225 insulin-treated adults with diabetes. Using a balanced incomplete block design, 330 clinicians who were highly experienced with CGM analysis and interpretation ranked the CGM tracings from best to worst quality of glycemia. We used principal component analysis and multiple regressions to develop a model to predict the clinician ranking based on seven standard metrics in an Ambulatory Glucose Profile: very low-glucose and low-glucose hypoglycemia; very high-glucose and high-glucose hyperglycemia; time in range; mean glucose; and coefficient of variation.ResultsThe analysis showed that clinician rankings depend on two components, one related to hypoglycemia that gives more weight to very low-glucose than to low-glucose and the other related to hyperglycemia that likewise gives greater weight to very high-glucose than to high-glucose. These two components should be calculated and displayed separately, but they can also be combined into a single Glycemia Risk Index (GRI) that corresponds closely to the clinician rankings of the overall quality of glycemia (r = 0.95). The GRI can be displayed graphically on a GRI Grid with the hypoglycemia component on the horizontal axis and the hyperglycemia component on the vertical axis. Diagonal lines divide the graph into five zones (quintiles) corresponding to the best (0th to 20th percentile) to worst (81st to 100th percentile) overall quality of glycemia. The GRI Grid enables users to track sequential changes within an individual over time and compare groups of individuals.ConclusionThe GRI is a single-number summary of the quality of glycemia. Its hypoglycemia and hyperglycemia components provide actionable scores and a graphical display (the GRI Grid) that can be used by clinicians and researchers to determine the glycemic effects of prescribed and investigational treatments

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

Deep Space 1: Testing New Technologies for Future Small Bodies Missions

Launched on October 24, 1998, Deep Space 1 (DS1) was the first mission of NASA's New Millennium Program, chartered to validate in space high-risk, new technologies important for future space science programs. The advanced technology payload that was tested on DS1 comprises solar electric propulsion, solar concentrator arrays, autonomous on-board navigation and other autonomous systems, several telecommunications and microelectronics devices, and two low-mass integrated science instrument packages. The mission met or exceeded all of its success criteria. The 12 technologies were rigorously exercised so that subsequent flight projects would not have to incur the cost and risk of being the fist users of these new capabilities. Examples of the benefits to future small body missions from DS1's technologies will be described

The DAWN Project's Transition to Mission Operations: on Its Way to Rendezvous with (4) Vesta and (1) Ceres

Dawn launched on 27 September 2007 on a mission to orbit main belt asteroids (4) Vesta in 2011 - 2012 and (1) Ceres in 2015. The operations team conducted an extensive set of assessments of the engineering subsystems and science instruments during the first 80 days of the mission. A major objective of this period was to thrust for one week with the ion propulsion system to verify flight and ground systems readiness for typical interplanetary operations. Upon successful conclusion of the checkout phase, the interplanetary cruise phase began, most of which will be devoted to thrusting. The flexibility afforded by the use of ion propulsion enabled the project to accommodate a launch postponement of more than 3 months caused by a combination of launch vehicle and tracking system readiness, unfavorable weather, and then conflicts with other launches. Even with the shift in the launch date, all of the science objectives are retained with the same schedule and greater technical margins. This paper describes the conclusion of the development phase of the project, launch operations, and the progress of mission operations

In-Flight Operation of the Dawn Ion Propulsion System Through the Low Altitude Mapping Orbit at Ceres

The Dawn mission, part of NASAs Discovery Program, has as its goal the scientific exploration of the two most massive main-belt objects, Vesta and Ceres. The Dawn spacecraft was launched from the Cape Canaveral Air Force Station on September 27, 2007 on a Delta-II 7925H- 9.5 (Delta-II Heavy) rocket that placed the 1218-kg spacecraft onto an Earth-escape trajectory. On-board the spacecraft is an ion propulsion system (IPS) developed at the Jet Propulsion Laboratory for the heliocentric transfer to Vesta, orbit capture at Vesta, transfer between Vesta science orbits, departure and escape from Vesta, heliocentric transfer to Ceres, orbit capture at Ceres, transfer between Ceres science orbits, and orbit maintenance maneuvers. Full-power thrusting from December 2007 through October 2008 was used to successfully target a Mars gravity assist flyby in February 2009 that provided an additional V of 2.6 km/s. Deterministic thrusting for the heliocentric transfer to Vesta resumed in June 2009 and concluded with orbit capture at Vesta on July 16, 2011. From July 2011 through September 2012 the IPS was used to transfer to all the different science orbits at Vesta and to escape from Vesta orbit. Cruise for a rendezvous with Ceres began in August 2012 and completed in late December 2014. From December 2014 through June 2016 the IPS was used for transiting the spacecraft to the Approach phase, survey orbit, the high altitude mapping orbit (HAMO), and the low altitude mapping orbit (LAMO) with arrival to LAMO on December 13, 2015, almost eight years after the start of deterministic thrusting to Vesta. The LAMO orbit, at a mean altitude above Ceres of approximately 385 km, is the spacecrafts final destination and there are no plans to move the spacecraft from LAMO once science operations there are completed. Since arrival at LAMO Dawns IPS has been used for occasional orbit maintenance maneuvers while the spacecraft performs scientific investigations. Dawn has successfully completed its science goals and Dawns primary mission is scheduled to end June 30, 2016. To date the IPS has been operated for approximately 48,458 hours, consumed approximately 401 kg of xenon, and provided a delta-V of over 11.0 km/s, a record for an on-board propulsion system. The IPS performance characteristics are close to the expected performance based on analysis and testing performed pre-launch. Dawns IPS continues to be fully operational as of June 2016. This paper provides an overview of Dawns mission objectives and the results of Dawn IPS mission operations from Survey orbit through the completion of Dawns primary mission

In-Flight Operation of the Dawn Ion Propulsion System Through Survey Science Orbit at Ceres

The Dawn mission, part of NASA's Discovery Program, has as its goal the scientific exploration of the two most massive main-belt objects, Vesta and Ceres. The Dawn spacecraft was launched from the Cape Canaveral Air Force Station on September 27, 2007 on a Delta-II 7925H- 9.5 (Delta-II Heavy) rocket that placed the 1218-kg spacecraft onto an Earth-escape trajectory. On-board the spacecraft is an ion propulsion system (IPS) developed at the Jet Propulsion Laboratory which will provide a total delta V of 11 km/s for the heliocentric transfer to Vesta, orbit capture at Vesta, transfer between Vesta science orbits, departure and escape from Vesta, heliocentric transfer to Ceres, orbit capture at Ceres, and transfer between Ceres science orbits. Full-power thrusting from December 2007 through October 2008 was used to successfully target a Mars gravity assist flyby in February 2009 that provided an additional delta V of 2.6 km/s. Deterministic thrusting for the heliocentric transfer to Vesta resumed in June 2009 and concluded with orbit capture at Vesta on July 16, 2011. From July 2011 through September 2012 the IPS was used to transfer to all the different science orbits at Vesta and to escape from Vesta orbit. Cruise for a rendezvous with Ceres began in September 2012 and concluded with the start of the approach to Ceres phase on December 26, 2015, leading to orbit capture on March 6, 2015. Deterministic thrusting continued during approach to place the spacecraft in its first science orbit, called RC3, which was achieved on April 23, 2015. Following science operations at RC3 ion thrusting was resumed for twenty-five days leading to arrival to the next science orbit, called survey orbit, on June 3, 2015. The IPS will be used for all subsequent orbit transfers and trajectory correction maneuvers until completion of the primary mission in approximately June 2016. To date the IPS has been operated for over 46,774 hours, consumed approximately 393 kg of xenon, and provided a delta V of over 10.8 km/s to the spacecraft. The IPS performance characteristics are very close to the expected performance based on analysis and testing performed pre-launch. This paper provides an overview of Dawn's mission objectives and the results of Dawn IPS mission operations through arrival at the second science orbit at Ceres

DAWN'S Operations in Cruise from Vesta to Ceres

On 5 September 2012, Dawn concluded its successful exploration of Vesta, the second most massive object in the main asteroid belt. The spacecraft departed after 14 months in orbit and is now using its ion propulsion system to travel to dwarf planet Ceres, the most massive main-belt asteroid. The principal activity now is thrusting with the ion propulsion system to provide the 3.4 km/s required to rendezvous with Ceres early in 2015. Because two of the four reaction wheels have experienced faults and are likely unrecoverable, a substantial effort has been invested in preparing for Ceres operations with alternate attitude control methods. The project has engaged in an intensive campaign to reduce hydrazine expenditures, which has resulted in a significant increase in the hydrazine expected to be available for Ceres. Based on this work, studies provide good confidence that the required activities at Ceres can be completed. This paper describes post-Vesta operations, including measures taken to conserve hydrazine as well as other preparations for Ceres