Mathematical simulations for better aquifer management

CER-66-67 MWB 10.Extract of publication no. 72 of the I.A.S.H. Symposium of Haifa.Includes bibliographical references.Manipulation of groundwater storage in conjunction with surface water supplies often requires simultaneous consideration of varied aquifer hydraulic and geometric characteristics, highly variable pumping patterns in time and space, imperfectly connected bodies of surface water and non-deterministic natural recharge. In addition, legal, economic and social conditions impose constraints which must be considered in aquifer operation and management. This paper describes mathematical modeling and computer analysis techniques that allow consideration of the many varied and changing factors mentioned above. Application is made to specific aquifer management problems

Exploration and Production Program for Locating and Producing Prospective Aquifers Containing Solution Gas and Free Gas Texas Gulf Coast - Annual Report

The Port Arthur field in Jefferson County, Texas, has been identified as a promising candidate for secondary enhanced gas recovery methods due to its multiple watered-out gas reservoirs, thick aquifers, and gas stringer sandstones at depths ranging from 10,850 to 11,700 feet. Sidewall core data indicate an average porosity of 30 percent and average permeability of 60 millidarcies (md). Reservoir simulation studies suggest that approximately 3.91 billion standard cubic feet of unconventional gas can be recovered through natural flow from the 11 C" sandstone over a 10-year period, by reducing reservoir pressure from 6,500 to 4,018 pounds per square inch gauge (psig). The break-even gas price is estimated to be $3.45 per thousand standard cubic feet for a 15-percent rate of return. Additional gas recovery opportunities exist through co-production from other sandstones and by further reducing reservoir pressure using artificial lift methods. It is recommended to drill a design test well to a depth of 11,650 feet at a location near the Meredith No. 2 Doornbos (Well No. 14). This test well will help evaluate the feasibility and effectiveness of secondary enhanced gas recovery techniques in the Port Arthur field.Bureau of Economic Geolog

Prospectus for a Design Well in the Blessing Area Matagorda County, Texas

In recent years, the Bureau of Economic Geology has conducted regional subsurface studies of the Wilcox Group and Frio Formation of Texas as part of the U. S. Department of Energy's assessment of deep geopressured geothermal resources along the Gulf Coast. These studies resulted in two reports (Bebout and others, 1978; 1979) that describe several areas in Texas where temperatures are greater than 300°F and where the geology and reservoir conditions are suitable for resource testing by a design well. Throughout the Texas Coastal Plain, the 300°F isotherm generally occurs at depths ranging from 12,000 to 16,000 ft. The overlying geopressured sediments represent a substantial portion of the sedimentary column that contains significant quantities of entrained methane, making them a significant portion of the resource base (Gregory and others, 1980). The lower temperatures and pressures of these shallow geopressured sediments result in lower methane solubility, but drilling costs would be substantially lower, and perhaps reservoir quality would be better in comparison to the deep geopressured intervals. Although the latter condition has not been substantiated, several areas that are geologically favorable for testing shallow geopressured aquifers with temperatures less than 300°F were identified in a recently completed study (Weise and others, 1980) funded by the Gas Research Institute. The Blessing Prospect (fig. 1), one of the shallow prospects in Matagorda County, Texas, is presented in this prospectus as a candidate for the DOE design well program. The prospectus focuses on the geological and engineering aspects of the test site. Although legal and environmental considerations are mentioned, they have not been studied in detail and additional work would necessarily follow if the prospect is approved for drilling and testing. Likewise, a drilling program and an economic analysis would be necessary before final approval of a design well.Bureau of Economic Geolog

The combined tensile and torsional behavior of irregular fibers

Most fibers are irregular, and they are often subjected to combined loading conditions during processing and end-use. In this paper, polyester and wool fibers under the combined tensile and torsional loads have been studied for the first time, using the finite element method (FEM). The dimensional irregularities of these fibers are simulated with sine waves of different magnitude and frequency. The breaking load and breaking extension of the fibers at different twist or torsion levels are then calculated from the finite element model. The results indicate that twist and level of fiber irregularity have a major impact on the mechanical properties of the fiber and the effect of the frequency of irregularity is relatively small.<br /

Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding

Background: Atherosclerosis is an inflammatory process that develops in individuals with known risk factors that include hypertension and hyperlipidaemia, influenced by diet. However, the interplay between diet, inflammatory mechanisms and vascular risk factors requires further research. We hypothesised that interleukin-1 (IL-1) signaling in the vessel wall would raise arterial blood pressure and promote atheroma. Methodology/Principal Findings: Apoe(-/-) and Apoe(-/-)/IL-1R1(-/-) mice were fed high fat diets for 8 weeks, and their blood pressure and atherosclerosis development measured. Apoe(-/-)/IL-R1(-/-) mice had a reduced blood pressure and significantly less atheroma than Apoe(-/-) mice. Selective loss of IL-1 signaling in the vessel wall by bone marrow transplantation also reduced plaque burden (p<0.05). This was associated with an IL-1 mediated loss of endothelium-dependent relaxation and an increase in vessel wall Nox 4. Inhibition of IL-1 restored endothelium-dependent vasodilatation and reduced levels of arterial oxidative stress. Conclusions/Significance: The IL-1 cytokine system links atherogenic environmental stimuli with arterial inflammation, oxidative stress, increased blood pressure and atherosclerosis. This is the first demonstration that inhibition of a single cytokine can block the rise in blood pressure in response to an environmental stimulus. IL-1 inhibition may have profound beneficial effects on atherogenesis in man

Periconceptional bread intakes indicate New Zealand's proposed mandatory folic acid fortification program may be outdated: results from a postpartum survey

Abstract Background In September 2009, a folic acid fortification mandate (135 μg/100 g bread) was to be implemented in New Zealand. However, due to political and manufacturer objection, fortification was deferred until May 2012. Based on estimates of bread consumption derived from a 1997 nationally representative survey, this program was intended to deliver a mean additional intake of 140 μg folic acid/d to women of childbearing age. Little is known about current bread consumption patterns in this target group. The aim of this study was to assess bread consumption among women prior to and during pregnancy with the intent to estimate periconceptional folic acid intakes that would be derived from bread if mandatory fortification were implemented as currently proposed. Methods A retrospective survey of 723 postpartum women in hospitals and birthing centres across New Zealand was conducted using a self-administered questionnaire on bread intake prior to and during pregnancy and maternal socio-demographic and obstetric characteristics. Results Median bread intake before conception (2 slices/d) was below that of previous data upon which the current fortification proposal was modeled (3-4 slices/d). If mandatory fortification is implemented as proposed, only 31% (95% CI = 24%-37%) of childbearing-age women would attain an additional folic acid intake of ≥ 140 μg/d, with a mean of 119 μg/d (95% CI = 107 μg/d-130 μg/d). Based on these data, a fortification level of 160 μg/100 g bread is required to achieve the targeted mean of 140 μg folic acid/d. Nonetheless, under the current proposal additional folic acid intakes would be greatest among the least advantaged segments of the target population: Pacific and indigenous Māori ethnic groups; those with increased parity, lower income and education; younger and single mothers; and women with unplanned pregnancies. Subgroups predicted to derive less than adequate folic acid intakes from the proposed policy were women of Asian descent and those with a postgraduate education. Conclusions This study provides insight on the ability of a fortification policy to benefit the groups at highest risk of poor folate intakes in a population. However, bread consumption among the target group of childbearing women appears to have declined since the data used in previous dietary modeling were collected. Thus, it seems prudent to re-model dietary folic acid intakes based on more recent national survey data prior to the implementation of a mandatory folic acid fortification policy.</p

Radiation-Induced c-Jun Activation Depends on MEK1-ERK1/2 Signaling Pathway in Microglial Cells

Radiation-induced normal brain injury is associated with acute and/or chronic inflammatory responses, and has been a major concern in radiotherapy. Recent studies suggest that microglial activation is a potential contributor to chronic inflammatory responses following irradiation; however, the molecular mechanism underlying the response of microglia to radiation is poorly understood. c-Jun, a component of AP-1 transcription factors, potentially regulates neural cell death and neuroinflammation. We observed a rapid increase in phosphorylation of N-terminal c-Jun (on serine 63 and 73) and MAPK kinases ERK1/2, but not JNKs, in irradiated murine microglial BV2 cells. Radiation-induced c-Jun phosphorylation is dependent on the canonical MEK-ERK signaling pathway and required for both ERK1 and ERK2 function. ERK1/2 directly interact with c-Jun in vitro and in cells; meanwhile, the JNK binding domain on c-Jun is not required for its interaction with ERK kinases. Radiation-induced reactive oxygen species (ROS) potentially contribute to c-Jun phosphorylation through activating the ERK pathway. Radiation stimulates c-Jun transcriptional activity and upregulates c-Jun-regulated proinflammatory genes, such as tumor necrosis factor-α, interleukin-1β, and cyclooxygenase-2. Pharmacologic blockade of the ERK signaling pathway interferes with c-Jun activity and inhibits radiation-stimulated expression of c-Jun target genes. Overall, our study reveals that the MEK-ERK1/2 signaling pathway, but not the JNK pathway, contributes to the c-Jun-dependent microglial inflammatory response following irradiation

Different Vocal Parameters Predict Perceptions of Dominance and Attractiveness

Low mean fundamental frequency (F0) in men’s voices has been found to positively influence perceptions of dominance by men and attractiveness by women using standardized speech. Using natural speech obtained during an ecologically valid social interaction, we examined relationships between multiple vocal parameters and dominance and attractiveness judgments. Male voices from an unscripted dating game were judged by men for physical and social dominance and by women in fertile and non-fertile menstrual cycle phases for desirability in short-term and long-term relationships. Five vocal parameters were analyzed: mean F0 (an acoustic correlate of vocal fold size), F0 variation, intensity (loudness), utterance duration, and formant dispersion (Df, an acoustic correlate of vocal tract length). Parallel but separate ratings of speech transcripts served as controls for content. Multiple regression analyses were used to examine the independent contributions of each of the predictors. Physical dominance was predicted by low F0 variation and physically dominant word content. Social dominance was predicted only by socially dominant word content. Ratings of attractiveness by women were predicted by low mean F0, low Df, high intensity, and attractive word content across cycle phase and mating context. Low Df was perceived as attractive by fertile-phase women only. We hypothesize that competitors and potential mates may attend more strongly to different components of men’s voices because of the different types of information these vocal parameters provide