Conflicts of interest in dermatology

Conflicts of interest exist in dermatology when professional judgement concerning a primary interest, such as research validity, may be influenced by a secondary interest, such as financial gain from a for-profit organization. Conflict of interest is a condition and not a behaviour, although there is clear evidence that gifts influence behaviour. Little has been written about conflicts of interest in dermatology. This series of papers raises awareness of the subject by exploring it in greater depth from the perspective of a dermatology researcher, an industry researcher, a dermatology journal editor, a health services researcher and a patient representative. Collectively, they illustrate the many ways in which conflicts can pervade the world of dermatology publications and patient support group activities

An Update on Automatic Positioning, Inspection, and Signal Processing Techniques in the RFC/NDE Inspection System

This paper updates several techniques developed for the Retirement For Cause (RFC) Nondestructive Evaluation (NDE) Inspection System eddy current inspection module. Techniques to be discussed include: (1) Scallop Centering — development of an automatic scallop centering routine makes scallop inspections reliable.; (2) Soft Survey Mode — improvements have been made for fast peak detection.; (3) Method 2 Select Mode — a fine flaw detection technique based on the acquired waveform.; (4) Antirotation Window Inspection — a frequency select mode has been established for detecting flaws in antirotation windows.; (5) Scaling of Flaw Depth — a scaling factor has been developed, based on Phase I Reliability Test data, which converts flaw signal amplitude into estimated flaw depth

The interstellar medium and feedback in the progenitors of the compact passive galaxies at z~2

Quenched galaxies at z>2 are nearly all very compact relative to z~0, suggesting a physical connection between high stellar density and efficient, rapid cessation of star-formation. We present restframe UV spectra of Lyman-break galaxies (LBGs) at z~3 selected to be candidate progenitors of quenched galaxies at z~2 based on their compact restframe optical sizes and high surface density of star-formation. We compare their UV properties to those of more extended LBGs of similar mass and star formation rate (non-candidates). We find that candidate progenitors have faster ISM gas velocities and higher equivalent widths of interstellar absorption lines, implying larger velocity spread among absorbing clouds. Candidates deviate from the relationship between equivalent widths of Lyman-alpha and interstellar absorption lines in that their Lyman-alpha emission remains strong despite high interstellar absorption, possibly indicating that the neutral HI fraction is patchy such that Lyman-alpha photons can escape. We detect stronger CIV P-Cygni features (emission and absorption) and HeII emission in candidates, indicative of larger populations of metal rich Wolf-Rayet stars compared to non-candidates. The faster bulk motions, broader spread of gas velocity, and Lyman-alpha properties of candidates are consistent with their ISM being subject to more energetic feedback than non-candidates. Together with their larger metallicity (implying more evolved star-formation activity) this leads us to propose, if speculatively, that they are likely to quench sooner than non-candidates, supporting the validity of selection criteria used to identify them as progenitors of z~2 passive galaxies. We propose that massive, compact galaxies undergo more rapid growth of stellar mass content, perhaps because the gas accretion mechanisms are different, and quench sooner than normally-sized LBGs at these early epochs.Comment: Accepted for publication in the Astrophysical Journa

Pion-nucleus elastic scattering on 12C, 40Ca, 90Zr, and 208Pb at 400 and 500 MeV

Pion-nucleus elastic scattering at energies above the Delta(1232) resonance is studied using both pi+ and pi- beams on 12C, 40Ca, 90Zr, and 208Pb. The present data provide an opportunity to study the interaction of pions with nuclei at energies where second-order corrections to impulse approximation calculations should be small. The results are compared with other data sets at similar energies, and with four different first-order impulse approximation calculations. Significant disagreement exists between the calculations and the data from this experiment

20th to 21st Century Relative Sea and Land Level Changes in Northern California: Tectonic Land Level Changes and their Contribution to Sea-Level Rise, Humboldt Bay Region, Northern California

Sea-level changes are modulated in coastal northern California by land-level changes due to the earthquake cycle along the Cascadia subduction zone, the San Andreas plate boundary fault system, and crustal faults. Sea-level rise (SLR) subjects ecological and anthropogenic infrastructure to increased vulnerability to changes in habitat and increased risk for physical damage. The degree to which each of these forcing factors drives this modulation is poorly resolved. We use NOAA tide gage data and ‘campaign’ tide gage deployments, Global Navigation Satellite System (GNSS) data, and National Geodetic Survey (NGS) first-order levelling data to calculate vertical land motion (VLM) rates in coastal northern California. Sea-level observations, highway level surveys, and GNSS data all confirm that land is subsiding in Humboldt Bay, in contrast to Crescent City where the land is rising. Subtracting absolute sea-level rate (~1.99 mm/year) from Crescent City (CC) and North Spit (NS) gage relative sea-level rates reveals that CC is uplifting at ~2.83 mm/year and NS is subsiding at ~3.21mm/year. GNSS vertical deformation reveals similar rates of ~2.60 mm/year of uplift at Crescent City. In coastal northern California, there is an E-W trending variation in vertical land motion that is primarily due to Cascadia megathrust fault seismogenic coupling. This interseismic subsidence also dominates the N-S variation in vertical land motion in most of the study region. There exists a second-order heterogeneous N-S trend in vertical land motion that we associate to crustal fault-related strain. There may be non-tectonic contributions to the observed VLM rates

WFPC2 Observations of the Hubble Deep Field-South

The Hubble Deep Field-South observations targeted a high-galactic-latitude field near QSO J2233-606. We present WFPC2 observations of the field in four wide bandpasses centered at roughly 300, 450, 606, and 814 nm. Observations, data reduction procedures, and noise properties of the final images are discussed in detail. A catalog of sources is presented, and the number counts and color distributions of the galaxies are compared to a new catalog of the HDF-N that has been constructed in an identical manner. The two fields are qualitatively similar, with the galaxy number counts for the two fields agreeing to within 20%. The HDF-S has more candidate Lyman-break galaxies at z > 2 than the HDF-N. The star-formation rate per unit volume computed from the HDF-S, based on the UV luminosity of high-redshift candidates, is a factor of 1.9 higher than from the HDF-N at z ~ 2.7, and a factor of 1.3 higher at z ~ 4.Comment: 93 pages, 25 figures; contains very long table

Cortical thickness, surface area and volume measures in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy

OBJECTIVE Parkinson's disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) are neurodegenerative diseases that can be difficult to distinguish clinically. The objective of the current study was to use surface-based analysis techniques to assess cortical thickness, surface area and grey matter volume to identify unique morphological patterns of cortical atrophy in PD, MSA and PSP and to relate these patterns of change to disease duration and clinical features. METHODS High resolution 3D T1-weighted MRI volumes were acquired from 14 PD patients, 18 MSA, 14 PSP and 19 healthy control participants. Cortical thickness, surface area and volume analyses were carried out using the automated surface-based analysis package FreeSurfer (version 5.1.0). Measures of disease severity and duration were assessed for correlation with cortical morphometric changes in each clinical group. RESULTS Results show that in PSP, widespread cortical thinning and volume loss occurs within the frontal lobe, particularly the superior frontal gyrus. In addition, PSP patients also displayed increased surface area in the pericalcarine. In comparison, PD and MSA did not display significant changes in cortical morphology. CONCLUSION These results demonstrate that patients with clinically established PSP exhibit distinct patterns of cortical atrophy, particularly affecting the frontal lobe. These results could be used in the future to develop a useful clinical application of MRI to distinguish PSP patients from PD and MSA patients

Entropy of random coverings and 4D quantum gravity

We discuss the counting of minimal geodesic ball coverings of $n$-dimensional riemannian manifolds of bounded geometry, fixed Euler characteristic and Reidemeister torsion in a given representation of the fundamental group. This counting bears relevance to the analysis of the continuum limit of discrete models of quantum gravity. We establish the conditions under which the number of coverings grows exponentially with the volume, thus allowing for the search of a continuum limit of the corresponding discretized models. The resulting entropy estimates depend on representations of the fundamental group of the manifold through the corresponding Reidemeister torsion. We discuss the sum over inequivalent representations both in the two-dimensional and in the four-dimensional case. Explicit entropy functions as well as significant bounds on the associated critical exponents are obtained in both cases.Comment: 54 pages, latex, no figure

Combining music and life story work to enhance participation in family interaction in semantic dementia: a longitudinal study of one family's experience.

Background: Semantic dementia is a rarer dementia, classified as a type of frontotemporal dementia and a variant of primary progressive aphasia. Studies examining conversation in this condition and interventions to enhance participation in family life present as gaps in the research literature. Methods: Working with one family on a longitudinal basis, this study used conversation analysis and narrative analysis to provide a detailed assessment of communication . This information was used to design an individually tailored life story intervention to facilitate family interaction: a co-produced life story music DVD. Results: This intervention offered the family a resource that allowed the person with semantic dementia to display areas of retained competence and enhanced participation in interaction in a way that was not typically present in everyday conversation. Conclusions: It is argued that fostering greater opportunities for such in-the-moment connections is an important goal for intervention, particularly when language may be significantly compromised