Towards deep generation of guided wave representations for composite materials

Laminated composite materials are widely used in most fields of engineering. Wave propagation analysis plays an essential role in understanding the short-duration transient response of composite structures. The forward physics-based models are utilized to map from elastic properties space to wave propagation behavior in a laminated composite material. Due to the high-frequency, multi-modal, and dispersive nature of the guided waves, the physics-based simulations are computationally demanding. It makes property prediction, generation, and material design problems more challenging. In this work, a forward physics-based simulator such as the stiffness matrix method is utilized to collect group velocities of guided waves for a set of composite materials. A variational autoencoder (VAE)-based deep generative model is proposed for the generation of new and realistic polar group velocity representations. It is observed that the deep generator is able to reconstruct unseen representations with very low mean square reconstruction error. Global Monte Carlo and directional equally-spaced samplers are used to sample the continuous, complete and organized low-dimensional latent space of VAE. The sampled point is fed into the trained decoder to generate new polar representations. The network has shown exceptional generation capabilities. It is also seen that the latent space forms a conceptual space where different directions and regions show inherent patterns related to the generated representations and their corresponding material properties

Polarization in young open cluster NGC 6823

We present multiwavelength linear polarimetric observations of 104 stars towards the region of young open cluster NGC 6823. The polarization towards NGC 6823 is dominated by foreground dust grains and we found the evidence for the presence of several layers of dust towards the line of sight. The first layer of dust is located approximately within 200 pc towards the cluster, which is much closer to the Sun than the cluster (~ 2.1 kpc). The radial distribution of the position angles for the member stars are found to show a systematic change while the polarization found to reduce towards the outer parts of the cluster and the average position angle of coronal region of the cluster is very close to the inclination of the Galactic parallel (~ 32 degree). The size distribution of the grains within NGC 6823 is similar to those in general interstellar medium. The patchy distribution of foreground dust grains are suggested to be mainly responsible for the both differential reddening and polarization towards NGC 6823. The majority of the observed stars do not show the evidence of intrinsic polarization in their light.Comment: 16 pages, 6 tables, 11 figures, Accepted for publication in MNRA

Multi-wavelength polarimetric study towards the open cluster NGC 1893

We present multi-wavelength linear polarimetric observations for 44 stars of the NGC 1893 young open cluster region along with V-band polarimetric observations of stars of other four open clusters located between l ~160 to ~175 degree. We found evidence for the presence of two dust layers located at a distance of ~170 pc and ~360 pc. The dust layers produce a polarization Pv ~2.2%. It is evident from the clusters studied in the present work that, in the Galactic longitude range l ~160 to 175 degree and within the Galactic plane (|b| < 2 degree), the polarization angles remain almost constant, with a mean ~163 degree and a dispersion of 6 degree. The small dispersion in polarization angle could be due to the presence of uniform dust layer beyond 1 kpc. Present observations reveal that in case of NGC 1893, the foreground two dust layers, in addition to the intracluster medium, seems to be responsible for the polarization effects. It is also found that towards the direction of NGC 1893, the dust layer that exists between 2-3 kpc has a negligible contribution towards the total observed polarization. The weighted mean for percentage of polarization (Pmax) and the wavelength at maximum polarization ({\lambda}max) are found to be 2.59 \pm 0.02% and 0.55 \pm 0.01 \mum respectively. The estimated mean value of {\lambda}max indicates that the average size of the dust grains within the cluster is similar to that in the general interstellar medium. The spatial variation of the polarization is found to decrease towards the outer region of the cluster. In the present work, we support the notion, as already has been shown in previous studies, that polarimetry, in combination with (U-B)/(B-V) colour-colour diagram, is a useful tool for identifying non-members in a cluster.Comment: 36 pages, 12 figures, 10 tables, accepted for the publication in MNRA

Repositioning: the fast track to new anti-malarial medicines?

Repositioning of existing drugs has been suggested as a fast track for developing new anti-malarial agents. The compound libraries of GlaxoSmithKline (GSK), Pfizer and AstraZeneca (AZ) comprising drugs that have undergone clinical studies in other therapeutic areas, but not achieved approval, and a set of US Food and Drug Administration (FDA)-approved drugs and other bio-actives were tested against Plasmodium falciparum blood stages. Repositioning of existing therapeutics in malaria is an attractive proposal. Compounds active in vitro at muM concentrations were identified. However, therapeutic concentrations may not be effectively achieved in mice or humans because of poor bio-availability and/or safety concerns. Stringent safety requirements for anti-malarial drugs, given their widespread use in children, make this a challenging area in which to reposition therapy.This work was supported by the Medicines Malaria Venture, St Jude Children's Research Hospital, GlaxoSmithKline Plc and Pfizer Inc

LO Pegasi: An investigation of multi-band optical polarization

We present BVR polarimetric study of the cool active star LO Peg for the first time. LO Peg was found to be highly polarized among the cool active stars. Our observations yield average values of polarization in LO Peg: $P_B =0.387\pm 0.004$, $\theta_B = 88\deg\pm1\deg$; $P_V=0.351\pm0.004$, $\theta_V=91\deg\pm1\deg$; and $P_R= 0.335\pm0.003$, $\theta_R = 91\deg\pm1\deg$. Both the degree of polarization and the position angle are found to be variable. The semi-amplitude of the polarization variability in B, V and R bands are found to be $0.18\pm0.02$%, $0.13\pm0.01$% and $0.10\pm0.02$%, respectively. We suggest that the levels of polarization observed in LO Peg could be the result of scattering of an anisotropic stellar radiation field by an optically thin circumstellar envelope or scattering of the stellar radiation by prominence-like structures.Comment: 9 pages, 6 figures and 5 tables, Accepted for publication in MNRA

The effects of pulmonary rehabilitation in patients with non-cystic fibrosis bronchiectasis: protocol for a randomised controlled trial

BACKGROUND: Non-cystic fibrosis bronchiectasis is characterised by sputum production, exercise limitation and recurrent infections. Although pulmonary rehabilitation is advocated for this patient group, its effects are unclear. The aims of this study are to determine the short and long term effects of pulmonary rehabilitation on exercise capacity, cough, quality of life and the incidence of acute pulmonary exacerbations. METHODS/DESIGN: This randomised controlled trial aims to recruit 64 patients with bronchiectasis from three tertiary institutions. Participants will be randomly allocated to the intervention group (supervised, twice weekly exercise training with regular review of airway clearance therapy) or a control group (twice weekly telephone support). Measurements will be taken at baseline, immediately following the intervention and at six and 12 months following the intervention period by a blinded assessor. Exercise capacity will be measured using the incremental shuttle walk test and the six-minute walk test. Quality of life and health status will be measured using the Chronic Respiratory Questionnaire, Leicester Cough Questionnaire, Assessment of Quality of Life Questionnaire and the Hospital Anxiety and Depression Scale. The rate of hospitalisation will be captured as well as the incidence of acute pulmonary exacerbations using a daily symptom diary. DISCUSSION: Results from this study will help to determine the efficacy of supervised twice-weekly pulmonary rehabilitation upon exercise capacity and quality of life in patients with bronchiectasis and will contribute to clinical practice guidelines for physiotherapists in the management of this population. TRIAL REGISTRATION: This study protocol is registered with ClinicalTrials.gov (NCT00885521)