A Case Base Approach for Evaluation of Manufacturing Effectiveness of a Firm Using Analytical Hierarchical Process

High level of Manufacturing Capability (MC) (effectiveness) plays significant role in providing competitive advantage to a firm. However, it is difficult for the firm to evaluate the level of MC, which is given by the consistency of decisions taken in the particular manufacturing environment. For example, in job shop production general purpose facilities and high skilled workforce is essential to obtain the desired level of outputs to satisfy customer expectations. First, Hayes and Wheelwright provided a four stage model for evaluating the level of MC and recently Miltenburg gave a framework that classified these four stages as infant, average, adult and world class. Evaluating MC facilitates the firm to know the present status and also provides a pointer to identify weak decisions for further improvement. This paper presents a case study on evaluating the MC of a firm involved in the production of low volume and high variety products. Job Shop Production System has been used to fulfill these demands. Objective of this research is to find out the current status (level) of MC of a firm based on the consistency of the decisions taken. For this, hierarchical model based on the overall goal as a MC index has been developed by using Analytical Hierarchical Process (AHP) a Multi Criteria Decision Making (MCDM) tool. The MC index of a firm under consideration is computed by evaluating the pattern of decisions taken in the manufacturing which are obtained after discussion with top executives of the company. The results obtained are then compared with ideally required decisions from the same category of manufacturing system (in this case job shop production system). Based on the comparison, status (level) of MC and weak decision areas of the firm have been identified and discussed with the executives

Reproductive potential in a case of Mosaic Turners syndrome with 46XY karyotype

This article describes a case of 18year-old-female who presented with primary amenorrhea, phenotypic features of Turners syndrome, which was confirmed later by Karyotype to have mosaic 45XO(8)/46XY(22). She had delayed puberty and proved (hormonally) to have ovarian failure, with absent Mullerian structures (radiologically and laparoscopy)

Microscopic Analysis of Carbon Nano tubes based Metal Matrix Composite

These days significant waste metal scrap is generated during the machining operations such as grinding, milling, shaping, forging etc. This waste/scrap is big challenge for the industry due to environmental litigation, such as in grinding industry the scarp contain organic and inorganic compounds. Thus, for reprocessing of this grinding waste will be difficult and it also crate environmental problems.  Current work focus to reuse and produce a value added product from the grinding waste. The Powder Injection Molding (PIM) approach used to create the value added product from the grinding waste. As the PIM product will be inferior in terms of mechanical properties, Carbon Nanotubes are added to improve the mechanical properties. To test the microscopic analysis of the PIM products are tested with SEM and it is observed that the PIM products are porous in nature. The hardness testing suggests that the PIM product will have higher harness number with less porosity

Carbon Nanotubes Based Porous Framework for Filtration Applications Using Industrial Grinding Waste

Forging, milling, turning, grinding and shaping etc. are the various industrial manufacturing processes which generate the metal waste. Grinding is extensively used in the finishing operation. The waste generated contains significant impurities apart from the metal particles. Due to these significant impurities, it becomes difficult to process and gets usually dumped in the landfills which create environmental problems. Therefore, it becomes essential to reuse metal waste to create value added products. Powder injection molding process is used for producing the porous metal matrix framework. This paper discusses the presented design of the porous framework to be used for the liquid filter application. Different parameters are optimized to obtain the better strength framework with variable porosity. Carbon nanotubes are used as reinforcing materials to enhance the strength of the metal matrix framework

Study of Oxidative Stress in Relation with Antioxidant Status in Chronic Bronchitis

Lipid peroxide plays an important role in inflammatory lung diseases. Increased epithelial permeability produced by cigarette smoke is likely to be mediated though depletion of the Total Antioxidant Capacity .Oxidative stress has been recognized as a central feature of smoke induced chronic bronchitis. Imbalance between oxidants and Total Anioxidant Capacity is also an established fact in these patients. 60 patients with chronic bronchitis included in the study. Their base line clinical examination, malondialdehyde (MDA), nitric oxide, alpha tochopherol and Total Antioxidant Capacity were measured. 100 healthy non-smokers\u27 were served as controls. The mean malondialdehyde levels and nitric oxide in the patients at base line were higher than Controls (p<0.001). Plasma alpha-tocopherol and total antioxidant capacity were lower (p<0.001) in the patients compared to controls. The present study shows that initially the plasma lipid peroxide (MDA) levels were high and antioxidants. (alpha- tocopherol, total antioxidant capacity) were low in patients with chronic bronchitis. Our results suggest the presence of oxidative stress and decrease in total antioxidant capacity in chronic bronchitis

SUSTAINABLE DIVERSIFIED AGRICULTURE AND LAND MANAGEMENT IN THE HIMALAYA: IMPLICATIONS FOR CLIMATE CHANGE ADAPTATION AND MITIGATION

The soil and land resources play a vital role in sustaining the local livelihoods of rural communities in the Himalaya. Most of the arable land has already been brought under cultivation, hence the ever-increasing demand for food and fiber has left farmers with no choice but to intensify agriculture. However, producing more crops and greater quantities of food, fiber and other materials on the same parcel of land can to soil fertility and productivity decline with overall degradation of land quality. Therefore, ways and means to intensify agriculture to enhance productivity without degrading the soil and land resource base have become imperative. Agro-forestry, agro-slivi-pastoral systems, and the adoption of a variety of crop, soil and water management and conservation practices offer potential to deliver multiple benefits without sacrificing the very resource upon which the human population depends. Presented herein are findings on approaches to sustainable intensification of agriculture and land management related to soil OM management and C sequestration for multiple benefits, and, agro-forestry as a crop diversification strategy with both livelihood, and climate change adaptation/mitigation benefits. The results indicate that sustainable soil management practices could lead to significant SOC accumulations (4-8 t/ha over 6 yrs). SOC and soil C stocks tend to increase with elevation due to cooler climate and slow decomposition rates. Carbon stocks for the 3 LU types was in the order CF&gt;AF/LH&gt;AG, suggesting that diversified cropping practices including agro-forestry have good potential sequester C while providing livelihood opportunities and climate adaptive capacity for local farming communities. Biochar amendment increased growth of both coffee plants and radish with mixed grass/weed biochar being most effective. Biochar application also significantly decreased emission of GHGs, especially N2O

Hepatitis B virus DNA polymerase gene polymorphism based prediction of genotypes in chronic HBV patients from Western India

Background: Hepatitis B Virus (HBV) infection is one of the major causes of liver cirrhosis, hepatocellular carcinoma and deaths due to the acute or chronic consequences worldwide. HBV is distributed into various genotypes based on nucleic acid sequence variation.Objectives: To develop a method of HBV genotyping and drug resistance interpretation using partial sequencing of polymerase gene.Methods: This study was performed on 98 HBV infected patients’ serum samples from Western India. A nested PCR protocol was designed for amplification of pol gene from HBV genome and Sanger’s sequencing of the gene fragment. Sequences were aligned with HBV reference sequences for phylogenetic analysis and for characterization of genetic diversity. Drug resistance mutations were screened using HBVSeq program from Stanford University.Results: Distribution of HBV genotypes showed predominance of genotype D, circulating in 76 (77.55%) patients (p &lt; 0.05). Genotypes A and C were less prevalent and were identified in 4 (4.08%) and 18 (18.37%) patients, respectively. Anti-retroviral drug resistance mutations were not detected in any patient.Conclusion: A method for determination of HBV genotypes using pol gene sequencing which simultaneously detects major drug resistance mutations has been established. HBV genetic diversity may play an important role in treatment decision.Keywords: Hepatitis B virus, nested PCR, genotype, sub-genotypes, YMDD mutation

Antimitotic Effect of Ethanol Fraction of Hibiscus mutabilis Leaf and Flowers

Hibiscus mutabilis is reported for bioactive constituent. Ethanol fraction of Hibiscus mutabilis leaf and flower were studied for antimitotic activity. Allium cepa roots were used to evaluate cytotoxicity effect of the extracts. Ethanol soluble part of leaf and flower showed inhibitory effect on root length and root number growth on third day of incubation which is comparable with paracetamol as standard drug used. Reduction in number of dividing cells in the root meristem due to ethanolic fraction of leaf reveals antimitotic activity which is dose dependant. The constituents present in ethanolic extract may be responsible for cytoskeleton or tubulin polymerization or degradation that demonstrates antimitotic behavior

Multi-Language based Android Application for Motor Control

some wise individual once aforementioned that system could be a system wherever we will finish off the machine whenever we'd like. That’s the distinction between controlled and uncontrolled system. Our project is regarding create this system economical and dynamic. Because the name instructed the automated management is for dominant the motor from remote place, look over its operational conditions; get feedback from the motor itself. Our target is to manage the motor from distant place by mobile DTMF tone and conjointly get feedback by SMS whereas it's in ON or OFF condition. We tend to conjointly make sure the safe operation of the motor by police investigation the voltage of the supply and guarantee feedback from system whereas it's over or below voltage. Once more we tend to conjointly get these feedbacks by SMS additionally. GSM network is all over in our country that’s why we decide GSM network to control our motor conjointly transferring feedback data through it. We tend to conjointly use GSM network as a result of if we tend to use it then we tend to don’t have to be compelled to establish further instrumentation for networking. To transmit feedback signals we tend to use GSM electronic equipment at the motor finish conjointly generate management signal by mobile DTMF as a result of it's terribly simple to get DTMF by mobile station and send feedback SMS by electronic equipment additionally. In industrial sector we tend to hope our project is become handy and value effective to control motor and provides its protection

Celastrus paniculatus and memantine prevent alcohol dependence and improve decision making in alcohol dependent C57BL6 mice

Background: Alcohol use disorder poses a huge burden with only a handful of approved drugs. AUD is associated with impaired decision-making that leads to compulsive drinking despite negative consequences. A drug that decreases alcohol consumption as well as improves decision-making may thus prove more useful. This study was planned to evaluate the effect of two drugs, Celastrus paniculatus and memantine on alcohol preference and decision impairment in alcohol-dependent mice. Methods: In part 1, the effect of both the study drugs on alcohol consumption was studied using intermittent access model in 70 male C57BL6 mice. In part 2, effect of drugs on decision making was studied using the rodent version of Iowa gambling task. Mice were divided in seven study groups: Group 1-3: Celastrus paniculatus (140, 280, and 560 mg/kg), Group 4: memantine (25 mg/kg), Group 5: vehicle control 1 (Milk), Group 6: vehicle control 2 (normal saline) and Group 7: naltrexone(1mg/kg). Results: Percentage alcohol preference was lower in test groups i.e., Celastrus paniculatus at medium (40.90±15.18%) and high doses (31.79±7.46%) vs. milk (82.74±8.53%; p&lt;0.05); and in memantine group (36.28±10.99%) vs. normal saline (83.27±5.51%; p&lt;0.05). The results were not significantly different to Naltrexone (19.70±6.90%). Percentage preference to disadvantageous arms was also lower in Celastrus paniculatus, at medium (50.52±1.92%) and high doses (48.11±2.43%) compared to milk (54.47±2.73%; p&lt;0.05) and memantine (47.45±1.67%) compared to normal saline (54.00±2.73%; p&lt;0.05), indicating better decision-making ability in the test groups. The findings were comparable to Naltrexone group (45.43±2.52%). Conclusions: These results indicate that Celastrus paniculatus and memantine reduce alcohol consumption and improve decision making in alcohol-dependent mice