Biodiversity in a forest island: reptiles and amphibians of the West African Togo Hills

Our recent surveys of the herpetological diversity of the West African Togo Hills documented a total of 65 reptile and amphibian species, making Kyabobo National Park one of the most diverse sites surveyed in Ghana. We provide accounts for all species recorded along with photographs to aid in identification. We recorded 26 amphibians, including six new records for Kyabobo N. P., one of which is a record for the Togo Hills. Our collection of reptile species (22 lizards, 16 snakes, and one crocodile) also provides new records and range extensions for Kyabobo N. P., such as the first observation of the dwarf crocodile, Osteolaemus tetraspis. Amphibian species still lacking from our surveys in the Togo Hills include several species that are adapted to fast running water or large closed forests, like the Togo toad, Bufo togoensis and the slippery frog, Conraua derooi. Appropriate habitat for such species still remains in Kyabobo, highlighting the need for additional survey work. We draw attention to the importance of conserving forest stream habitats, which will in turn help ensure the persistence of forest-restricted species. We also highlight those species that may prove most useful for evolutionary studies of West African rain forest biogeography

The Transcriptome of the Veiled Chameleon (\u3cem\u3eChamaeleo calyptratus\u3c/em\u3e): A Resource for Studying the Evolution and Development of Vertebrates

Purpose The veiled chameleon (Chamaeleo calyptratus) is an emerging model system for studying functional morphology and evolutionary developmental biology (evo‐devo). Chameleons possess body plans that are highly adapted to an arboreal life style, featuring laterally compressed bodies, split hands/ft for grasping, a projectile tongue, turreted independently moving eyes, and a prehensile tail. Despite being one of the most phenotypically divergent clades of tetrapods, genomic resources for chameleons are severely lacking. Methods To address this lack of resources, we used RNAseq to generate 288 million raw Illumina sequence reads from four adult tissues (male and female eyes and gonads) and whole embryos at three distinct developmental stages. We used these data to assemble a largely complete de novo transcriptome consisting of only 82 952 transcripts. In addition, a majority of assembled transcripts (67%) were successfully annotated. Results We then demonstrated the utility of these data in the context of studying visual system evolution by examining the content of veiled chameleon opsin genes to show that chameleons possess all five ancestral tetrapod opsins. Conclusion We present this de novo, annotated, multi‐tissue transcriptome assembly for the Veiled Chameleon, Chamaeleo calyptratus, as a resource to address a range of evolutionary and developmental questions. The associated raw reads and final annotated transcriptome assembly are freely available for use on NCBI and Figshare, respectively

Perspectivas literarias: traducción e intertextualidad

En este libro hemos reunido un conjunto de trabajos que exploran temas relacionados con la traducción literaria y con los estudios literarios desde una perspectiva múltiple y comparada, pues creemos que, en estos tiempos, es valioso detenerse a analizar experiencias complejas con respecto a las prácticas literarias que permiten la comunicación intercultural, ya que ésta es una vía para cuestionar visiones nacionalistas que, en ocasiones, tienden a achatar el panorama en lugar de reconocer la hibridez y la heterogeneidad de los discursos literarios. Se trata de analizar estos temas desde distintos ángulos, tales como la traducción, las intertextualidades temáticas, la formación de traductores, la perspectiva de los lectores, la construcción del canon por distintas instancias culturales y los estudios comparados

Bronchoarterial ratio in never‐smokers adults: Implications for bronchial dilation definition

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135610/1/resp12875_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135610/2/resp12875.pd

Dark Energy and Gravity

I review the problem of dark energy focusing on the cosmological constant as the candidate and discuss its implications for the nature of gravity. Part 1 briefly overviews the currently popular `concordance cosmology' and summarises the evidence for dark energy. It also provides the observational and theoretical arguments in favour of the cosmological constant as the candidate and emphasises why no other approach really solves the conceptual problems usually attributed to the cosmological constant. Part 2 describes some of the approaches to understand the nature of the cosmological constant and attempts to extract the key ingredients which must be present in any viable solution. I argue that (i)the cosmological constant problem cannot be satisfactorily solved until gravitational action is made invariant under the shift of the matter lagrangian by a constant and (ii) this cannot happen if the metric is the dynamical variable. Hence the cosmological constant problem essentially has to do with our (mis)understanding of the nature of gravity. Part 3 discusses an alternative perspective on gravity in which the action is explicitly invariant under the above transformation. Extremizing this action leads to an equation determining the background geometry which gives Einstein's theory at the lowest order with Lanczos-Lovelock type corrections. (Condensed abstract).Comment: Invited Review for a special Gen.Rel.Grav. issue on Dark Energy, edited by G.F.R.Ellis, R.Maartens and H.Nicolai; revtex; 22 pages; 2 figure

Getting the invite list right : a discussion of sepsis severity scoring systems in severe complicated intra-abdominal sepsis and randomized trial inclusion criteria

Background: Severe complicated intra-abdominal sepsis (SCIAS) is a worldwide challenge with increasing incidence. Open abdomen management with enhanced clearance of fluid and biomediators from the peritoneum is a potential therapy requiring prospective evaluation. Given the complexity of powering multi-center trials, it is essential to recruit an inception cohort sick enough to benefit from the intervention; otherwise, no effect of a potentially beneficial therapy may be apparent An evaluation of abilities of recognized predictive systems to recognize SCIAS patients was conducted using an existing intra-abdominal sepsis (IAS) database. Methods: All consecutive adult patients with a diffuse secondary peritonitis between 2012 and 2013 were collected from a quaternary care hospital in Finland, excluding appendicitis/cholecystitis. From this retrospectively collected database, a target population (93) of those with either ICU admission or mortality were selected. The performance metrics of the Third Consensus Definitions for Sepsis and Septic Shock based on both SOFA and quick SOFA, the World Society of Emergency Surgery Sepsis Severity Score (WSESSSS), the APACHE II score, Manheim Peritonitis Index (MPI), and the Calgary Predisposition, Infection, Response, and Organ dysfunction (CPIRO) score were all tested for their discriminant ability to identify this subgroup with SCIAS and to predict mortality. Results: Predictive systems with an area under-the-receiving-operating characteristic (AUQ curve >= 0.8 included SOFA, Sepsis-3 definitions, APACHE II, WSESSSS, and CPIRO scores with the overall best for CPIRO. The highest identification rates were SOFA score >= 2 (78.4%), followed by the WSESSSS score >= 8 (73.1%), SOFA >= 3 (752%), and APACHE II >= 14 (68.8%) identification. Combining the Sepsis-3 septic-shock definition and WSESSS >= 8 increased detection to 80%. Including CPIRO score >= 3 increased this to 82.8% (Sensitivity-SN; 83% Specificity-SP; 74%. Comparatively, SOFA >= 4 and WSESSSS >= 8 with or without septic-shock had 83.9% detection (SN; 84%, SP; 75%, 25% mortality). Conclusions: No one scoring system behaves perfectly, and all are largely dominated by organ dysfunction. Utilizing combinations of SOFA, CPIRO, and WSESSSS scores in addition to the Sepsis-3 septic shock definition appears to offer the widest "inclusion-criteria" to recognize patients with a high chance of mortality and ICU admission.Peer reviewe