Proceedings of the 16th Annual Meeting of the Society for Pediatric Dermatology

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75156/1/j.1525-1470.1992.tb00329.x.pd

Proceedings of the 14th Annual Meeting of the Society for Pediatric Dermatology Quebec City, Quebec, Canada June 22–24, 1989

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73710/1/j.1525-1470.1989.tb00922.x.pd

Turbine Remanufacture - One Option For Reliability And Efficiency Improvement.

LecturePg. 95-110A case study of a remanufacture of a steam turbine is presented. The turbine has been in service for 20 years. Thermal and physical stresses have taken their toll on the turbine casing and supporting hardware. Remanufacture was planned with innovative processes and state-of-the-art component upgrades. A unique heat treatment process was designed to reshape the casing and relieve residual stresses thermally induced into the casing over its operating life. Using heat to reshape the case minimized the amount of remachining time required. A team of three vendors was combined to maximize technical and physical resources and accomplish this task in 24 days. The goals of the remanufacture included: • Recovery of lost horsepower and efficiency due to steam path deterioration • Increase efficiency through the application of packing, tip, and nozzle seal upgrades • Elimination of chronic maintenance problems. Major topics include: • Casing disassembly and damage assessment • Weld restoration of erosion damage and steam path blading • Distortion modelling and evaluation • Heat treatment of case • Assessment of heat treatment results • Machining steps required • Design and installation of retractable packing • Design and installation of tip seals and nozzle seals • Successful startup and operational histor

Identification of Unreported Sources of Objects Containing High Release Nickel

Globally, nickel is the leading cause of allergic contact dermatitis (ACD). Nickel is ubiquitous, and published literature continues to index items most frequently associated with Ni-ACD. Unregulated nickel exposure in North America is evident by the unprecedented rates of sensitization seen in patch-tested cohorts, 18.5% in children (ages 0-18 years) and 28.1% in adults.1 Conservative estimates of ACD within the pediatric population suggest at least one million cases in the US yearly with roughly one-quarter of those cases due to nickel.2-3 The United States could potentially save $5.7 billion annually in health care costs, extrapolating current cost-saving data from Denmark post nickel regulation, by implementing similar regulation to that of the European Union (EU).2 To our knowledge, site surveys testing for items releasing nickel in public locations has yet to be performed

De norske fjelde - rodløse realiteter

I GeologiskNyt 5/2007 opsummerede vi et væld af oplysninger, der viser, at de norske fjelde har været udsat for vertikale bevægelser i kilometer-skala i Kænozoikum, og at fjeldene først har nået deres nuværende højder i Neogen. Søren B. Nielsen (SBN) kommenterer i GeologiskNyt 1/2008 vores indlæg, men kommer desværre ikke med yderligere argumenter for sin hypotese om, at de norske fjelde er resterne af den bjergkæde, der blev dannet under den kaledonske kollision mellem Baltica og Grønland for mere end 400 millioner år siden. Derimod skaber SBN usikkerhed om simple kendsgerninger, der er af afgørende betydning for vurderingen af de norske fjeldes alder og struktur

Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model.

Laser-induced experimental glaucoma (ExGl) in non-human primates (NHPs) is a common animal model for ocular drug development. While many features of human hypertensive glaucoma are replicated in this model, structural and functional changes in the unlasered portions of trabecular meshwork (TM) of laser-treated primate eyes are understudied. We studied NHPs with ExGl of several years duration. As expected, ExGl eyes exhibited selective reductions of the retinal nerve fiber layer that correlate with electrophysiologic measures documenting a link between morphologic and elctrophysiologic endpoints. Softening of unlasered TM in ExGl eyes compared to untreated controls was observed. The degree of TM softening was consistent, regardless of pre-mortem clinical findings including severity of IOP elevation, retinal nerve fiber layer thinning, or electrodiagnostic findings. Importantly, this softening is contrary to TM stiffening reported in glaucomatous human eyes. Furthermore, microscopic analysis of unlasered TM from eyes with ExGl demonstrated TM thinning with collapse of Schlemm's canal; and proteomic analysis confirmed downregulation of metabolic and structural proteins. These data demonstrate unexpected and compensatory changes involving the TM in the NHP model of ExGl. The data suggest that compensatory mechanisms exist in normal animals and respond to elevated IOP through softening of the meshwork to increase outflow

Discrete breathers in a two-dimensional hexagonal Fermi-Pasta-Ulam lattice

We consider a two-dimensional Fermi-Pasta-Ulam (FPU) lattice with hexagonal symmetry. Using asymptotic methods based on small amplitude ansatz, at third order we obtain a reduction to a cubic nonlinear Schrodinger equation (NLS) for the breather envelope. However, this does not support stable soliton solutions, so we pursue a higher-order analysis yielding a generalised NLS, which includes known stabilising terms. We present numerical results which suggest that long-lived stationary and moving breathers are supported by the lattice. We find breather solutions which move in an arbitrary direction, an ellipticity criterion for the wavenumbers of the carrier wave, asymptotic estimates for the breather energy, and a minimum threshold energy below which breathers cannot be found. This energy threshold is maximised for stationary breathers, and becomes vanishingly small near the boundary of the elliptic domain where breathers attain a maximum speed. Several of the results obtained are similar to those obtained for the square FPU lattice (Butt & Wattis, J Phys A, 39, 4955, (2006)), though we find that the square and hexagonal lattices exhibit different properties in regard to the generation of harmonics, and the isotropy of the generalised NLS equation.Comment: 29 pages, 14 Figure

BARRIER SYSTEM

A barrier system (100) includes first and second barrier segments (102) connected to one another such that crash energy is absorbed. The connection between the segments includes a pair of wedge-shaped connectors (102) disposed between angled faces (118) formed at the opposing ends of the segments. Elastic pads (700) are sandwiched between the respective segment faces and connectors (202)

Three-Dimensional Elastic Compatibility: Twinning in Martensites

We show how the St.Venant compatibility relations for strain in three dimensions lead to twinning for the cubic to tetragonal transition in martensitic materials within a Ginzburg-Landau model in terms of the six components of the symmetric strain tensor. The compatibility constraints generate an anisotropic long-range interaction in the order parameter (deviatoric strain) components. In contrast to two dimensions, the free energy is characterized by a "landscape" of competing metastable states. We find a variety of textures, which result from the elastic frustration due to the effects of compatibility. Our results are also applicable to structural phase transitions in improper ferroelastics such as ferroelectrics and magnetoelastics, where strain acts as a secondary order parameter

Increased CNV-Region Deletions in Mild Cognitive Impairment (MCI) and Alzheimer\u27s Disease (AD) Subjects in the ADNI Sample

We investigated the genome-wide distribution of CNVs in the Alzheimer\u27s disease (AD) Neuroimaging Initia- tive (ADNI) sample (146 with AD, 313 with Mild Cognitive Impairment (MCI), and 181 controls). Comparison of single CNVs between cases (MCI and AD) and controls shows overrepresentation of large hetero- zygous deletions in cases (p-value b 0.0001). The analysis of CNV-Regions identifies 44 copy number variable loci of heterozygous deletions, with more CNV-Regions among affected than controls (p = 0.005). Seven of the 44 CNV-Regions are nominally significant for association with cognitive impairment. We validated and con- firmed our main findings with genome re-sequencing of selected patients and controls. The functional pathway analysis of the genes putatively affected by deletions of CNV-Regions reveals enrichment of genes implicated in axonal guidance, cell–cell adhesion, neuronal morphogenesis and differentiation. Our findings support the role of CNVs in AD, and suggest an association between large deletions and the development of cognitive impairment