Inteligencia emocional, coaching educativo e interacción oral en lengua inglesa. Una propuesta para sexto de Educación Primaria

El presente Trabajo Fin de Grado tiene como objetivo la puesta en valor del desarrollo de la inteligencia emocional y del coaching educativo en el aprendizaje de la lengua inglesa. De esta manera, se pretende abordar un aprendizaje experiencial que permita a los alumnos pensar, sentir y reflexionar para poder desarrollar una sensibilización emocional, una reflexión de la misma, favoreciendo el desarrollo de la competencia comunicativa. Así mismo, se presenta una propuesta práctica para sexto curso de Educación Primaria orientada a la mejora de la competencia comunicativa y, en consecuencia, la interacción oral. Se concluye con unas reflexiones finales sobre el uso didáctico eventual de estos aspectos pedagógicos en el aula de Educación Primaria.Grado en Educación Primari

Eficiencia de los tests de laboratorio en una unidad de hospitalización de psiquiatría

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Psiquiatría. Fecha de lectura: 10-11-201

Chapter Mackintosh, Bayer y los Eames: diálogos entre tipografía y arquitectura

The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences

¿Es el protocolo Marik eficaz en shock séptico?

In recent years, numerous attempts have been made to reduce the mortality associated with septic shock, both from the point of view of early diagnosis and treatment optimization. New developments in the treatment include the use of vitamin C and thiamine associated with hydrocortisone, with several observational studies having been shown to improve survival and decrease in vasopressor use. However, this new clinical trial calls into question the role of vitamin C and thiamine, without finding significant differences between hydrocortisone monotherapy and the combination of all three.En los últimos años, se han realizado numerosos intentos para lograr disminuir la mortalidad asociada al shock séptico, tanto desde el punto de vista del diagnóstico precoz como de optimización del tratamiento. Entre las novedades en el tratamiento se incluye el uso de vitamina C y tiamina asociado a hidrocortisona, habiéndose comprobado en varios estudios observacionales la mejoría de la supervivencia y la disminución del uso de vasopresores. Sin embargo, este nuevo ensayo clínico pone en duda el papel de la vitamina C y la tiamina, sin encontrar diferencias significativas entre la monoterapia con hidrocortisona y la combinación de las tres.    

Bloqueantes neuromusculares y síndrome de distrés respiratorio

Early use of neuromuscular blockers agents (NMBAs) in moderate-severe adult respiratory distress syndrome (ARDS) has previously been associated with a mortality decrease in the ACURASYS trial in 2010. However, the recently published ROSE study (Reevaluation of Systemic Early Neuromuscular Blockade) points out the disagreement with this practice. El uso precoz de bloqueantes neuromusculares (BNM) en el síndrome de distrés respiratorio del adulto (SDRA) moderado-severo se había asociado a una disminución de la mortalidad en el ensayo ACURASYS en 2010. El recientemente publicado estudio ROSE (Reevaluation of Systemic Early Neuromuscular Blockade)  pone en evidencia esta práctica.

Bilingual children as interpreters in everyday life: how natural interpreting reinforces minority languages

Producción CientíficaThis study analyses different contextual and linguistic variables that define the natural interpreting instances produced in spontaneous interactions by 19 young bilingual children (average age: 3;7) with different language pairs. In particular, we aim at characterizing the bilingual practice used by these children and (i) involve the consecutive use of their two languages and (ii) are shaped by the communicative strategies used by parents at home. The analysis is based on freely available corpora in CHILDES (MacWhinney 2000) (i.e. FerFuLice, Pérez-Bazán, Ticio, Vila, Deuchar; GNP) and diary annotations (i.e. Ronjat 1913; Leopold 1935-1945; Lanza 1988, 1997, 2001) that comprise the spontaneous and longitudinal production of these children. Our results show that the language strategies followed by parents at home in combination with the linguistic communities where they live play a key role on this bilingual practice.2020-04-042020-04-04Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA046A06)Junta de Castilla y León y FEDER (programa de apoyo a proyectos de investigación - Ref.VA009P17Ministerio de Ciencia y Tecnología y FEDER (BFF2002-00442)Ministerio de Educación, Cultura y Deporte (HUM2007-62213/FILO

Optimización de modelos en elementos finitos de los maniquíes Hybrid-III percentiles 50% y 95% para su aplicación en transporte ferroviario

En este artículo se presenta la metodología seguida para el desarrollo de los modelos matemáticos de los maniquíes Hybrid-III 50% y 95%, los cuales son capaces de predecir correctamente los criterios de lesión asociados a cada región del cuerpo. Como aplicación práctica de los modelos, se evalúa la seguridad de butacas de tren mediante técnicas de simulación. En primer lugar se han desarrollado los modelos a través de su geometría tridimensional. También han sido asignados los diferentes materiales y propiedades de cada parte de los maniquíes. Posteriormente se ha seguido un proceso de optimización y de mejora que incluye la verificación y validación de los maniquíes virtuales. Dicha validación se realiza a partir de los maniquíes físicos y de los datos experimentales que posee el Laboratorio de Seguridad Pasiva (LSP) del INSIA de la UPM, utilizando los maniquíes en varias configuraciones. Finalmente, se realiza el proceso de optimización de estos modelos virtuales para que representen lo más fielmente posible la realidad, que su comportamiento sea preciso y que el tiempo de cálculo o coste computacional sea el menor posible. Una vez creados los modelos en elementos finitos de ambos maniquíes, se emplean para analizar la seguridad de las butacas de tren mediante la simulación de los ensayos dinámicos que se describen en la norma GM/RT2100. Esta norma exige dos configuraciones de ensayo para evaluar la seguridad de las butacas. La primera configuración sirve para evaluar la resistencia y la integridad estructural de la butaca y sus anclajes mediante el uso de dos maniquíes Hybrid-III 95%. La segunda configuración se utiliza para evaluar la protección que las butacas ofrecen al ocupante mediante el uso de un maniquí Hybrid-III 50% instrumentado. En ambas configuraciones se realizan impactos en sentido de la marcha y en el sentido contrario y se compran los valores registrados en los maniquíes tanto en los ensayos reales como en las simulaciones matemáticas

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery

AbstractThe Trypanosomatidae family, composed of unicellular parasites, causes severe vector-borne diseases that afflict human populations worldwide. Chagas disease, sleeping sickness, as well as different sorts of leishmaniases are amongst the most important infectious diseases produced by Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp., respectively. All these infections are closely related to weak health care services in low-income populations of less developed and least economically developed countries. Search for new therapeutic targets in order to hit these pathogens is of paramount priority, as no effective vaccine is currently in use against any of these parasites. Furthermore, present-day chemotherapy comprises old-fashioned drugs full of important side effects. Besides, they are prone to produce tolerance and resistance as a consequence of their continuous use for decades. DNA topoisomerases (Top) are ubiquitous enzymes responsible for solving the torsional tensions caused during replication and transcription processes, as well as in maintaining genomic stability during DNA recombination. As the inhibition of these enzymes produces cell arrest and triggers cell death, Top inhibitors are among the most effective and most widely used drugs in both cancer and antibacterial therapies. Top relaxation and decatenation activities, which are based on a common nicking–closing cycle involving one or both DNA strands, have been pointed as a promising drug target. Specific inhibitors that bind to the interface of DNA-Top complexes can stabilize Top-mediated transient DNA breaks. In addition, important structural differences have been found between Tops from the Trypanosomatidae family members and Tops from the host. Such dissimilarities make these proteins very interesting for drug design and molecular intervention. The present review is a critical update of the last findings regarding trypanosomatid’s Tops, their new structural features, their involvement both in the physiology and virulence of these parasites, as well as their use as promising targets for drug discovery

Spanish photovoltaic solar energy: institutional change, financial effects, and the business sector

Spain is a country with a high dependence on fossil fuels. For this reason, in 2007, it implemented a bonus system that aimed to encourage the production of renewable energies, particularly photovoltaic solar energy. These production bonuses, guaranteed by the Spanish government, led to an exponential increase in the number of companies in the market and, consequently, the MWh produced. However, in 2012, given the excessive budgetary burden involved in maintaining this “feed-in tariff” system and after several years of institutional instability, the aforementioned system of incentives for phoyovoltaic (PV) energy was eliminated. This paper has tried to analyze the consequences of this institutional change, a clear example of the “hold up” problem. For this purpose, a sample of 5354 companies, which was divided, geographically, into Spanish regions and, temporarily, into three different periods, has been taken, considering diverse economic and financial variables. The results show a notable weakening of the sector that, due to the effects of the regulatory change, has lost attractiveness and profitability for investors and is consequently suffering from stagnation, which has led to the disappearance of many companies in the sector.Raquel Fernández González gratefully acknowledge the financial support provided by the Xunta de Galicia under Grants ED431C2018/48 and ED431E2018/07 and the Ministry of Economy and Competitiveness under Grant RTI2018-099225-B-100. This research was funded by Regional Government of Castilla y León under the “Support Program for Recognized Research Groups of Public Universities of Castilla y León” (ORDEN EDU/667/2019) and the Spanish Ministry of Science, Innovation & Universities under the I + D + i state program “Challenges Research Projects” (Ref. RTI2018-098900-B-I00)