Research and the teaching in Design and Music

Um livro com diversas perspetivas sobre projetos e processos de investigação nas áreas do design e da música. São 50 escritos por autores de diferentes países, que contribuem para uma perspectiva ampla nestes domínios.info:eu-repo/semantics/publishedVersio

a quantitative approach

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Laboratório de Solos e Fertilidade.

Laboratório de Solos e Fertilidade.info:eu-repo/semantics/publishedVersio

Annular elastolytic giant cell granuloma: a "visible" diagnosis

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of undetermined cause, characterized by annular plaques with raised erythematous borders in sun-exposed skin. The typical histologic features are dermal infiltration by multinucleated giant cells, elastin degeneration, and elastophagocytosis. The authors describe a clinical case of AEGCG, which exhibited an excellent response to hydroxycloroquine.info:eu-repo/semantics/publishedVersio

A randomized trial of the close reading and creative writing program: an alternative educational method for adult group care intervention in type 2 diabetes management

Objectives: Group care for individuals with diabetes is a recognized educational practice, but techniques from narrative medicine using of literary works have never been incorporated in these programs. We designed a new educational model (i.e. the Close Reading and Creative Writing program) of group care for individuals with diabetes incorporating close reading and creative writing in group education. A randomized trial was designed to evaluate this intervention. Methods: A total of 49 individuals with type 2 diabetes, aged 6 years of school education, were randomized to 2 different group care dynamics: (a) a “control group,” with a classical structured educational approach currently used at our institution; and (b) an “intervention group,” with introduction of literary texts, narrative skills, close reading and creative writing. Evaluation included anthropometric measures, glycated hemoglobin (A1C) and questionnaires for psychological evaluation. Individual A1C levels in the 6-year period before the trial were collected from clinical records. Results: A significant reduction of A1C was observed in the intervention group, showing noninferiority in relation to the classical approach. A significant decrease in A1C was observed in relation to the 6 previous years. A significant increase in satisfaction with the therapist and group process was observed. Conclusions: This is the first randomized trial designed to evaluate a group care intervention to manage type 2 diabetes using narrative techniques. The results suggest that this may be a useful model for more highly schooled individuals, and may represent an alternative for the educational process.info:eu-repo/semantics/acceptedVersio

Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization

first_pagesettingsOrder Article Reprints Open AccessArticle Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization by Carlota J. F. Conceição 1,2ORCID,Elin Moe 3,4,Paulo A. Ribeiro 2ORCID andMaria Raposo 2,*ORCID 1 CEFITEC, Department of Physics, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal 2 Laboratory of Instrumentation, Biomedical Engineering and Radiation Physics (LIBPhys-UNL), Department of Physics, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal 3 Institute of Chemical and Biological Technology (ITQB NOVA), The New University of Lisbon, 2780-157 Oeiras, Portugal 4 Department of Chemistry, UiT—The Arctic University of Norway, N-9037 Tromsø, Norway * Author to whom correspondence should be addressed. Nanomaterials 2023, 13(10), 1613; https://doi.org/10.3390/nano13101613 Received: 4 April 2023 / Revised: 7 May 2023 / Accepted: 9 May 2023 / Published: 11 May 2023 (This article belongs to the Special Issue Application of Lipid Nanoparticles in Drug and Gene Delivery) Download Browse Figures Review Reports Versions Notes Abstract The development of a lipid nano-delivery system was attempted for three specific poly (ADP-ribose) polymerase 1 (PARP1) inhibitors: Veliparib, Rucaparib, and Niraparib. Simple lipid and dual lipid formulations with 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1′-glycerol) sodium salt (DPPG) and 1,2-dipalmitoyl-sn-glycero-3-phosphocoline (DPPC) were developed and tested following the thin-film method. DPPG-encapsulating inhibitors presented the best fit in terms of encapsulation efficiency (>40%, translates into concentrations as high as 100 µM), zeta potential values (below −30 mV), and population distribution (single population profile). The particle size of the main population of interest was ~130 nm in diameter. Kinetic release studies showed that DPPG-encapsulating PARP1 inhibitors present slower drug release rates than liposome control samples, and complex drug release mechanisms were identified. DPPG + Veliparib/Niraparib presented a combination of diffusion-controlled and non-Fickian diffusion, while anomalous and super case II transport was verified for DPPG + Rucaparib. Spectroscopic analysis revealed that PARP1 inhibitors interact with the DPPG lipid membrane, promoting membrane water displacement from hydration centers. A preferential membrane interaction with lipid carbonyl groups was observed through hydrogen bonding, where the inhibitors’ protonated amine groups may be the major players in the PARP1 inhibitor encapsulation mode

Critical Behaviour of Mixed Heisenberg Chains

The critical behaviour of anisotropic Heisenberg models with two kinds of antiferromagnetically exchange-coupled centers are studied numerically by using finite-size calculations and conformal invariance. These models exhibit the interesting property of ferrimagnetism instead of antiferromagnetism. Most of our results are centered in the mixed Heisenberg chain where we have at even (odd) sites a spin-S (S') SU(2) operator interacting with a XXZ like interaction (anisotropy $\Delta$). Our results indicate universal properties for all these chains. The whole phase, $1>\Delta>-1$, where the models change from ferromagnetic $( \Delta=1 )$ to ferrimagnetic $(\Delta=-1)$ behaviour is critical. Along this phase the critical fluctuations are ruled by a c=1 conformal field theory of Gaussian type. The conformal dimensions and critical exponents, along this phase, are calculated by studying these models with several boundary conditions.Comment: 21 pages, standard LaTex, to appear in J.Phys.A:Math.Ge