Networking of Tracking Radars of Two Different SAM Weapons to Protect the Missile in Intensive Jamming Environment

Many countries including India use the Russian made SAM-3 (Pechora) surface-to-air missile (SAM) weapon systems to protect their strategic and tactical infrastructure. The mathematical computations done in this paper, conclusively proves that SA-125 low-blow tracking radar of Pechora is vulnerable to jamming. A project was undertaken to overcome the jamming vulnerability of Pechora aiming to design and develop an electronic counter counter measure system. This system networked the Pechora tracking radar with a western tracking radar, Flycatcher, developed by HSA Holland. The latter radar works in a MMW band. When jamming (x band) is employed by enemy aircraft the Low blow radar failed to provide target coordinates. But the flycatcher tracking radar which is tracking in Ka band provided the tracking coordinates (after parallax correction) to the command guidance computer. This way the missile guidance is protected until missile warhead in missile blasts near the target. Extensive trials carried out with a number of aircraft sorties proved the success of this developed system against jamming

The clam resources

Che estuaries and backwaters along the coasts of India have immense clam resources which have been traditionally exploited by the coastal people. The clams form the basis of subsistence for the fishermen during seasons when sea fishing is at a low ebb and clam fishing is a regular activity in many coastal regions of Maharashtra, Goa, Karnataka and Kerala on the west coast. Along the east coast, clam fishing is restricted to a few centres such as the Kakinada Bay although, here and there, they are collected for culinary purposes elsewhere. This is an activity where, besides men and women, children participate. Clam marketing is highly localised in centres of collection. Apart from introduction of improved clam-scooping devices, the fishing method of hand-picking has largely remained unchanged over the years

Review on cephalopod resources, biology and stock assessment in Indian seas

Cephalopods are fished from the seas around India from very early times and at present contribute one of the most important exploited marine fishery resources oj the country (between 4 and 5% of the all India production). The production, which remained at very low level up to the early seventies, has shown a remarkable increase crossing the 1,00,000 tonne mark in 1994. The taxonomy, biology and stock assessment of the various exploited species have been studied since the early seventies by the CMFRI. Studies indicate that uplo 1994 tlie exploitation has remained within rational limits in almost all maritime states. The recent rapid increase in production warrants close monitoring of this short-lived resource from the viewpoint of Judicious management

Atlas of Clam Resources of Karnataka

Among the renewable molluscan resources in India, the clams of the estuarine and backwater regions provide livelihood for the poor who exploit them for their meat and shells. The clam meat is rich in protein and is also cheap when compared to prawns and fishes. It is relished by the rich and the poor alike in Karnataka. The clam shells, made up of mostly calcium carbonate, are used for industrial purposes. The export of frozen clam meat started recently during the eighties enhanced the rate of exploitation considerably in states like Kerala causing concern. Therefore the study of this resource has gained Importance in recent years

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: “Some College” (yes/no, for any education beyond high school) and “Graduated College” (yes/no, for completing a 4-year college degree). Genome-wide significant (p &lt; 5 × 10−8) and suggestive (p &lt; 1 × 10−6) variants were identified in Stage 1 (in up to 108,784 individuals) through genome-wide analysis, and those variants were followed up in Stage 2 studies (in up to 117,531 individuals). Results: In combined analysis of Stages 1 and 2, we identified 18 novel lipid loci (nine for LDL, seven for HDL, and two for TG) by two degree-of-freedom (2 DF) joint tests of main and interaction effects. Four loci showed significant interaction with educational attainment. Two loci were significant only in cross-population analyses. Several loci include genes with known or suggested roles in adipose (FOXP1, MBOAT4, SKP2, STIM1, STX4), brain (BRI3, FILIP1, FOXP1, LINC00290, LMTK2, MBOAT4, MYO6, SENP6, SRGAP3, STIM1, TMEM167A, TMEM30A), and liver (BRI3, FOXP1) biology, highlighting the potential importance of brain-adipose-liver communication in the regulation of lipid metabolism. An investigation of the potential druggability of genes in identified loci resulted in five gene targets shown to interact with drugs approved by the Food and Drug Administration, including genes with roles in adipose and brain tissue. Discussion: Genome-wide interaction analysis of educational attainment identified novel lipid loci not previously detected by analyses limited to main genetic effects.</p

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe