Evaluation of total phenols and antibacterial activity of certain drug plants against some bacterial species

The present paper deals with antimicrobial activity of Glycyrrhiza glabra, Tinospora cordifolia, Tribulus terrestris, Thevetia peruviana, Adhatoda vasica, Vitex negungo, Apium graveolens and, Annona squamosa. It was studied against Bacillus cereus, Staphylococcus aureus, Salmonella typhy B (STB), Shigella dysenteriae using solvent (methanol and petroleum ether) extraction method. Methanol extract of all eight plants showed prominent inhibitory activity against S. dysenteriae and STB while G. glabra, V. negundo, and T. peruviana showed maximum zone of inhibition against four studied bacterial species. These results suggest that methanol extract is more effective than petroleum ether for the antimicrobial activity. Further total phenols were estimated and antibacterial activity of these plants in relation to total phenolic content is discussed

Effect of Mulaka (Raphanus sativus Linn.) panchanga and Mulaka kshara against cisplatin–induced nephrotoxicity

318-324Ayurveda has given prime importance to Mutravaha srotas (urinary system) and Srotogata vikaras (urinary disorders). Acharyas of Ayurveda has described many aspects of Mutravaha srotasa (urinary system) and described diseases pertaining to it. Mulaka (Raphanus sativus Linn.) belongs to family Brasicassea, traditionally being used in kidney disorders. Mulaka was firstly introduced in Charak Samhita and used for urinary system related problems. Hence, present study was planned with an aim to prove the traditional claims on Ayurvedic formulations of Mulaka i.e., powder of Mulaka panchanga and Mulaka kshara. Mulaka panchanga (450 and 900 mg/kg) and Mulaka kshara (90 and 180 mg/kg) were evaluated for nephroprotective activity by using cisplatin (5 mg/kg, ip) –induced nephrotoxicity in albino rats. Cisplatin increases the levels of blood urea, uric acid and serum creatinine which suggest the kidney damage in rats. Cisplatin–induced the hepatotoxicity was confirmed by increase in the level of serum transaminases, alkaline phosphatase and bilirubin with increase in the level of serum cholesterol and triglyceride. Both formulations reversed the serum biochemical parameters and urine creatinine levels with an increase in the urine volume. Further, powder of Mulaka panchanga and Mulaka kshara, attenuated the level of free radicals with concomitantly increase in antioxidant parameters in kidney tissue homogenate and thus, protect the kidney cytoarchitecture in histopathological study. The result of present study indicates that Mulaka panchanga and Mulaka kshara both having nephroprotective and antioxidant properties in dose dependent manner in cisplatin–induced nephrotoxicity in rats

Effect of Mulaka (Raphanus sativus Linn.) panchanga and Mulaka kshara against cisplatin–induced nephrotoxicity

318-324Ayurveda has given prime importance to Mutravaha srotas (urinary system) and Srotogata vikaras (urinary disorders). Acharyas of Ayurveda has described many aspects of Mutravaha srotasa (urinary system) and described diseases pertaining to it. Mulaka (Raphanus sativus Linn.) belongs to family Brasicassea, traditionally being used in kidney disorders. Mulaka was firstly introduced in Charak Samhita and used for urinary system related problems. Hence, present study was planned with an aim to prove the traditional claims on Ayurvedic formulations of Mulaka i.e., powder of Mulaka panchanga and Mulaka kshara. Mulaka panchanga (450 and 900 mg/kg) and Mulaka kshara (90 and 180 mg/kg) were evaluated for nephroprotective activity by using cisplatin (5 mg/kg, ip) –induced nephrotoxicity in albino rats. Cisplatin increases the levels of blood urea, uric acid and serum creatinine which suggest the kidney damage in rats. Cisplatin–induced the hepatotoxicity was confirmed by increase in the level of serum transaminases, alkaline phosphatase and bilirubin with increase in the level of serum cholesterol and triglyceride. Both formulations reversed the serum biochemical parameters and urine creatinine levels with an increase in the urine volume. Further, powder of Mulaka panchanga and Mulaka kshara, attenuated the level of free radicals with concomitantly increase in antioxidant parameters in kidney tissue homogenate and thus, protect the kidney cytoarchitecture in histopathological study. The result of present study indicates that Mulaka panchanga and Mulaka kshara both having nephroprotective and antioxidant properties in dose dependent manner in cisplatin–induced nephrotoxicity in rats

Installation, commissioning, and testing of the HB650 CM at PIP2IT

The Proton Improvement Plan-II (PIP-II) is a major upgrade to the Fermilab accelerator complex, featuring a new 800-MeV Superconducting Radio-Frequency (SRF) linear accelerator (LINAC) powering the accelerator complex to provide the world's most intense high-energy neutrino beam. This paper describes the conversion of the PIP-II Injector Test Facility (PIP2IT) cryogenic system into a test stand for PIP-II High-Beta 650 MHz (HB650) cryomodules at Fermilab's Cryomodule Test Facility (CMTF). A description of the associated mechanical, electrical, and controls modifications necessary for testing HB650 cryomodules are provided. The cooldown and warmup requirements, procedures and associated controls logic is described.Comment: 2023 Cryogenic Engineering Conference and International Cryogenic Materials Conference (CEC/ICMC