Hacia los orígenes del derecho civil europeo. Algunas observaciones sobre las relaciones entre pandectística alemana y doctrina civilista italiana en materia de negocio jurídico

The history of Italian civil law of the last century was marked by a major event: the replacement of French influence by German influence. Nevertheless, this influence has decreased since few decades ago. Nowadays, interest that Italian culture shows in Anglo-American model is marked. Notwithstanding that, the study of this fundamental chapter of recent European private law history, which may be called «Italian pandectistic», could facilitate greater understanding of some structural characters of Italian civil law and keep alive conscious of one aspect of civil law culture that Italy shares with Germany and other European countries.La historia del derecho civil italiano del último siglo estuvo marcada por un acontecimiento de gran relevancia: la sustitución de la influencia francesa por la alemana. Sin embargo, esta influencia ha disminuido desde hace algunas décadas. Hoy en día es marcado el interés que la cultura italiana muestra por el modelo angloamericano. A pesar de ello, el estudio de este capítulo fundamental de la reciente historia del derecho privado europeo, al cual podemos denominar “pandectística italiana”, podría facilitar la comprensión de ciertos caracteres estructurales del derecho civil italiano y mantener en vida la conciencia de un aspecto de la cultura iusprivatista que Italia comparte con Alemania y otros países europeos

Uncovering the host galaxy of the γ\gamma-ray-emitting narrow-line Seyfert 1 galaxy FBQS J1644+2619

The discovery of $\gamma$-ray emission from radio-loud narrow-line Seyfert 1 (NLSy1) galaxies has questioned the need for large black hole masses (> 10$^8$ M$_{\odot}$) to launch relativistic jets. We present near-infrared data of the $\gamma$-ray-emitting NLSy1 FBQS J1644+2619 that were collected using the camera CIRCE (Canarias InfraRed Camera Experiment) at the 10.4-m Gran Telescopio Canarias to investigate the structural properties of its host galaxy and to infer the black hole mass. The 2D surface brightness profile is modelled by the combination of a nuclear and a bulge component with a S\'ersic profile with index $n$ = 3.7, indicative of an elliptical galaxy. The structural parameters of the host are consistent with the correlations of effective radius and surface brightness against absolute magnitude measured for elliptical galaxies. From the bulge luminosity, we estimated a black hole mass of (2.1$\pm$0.2) $\times$10$^8$ M$_{\odot}$, consistent with the values characterizing radio-loud active galactic nuclei.Comment: 5 pages, 3 figures, 1 table. Monthly Notices of the Royal Astronomical Society Letter, Vol. 469, L11-L1

4D-Flow Cardiovascular Magnetic Resonance Sequence for Aortic Assessment: Multi-Vendor and Multi-Magnetic Field Reproducibility in Healthy Volunteers

Objectives: Four-dimensional (4D) flow cardiac magnetic resonance (CMR) represents an emerging technique for non-invasive evaluation of the aortic flow. The aim of this study was to investigate a 4D-flow CMR sequence for the assessment of thoracic aorta comparing different vendors and different magnetic fields of MR scanner in fifteen healthy volunteers. Methods: CMR was performed on three different MRI scanners: one at 1.5 T and two at 3 T. Flow parameters and planar wall shear stress (WSS) were extracted from six transversal planes along the full thoracic aorta by three operators. Inter-vendor comparability as well as scan-rescan, intra- and interobserver reproducibility were examined. Results: A high heterogeneity was found in the comparisons for each operator and for each scanner in the six transversal planes analysis (Friedman rank-sum test; p-value <= 0.05). Among all, the most reproducible measures were extracted for the sinotubular junction plane and for the flow parameters. Conclusions: Our results suggest that standardized procedures have to be defined to make more comparable and reproducible 4D-flow parameters and mainly, clinical impactfulness. Further studies on sequences development are needed to validate 4D-flow MRI assessment across vendors and magnetic fields also compared to a missing gold standard

The host galaxy of the gamma-ray-emitting narrow-line Seyfert 1 galaxy PKS 1502+036

The detection of gamma-ray emission from narrow-line Seyfert 1 galaxies (NLSy1) has challenged the idea that large black hole (BH) masses ($\ge$10$^8$ M$_{\odot}$) are needed to launch relativistic jets. We present near-infrared imaging data of the gamma-ray-emitting NLSy1 PKS 1502+036 obtained with the Very Large Telescope. Its surface brightness profile, extending to $\sim$ 20 kpc, is well described by the combination of a nuclear component and a bulge with a Sersic index $n$ = 3.5, which is indicative of an elliptical galaxy. A circumnuclear structure observed near PKS 1502+036 may be the result of galaxy interactions. A BH mass of about $\sim 7 \times 10^{8}$ M$_{\odot}$ has been estimated by the bulge luminosity. The presence of an additional faint disc component cannot be ruled out with the present data, but this would reduce the BH mass estimate by only $\sim$ 30%. These results, together with analogous findings obtained for FBQS J1644+2619, indicate that the relativistic jets in gamma-ray-emitting NLSy1 are likely produced by massive black holes at the center of elliptical galaxies.Comment: 5 pages, 2 figures, 1 table, and 2 supplementary figures. Monthly Notices of the Royal Astronomical Society Letters, Volume 478, Issue 1, L66-L7

Hyperthermic intraperitoneal chemotherapy and colorectal cancer: From physiology to surgery

The pursuit of this paper is to collect principal reviews and systematic reviews about hyperthermic intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery (CRS) used in colorectal cancer (CRC). We focus on principal biological aspects of CRC, hyperthermia effects, and surgical procedures. We searched PubMed/MEDLINE for the principal reviews and systematic reviews published from 2010 to 2021 regarding the bimodal treatment (CRS + HIPEC) against local and advanced CRC. In the literature, from several studies, it seems that the efficacy of bimodal treatment with an accurate CRS can extend overall survival. Despite these studies, there are not still any straight guidelines more detailed and scheduled about the use of combined treatment in patients with CRC. Even if the concept is still not very clear and shared, after a careful evaluation of the published data, and after some technical and pathophysiological descriptions, we concluded that it is possible to improve the overall survival and quality of life and to reduce the tumor relapse in patients affected by locally advanced (pT4) CRC with peritoneal metastases

Circulating plasma factors induce tubular and glomerular alterations in septic burns patients

Background Severe burn is a systemic illness often complicated by sepsis. Kidney is one of the organs invariably affected, and proteinuria is a constant clinical finding. We studied the relationships between proteinuria and patient outcome, severity of renal dysfunction and systemic inflammatory state in burns patients who developed sepsis-associated acute renal failure (ARF). We then tested the hypothesis that plasma in these patients induces apoptosis and functional alterations that could account for proteinuria and severity of renal dysfunction in tubular cells and podocytes. Methods We studied the correlation between proteinuria and indexes of systemic inflammation or renal function prospectively in 19 severe burns patients with septic shock and ARF, and we evaluated the effect of plasma on apoptosis, polarity and functional alterations in cultured human tubular cells and podocytes. As controls, we collected plasma from 10 burns patients with septic shock but without ARF, 10 burns patients with septic shock and ARF, 10 non-burns patients with septic shock without ARF, 10 chronic uremic patients and 10 healthy volunteers. Results Septic burns patients with ARF presented a severe proteinuria that correlated to outcome, glomerular (creatinine/urea clearance) and tubular (fractional excretion of sodium and potassium) functional impairment and systemic inflammation (white blood cell (WBC) and platelet counts). Plasma from these patients induced a pro-apoptotic effect in tubular cells and podocytes that correlated with the extent of proteinuria. Plasma-induced apoptosis was significantly higher in septic severe burns patients with ARF with respect to those without ARF or with septic shock without burns. Moreover, plasma from septic burns patients induced an alteration of polarity in tubular cells, as well as reduced expression of the tight junction protein ZO-1 and of the endocytic receptor megalin. In podocytes, plasma from septic burns patients increased permeability to albumin and decreased the expression of the slit diaphragm protein nephrin. Conclusion Plasma from burns patients with sepsis-associated ARF contains factors that affect the function and survival of tubular cells and podocytes. These factors are likely to be involved in the pathogenesis of acute tubular injury and proteinuria, which is a negative prognostic factor and an index of renal involvement in the systemic inflammatory reaction

Do changes in Lactuca sativa metabolic performance, induced by mycorrhizal symbionts and leaf UV-B irradiation, play a role towards tolerance to a polyphagous insect pest?

: The increased ultraviolet radiation (UV) due to the altered stratospheric ozone leads to multiple plant physiological and biochemical adaptations, likely affecting their interaction with other organisms, such as pests and pathogens. Arbuscular mycorrhizal fungi (AMF) and UV-B treatment can be used as eco-friendly techniques to protect crops from pests by activating plant mechanisms of resistance. In this study, we investigated plant (Lactuca sativa) response to UV-B exposure and Funneliformis mosseae (IMA1) inoculation as well as the role of a major insect pest, Spodoptera littoralis. Lettuce plants exposed to UV-B were heavier and taller than non-irradiated ones. A considerable enrichment in phenolic, flavonoid, anthocyanin, and carotenoid contents and antioxidant capacity, along with redder and more homogenous leaf color, were also observed in UV-B-treated but not in AMF-inoculated plants. Biometric and biochemical data did not differ between AMF and non-AMF plants. AMF-inoculated plants showed hyphae, arbuscules, vesicles, and spores in their roots. AMF colonization levels were not affected by UV-B irradiation. No changes in S. littoralis-feeding behavior towards treated and untreated plants were observed, suggesting the ability of this generalist herbivore to overcome the plant chemical defenses boosted by UV-B exposure. The results of this multi-factorial study shed light on how polyphagous insect pests can cope with multiple plant physiological and biochemical adaptations following biotic and abiotic preconditioning

COVID-19-associated Guillain-Barré syndrome in the early pandemic experience in Lombardia (Italy)

Objective To estimate the incidence and describe clinical characteristics and outcome of GBS in COVID-19 patients (COVID19-GBS) in one of the most hit regions during the frst pandemic wave, Lombardia. Methods Adult patients admitted to 20 Neurological Units between 1/3–30/4/2020 with COVID19-GBS were included as part of a multi-center study organized by the Italian society of Hospital Neuroscience (SNO). Results Thirty-eight COVID19-GBS patients had a mean age of 60.7 years and male frequency of 86.8%. CSF albuminocytological dissociation was detected in 71.4%, and PCR for SARS-CoV-2 was negative in 19 tested patients. Based on neurophysiology, 81.8% of patients had a diagnosis of AIDP, 12.1% of AMSAN, and 6.1% of AMAN. The course was favorable in 76.3% of patients, stable in 10.5%, while 13.2% worsened, of which 3 died. The estimated occurrence rate in Lombardia ranges from 0.5 to 0.05 GBS cases per 1000 COVID-19 infections depending on whether you consider positive cases or estimated seropositive cases. When we compared GBS cases with the pre-pandemic period, we found a reduction of cases from 165 to 135 cases in the 2-month study period in Lombardia. Conclusions We detected an increased incidence of GBS in COVID-19 patients which can refect a higher risk of GBS in COVID-19 patients and a reduction of GBS events during the pandemic period possibly due to a lower spread of more common respiratory infectious diseases determined by an increased use of preventive measures

Tracker Operation and Performance at the Magnet Test and Cosmic Challenge

During summer 2006 a fraction of the CMS silicon strip tracker was operated in a comprehensive slice test called the Magnet Test and Cosmic Challenge (MTCC). At the MTCC, cosmic rays detected in the muon chambers were used to trigger the readout of all CMS sub-detectors in the general data acquisition system and in the presence of the 4 T magnetic field produced by the CMS superconducting solenoid. This document describes the operation of the Tracker hardware and software prior, during and after data taking. The performance of the detector as resulting from the MTCC data analysis is also presented