Redefining monetary policy rules: A threshold approach

In this paper, we try to analyse the extent to which a redefinition of the monetary policy rule would help to avoid the zero-lower bound, as well as to explore the conditions needed to avoid that constraint. To that aim, we estimate the threshold values of the key variables of the policy rule: the inflation gap and the output gap. The threshold model allows us to know which are the turning points from which the relationship between the key variables and the interest rate revert. In the Eurozone countries, we have found that the inflation gap always contributes to increasing the nominal interest rate. On the contrary, the output gap works differently when it reaches values above or below the threshold value, which would favour the reduction of the interest rates towards the zero levelSpanish Ministry of Economy, Industry and Competitiveness through the project ECO2015-65826-

Balances de agua y calor en la marisma de Doñana

Este trabajo expone los principales resultados del estudio de los balances hídrico y térmico de la marisma de Doñana. El estudio se ha basado en una amplia base de datos hidrometeorológicos tomados a intervalos de 10 minutos entre los años 2006 y 2011 por una red de seis estaciones de medida localizadas en áreas no vegetadas de la marisma. Esta información ha permitido caracterizar, a diferente escala temporal, el comportamiento térmico de la marisma mediante la modelización y análisis de los flujos de calor entre el agua y el suelo inundado, así como los procesos de transferencia de calor entre la superficie libre del agua y la atmósfera. Se ha puesto especial atención en la cuantificación de la evaporación, de la que depende en gran medida el proceso de vaciado de la marisma

Inter-individual and inter-strain differences in cognitive and social abilities of Dark Agouti and Wistar Han rats

BACKGROUND: Healthy animals showing extreme behaviours spontaneously that resemble human psychiatric symptoms are relevant models to study the natural psychobiological processes of maladapted behaviours. Healthy poor decision makers (PDMs) identified using a Rat Gambling Task, co-express a combination of cognitive and reward-based characteristics similar to symptoms observed in human patients with impulse-control disorders. The main goals of this study were to 1) confirm the existence of PDMs and their unique behavioural phenotypes in the Dark Agouti (DA) and WH, 2) to extend the behavioural profile of the PDMs to probability-based decision-making and social behaviours and 3) to discuss how the key traits of each strain could be relevant for biomedical research. METHODS: We compared cognitive abilities, natural behaviours and physiological responses in DA and WH rats using several tests. We analysed the results at the strain and the individual level. RESULTS: Previous findings in WH rats were reproduced and could be generalized to DA. Each PDM of either strain displayed a similar, naturally occurring, combination of behavioural traits, including possibly higher social rank, but no deficits in probability-based decision-making. A Random forest analysis revealed interesting discriminating traits between WH and DA. CONCLUSION: The reproducibility and conservation of the socio-cognitive and behavioural phenotypes of GDM and PDM individuals in the two genetically different strains of WH and DA support a good translational validity of these phenotypes. Both DA and WH rat strains present large phenotypic variations in behaviour pertinent for the study of the underlying mechanisms of poor decision making and associated disorders

Water and heat balances in Doñana wetlands

[EN] This paper presents the main results of the study of water balance and surface heat balance in the Doñana marshlands. The study was based on a broad base of hydrometeorological data taken at 10 minute intervals from 2006 to 2011 by a network of six measuring stations located in areas of vegetation-free marsh. This information is used to characterize, at different time scales, the thermal behavior of the marsh by analyzing its hydrometeorology centering on the surface heat fluxes. Thus, we have modeled and analyzed the heat flux between the water and flooded soil and the processes of heat transfer between the water surface and the atmosphere. Special attention has been paid to evaporation, on which the marsh draining process depends[ES] Este trabajo expone los principales resultados del estudio de los balances hídrico y térmico de la marisma de Doñana. El estudio se ha basado en una amplia base de datos hidrometeorológicos tomados a intervalos de 10 minutos entre los años 2006 y 2011 por una red de seis estaciones de medida localizadas en áreas no vegetadas de la marisma. Esta información ha permitido caracterizar, a diferente escala temporal, el comportamiento térmico de la marisma mediante la modelización y análisis de los flujos de calor entre el agua y el suelo inundado, así como los procesos de transferencia de calor entre la superficie libre del agua y la atmósfera. Se ha puesto especial atención en la cuantificación de la evaporación, de la que depende en gran medida el proceso de vaciado de la marisma.Los autores agradecen la asistencia del Espacio Natural Doñana y de la Estación Biológica de Doñana en la instalación y mantenimiento de la instrumentación de medida, labores esenciales realizadas por D. Ninyerola y J. Rabadà (Flumen, UPCCINME). Este estudio ha contado con la financiación de la Confederación Hidrográfica del Guadalquivir, de un convenio con la Empresa de Gestión Ambiental (EGMASA) adscrita a la Consejería de Medio Ambiente de la Junta de Andalucía, de la acción complementaria CMT2007-30881-E/TECNO del Ministerio de Educación y Cultura, y del contrato GOCE-CT-2006-037081 del programa FP6 de la Unión Europea. Uno de los autores (ARF) contó con una beca FPI del Ministerio de Educación y Ciencia.Este estudio ha contado con la financiación de la Confederación Hidrográfica del Guadalquivir, de un convenio con la Empresa de Gestión Ambiental (EGMASA) adscrita a la Consejería de Medio Ambiente de la Junta de Andalucía, de la acción complementaria CMT2007-30881-E/TECNO del Ministerio de Educación y Cultura, y del contrato GOCE-CT-2006-037081 del programa FP6 de la Unión Europea. Uno de los autores (ARF) contó con una beca FPI del Ministerio de Educación y Ciencia.Ramos-Fuertes, A.; Prats, J.; Dolz, J. (2016). Balances de agua y calor en la marisma de Doñana. Ingeniería del Agua. 20(4):169-179. https://doi.org/10.4995/ia.2016.4720SWORD169179204Aragonés, D., Díaz-Delgado, R., Bustamante, J. (2005). Tratamiento de una serie temporal larga de imágenes Landsat para la cartografía de la inundación histórica de las marismas de Doñana. XI Congreso Nacional de Teledetección, 21-23 Septiembre, Puerto de la Cruz, Tenerife, España.Arya, S. (2001). Introduction to micrometeorology. (2ª ed.). Academic Press, San Diego, CA.Bayán, B.J., Dolz, J. (1995). Las aguas superficiales del Parque Nacional de Doñana. Revista de Obras Públicas, 142(3340), 17-29.Bladé, E., Cea, L., Corestein, G., Escolano, E., Puertas, J., Vázquez-Cendón, E., Dolz, J., Coll, A. (2014). Iber: herramienta de simulación numérica del flujo en ríos. Revista Internacional de Métodos Numéricos para Cálculo y Diseño en Ingeniería, 30(1), 1-10, doi:10.1016/j.rimni.2012.07.004Cambronero, G., De Pourq, K. (2006). Modelo Digital del Terreno de la Marisma de Doñana obtenido a partir de un vuelo láser escáner (LIDAR). Grupo de Investigación Flumen, E.T.S. d'Enginyers de Camins Canals i Ports de la Universitat Politècnica de Catalunya, Barcelona, España.CICCP (Colegio de Ingenieros de Caminos, Canales y Puertos). (1977). Informe sobre los problemas del Parque Nacional de Doñana. Revista de Obras Públicas, 124(3142), 91-114.Custodio, E., Dolz, J., Manzano, M. (2006). Recursos de agua de la comarca de Doñana. Almonte, Huelva: Fundación Doñana 21.Dolz, J., Velasco, E. (1990). Análisis cualitativo de la hidrología superficial de las cuencas vertientes a la marisma del Parque Nacional de Doñana. Universitat Politècnica de Catalunya, Barcelona, España.Dolz, J., Bladé, E., Gili, J. (2006). Modelo numérico de la hidrodinámica de la Marisma. En: Doñana: Agua y biosfera (F. García Novo y C. Marín, eds.). Ministerio de Medio Ambiente, Confederación Hidrográfica del Guadalquivir, Sevilla, España, 149-150.Drexler, J.Z., Snyder, R.L., Spano, D., Paw U, K.T. (2004). A review of models and micrometeorological methods used to estimate wetland evapotranspiration. Hydrological Processes, 18(11), 2071-2101, doi:10.1002/hyp.1462Junta de Andalucía. (2010). II Plan de Desarrollo Sostenible de Doñana. Consejería de Medio Ambiente, Sevilla, España.Martí-Cardona, B. (2014). Spaceborne SAR Imagery for Monitoring the Inundation in the Doñana Wetlands. Tesis doctoral. Escola Tècnica Superior d'Enginyers de Camins, Universitat Politècnica de Catalunya, Barcelona, España.Marti-Cardona, B., Lopez-Martinez, C., Dolz-Ripolles, J., Bladè-Castellet, E. (2010). ASAR polarimetric, multi-incidence angle and multitemporal characterization of Doñana wetlands for flood extent monitoring. Remote Sensing of Environment, 114(11), 2802-2815, doi:10.1016/j.rse.2010.06.015Ministerio de Medio Ambiente (MMA). (2001). Documento marco para el desarrollo del Proyecto Doñana 2005: regeneración hídrica de las cuencas y cauces vertientes a las marismas del Parque Nacional de Doñana. Madrid, España.Mintegui Aguirre, J.A., Robredo Sánchez, J.C., García Viñas, J.I. (2004). Importancia de los trabajos de campo en la confección del modelo del terreno para aplicaciones en ecología. Investigación agraria. Sistemas y recursos forestales, 13(Nº Extra 1), 164-175.Prats, J., Ramos, A., Armengol, J., Dolz, J. (2011). Comparison of models for calculation of diel sediment-water heat flux from water temperatures. Journal of Hydraulic Engineering, 137(10), 1135-1147, doi:10.1061/(asce)hy.1943-7900.0000434Prats, J., Ramos, A., Armengol, J., Dolz, J. (2012). Discussion on "Experimental determination of soil heat storage for the simulation of heat transport in a coastal wetland." Journal of Hydrology, 466-467, 188-190, doi:10.1016/j.jhydrol.2012.06.060Prats, J., Morales-Baquero, R., Dolz, J., Armengol, J. (2014). Aportaciones de la limnología a la gestión de embalses. Ingeniería delAgua, 18(1), 83-97. doi:10.4995/ia.2014.3145Ramos Fuertes, A. (2012). Hidrometeorología y balance térmico de la marisma de Doñana. Tesis doctoral. Escola Tècnica Superior d'Enginyers de Camins, Universitat Politècnica de Catalunya, Barcelona, España.Ramos-Fuertes, A., Marti-Cardona, B., Bladé, E. Dolz, J. (2014). Envisat/ASAR Images for the Calibration of Wind Drag Action in the Doñana Wetlands 2D Hydrodynamic Model. Remote Sensing, 6(1), 379-406, doi:10.3390/rs6010379Rodríguez-Ramírez, A., Clemente Salas, L. (2002). Hidrología superficial. En: Parque Nacional de Doñana. Canseco Editores, Talavera de la Reina, España, 57-68.Ruiz, F., Rodríguez-Ramírez, A., Cáceres, L.M., Rodríguez Vidal, J., Carretero, M.I., Clemente, L., Muñoz, J.M., Yañez, C., Abad, M. (2004). Late Holocene evolution of the southwestern Doñana National Park (Guadalquivir Estuary, SW Spain): a multivariate approach. Palaeogeography, Palaeoclimatology, Palaeoecology, 204(1-2), 47-64, doi:10.1016/S0031-0182(03)00721-

Enhancement of the non-invasive electroenterogram to identify intestinal pacemaker activity

Surface recording of electroenterogram (EEnG) is a non-invasive method for monitoring intestinal myoelectrical activity. However, surface EEnG is seriously affected by a variety of interferences: cardiac activity, respiration, very low frequency components and movement artefacts. The aim of this study is to eliminate respiratory interference and very low frequency components from external EEnG recording by means of empirical mode decomposition (EMD), so as to obtain more robust indicators of intestinal pacemaker activity from external EEnG signal. For this purpose, 11 recording sessions were performed in an animal model under fasting conditions and in each individual session the myoelectrical signal was recorded simultaneously in the intestinal serosa and the external abdominal surface in physiological states. Various parameters have been proposed for evaluating the efficacy of the method in reducing interferences: the signal-to-interference ratio (S/I ratio), attenuation of the target and interference signals, the normal slow wave percentage and the stability of the dominant frequency (DF) of the signal. The results show that the S/I ratio of the processed signals is significantly greater than the original values (9.66±4.44 dB vs. 1.23±5.13 dB), while the target signal was barely attenuated (-0.63±1.02 dB). The application of the EMD method also increased the percentage of the normal slow wave to 100% in each individual session and enabled the stability of the DF of the external signal to be increased considerably. Furthermore, the variation coefficient of the DF derived from the external processed signals is comparable to the coefficient obtained using internal recordings. Therefore the EMD method could be a very useful tool to improve the quality of external EEnG recording in the low frequency range, and therefore to obtain more robust indicators of the intestinal pacemaker activity from non invasive EEnG recordingsThe authors would like to thank D Alvarez-Martinez, Dr C Vila and the Veterinary Unit of the Research Centre of 'La Fe' University Hospital (Valencia, Spain), where the surgical interventions and recording sessions were carried out, and the R+D+I Linguistic Assistance Office at the UPV for their help in revising this paper. This research study was sponsored by the Ministerio de Ciencia y Tecnologia de Espana (TEC2007-64278) and by the Universidad Politecnica de Valencia, as part of a UPV research and development Grant Programme.Ye Lin, Y.; Garcia Casado, FJ.; Prats Boluda, G.; Ponce, JL.; Martínez De Juan, JL. (2009). Enhancement of the non-invasive electroenterogram to identify intestinal pacemaker activity. PHYSIOLOGICAL MEASUREMENT. 30(9):885-902. https://doi.org/10.1088/0967-3334/30/9/002S885902309Amaris, M. A., Sanmiguel, C. P., Sadowski, D. C., Bowes, K. L., & Mintchev, M. P. (2002). Digestive Diseases and Sciences, 47(11), 2480-2485. doi:10.1023/a:1020503908304Bass, P., & Wiley, J. N. (1965). Electrical and extraluminal contractile-force activity of the duodenum of the dog. The American Journal of Digestive Diseases, 10(3), 183-200. doi:10.1007/bf02233747Bradshaw, L. A., Allos, S. H., Wikswo, J. P., & Richards, W. O. (1997). Correlation and comparison of magnetic and electric detection of small intestinal electrical activity. American Journal of Physiology-Gastrointestinal and Liver Physiology, 272(5), G1159-G1167. doi:10.1152/ajpgi.1997.272.5.g1159Camilleri, M., Hasler, W. L., Parkman, H. P., Quigley, E. M. M., & Soffer, E. (1998). Measurement of gastrointestinal motility in the GI laboratory. Gastroenterology, 115(3), 747-762. doi:10.1016/s0016-5085(98)70155-6Chen, J. D. Z., & Lin, Z. (1993). Adaptive cancellation of the respiratory artifact in surface recording of small intestinal electrical activity. Computers in Biology and Medicine, 23(6), 497-509. doi:10.1016/0010-4825(93)90097-kChen, J., & McCallum, R. W. (1991). Electrogastrography: measuremnt, analysis and prospective applications. Medical & Biological Engineering & Computing, 29(4), 339-350. doi:10.1007/bf02441653Chen, J. D. Z., Schirmer, B. D., & McCallum, R. W. (1993). Measurement of electrical activity of the human small intestine using surface electrodes. IEEE Transactions on Biomedical Engineering, 40(6), 598-602. doi:10.1109/10.237682Garcia-Casado, J., Martinez-de-Juan, J. L., & Ponce, J. L. (2005). Noninvasive Measurement and Analysis of Intestinal Myoelectrical Activity Using Surface Electrodes. IEEE Transactions on Biomedical Engineering, 52(6), 983-991. doi:10.1109/tbme.2005.846730Gordon, A. D. (1987). A Review of Hierarchical Classification. Journal of the Royal Statistical Society. Series A (General), 150(2), 119. doi:10.2307/2981629Huang, N. E., Shen, Z., Long, S. R., Wu, M. C., Shih, H. H., Zheng, Q., … Liu, H. H. (1998). The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis. Proceedings of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences, 454(1971), 903-995. doi:10.1098/rspa.1998.0193Irimia, A., & Bradshaw, L. A. (2005). Artifact reduction in magnetogastrography using fast independent component analysis. Physiological Measurement, 26(6), 1059-1073. doi:10.1088/0967-3334/26/6/015Lammers, W. J. E. P., & Stephen, B. (2008). Origin and propagation of individual slow waves along the intact feline small intestine. Experimental Physiology, 93(3), 334-346. doi:10.1113/expphysiol.2007.039180Liang, H. (2001). Adaptive independent component analysis of multichannel electrogastrograms. Medical Engineering & Physics, 23(2), 91-97. doi:10.1016/s1350-4533(01)00019-4Liang, J., Cheung, J. Y., & Chen, J. D. Z. (1997). Detection and deletion of motion artifacts in electrogastrogram using feature analysis and neural networks. Annals of Biomedical Engineering, 25(5), 850-857. doi:10.1007/bf02684169Liang, H., Lin, Z., & McCallum, R. W. (2000). Artifact reduction in electrogastrogram based on empirical mode decomposition method. Medical & Biological Engineering & Computing, 38(1), 35-41. doi:10.1007/bf02344686Zhi-Yue Lin, Chen, Z., & Jian De. (1994). Time-frequency representation of the electrogastrogram-application of the exponential distribution. IEEE Transactions on Biomedical Engineering, 41(3), 267-275. doi:10.1109/10.284945Lin, Z. Y., & Chen, J. D. Z. (1994). Recursive running DCT algorithm and its application in adaptive filtering of surface electrical recording of small intestine. Medical & Biological Engineering & Computing, 32(3), 317-322. doi:10.1007/bf02512529Lin, Z., & Chen, J. D. Z. (1995). Comparison of three running spectral analysis methods for electrogastrographic signals. Medical & Biological Engineering & Computing, 33(4), 596-604. doi:10.1007/bf02522520Maestri, R., Pinna, G. D., Porta, A., Balocchi, R., Sassi, R., Signorini, M. G., … Raczak, G. (2007). Assessing nonlinear properties of heart rate variability from short-term recordings: are these measurements reliable? Physiological Measurement, 28(9), 1067-1077. doi:10.1088/0967-3334/28/9/008Martinez-de-Juan, J. ., Saiz, J., Meseguer, M., & Ponce, J. . (2000). Small bowel motility: relationship between smooth muscle contraction and electroenterogram signal. Medical Engineering & Physics, 22(3), 189-199. doi:10.1016/s1350-4533(00)00032-1Mintchev, M. P., Kingma, Y. J., & Bowes, K. L. (1993). Accuracy of cutaneous recordings of gastric electrical activity. Gastroenterology, 104(5), 1273-1280. doi:10.1016/0016-5085(93)90334-9Prats-Boluda, G., Garcia-Casado, J., Martinez-de-Juan, J. L., & Ponce, J. L. (2007). Identification of the slow wave component of the electroenterogram from Laplacian abdominal surface recordings in humans. Physiological Measurement, 28(9), 1115-1133. doi:10.1088/0967-3334/28/9/012Quigley, E. M. M. (1996). GASTRIC AND SMALL INTESTINAL MOTILITY IN HEALTH AND DISEASE. Gastroenterology Clinics of North America, 25(1), 113-145. doi:10.1016/s0889-8553(05)70368-xSeidel, S. A., Bradshaw, L. A., Ladipo, J. K., Wikswo, J. P., & Richards, W. O. (1999). Noninvasive detection of ischemic bowel. Journal of Vascular Surgery, 30(2), 309-319. doi:10.1016/s0741-5214(99)70142-4Tomomasa, T., Morikawa, A., Sandler, R. H., Mansy, H. A., Koneko, H., Masahiko, T., … Itoh, Z. (1999). Gastrointestinal Sounds and Migrating Motor Complex in Fasted Humans. American Journal of Gastroenterology, 94(2), 374-381. doi:10.1111/j.1572-0241.1999.00862.xWang, Z. S., Cheung, J. Y., & Chen, J. D. Z. (1999). Blind separation of multichannel electrogastrograms using independent component analysis based on a neural network. Medical & Biological Engineering & Computing, 37(1), 80-86. doi:10.1007/bf0251327

The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth. We discovered, through an unbiased proteomics screen, that the immune checkpoint inhibitor programmed cell death 1 ligand 2 (PD-L2) is highly upregulated upon induction of senescence in different types of cancer cells. PD-L2 is not required for cells to undergo senescence, but it is critical for senescent cells to evade the immune system and persist intratumorally. Indeed, after chemotherapy, PD-L2-deficient senescent cancer cells are rapidly eliminated and tumors do not produce the senescence-associated chemokines CXCL1 and CXCL2. Accordingly, PD-L2-deficient pancreatic tumors fail to recruit myeloid-derived suppressor cells and undergo regression driven by CD8 T cells after chemotherapy. Finally, antibody-mediated blockade of PD-L2 strongly synergizes with chemotherapy causing remission of mammary tumors in mice. The combination of chemotherapy with anti-PD-L2 provides a therapeutic strategy that exploits vulnerabilities arising from therapy-induced senescence. © 2024, The Author(s)

Desert dust outbreak in the Canary Islands (February 2020): assessment and impacts

World Weather Research Programme (WWRP 2021–1

Twenty years of ground-based NDACC FTIR spectrometry at Izaña Observatory-overview and long-term comparison to other techniques

High-resolution Fourier transform infrared (FTIR) solar observations are particularly relevant for climate studies, as they allow atmospheric gaseous composition and multiple climate processes to be monitored in detail. In this context, the present paper provides an overview of 20 years of FTIR measurements taken in the framework of the NDACC (Network for the Detection of Atmospheric Composition Change) from 1999 to 2018 at the subtropical Izaña Observatory (IZO, Spain). Firstly, long-term instrumental performance is comprehensively assessed, corroborating the temporal stability and reliable instrumental characterization of the two FTIR spectrometers installed at IZO since 1999. Then, the time series of all trace gases contributing to NDACC at IZO are presented (i.e. C$_{2}$H$_{6}$, CH$_{4}$, ClONO$_{2}$, CO, HCl, HCN, H$_{2}$CO, HF, HNO$_{3}$, N$_{2}$O, NO$_{2}$, NO, O$_{3}$, carbonyl sulfide (OCS), and water vapour isotopologues H$_{2}$$^{16}$O, H$_{2}$$^{18}$O, and HD$^{16}$O), reviewing the major accomplishments drawn from these observations. In order to examine the quality and long-term consistency of the IZO FTIR observations, a comparison of those NDACC products for which other high-quality measurement techniques are available at IZO has been performed (i.e. CH$_{4}$, CO, H$_{2}$O, NO$_{2}$, N$_{2}$O, and O$_{3}$). This quality assessment was carried out on different timescales to examine what temporal signals are captured by the FTIR records, and to what extent. After 20 years of operation, the IZO NDACC FTIR observations have been found to be very consistent and reliable over time, demonstrating great potential for climate research. Long-term NDACC FTIR data sets, such as IZO, are indispensable tools for the investigation of atmospheric composition trends, multi-year phenomena, and complex climate feedback processes, as well as for the validation of past and present space-based missions and chemistry climate models

Metabolically Healthy Obesity and High Carotid Intima-Media Thickness in Children and Adolescents: International Childhood Vascular Structure Evaluation Consortium

OBJECTIVE It has been argued that metabolically healthy obesity (MHO) does not increase cardiovascular disease (CVD) risk. This study examines the association of MHO with carotid intima-media thickness (cIMT), a proxy of CVD risk, in children and adolescents. RESEARCH DESIGN AND METHODS Data were available for 3,497 children and adolescents aged 6–17 years from five population-based cross-sectional studies in Brazil, China, Greece, Italy, and Spain. Weight status categories (normal, overweight, and obese) were defined using BMI cutoffs from the International Obesity Task Force. Metabolic status (defined as "healthy" [no risk factors] or "unhealthy" [one or more risk factors]) was based on four CVD risk factors: elevated blood pressure, elevated triglyceride levels, reduced HDL cholesterol, and elevated fasting glucose. High cIMT was defined as cIMT ≥90th percentile for sex, age, and study population. Logistic regression model was used to examine the association of weight and metabolic status with high cIMT, with adjustment for sex, age, race/ethnicity, and study center. RESULTS In comparison with metabolically healthy normal weight, odds ratios (ORs) for high cIMT were 2.29 (95% CI 1.58–3.32) for metabolically healthy overweight and 3.91 (2.46–6.21) for MHO. ORs for high cIMT were 1.44 (1.03–2.02) for unhealthy normal weight, 3.49 (2.51–4.85) for unhealthy overweight, and 6.96 (5.05–9.61) for unhealthy obesity. CONCLUSIONS Among children and adolescents, cIMT was higher for both MHO and metabolically healthy overweight compared with metabolically healthy normal weight. Our findings reinforce the need for weight control in children and adolescents irrespective of their metabolic status

Izaña Atmospheric Research Center. Activity Report 2015-2016

This report is a summary of the many activities at the Izaña Atmospheric Research Center to the broader community. The combination of operational activities, research and development in state-of-the-art measurement techniques, calibration and validation and international cooperation encompass the vision of WMO to provide world leadership in expertise and international cooperation in weather, climate, hydrology and related environmental issues