Recursos interactivos para prácticas con Software Estadístico en Informática

Depto. de Estadística e Investigación OperativaFac. de Ciencias MatemáticasFALSEsubmitte

Lactancia materna y hábitos bucales deformantes

Introducción: la lactancia materna, es un método eficaz para estimular el desarrollo adecuado del aparato estomatognático y previene la aparición de hábitos bucales deformantes y de maloclusiones.Objetivos: identificar la relación de lactancia materna con la adopción de hábitos bucales deformantes.Métodos: se realizó un estudio descriptivo de corte transversal. La muestra quedó constituida por 69 niños de 6 a 12 años del consultorio No 71.1 del Policlínico Docente “Marcio Manduley”, La Habana. La información se obtuvo mediante el interrogatorio y el examen bucal. Las variables estudiadas fueron: período de lactancia materna y presencia de hábitos bucales deformantes. Se determinó las frecuencias absolutas, los porcentajes y el Chi cuadrado, para determinar el grado de asociación entre algunas variables.Resultados: el 71 % de los niños lactaron, el 26 % mantuvo una lactancia materna exclusiva, el 39,1 % lo efectuaron hasta los 3 meses y el 5.7 % hasta los 12 meses. De los niños que lactaron hasta los 3 meses el 77,7 % presentan hábitos, el 55,5 % de los niños que recibieron lactancia exclusiva están afectados, mientras que el 25 % que lactaron hasta los 12 meses presentan hábitos, existiendo una relación estadísticamente significativa.Conclusiones: la lactancia materna exclusiva fue baja. La presencia de hábitos bucales deformantes es elevado, existe una  relación significativa entre la presencia de hábitos bucales deformantes y los periodos de la lactancia materna

Grb2 and Its Apoptotic Isoform Grb3-3 Associate with Heterogeneous Nuclear Ribonucleoprotein C, and These Interactions Are Modulated by Poly(U) RNA

Grb2 is an adaptor molecule comprising one Src homology (SH) 2 and two SH3 domains. This protein has a natural isoform named Grb3-3 with a deletion within the SH2 domain. Numerous evidence points to a functional connection between SH2- and SH3-containing proteins and molecules implicated in RNA biogenesis. In this context, we have examined the binding of Grb2 and Grb3-3 to heterogeneous nuclear ribonucleoprotein (hnRNP) C. By the use of an in vivo genetic approach and through in vitroexperiments, we furnish evidence that both Grb2 and Grb3-3 interact with hnRNP C proteins. Subcellular fractionation studies clearly show that Grb2 is partially localized in the nucleus. In addition, coimmunoprecipitation experiments demonstrate that Grb2·hnRNP C complexes exist in intact hematopoietic cells. The carboxyl-terminal SH3 domains of Grb2 and Grb3-3 are primarily responsible for the association with hnRNP C. However, although the proline-rich motif of hnRNP C is involved in the interaction with Grb2, it is not in the binding to Grb3-3. Furthermore, poly(U) RNA inhibits the association of Grb2 with hnRNP C, whereas it enhances the interaction between Grb3-3 and hnRNP C. These findings suggest that the Grb2/Grb3-3-hnRNP C interactions might fulfill different biological functions

Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers

Long-COVID is a new emerging syndrome worldwide that is characterized by the persistence of unresolved signs and symptoms of COVID-19 more than 4 weeks after the infection and even after more than 12 weeks. The underlying mechanisms for Long-COVID are still undefined, but a sustained inflammatory response caused by the persistence of SARS-CoV-2 in organ and tissue sanctuaries or resemblance with an autoimmune disease are within the most considered hypotheses. In this study, we analyzed the usefulness of several demographic, clinical, and immunological parameters as diagnostic biomarkers of Long-COVID in one cohort of Spanish individuals who presented signs and symptoms of this syndrome after 49 weeks post-infection, in comparison with individuals who recovered completely in the first 12 weeks after the infection. We determined that individuals with Long-COVID showed significantly increased levels of functional memory cells with high antiviral cytotoxic activity such as CD8+ TEMRA cells, CD8±TCRγδ+ cells, and NK cells with CD56+CD57+NKG2C+ phenotype. The persistence of these long-lasting cytotoxic populations was supported by enhanced levels of CD4+ Tregs and the expression of the exhaustion marker PD-1 on the surface of CD3+ T lymphocytes. With the use of these immune parameters and significant clinical features such as lethargy, pleuritic chest pain, and dermatological injuries, as well as demographic factors such as female gender and O+ blood type, a Random Forest algorithm predicted the assignment of the participants in the Long-COVID group with 100% accuracy. The definition of the most accurate diagnostic biomarkers could be helpful to detect the development of Long-COVID and to improve the clinical management of these patients.This work was supported by the Coordinated Research Activities at the National Center of Microbiology (CNM, Instituto de Salud Carlos III) (COV20_00679) to promote an integrated response against SARS-CoV-2 in Spain (Spanish Ministry of Science and Innovation), which is coordinated by Dr Inmaculada Casas (WHO National Influenza Center of the CNM); a generous donation provided by Chiesi España, S.A.U. (Barcelona, Spain); the Spanish Ministry of Science and Innovation (PID2019-110275RB-I00); and the Spanish AIDS Research Network RD16CIII/0002/0001 that is included in Acción Estratégica en Salud, Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica 2016-2020, Instituto de Salud Carlos III, European Region Development Fund (ERDF). The work of ML-H and SR-M is financed by NIH grant R01AI143567. The work of MT is supported by Instituto de Salud Carlos III (COV20_00679). The work of LV is supported by a pre-doctoral grant from Instituto de Salud Carlos III (FIS PI16CIII/00034-ISCIII-FEDER). The work of FR-M is financed by the Spanish Ministry of Science and Innovation (PID2019-110275RB-I00).S

Aspergilosis invasiva neuropulmonar

This is a 68 year old male patient, white, with a history of bronchial asthma , hypothyroidism, benign prostatic hyperplasia, chronic liver  and chronic renal disease monitoring by Nephrology Specialist . Presented various income for respiratory diagnosed with bronchopneumonia plus low hemoglobin, the proteinuria was found in nephrotic range and the possibility of renal biopsy was assessed. Immunological studies and microbiological hemochemical and included  tests, with blood cultures positive for Staphylococcus aureus. It evolved unfavorably with acid-base imbalance and marked general malaise to extreme bradycardia and death. At autopsy the presence of membranoproliferative glomerulonephritis secondary to hepatotropic viruses with chronic liver damage leading to immunosuppression and the resulting Aspergillus infestation with meningoencephalic invasion and lung was found . Invasive aspergillosis is a major cause of morbidity and mortality in immunocompromised patients.Se trata de un paciente de 68 años, masculino, blanco, con antecedentes de asma bronquial, hipotiroidismo, hiperplasia benigna de próstata, hepatopatía crónica y enfermedad renal crónica con seguimiento por el Especialista en Nefrología. Presentó varios ingresos por cuadro respiratorio con diagnóstico de bronconeumonía además de cifras bajas de hemoglobina, se constató proteinuria en rango nefrótico y se valoró la posibilidad de realizar biopsia renal. Se incluyen en los exámenes estudios inmunológicos y hemoquímicos así como microbiológicos, con hemocultivos positivos para estafilococo aureus. Evolucionó desfavorablemente con desequilibrio ácido básico y marcada toma del estado general hasta la bradicardia extrema y la muerte. En la autopsia se encontró la presencia de una glomerulonefritis membranoproliferativa secundaria a virus hepatotropos con daño hepático crónico que llevó a la consiguiente inmunosupresión y a la infestación por aspergilus, con invasión meningoencefálica y pulmonar. La aspergilosis invasora es una causa importante de morbilidad y mortalidad en enfermos inmunosuprimidos

Effectiveness and Safety of the Sequential Use of a Second and Third Anti-TNF Agent in Patients With Inflammatory Bowel Disease: Results From the Eneida Registry

Background: The effectiveness of the switch to another anti-tumor necrosis factor (anti-TNF) agent is not known. The aim of this study was to analyze the effectiveness and safety of treatment with a second and third anti-TNF drug after intolerance to or failure of a previous anti-TNF agent in inflammatory bowel disease (IBD) patients. Methods: We included patients diagnosed with IBD from the ENEIDA registry who received another anti-TNF after intolerance to or failure of a prior anti-TNF agent. Results: A total of 1122 patients were included. In the short term, remission was achieved in 55% of the patients with the second anti-TNF. The incidence of loss of response was 19% per patient-year with the second anti-TNF. Combination therapy (hazard ratio [HR], 2.4; 95% confidence interval [CI], 1.8-3; P < 0.0001) and ulcerative colitis vs Crohn's disease (HR, 1.6; 95% CI, 1.1-2.1; P = 0.005) were associated with a higher probability of loss of response. Fifteen percent of the patients had adverse events, and 10% had to discontinue the second anti-TNF. Of the 71 patients who received a third anti-TNF, 55% achieved remission. The incidence of loss of response was 22% per patient-year with a third anti-TNF. Adverse events occurred in 7 patients (11%), but only 1 stopped the drug. Conclusions: Approximately half of the patients who received a second anti-TNF achieved remission; nevertheless, a significant proportion of them subsequently lost response. Combination therapy and type of IBD were associated with loss of response. Remission was achieved in almost 50% of patients who received a third anti-TNF; nevertheless, a significant proportion of them subsequently lost response

The earliest basketry in southern Europe: Hunter-gatherer and farmer plant-based technology in Cueva de los Murciélagos (Albuñol)

Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).Plant material culture can offer unique insights into the ways of life of prehistoric societies; however, its perishable nature has prevented a thorough understanding of its diverse and complex uses. Sites with exceptional preservation of organic materials provide a unique opportunity for further research. The burial site of Cueva de los Murciélagos in southern Iberia, uncovered during 19th-century mining activities, contained the best-preserved hunter-gatherer basketry in southern Europe, together with other unique organic artifacts associated with the first farming communities, such as sandals and a wooden hammer. We present 14 14C dates for the perishable artifacts (N = 76), situating the assemblage between the Early and Middle Holocene (c. 7500 to 4200 cal BCE). Our integrated analysis includes raw material determination and technological and chrono-cultural contextualization of this unique and important set of materials.This work was supported by the project “De los museos al territorio: actualizando el estudio de la Cueva de los Murciélagos de Albuñol (Granada)” (MUTERMUR) (Referencia CM/JIN/2021-009) financed by the program of Young Researchers of Comunidad de Madrid (directed by F.M.-S. as the principal investigator). J.S. is funded by Ramon y Cajal fellowship (RYC2019-028346) by the Spanish Ministry of Science and Innovation (MCIN). M.C. is funded by a Ramón y Cajal fellowship (RYC2019-026697-I) and by the Spanish Ministry of Science and Innovation (MCIN). R.P.H., M.H.-O., and A.P.P. are members of the research group 2021-SGR 00190 funded by the AGAUR. R.P.H. is an ICREA academia researcher. M.M.-S. was funded by the Beatriz Galindo program as Junior Distinguished Researcher (BG20/00076)Peer reviewe

The earliest basketry in southern Europe: Hunter- gatherer and farmer plant-based technology in Cueva de los Murciélagos (Albuñol)

Plant material culture can offer unique insights into the ways of life of prehistoric societies; however, its perish- able nature has prevented a thorough understanding of its diverse and complex uses. Sites with exceptional preservation of organic materials provide a unique opportunity for further research. The burial site of Cueva de los Murciélagos in southern Iberia, uncovered during 19th-century mining activities, contained the best-pre- served hunter-gatherer basketry in southern Europe, together with other unique organic artifacts associated with the first farming communities, such as sandals and a wooden hammer. We present 14 14C dates for the perishable artifacts (N = 76), situating the assemblage between the Early and Middle Holocene (c. 7500 to 4200 cal BCE). Our integrated analysis includes raw material determination and technological and chrono-cul- tural contextualization of this unique and important set of materials.Peer reviewe

Artistas sobre outras obras

A pós modernidade encerra a interrogação crítica do homem sobre o homem: a linguagem ameaça o que é significante, o que é corpo. O sujeito é falado, e assim constituído depois da linguagem (Althusser, 1976). O jovem Arthur Rimbaud sintetiza-o, aos dezassete anos, numa carta ao seu professor de retórica Georges Izambard, datada de 13 de maio 1871: «C’est faux de dire: je pense: on devrait dire on me pense. Pardon du jeu de mots. Je est un autre». (Rimbaud, 1999: 237) A identidade resiste à linguagem dos homens. A linguagem é transmitida entre as gerações e com ela transporta os sujeitos, ou, o que é dizer o mesmo, a possível interrogação: quem me fala? É esta também a perplexidade que motivou o tema desta revista Estúdio. Reuniram-se, nesta edição, 22 artigos, provenientes de diferentes autores da Argentina, Brasil, Portugal e Espanha, que se debruçam sobre artistas cuja identidade se mostra e merece ser interrogada: são espaços ‘ex-cêntricos,’ para se descobrir.info:eu-repo/semantics/publishedVersio