Existence and stability of traveling waves in a biologically constrained model of seizure wave propagation

Epilepsy -- the condition of recurrent, unprovoked seizures -- manifests in brain voltage activity with characteristic spatio-temporal patterns. One of the patterns typically observed during a seizure is a traveling wave. To characterize these waves, we analyze high-density local field potential (LFP) data recorded in vivo from human cortex during a seizure from three patients. We show that traveling wave patterns emerge in the LFP with consistent quantitative features. Using a mean-field approach we model the neuronal population activity observed in the LFP and obtain explicit traveling wave solutions for this model. We then employ the LFP data to constrain the model and obtain parameter configurations that support traveling wave solutions with features consistent with the observed LFP waves. In particular, our model formulation is able to capture the "reverberation" of the activity following the traveling wave that was found in the clinical data. We obtain biologically reasonable parameter estimates for two important features: the timescales of the model and the extent of the connectivity. In this way, we link the observed LFP waves during seizure to proposed biological mechanisms. We also study the linear stability of the traveling wave solutions by constructing an Evans function. We find for some parameters the existence of two waves: one wave is slow and narrow whereas the other wave is fast and wide. Moreover, the fast and wide wave has speed and width consistent with the observed LFP waves. We numerically analyze the Evans function to determine stability (instability) of the fast (slow) wave

Perceveid Social Support in middle school students

Research on school climate has among its purposes to contribute to improving the quality of education, one of the main challenges of the Mexican educational system, particularly at the level of basic education. Our aim was to explore the relationships between the dimensions of school climate of perceived social the support teacher-student, support student-student and opportunities for autonomy and academic performance. The study was non-experimental and correlational. The sample consisted of 325 students from a middle school in northeastern Mexico, with a mean age of 13.4 years who responded to a scale of perceived school climate. The results show that students perceive great teacher support associated with student-student support and opportunities for autonomy. In addition, we found that academic achievement related to teacher support and opportunities for autonomy. These data are consistent with the country´s educational policy, which emphasizes the teacher´s role as facilitator of student learning to improve learning outcomes and the quality of education.Fil: Rodriguez, María Concepción. Universidad Autónoma de Nuevo León; MéxicoFil: Vivas, Jorge Ricardo. Universidad Nacional de Mar del Plata. Facultad de Psicología. Centro de Investigación en Procesos Básicos, Metodologías y Educación; ArgentinaFil: Comesaña, Ana. Universidad Nacional de Mar del Plata. Facultad de Psicología. Centro de Investigación en Procesos Básicos, Metodologías y Educación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Ramirez, Laura Minerva. Universidad Autónoma de Nuevo León; MéxicoFil: Peña, José Armando. Universidad Autónoma de Nuevo León; Méxic

A Chandra View Of Nonthermal Emission In The Northwestern Region Of Supernova Remnant RCW 86: Particle Acceleration And Magnetic Fields

The shocks of supernova remnants (SNRs) are believed to accelerate particles to cosmic ray (CR) energies. The amplification of the magnetic field due to CRs propagating in the shock region is expected to have an impact on both the emission from the accelerated particle population, as well as the acceleration process itself. Using a 95 ks observation with the Advanced CCD Imaging Spectrometer (ACIS) onboard the Chandra X-ray Observatory, we map and characterize the synchrotron emitting material in the northwestern region of RCW 86. We model spectra from several different regions, filamentary and diffuse alike, where emission appears dominated by synchrotron radiation. The fine spatial resolution of Chandra allows us to obtain accurate emission profiles across 3 different non-thermal rims in this region. The narrow width (l = 10''-30'') of these filaments constrains the minimum magnetic field strength at the post-shock region to be approximately 80 {\mu}G.Comment: 7 pages, 3 figures, submitted for publication at the Astrophysical Journa

Different cranial ontogeny in Europeans and Southern Africans

Modern human populations differ in developmental processes and in several phenotypic traits. However, the link between ontogenetic variation and human diversification has not been frequently addressed. Here, we analysed craniofacial ontogenies by means of geometric-morphometrics of Europeans and Southern Africans, according to dental and chronological ages. Results suggest that different adult cranial morphologies between Southern Africans and Europeans arise by a combination of processes that involve traits modified during the prenatal life and others that diverge during early postnatal ontogeny. Main craniofacial changes indicate that Europeans differ from Southern Africans by increasing facial developmental rates and extending the attainment of adult size and shape. Since other studies have suggested that native subsaharan populations attain adulthood earlier than Europeans, it is probable that facial ontogeny is linked with other developmental mechanisms that control the timing of maturation in other variables. Southern Africans appear as retaining young features in adulthood. Facial ontogeny in Europeans produces taller and narrower noses, which seems as an adaptation to colder environments. The lack of these morphological traits in Neanderthals, who lived in cold environments, seems a paradox, but it is probably the consequence of a warm-adapted faces together with precocious maturation. When modern Homo sapiens migrated into Asia and Europe, colder environments might establish pressures that constrained facial growth and development in order to depart from the warm-adapted morphology. Our results provide some answers about how cranial growth and development occur in two human populations and when developmental shifts take place providing a better adaptation to environmental constraints.Facultad de Ciencias Naturales y Muse

BIRTH SEASONALITY IN THE BAKA PYGMIES

International audienc

Developmental connections between cranial components and the emergence of the first permanent molar in humans

The age of emergence of the first molar (M1) is a developmental event correlated with many variables of primate life history, such as adult brain size. The evolution of human life history is characterized by the inclusion of childhood, which takes place between weaning and M1 emergence. Children still depend on adults for nutrition due to their small digestive system and their immature brains. By contrast, juveniles are not dependent because of M1 emergence, which enables shifting to adult type diet, and attainment of nearly adult brain size. In this study, developmental connections between M1 emergence and growth of cranial components were explored in two ways in order to understand the developmental basis of their evolutionary connections: (1) differences in growth trajectories of cranial components with respect to M1 emergence and (2) differences between individuals with and without fully emerged M1. Growth of anteroneural, midneural, posteroneural, otic, optic, respiratory, masticatory and alveolar cranial components was analysed in human skulls of individuals aged 0-20 years and in an adult reference skull. Volumetric indices were calculated to estimate size. Two subsamples were selected in order to focus on the transition between deciduous and permanent dentition: those with full deciduous dentition and before M1 reaches the occlusal plane; and those who present M1 in full emergence and no other cheek-tooth at the occlusal plane. The principal results were as follows. (1) Trajectories fitted using the whole sample are characterized by an inflection point that takes place before M1 emergence for neural components and around M1 emergence for facial components. (2) Associations between growth and age tend to be strong in those with full deciduous dentition, and weak in those who present M1 in full emergence. (3) Individuals who present M1 in full emergence are larger than those with full deciduous dentition. (4) Growth of components linked to the central nervous system is not linear until M1 emergence. Individuals who present M1 in full emergence are only larger than individuals with full deciduous dentition by 4-5% of adult size. (5) The alveolar component does not show increments between full deciduous dentition and M1 emergence. (6) When volumetric indices were standardized by age, the growth trajectories of individuals with full deciduous dentition and of those with M1 were not decoupled. In general terms, M1 emergence does not show a strong association with growth of the components that may explain differences in life histories. However, the main changes in neural and alveolar components occur in the first 3 years of life, which may be developmentally connected with M1 crown formation.Facultad de Ciencias Naturales y Muse

Climate change in the Catalan Pyrenees intersects with socioeconomic factors to shape crop diversity and management

Acord transformatiu CRUE-CSICUnidad de excelencia María de Maeztu CEX2019-000940-MMost studies on climate change's impacts on agriculture focus on modeling techniques based on large-scale meteorological data, while few have investigated how farmer's perception of climate change's impacts can affect crop diversity and crop management practices, especially in industrialized contexts. To fill this gap, we conducted 24 semi-structured interviews in a study site located in the Catalan Pyrenees. Our results show for the first time in an industrialized context that farmers perceive multiple interrelated climate change impacts on local agroecosystems. For instance, snowfall and freeze events have decreased, which respondents associated with the increase of pests and diseases affecting both wild flora and cultivated plants. Similarly, changes in precipitation patterns lead to a perceived decrease in useful rain for agriculture. Farmers are also reporting changes in their management practices, such as increased irrigation or use of pesticides, which respond to these climatic factors but also to changes in the crops that are cultivated. Crop diversity is in decline in the area both at the species and landrace levels, especially in rainfed fields. This is mainly driven by socioeconomic factors such as agricultural abandonment or access to commercial seeds, although climate change factors such as increased pests or decreased rainfall can have an impact. Despite the crop diversity losses found, many landraces have been maintained, mainly due to their cultural value, and also new crop species have been introduced, which are now viable due to the increase in temperature. Although we focused on a specific case study, we found several trends that are also present in other contexts. Therefore, the results of this research are relevant at a global scale since they show that climate change is affecting mountain agroecosystems in industrialized contexts and may affect more drastically both agrobiodiversity and crop management practices in agroecosystems worldwide

Developmental connections between cranial components and the emergence of the first permanent molar in humans

The age of emergence of the first molar (M1) is a developmental event correlated with many variables of primate life history, such as adult brain size. The evolution of human life history is characterized by the inclusion of childhood, which takes place between weaning and M1 emergence. Children still depend on adults for nutrition due to their small digestive system and their immature brains. By contrast, juveniles are not dependent because of M1 emergence, which enables shifting to adult type diet, and attainment of nearly adult brain size. In this study, developmental connections between M1 emergence and growth of cranial components were explored in two ways in order to understand the developmental basis of their evolutionary connections: (1) differences in growth trajectories of cranial components with respect to M1 emergence and (2) differences between individuals with and without fully emerged M1. Growth of anteroneural, midneural, posteroneural, otic, optic, respiratory, masticatory and alveolar cranial components was analysed in human skulls of individuals aged 0-20 years and in an adult reference skull. Volumetric indices were calculated to estimate size. Two subsamples were selected in order to focus on the transition between deciduous and permanent dentition: those with full deciduous dentition and before M1 reaches the occlusal plane; and those who present M1 in full emergence and no other cheek-tooth at the occlusal plane. The principal results were as follows. (1) Trajectories fitted using the whole sample are characterized by an inflection point that takes place before M1 emergence for neural components and around M1 emergence for facial components. (2) Associations between growth and age tend to be strong in those with full deciduous dentition, and weak in those who present M1 in full emergence. (3) Individuals who present M1 in full emergence are larger than those with full deciduous dentition. (4) Growth of components linked to the central nervous system is not linear until M1 emergence. Individuals who present M1 in full emergence are only larger than individuals with full deciduous dentition by 4-5% of adult size. (5) The alveolar component does not show increments between full deciduous dentition and M1 emergence. (6) When volumetric indices were standardized by age, the growth trajectories of individuals with full deciduous dentition and of those with M1 were not decoupled. In general terms, M1 emergence does not show a strong association with growth of the components that may explain differences in life histories. However, the main changes in neural and alveolar components occur in the first 3 years of life, which may be developmentally connected with M1 crown formation.Facultad de Ciencias Naturales y Muse

The Role of Stellar Feedback in the Dynamics of HII Regions

Stellar feedback is often cited as the biggest uncertainty in galaxy formation models today. This uncertainty stems from a dearth of observational constraints as well as the great dynamic range between the small scales (<1 pc) where the feedback occurs and the large scales of galaxies (>1 kpc) that are shaped by this feedback. To bridge this divide, in this paper we aim to assess observationally the role of stellar feedback at the intermediate scales of HII regions. In particular, we employ multiwavelength data to examine several stellar feedback mechanisms in a sample of 32 HII regions in the Large and Small Magellanic Clouds (LMC and SMC, respectively). Using optical, infrared, radio, and X-ray images, we measure the pressures exerted on the shells from the direct stellar radiation, the dust-processed radiation, the warm ionized gas, and the hot X-ray emitting gas. We find that the warm ionized gas dominates over the other terms in all of the sources, although two have comparable dust-processed radiation pressures to their warm gas pressures. The hot gas pressures are comparatively weak, while the direct radiation pressures are 1-2 orders of magnitude below the other terms. We discuss the implications of these results, particularly highlighting evidence for hot gas leakage from the HII shells and regarding the momentum deposition from the dust-processed radiation to the warm gas. Furthermore, we emphasize that similar observational work should be done on very young HII regions to test whether direct radiation pressure and hot gas can drive the dynamics at early times.Comment: 19 pages, 8 figures; accepted by Ap