Galaxy properties from J-PAS narrow-band photometry

We study the consistency of the physical properties of galaxies retrieved from SED-fitting as a function of spectral resolution and signal-to-noise ratio (SNR). Using a selection of physically motivated star formation histories, we set up a control sample of mock galaxy spectra representing observations of the local universe in high-resolution spectroscopy, and in 56 narrow-band and 5 broad-band photometry. We fit the SEDs at these spectral resolutions and compute their corresponding the stellar mass, the mass- and luminosity-weighted age and metallicity, and the dust extinction. We study the biases, correlations, and degeneracies affecting the retrieved parameters and explore the r\^ole of the spectral resolution and the SNR in regulating these degeneracies. We find that narrow-band photometry and spectroscopy yield similar trends in the physical properties derived, the former being considerably more precise. Using a galaxy sample from the SDSS, we compare more realistically the results obtained from high-resolution and narrow-band SEDs (synthesized from the same SDSS spectra) following the same spectral fitting procedures. We use results from the literature as a benchmark to our spectroscopic estimates and show that the prior PDFs, commonly adopted in parametric methods, may introduce biases not accounted for in a Bayesian framework. We conclude that narrow-band photometry yields the same trend in the age-metallicity relation in the literature, provided it is affected by the same biases as spectroscopy; albeit the precision achieved with the latter is generally twice as large as with the narrow-band, at SNR values typical of the different kinds of data.Comment: 26 pages, 15 figures. Accepted for publication in MNRA

Intracellular calcium movements of boar spermatozoa during 'in vitro' capacitation and subsequent acrosome exocytosis follow a multiple-storage place, extracellular calcium-dependent model

This work analysed intracellular calcium stores of boar spermatozoa subjected to invitro' capacitation (IVC) and subsequent progesterone-induced acrosome exocytosis (IVAE). Intracellular calcium was analysed through two calcium markers with different physico-chemical properties, Fluo-3 and Rhod-5N. Indicative parameters of IVC and IVAE were also evaluated. Fluo-3 was located at both the midpiece and the whole head. Rhod-5N was present at the sperm head. This distribution did not change in any of the assayed conditions. Induction of IVC was concomitant with an increase in both head and midpiece Ca2+ signals. Additionally, while IVC induction was concurrent with a significant (p<0.05) increase in sperm membrane permeability, no significant changes were observed in O-2 consumption and ATP levels. Incubation of boar spermatozoa in the absence of calcium showed a loss of both Ca2+ labellings concomitantly with the sperm's inability to achieve IVC. The absence of extracellular calcium also induced a severe decrease in the percentage of spermatozoa exhibiting high mitochondrial membrane potential (hMMP). The IVAE was accompanied by a fast increase in both Ca2+ signalling in control spermatozoa. These peaks were either not detected or much lessened in the absence of calcium. Remarkably, Fluo-3 marking at the midpiece increased after progesterone addition to sperm cells incubated in a medium without Ca2+. The simultaneous addition of progesterone with the calcium chelant EGTA inhibited IVAE, and this was accompanied by a significant (p<0.05) decrease in the intensity of progesterone Ca2+-induced peak, O-2 consumption and ATP levels. Our results suggest that boar spermatozoa present different calcium deposits with a dynamic equilibrium among them and with the extracellular environment. Additionally, the modulation role of the intracellular calcium in spermatozoa function seems to rely on its precise localization in boar spermatozoa

J-PLUS: analysis of the intracluster light in the Coma cluster

The intracluster light (ICL) is a luminous component of galaxy clusters composed of stars that are gravitationally bound to the cluster potential but do not belong to the individual galaxies. Previous studies of the ICL have shown that its formation and evolution are intimately linked to the evolutionary stage of the cluster. Thus, the analysis of the ICL in the Coma cluster will give insights into the main processes driving the dynamics in this highly complex system. Using a recently developed technique, we measure the ICL fraction in Coma at several wavelengths, using the J-PLUS unique filter system. The combination of narrow- and broadband filters provides valuable information on the dynamical state of the cluster, the ICL stellar types, and the morphology of the diffuse light. We use the Chebyshev-Fourier Intracluster Light Estimator (CICLE) to disentangle the ICL from the light of the galaxies, and to robustly measure the ICL fraction in seven J-PLUS filters. We obtain the ICL fraction distribution of the Coma cluster at different optical wavelengths, which varies from $\sim 7\%-21\%$, showing the highest values in the narrowband filters J0395, J0410, and J0430. This ICL fraction excess is distinctive pattern recently observed in dynamically active clusters (mergers), indicating a higher amount of bluer stars in the ICL compared to the cluster galaxies. Both the high ICL fractions and the excess in the bluer filters are indicative of a merging state. The presence of younger/lower-metallicity stars the ICL suggests that the main mechanism of ICL formation for the Coma cluster is the stripping of the stars in the outskirts of infalling galaxies and, possibly, the disruption of dwarf galaxies during past/ongoing mergers.Comment: 10 pages, 3 figures, 1 table. Accepted for publication in A&

Anàlisis de la dispensació d'ustekinumab des del Servei de Farmàcia per a pacients externs amb psoriasi o artritis psoriàsica

Objectiu: Els biològics han revolucionat l a teràpia de l'espectre de les malalties psoriàsiques. L'objectiu d'aquest estudi és analitzar l'administració d'ustekinumab a pacients ambulatoris amb psoriasi o artritis psoriàsica. Mètodes: Estudi retrospectiu, observacional realitzat al Departament de Farmàcia del 2009 al 2017. Es van recollir: dades demogràfiques, informació sobre si la inducció era correcta, sobre les dosis, les línies de tractament, la primera i darrera data i temps total de tractament, les altres teràpies, PASI, DLQUI i el temps mitjà de dispensació. Resultats: Dels 115 pacients analitzats, 61 encara estaven en tractament el març de 2017. En general, el 90% tenia psoriasi i 10% artritis psoriàsica. Un 98% va utilitzar Ustekinumab després del fracàs de la teràpia convencional, més de la meitat com a primera línia i el 83 a 87% en monoteràpia. La inducció, les dosis i el temps d'administració van ser correctes i no va haver-hi diferències significatives ni per sexe ni per grups de diagnòstic; el temps mitjà de dispensació va mostrar una tendència significativa en pacients amb teràpia concomitant (3,26 mesos (DE 0,17) en comparació amb monoterapia (3,06 mesos (DE 0,25) (F = 2,01; p = 0,096). Al darrer control, 42,8% pacients PASI = 1 i 53,6% DLQI =0. Conclusió: l'ustekinumab és un tractament efectiu enfront de la psoriasi, ja que ajuda a controlar la simptomatologia i millora remarcablement la qualitat de vida dels pacients

J-PLUS: Identification of low-metallicity stars with artificial neural networks using SPHINX

We present a new methodology for the estimation of stellar atmospheric parameters from narrow- and intermediate-band photometry of the Javalambre Photometric Local Universe Survey (J-PLUS), and propose a method for target pre-selection of low-metallicity stars for follow-up spectroscopic studies. Photometric metallicity estimates for stars in the globular cluster M15 are determined using this method. By development of a neural-network-based photometry pipeline, we aim to produce estimates of effective temperature, $T_{\rm eff}$, and metallicity, [Fe/H], for a large subset of stars in the J-PLUS footprint. The Stellar Photometric Index Network Explorer, SPHINX, is developed to produce estimates of $T_{\rm eff}$ and [Fe/H], after training on a combination of J-PLUS photometric inputs and synthetic magnitudes computed for medium-resolution (R ~ 2000) spectra of the Sloan Digital Sky Survey. This methodology is applied to J-PLUS photometry of the globular cluster M15. Effective temperature estimates made with J-PLUS Early Data Release photometry exhibit low scatter, \sigma($T_{\rm eff}$) = 91 K, over the temperature range 4500 < $T_{\rm eff}$ (K) < 8500. For stars from the J-PLUS First Data Release with 4500 < $T_{\rm eff}$ (K) < 6200, 85 $\pm$ 3% of stars known to have [Fe/H] <-2.0 are recovered by SPHINX. A mean metallicity of [Fe/H]=-2.32 $\pm$ 0.01, with a residual spread of 0.3 dex, is determined for M15 using J-PLUS photometry of 664 likely cluster members. We confirm the performance of SPHINX within the ranges specified, and verify its utility as a stand-alone tool for photometric estimation of effective temperature and metallicity, and for pre-selection of metal-poor spectroscopic targets.Comment: 18 pages, 12 figure

Rules, Standards, and the Internal Point of View

Large scale structure and cosmolog

Effects of Essential Oils and Polyunsaturated Fatty Acids on Canine Skin Equivalents : Skin Lipid Assessment and Morphological Evaluation

A canine skin equivalent model has been validated for the assessment of a topical formulation effects. Skin equivalents were developed from freshly isolated cutaneous canine fibroblasts and keratinocytes, after enzymatic digestion of skin samples (n = 8) from different breeds. Fibroblasts were embedded into a collagen type I matrix, and keratinocytes were seeded onto its surface at air-liquid interface. Skin equivalents were supplemented with essential oils and polyunsaturated fatty acid formulation or with vehicle. Skin equivalents were histopathologically and ultrastructurally studied, and the three main lipid groups (free fatty acids, cholesterol, and ceramides) were analyzed. Results showed that the culture method developed resulted in significant improvements in cell retrieval and confluence. Treated samples presented a thicker epidermis with increased number of viable cell layers, a denser and compact stratum corneum, and a more continuous basal membrane. Regarding lipid profile, treated skin equivalents showed a significant increase in ceramide content (51.7 ± 1.3) when compared to untreated (41.6 ± 1.4) samples. Ultrastructural study evidenced a compact and well-organized stratum corneum in both treated and control skin equivalents. In conclusion, cell viability and ceramides increase, after lipid supplementation, are especially relevant for the treatment of skin barrier disruptions occurring in canine atopic dermatitis

J-PLUS: A wide-field multi-band study of the M15 globular cluster. Evidence of multiple stellar populations in the RGB

The Javalambre Photometric Local Universe Survey (J-PLUS) provides wide field-of-view images in 12 narrow, intermediate and broad-band filters optimized for stellar photometry. Here we have applied J-PLUS data for the first time for the study of Galactic GCs using science verification data obtained for the very metal-poor GC M\,15. Our J-PLUS data provide low-resolution spectral energy distributions covering the near-UV to the near-IR, allowing us to search for MPs based on pseudo-spectral fitting diagnostics. J-PLUS CMDs are found to be particularly useful to search for splits in the sequences formed by the upper red giant branch (RGB) and asymptotic giant branch (AGB) stars. We interpret these split sequences as evidence for the presence of MPs. This demonstrates that the J-PLUS survey will have sufficient spatial coverage and spectral resolution to perform a large statistical study of GCs through multi-band photometry in the coming years.Comment: 11 pages, 11 figures. Accepted for publication @ A&

Four-year safety and effectiveness data from patients with multiple sclerosis treated with fingolimod : The Spanish GILENYA registry

Objective To describe the profile of patients with multiple sclerosis (MS) treated with fingolimod in Spain and to assess the effectiveness and safety of fingolimod after 4 years of inclusion in the Spanish Gilenya Registry. Methods An observational, retrospective/prospective, multicenter case registry, including all patients with relapsing-remitting MS (RRMS) starting treatment with fingolimod in 43 centers in Spain. Analyses were performed in the overall population and in subgroups according to prior disease-modifying therapy (DMT): glatiramer acetate/interferon beta-1 (BRACE), natalizumab, other treatment, or naïve. Results Six hundred and sixty-six evaluable patients were included (91.1% previously treated with at least one DMT). The mean annualized relapse rate (ARR) prior to fingolimod was 1.12, and the mean EDSS at fingolimod initiation was 3.03. Fingolimod reduced the ARR by 71.4%, 75%, 75.5%, and 80.3%, after 1, 2, 3 and 4 years, respectively (p<0.001). This significant reduction in the ARR continuedto be observed in all subgroups. After 4 years, the EDSS showed a minimal deterioration, with the EDSS scores from year 1 to year 4 remaining mostly stable. The percentage of patients without T1 Gd+ lesions progressively increased from 45.6% during the year prior to fingolimod initiation to 88.2% at year 4. The proportion of patients free from new/enlarged T2 lesions after 4 years of fingolimod treatment was 80.3%. This trend in both radiological measures was also observed in the subgroups. Adverse events (AEs) were experienced by up to 41.6% of patients (most commonly: lymphopenia [12.5%] and urinary tract infection [3.7%]). Most AEs were mild in severity, 3.6% of patients had serious AEs. Conclusions The patient profile was similar to other observational studies. The results obtained from the long-term use of fingolimod showed that it was effective, regardless of prior DMT, and it had adequate safety results, with a positive benefit-risk balance