Study on one-pot four-component synthesis of 9-aryl-hexahydro-acridine-1,8- diones using SiO2-I as a new heterogeneous catalyst and their anticancer activity

A simple, efficient and cost-effective method for the synthesis of 9-aryl-hexahydro-acridine-1,8-diones by a one-pot four-component cyclocondensation of dimedone, aromatic aldehydes and ammonium acetate as a nitrogen source in the presence of a new heterogeneous catalyst silica iodide (SiO2-I) in EtOH at 80 °C is described. SiO2-I was subjected to SEM-EDX and found to have iodo group bound to the catalyst. Some of the prepared acridine-diones were found to exhibit promising anti-cancer activity against HepG2 and MCF-7 cell lines. © 2014 Elsevier Ltd. All rights reserved

SIMPLE AND SENSITIVE SPECTROPHOTO¬METRIC ASSAY OF OFLOXACIN IN PHARMACEUTICALS BASED ON ION-PAIR REACTION

Two simple, sensitive, economical and extraction-free spectrophotometric methods have been developed for the determination of ofloxacin (OFX) in pure form and in tablets. The methods are based on the interaction of OFX with two sulphonphthalein dyes, namely, bromothymol blue (method A) and bromophenol blue (method B) in dichloromethane medium to form stable, yellow-colored ion–pair complexes peaking at 410 nm. Under the optimum conditions, OFX could be assayed in the concentration ranges 1.25-20 and 1.0-16 µg mL-1 OFX by methods A and B, respectively, with correlation coefficient of 0.999 in both methods. The apparent molar absorptivity values are calculated to be 1.74104 and 2.18104, L moL-1 cm-1, for method A and B, respectively, with corres¬pond¬ing Sandell sensitivity values of 0.021 and 0.017 µg cm-2. The limits of detec¬tion (LOD) and quantification (LOQ) are also reported. The stoichiometry of the reaction was found to be 1:1 in both cases and the conditional stability cons¬tants (Kf) of the complexes have also been reported. The intra-day and inter-day variation was assessed. The methods were applied to determine OFX from marked tablet formulations. Statistical analysis proved that the proposed methods were both accurate and precise

The G-O Rule and Waldmeier Effect in the Variations of the Numbers of Large and Small Sunspot Groups

We have analysed the combined Greenwich and Solar Optical Observing Network (SOON) sunspot group data during the period of 1874-2011 and determined variations in the annual numbers (counts) of the small, large and big sunspot groups (these classifications are made on the basis of the maximum areas of the sunspot groups). We found that the amplitude of an even-numbered cycle of the number of large groups is smaller than that of its immediately following odd-numbered cycle. This is consistent with the well known Gnevyshev and Ohl rule or G-O rule of solar cycles, generally described by using the Zurich sunspot number (Rz). During cycles 12-21 the G-O rule holds good for the variation in the number of small groups also, but it is violated by cycle pair (22, 23) as in the case of Rz. This behaviour of the variations in the small groups is largely responsible for the anomalous behaviour of Rz in cycle pair (22, 23). It is also found that the amplitude of an odd-numbered cycle of the number of small groups is larger than that of its immediately following even-numbered cycle. This can be called as `reverse G-O rule'. In the case of the number of the big groups, both cycle pairs (12, 13) and (22, 23) violated the G-O rule. In many cycles the positions of the peaks of the small, large, and big groups are different and considerably differ with respect to the corresponding positions of the Rz peaks. In the case of cycle 23, the corresponding cycles of the small and large groups are largely symmetric/less asymmetric (Waldmeier effect is weak/absent) with their maxima taking place two years later than that of Rz. The corresponding cycle of the big groups is more asymmetric (strong Waldmeier effect) with its maximum epoch taking place at the same time as that of Rz.Comment: 13 pages, 5 figures, 1 table, accepted by Solar Physic

Nuclear Fusion Reactors: Challenges and Potential as a Future Energy Source

This review article delves into the promising yet challenging realm of nuclear fusion reactors as a potential future energy source. The paper provides a comprehensive overview of global fusion research, highlighting its potential benefits and the technical obstacles that have hindered its widespread commercial adoption. Fusion energy, with its abundant resources, minimal waste generation, and low emissions, emerges as a long-term solution for a sustainable energy future. However, its technical complexities suggest that its widespread commercialization may not be realized until the end of the century. The article further explores the environmental compatibility, safety, and resource implications of fusion energy. A significant emphasis is placed on the paramount importance of safety in the development of fusion power reactors. The review underscores the need for robust safety cases, accident identification methods, and the establishment of internationally recognized safety standards. Additionally, the paper identifies knowledge gaps and areas necessitating further research, ensuring that fusion power stations meet rigorous safety objectives while minimizing environmental impact. Through a holistic examination of fusion’s potential and challenges, this review offers insights into its role in shaping the future energy landscape

Blast Disease of Millets: Present Status and Future Perspectives

Millet crops are affected by various biotic and abiotic stresses. Among biotic stresses, blast disease caused by Pyricularia grisea (finger, pearl and proso millets) and Pyricularia setariae (foxtail millet) is the most devastating and widespread disease that causes substantial grain and forage yield losses and is a key constraint to pearl millet, finger millet and foxtail millet production in most of finger millet growing areas, and recently, it is also reported in barnyard millet in few locations. This book chapter emphasizes mainly on occurrence, distribution, symptoms, yield loss, etiology, genetic diversity, mode of spread of the pathogen and survival and integrated disease management approaches for mitigating of disease. This information will be highly helpful for better understanding of the disease. Further, it will be useful to enhance production and productivity of millets and to reinforce the food and nutritional security in the developing countries of Asia and Africa continents where the millets are mainly grown as staple food crops

Solar cycle variations in the growth and decay of sunspot groups

We analysed the combined Greenwich (1874-1976) and Solar Optical Observatories Network (1977-2011) data on sunspot groups. The daily rate of change of the area of a spot group is computed using the differences between the epochs of the spot group observation on any two consecutive days during its life-time and between the corrected whole spot areas of the spot group at these epochs. Positive/negative value of the daily rate of change of the area of a spot group represents the growth/decay rate of the spot group. We found that the total amounts of growth and decay of spot groups whose life times > or = 2 days in a given time interval (say one-year) well correlate to the amount of activity in the same interval. We have also found that there exists a reasonably good correlation and an approximate linear relationship between the logarithmic values of the decay rate and area of the spot group at the first day of the corresponding consecutive days, largely suggesting that a large/small area (magnetic flux) decreases in a faster/slower rate. There exists a long-term variation (about 90-year) in the slope of the linear relationship. The solar cycle variation in the decay of spot groups may have a strong relationship with the corresponding variations in solar energetic phenomena such as solar flare activity. The decay of spot groups may also substantially contribute to the coherence relationship between the total solar irradiance and the solar activity variations.Comment: 12 pages, 7 figures, Accepted for publication in Astrophysics & Space Science. arXiv admin note: substantial text overlap with arXiv:1105.106

Combined heat and mass transfer and thermodynamic irreversibilities in the stagnation-point flow of Casson rheological fluid over a cylinder with catalytic reactions and inside a porous medium under local thermal nonequilibrium

The transport of heat and mass from the surface of a cylinder coated with a catalyst and subject to an impinging flow of a Casson rheological fluid is investigated. The cylinder features circumferentially non-uniform transpiration and is embedded inside a homogeneous porous medium. The non-equilibrium thermodynamics of the problem, including Soret and Dufour effects and local thermal non-equilibrium in the porous medium, are considered. Through the introduction of similarity variables, the governing equations are reduced to a set of non-linear ordinary differential equations which are subsequently solved numerically. This results in the prediction of hydrodynamic, temperature, concentration and entropy generation fields, as well as local and average Nusselt, Sherwood and Bejan numbers. It is shown that, for low values of the Casson parameter and thus strong non-Newtonian behaviour, the porous system has a significant tendency towards maintaining local thermal equilibrium. Furthermore, the results show a major reduction in the average Nusselt number during the transition from Newtonian to non-Newtonian fluid, while the reduction in the Sherwood number is less pronounced. It is also demonstrated that flow, thermal and mass transfer irreversibilities are significantly affected by the fluid’s strengthened non-Newtonian characteristics. The physical reasons for these behaviours are discussed by exploring the influence of the Casson parameter and other pertinent factors upon the thickness of thermal and concentration boundary layers. It is noted that this study is the first systematic investigation of the stagnation-point flow of Casson fluid in cylindrical porous media

A Bayesian Analysis of the Correlations Among Sunspot Cycles

Sunspot numbers form a comprehensive, long-duration proxy of solar activity and have been used numerous times to empirically investigate the properties of the solar cycle. A number of correlations have been discovered over the 24 cycles for which observational records are available. Here we carry out a sophisticated statistical analysis of the sunspot record that reaffirms these correlations, and sets up an empirical predictive framework for future cycles. An advantage of our approach is that it allows for rigorous assessment of both the statistical significance of various cycle features and the uncertainty associated with predictions. We summarize the data into three sequential relations that estimate the amplitude, duration, and time of rise to maximum for any cycle, given the values from the previous cycle. We find that there is no indication of a persistence in predictive power beyond one cycle, and conclude that the dynamo does not retain memory beyond one cycle. Based on sunspot records up to October 2011, we obtain, for Cycle 24, an estimated maximum smoothed monthly sunspot number of 97 +- 15, to occur in January--February 2014 +- 6 months.Comment: Accepted for publication in Solar Physic

Genetic trends in CIMMYT’s tropical maize breeding pipelines

Fostering a culture of continuous improvement through regular monitoring of genetic trends in breeding pipelines is essential to improve efficiency and increase accountability. This is the first global study to estimate genetic trends across the International Maize and Wheat Improvement Center (CIMMYT) tropical maize breeding pipelines in eastern and southern Africa (ESA), South Asia, and Latin America over the past decade. Data from a total of 4152 advanced breeding trials and 34,813 entries, conducted at 1331 locations in 28 countries globally, were used for this study. Genetic trends for grain yield reached up to 138 kg ha−1 yr−1 in ESA, 118 kg ha−1 yr−1 South Asia and 143 kg ha−1 yr−1 in Latin America. Genetic trend was, in part, related to the extent of deployment of new breeding tools in each pipeline, strength of an extensive phenotyping network, and funding stability. Over the past decade, CIMMYT’s breeding pipelines have significantly evolved, incorporating new tools/technologies to increase selection accuracy and intensity, while reducing cycle time. The first pipeline, Eastern Africa Product Profile 1a (EA-PP1a), to implement marker-assisted forward-breeding for resistance to key diseases, coupled with rapid-cycle genomic selection for drought, recorded a genetic trend of 2.46% per year highlighting the potential for deploying new tools/technologies to increase genetic gain