5,422 research outputs found
Theoretical analysis of perching and hovering maneuvers
Unsteady aerodynamic phenomena are encountered in a large number of modern aerospace and non-aerospace applications. Leading edge vortices (LEVs) are of particular interest because of their large impact on the forces and performance. In rotorcraft applications, they cause large vibrations and torsional loads (dynamic stall), affecting the performance adversely. In insect
flight however, they contribute positively by enabling high-lift flight. Identifying the conditions that result in LEV formation and modeling their effects on the flow is an important ongoing challenge. Perching (airfoil decelerates to rest) and hovering (zero freestream velocity) maneuvers are of special interest. In earlier work by the authors, a Leading Edge Suction Parameter (LESP) was developed to predict LEV formation for airfoils undergoing arbitrary variation in pitch and plunge at a constant freestream velocity. In this research, the LESP criterion is extended to situations where the freestream velocity is varying or zero. A point-vortex model based on this criterion is developed and results from the model are compared against those from a computational fluid dynamics (CFD) method. Abstractions of perching and hovering maneuvers are used to validate the low-order model's performance in highly unsteady vortex-dominated flows, where the time-varying freestream/translational velocity is small in magnitude compared to the other contributions to the velocity experienced by the leading edge region of the airfoil. Time instants of LEV formation, flow topologies and force coefficient histories for the various motion kinematics from the low-order model and CFD are obtained and compared. The LESP criterion is seen to be successful in predicting the start of LEV formation and the point-vortex method is effective in modeling the flow development and forces on the airfoil. Typical run-times for the low-order method are between 30-40 seconds, making it a potentially convenient tool for control/design applications
Significance of thermal fluctuations and hydrodynamic interactions in receptor-ligand mediated adhesive dynamics of a spherical particle in wall bound shear flow
The dynamics of adhesion of a spherical micro-particle to a ligand-coated
wall, in shear flow, is studied using a Langevin equation that accounts for
thermal fluctuations, hydrodynamic interactions and adhesive interactions.
Contrary to the conventional assumption that thermal fluctuations play a
negligible role at high Pclet numbers, we find that for particles
with low surface densities of receptors, rotational diffusion caused by
fluctuations about the flow and gradient directions aids in bond formation,
leading to significantly greater adhesion on average, compared to simulations
where thermal fluctuations are completely ignored. The role of wall
hydrodynamic interactions on the steady state motion of a particle, when the
particle is close to the wall, has also been explored. At high Pclet
numbers, the shear induced force that arises due to the stresslet part of the
Stokes dipole, plays a dominant role, reducing the particle velocity
significantly, and affecting the states of motion of the particle. The coupling
between the translational and rotational degrees of freedom of the particle,
brought about by the presence of hydrodynamic interactions, is found to have no
influence on the binding dynamics. On the other hand, the drag coefficient,
which depends on the distance of the particle from the wall, plays a crucial
role at low rates of bond formation. A significant difference in the effect of
both the shear force and the position dependent drag force, on the states of
motion of the particle, is observed when the Plet number is small.Comment: The manuscript has been accepted as an article in Physical Review E
Journa
ScALPEL: A Scalable Adaptive Lightweight Performance Evaluation Library for application performance monitoring
As supercomputers continue to grow in scale and capabilities, it is becoming
increasingly difficult to isolate processor and system level causes of
performance degradation. Over the last several years, a significant number of
performance analysis and monitoring tools have been built/proposed. However,
these tools suffer from several important shortcomings, particularly in
distributed environments. In this paper we present ScALPEL, a Scalable Adaptive
Lightweight Performance Evaluation Library for application performance
monitoring at the functional level. Our approach provides several distinct
advantages. First, ScALPEL is portable across a wide variety of architectures,
and its ability to selectively monitor functions presents low run-time
overhead, enabling its use for large-scale production applications. Second, it
is run-time configurable, enabling both dynamic selection of functions to
profile as well as events of interest on a per function basis. Third, our
approach is transparent in that it requires no source code modifications.
Finally, ScALPEL is implemented as a pluggable unit by reusing existing
performance monitoring frameworks such as Perfmon and PAPI and extending them
to support both sequential and MPI applications.Comment: 10 pages, 4 figures, 2 table
Calcification in a marginal sea - influence of seawater [Ca2+] and carbonate chemistry on bivalve shell formation
In estuarine coastal systems such as the Baltic Sea, mussels suffer from low salinity which limits their distribution. Anthropogenic climate change is expected to cause further desalination which will lead to local extinctions of mussels in the low saline areas. It is commonly accepted that mussel distribution is limited by osmotic stress. However, along the salinity gradient environmental conditions for biomineralization are successively becoming more adverse as a result of reduced [Ca2+] and dissolved inorganic carbon (CT) availability. In larvae, calcification is an essential process starting during early development with formation of the prodissoconch I (PD I) shell which is completed under optimal conditions within 2 days.
Experimental manipulations of seawater [Ca2+] start to impair PD I formation in Mytilus larvae at concentrations below 3 mM, which corresponds to conditions present in the Baltic at salinities below 8 g kg-1. In addition, lowering dissolved inorganic carbon to critical concentrations (< 1 mM) similarly affected PD I size which was well correlated with calculated ΩAragonite and [Ca2+][HCO3-]/[H+] in all treatments. Comparing results for larvae from the western Baltic with a population from the central Baltic revealed significantly higher tolerance of PD I formation to lowered [Ca2+] and [Ca2+][HCO3-]/[H+] in the low saline adapted population. This may result from genetic adaptation to the more adverse environmental conditions prevailing in the low saline areas of the Baltic.
The combined effects of lowered [Ca2+] and adverse carbonate chemistry represent major limiting factors for bivalve calcification and can thereby contribute to distribution limits of mussels in the Baltic Sea
Inverse problem of photoelastic fringe mapping using neural networks
This paper presents an enhanced technique for inverse analysis of photoelastic fringes using neural networks to determine the applied load. The technique may be useful in whole-field analysis of photoelastic images obtained due to external loading, which may find application in a variety of specialized areas including robotics and biomedical engineering. The presented technique is easy to implement, does not require much computation and can cope well within slight experimental variations. The technique requires image acquisition, filtering and data extraction, which is then fed to the neural network to provide load as output. This technique can be efficiently implemented for determining the applied load in applications where repeated loading is one of the main considerations. The results presented in this paper demonstrate the novelty of this technique to solve the inverse problem from direct image data. It has been shown that the presented technique offers better result for the inverse photoelastic problems than previously published works
Curvature Effects and Flow Uniformity Optimization of a Blood Microchannel
An important field of study in microfluidics is in the realm of blood rheology in microdevices. Many types of geometries have been developed for different lab-on-chip applications for sampling and analysis. The majority of experimental and numerical studies have revolved around straight blood vessel geometries, but in recent years there have been more complex profiles analyzed, such as microbifurcations. Some devices are developed to study blood flow similar to the microvascular network, such as diverging and converging bifurcations to study arterioles, which form a closed network. Cell adhesion studies of microchannels are also common, where symmetric bifurcation and confluence has been examined. Since sharp turns as well as bifurcation and confluence are common, the hemodynamics should be examined for many different shapes and the effects of channel geometry to the adhesion phenomena should be looked at. Different devices have different goals, such as isolating circulating tumor cells from blood, separating leukocytes from blood and isolating circulating tumor cells from peripheral blood. Studies have been targeted in breast cancer, cervical cancer and smooth muscle cell applications. Some studies provide result as to the role that the hemodynamic forces have on the recruitment of the metastatic cancer cells to endothelial cells, but the effects of device geometry on adhesion isn’t typically discussed formally. It has been shown that more complex geometries exhibit more non-uniform cell adhesion, adding to the confusion in the results and that an improvement in the velocity uniformity has been shown to improve the uniformity of the cell adhesion in sharp turn devices
Preparation and Characterization of Nano-Dy 2
Composite polymer electrolyte films containing various concentrations of nano-Dy2O3 (1.0 to 4.0%) in PVA + sodium citrate (90 : 10) are synthesized adopting solution cast method and are characterized using FTIR, XRD, SEM, and DSC techniques. The investigations indicate that all components are homogenously dispersed. Films containing 3% of nano-Dy2O3 are more homogenous and less crystalline, and the same is supported by DSC studies indicating the friendly nature to ionic conductivity. Transference number studies reveal that the major charge carriers are ions. With the increase in % of nano-Dy2O3, the conductivity increases and reaches maximum in 3% film with a value of 1.06 × 10−4 S/cm (at 303 K). Further, the conductivity of the film increases with raise in temperature due to the hopping of interchain and intrachain ion movements and fall in microscopic viscosity at the matrix interface of the film. Electrochemical cells are fabricated using these films with the configuration “anode (Mg + MgSO4)/[PVA (90%) + Na3C6H5O7 (10%) + (1–4% nano-Dy2O3)]/cathode (I2 + C + electrolyte),” and various discharge characteristics are evaluated. With 3% nano-Dy2O3 film, the maximum discharge time of 118 hrs with open-circuit voltage of 2.68 V, power density of 0.91 W/kg, and energy density of 107.5 Wh/kg are observed. These findings reflect the successful adoption of the developed polymer electrolyte films in electrochemical cells
Scale Up Sediment Microbial Fuel Cell for Powering Led Lighting
Sediment microbial fuel cells (SMFCs) are expected to be utilized as a sustainable power source for remote environmental observing 30 day's investigations of experiment to understand the long-term performance of SMFCs. The point of this investigation is to increase power generation, 8 individual sediment microbial fuel cells is stacked together either in series or in hybrid connection. Two combinations, of the hybrid connection, are proving to be the more effective one, step-up both the voltage and current of the framework, mutually. Polarization curve tests are done for series and hybrid connected sediment microbial fuel cell. The maximum study state voltage and current are obtained 8.150V and 435.25µA from series and 4.078V and 870.75µA hybrid connected SMFC. This study suggests that power of SMFC scale-up by connecting series and hybrid for practical use of the device.Article History: Received : September 26th 2017; Received: December 24th 2017; Accepted: January 4th 2018; Available onlineHow to Cite This Article: Prasad, J and Tripathi, R.K. (2018) Scale Up Sediment Microbial Fuel Cell For Powering Led Lighting. International Journal of Renewable Energy Development, 7(1), 53-58.https://doi.org/10.14710/ijred.7.1.53-5
DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with Ulcerative Colitis (UC)
Introduction: Epigenetic marking such as DNA methylation influence gene transcription and chromosomal stability and may also be affected by environmental exposures. Few studies exist on alteration in DNA methylation profiles (genomic and gene specific methylation) in patients with Ulcerative Colitis (UC) and none assessing its relationship with lifestyle exposures.
Aims & Methods: To assess genomic methylation and promoter methylation of the ESR-1 (oestrogen receptor - 1) and N-33 (tumour suppressor candidate-3) genes in the macroscopically normal mucosa of UC patients as well as to investigate effects of anthropometric and lifestyle exposures on DNA methylation. Sixty eight subjects were recruited (24 UC and 44 age and sex matched controls). Colorectal mucosal biopsies were obtained and DNA was extracted. Genomic DNA methylation was quantified using the tritium-labelled cytosine extension assay (3[H] dCTP) whilst gene specific methylation was quantified using the COBRA method.
Results: The methylation level of both ESR-1 and N-33 genes were significantly higher in UC subjects compared with controls (7.9% vs 5.9%; p = 0.015 and 66% vs 9.3%; p < 0.001 respectively). There was no detectable difference in global DNA methylation between patients with UC and age and sex matched controls. No associations between indices of DNA methylation and anthropometric measures or smoking patterns were detected.
Conclusions: For the first time, we have shown increased methylation in the promoter regions of the putative tumour suppressor gene N-33 in macroscopically normal mucosa of patients with UC. In addition, we have confirmed that methylation of ESR-1 promoter is higher in UC patients compared with age and sex matched controls. These findings suggests that, inactivation through methylation of the putative tumour suppressor genes N-33 and ESR-1, may not be associated with colorectal carcinogenesis in UC
An Accretion Model for Anomalous X-Ray Pulsars
We present a model for the anomalous X-ray pulsars (AXPs) in which the
emission is powered by accretion from a fossil disk, established from matter
falling back onto the neutron star following its birth. The time-dependent
accretion drives the neutron star towards a ``tracking'' solution in which the
rotation period of the star increases slowly, in tandem with the declining
accretion rate. For appropriate choices of disk mass, neutron star magnetic
field strength and initial spin period, we demonstrate that a rapidly rotating
neutron star can be spun down to periods characteristic of AXPs on timescales
comparable to the estimated ages of these sources. In other cases, accretion
onto the neutron star switches off after a short time, and the star becomes an
ordinary radio pulsar. Thus, in our picture, radio pulsars and AXPs are drawn
from the same underlying population, in contrast to models involving neutron
stars with ultrastrong magnetic fields, which require a new population of stars
with very different properties.Comment: 15 pages and 3 Postscript figure
- …