IgE-Mediated Reaction to Metamizole: Evaluation of a Patient with Severe Anaphylaxis

Metamizol, temel olarak analjezik ve antipiretik etkili, ayrıca kısmen antiinflamatuvar ve spazmolitik etkileri de olan bir ilaçtır. Metamizole bağlı birçok istenmeyen etki tanımlanmıştı. Erken ya da geç başlangıçlı sistemik reaksiyonlara ve kemik iliği baskılanması ile ilişkili reaksiyonlara neden olabilir. Bu makalede, parenteral metamizol (Novalgin ampul; Sanofi aventis, İstanbul, Türkiye) uygulanmasını takiben sistemik reaksiyon gelişen bir hastada reaksiyonun mekanizmasına yönelik araştırmalar sunularak tartışılmaktadır.Metamizole, a non-steroidal anti-inflammatory drug with weak anti-inflammatory and spasmolytic effects, is used as an analgesic and antipyretic agent. Many adverse reactions to metamizole, such as early or late-onset systemic reactions and bone marrow suppression, have been identified. In this report, we present a case of systemic reaction after the application of parenteral metamizole (Novalgin® ampoule; Sanofi Aventis, İstanbul, Turkey) and discuss the mechanism underlying the reaction

Familial Mediterranean Fever

Familial Mediterranean Fever is an autosomal recessive inherited disease with a course of autoinflammation, which is characterized by the episodes of fever and serositis. It affects the populations from Mediterranean basin. Genetic mutation of the disease is on MEFV gene located on short arm of Chromosome 16. The disease is diagnosed based on clinical evaluation. Amyloidosis is the most important complication. The only agent that decreases the development of amyloidosis and the frequency and severity of the episodes is colchicine, which has been used for about 40 years. In this review, we aimed to discuss especially the most recent advances about Familial Mediterranean Fever which is commonly seen in our population

Is Preoperative Neutrophil Lymphocyte Ratio a Reliable Prognostic Parameter for Localized Prostate Cancer?

Objective: In spite of all efforts, prostate cancer is still the 2nd highest cause of cancer-related deaths in men. For this reason new developments are needed in diagnosis, treatment and follow-up of prostate cancer. Neutrophil/lymphocyte (N/L) ratio is a cheap and effective parameter used for research into many solid tumors; but there are not enough studies on the reliability of this parameter in prostate cancer. In this study we researched the efficacy of N/L ratio in localized prostate cancer. Materials and Methods: Between March 9, 2012 and April 23, 2017, the data of 140 patients who underwent radical prostatectomy with localized prostate cancer were screened retrospectively. The patients' ages, preoperative prostate specific antigen (PSA) and N/L ratio, pathologic stage, pathologic Gleason score, tumor volume, lymph node involvement, surgical margin positivity and presence or absence of 3rd month biochemical recurrence were noted. The correlations between N/L ratio with age, PSA, pathologic parameters, surgical margin positivity and biochemical recurrence were investigated. Results: The mean age of patients was 63.0 +/- 5.9 years, mean PSA value was 10.8 +/- 8.5 ng/mL and mean N/L ratio was 2.5 +/- 1.9. There was no correlation found between N/L ratio and PSA, pathologic stage, Gleason score, lymph node involvement, tumor volume, surgical margin positivity and biochemical recurrence (p>0.05). Conclusion: In our study investigating 140 patients with localized prostate cancer, we did not identify any correlation between N/L ratio and PSA, surgical stage and Gleason score, surgical margin positivity, and 3rd month biochemical recurrence. When the literature is investigated, it appears that N/L ratio is effective for metastatic prostate cancer. To provide a more accurate judgment of the role of N/L ratio in localized prostate cancer, there is a need for new studies with broader patient series

Multidetector computed tomography and magnetic resonance imaging findings in pulmonary hydatid cysts

Aim: Computed tomography (CT) and magnetic resonance imaging (MRI) are diagnostic modalities in pulmonary hydatid disease.We aimed to present CT and MRI findings in pulmonary hydatid disease.Material and Methods: CT and MRI findings of pulmonary hydatid cysts from January 2011 through June 2018 were evaluatedretrospectively. CT images of 112 patients and MRI images of 27 patients were evaluated. Patients’ gender and ages, lesion numberand distribution, concomitant organ involvement, complications, HU density of lesions on CT and signal characteristics of lesions onMRI were analyzed. T2 hypointense rim, T1 and T2 signal intensity, daughter vesicle and detached membranes were the evaluatedparameters on MRI.Results: 147 hydatid cyst lesions of 119 (66 female, 53 male) patients with a mean age of 39.419.6 years were included in the study62 (52.1%) of patients had isolated lung involvement. 79 of 119 patients (66.4%) had solitary lung lesion. Mean CT density of cystswere 16 HU. 25 of 32 cysts showed T2 hypointense rim on MRI.Conclusion: Imaging plays important role in diagnosis and presurgical evaluation of pulmonary hydatid disease. CT is mostly usedin diagnosis; MRI should be a choice particularly in pediatric population

Association with Leptin Gene c.-2548 G > A Polymorphism, Serum Leptin Levels, and Body Mass Index in Turkish Obese Patients

WOS: 000315161000019PubMed ID: 23054910Leptin is a protein hormone which plays a critical role in the regulation of both body-weight through reducing food intake and stimulating energy expenditure. Several polymorphisms in leptin gene (LEP), which encodes for leptin, have been described. However, its association with obesity is still controversial. Therefore, in the present study, we aimed to investigate whether LEP c.-2548 G > A polymorphism was associated with serum leptin levels, lipid parameters, and body mass index in Turkish obese patients. Forty-seven obese patients and 48 healthy individuals were included in the study. Blood samples were collected for DNA extraction. LEP c.-2548 G > A polymorphism were detected using polymerase chain reaction-restriction fragment length polymorphism technique. Serum leptin levels and lipid parameters were measured by ELISA and enzyme colorimetric assay techniques, respectively. GA or AA genotypes and A allele carrier frequencies of the c.-2548 G > A polymorphism in the LEP were higher in obese (38.3, 34.0 and 72.3 %) when compared with controls (14.6, 12.5, and 27.1 %; p = 0.011, 0.016, and 0.002, respectively). On the other hand, AA or AG genotypes were also related to increased serum leptin levels (p < 0.001) and body mass index (p < 0.0001). All these consequences showed that LEP -2548 AA or AG genotypes are important predictors for increased levels of leptin and BMI in Turkish obese patients and it may be a useful marker for obesity risk in our population.Mustafa Kemal University Scientific Research Projects Unit, Hatay, Turkey [MKUBAP1002Y0102]This study was supported by a grant from the Mustafa Kemal University Scientific Research Projects Unit, Hatay, Turkey (Project Nr. MKUBAP1002Y0102)

Fatty Acid Composition and Antioxidant Potential of Ten Cephalaria Species

This paper focused on the assessment of fatty acid composition and antioxidant properties of ten Cephalaria (C. aytachii, C. taurica, C. tuteliana, C. procera, C. speciosa, C. tchihatchewii, C. hirsuta, C. elazigensis var. elazigensis, C. anatolica and C. aristata) species. The principal fatty acids in all species were oleic acid (10.28-31.65%), linoleic acid (17.81-37.67%) and palmitic acid (10.54-23.81%). Linolenic acid was also the most abundant fatty acid component in C. tuteliana (24.42%) and in C. speciosa (36.65%). In vitro antioxidant capacity of the hexane extracts of ten Cephalaria species was investigated by CUPRAC and DPPH methods. Total phenolic content of hexane extracts was also examined. The results showed that all species of Cephalaria have antioxidant properties with the highest trolox equivalent antioxidant capacity (1.005 +/- 0.13 mmol trolox equivalent per gram extact) in C. aristata and the highest radical scavenging activity (IC50 value 3.768 +/- 0.67 mg/mL) in C. tchihatchewii. It was found that reducing power of C. aristata and radical scavenging potential of C. tchihatchewii were mainly due to highest phenolic contents of these species (2.907 +/- 0.146 and 3.037 +/- 0.156 mg gallic acid equivalent per gram extract, respectively). These findings suggest that the Cephalaria species might be used as a potential source of unsaturated fatty acids as well as phenolic constituents possessing antioxidant activity in food, cosmetics and pharmaceutical industries

External Hemorrhage from a Portacaval Anastomosis in a Patient with Liver Cirrhosis

Variceal bleeding is the major complication of portal hypertension in patients with liver cirrhosis. Hemorrhage mainly occurs in gastrointestinal lumen. Extraluminal hemorrhages are quite rare, such as intraperitoneal hemorrhages. We aimed to present a variceal bleeding case from the anastomosis on the anterior abdominal wall, as an extraordinary bleeding location, in a patient with portal hypertension in whom there were no esophageal and gastric varices