Is knowledge exchange and combination always useful for innovation?

Using the resource-based view, this paper aims to provide a better understanding of the effect of knowledge on innovation. With this general aim in mind, we relate knowledge’s nature (tacit vs. explicit) and the process (e.g., knowledge exchange and combination) to innovation. Using a sample of 105 marketing and 176 R&D managers from 105 innovative firms, we find a positive linear effect of tacit knowledge on innovation and a U-shaped relationship between knowledge exchange and combination and innovation. We also find an enhancing effect of tacit knowledge on the first part of the curvilinear relationship between knowledge exchange and combination and innovation.: R&D, patents, knowledge, inventions

How does knowledge matter patenting inventions?

While there is robust empirical evidence that firm patenting is positively associated with various measures of overall performance and competitiveness, less is known about what determines the patenting choice. For this reason, this paper examines whether R&D expenditure and the type of knowledge used in the invention determine the decision to patent. With this aim, we use a sample of firms and the European Patent Office to analyse how the combination of R&D expenditure and knowledge codifiability, observability and simplicity influences the patent decision. Our results contribute to the literature and assist R&D managers by showing that both R&D and codified knowledge have a positive impact on the number of inventions patented by a firm, while observable knowledge has a negative impact on patents. Furthermore, we find that the effect of R&D expenditure on the propensity to patent inventions is negatively moderated by knowledge observability and simplicity.: R&D, patents, knowledge, invent

Bioethics and health law: the living will. Proposal to create a living will record in Europe

In this piece of work, we present a proposal to create a living will record in Europe that will allow people to have the same rights wherever they are. Therefore, this article will be studied from the bioethics and health law theory

European women: Why do(n't) they work?

This paper provides an empirical study of the determinants of female participation decisions in the European Union. The analysis is performed by estimating participation equations for different age groups (i.e. young, prime-age and older females), using annual data for a panel of 12 EU-15 countries over the period 1980-2000. Our findings show that the strictness of labour market institutions negatively affects the participation rate. Decisions linked to individual preferences with regards to education or fertility are also found relevant to participation of the youngest and prime-age females respectively. The inclusion of a proxy to capture cohort effects is crucial in order to explain the oldest females’ participation. JEL Classification: J21labour force participation, Labour market institutions

Are black friday deals worth it? Mining twitter users' sentiment and behavior response

The Black Friday event has become a global opportunity for marketing and companies’ strategies aimed at increasing sales. The present study aims to understand consumer behavior through the analysis of user-generated content (UGC) on social media with respect to the Black Friday 2018 offers published by the 23 largest technology companies in Spain. To this end, we analyzed Twitter-based UGC about companies’ offers using a three-step data text mining process. First, a Latent Dirichlet Allocation Model (LDA) was used to divide the sample into topics related to Black Friday. In the next step, sentiment analysis (SA) using Python was carried out to determine the feelings towards the identified topics and offers published by the companies on Twitter. Thirdly and finally, a data-text mining process called textual analysis (TA) was performed to identify insights that could help companies to improve their promotion and marketing strategies as well as to better understand the customer behavior on social media. The results show that consumers had positive perceptions of such topics as exclusive promotions (EP) and smartphones (SM); by contrast, topics such as fraud (FA), insults and noise (IN), and customer support (CS) were negatively perceived by customers. Based on these results, we offer guidelines to practitioners to improve their social media communication. Our results also have theoretical implications that can promote further research in this area

Wt1 is involved in pancreas development and adult pancreatic homeostasis

The embryonic mesothelium lining the visceral organs gives rise to mesenchymal cells through a localized epithelial-mesenchymal transition (EMT). This has been extensively studied in some cases, such as the heart, where the epicardium gives rise to epicardial-derived cells that contribute to the cardiac vascular and connective tissues. In other organs, such as the lungs, liver and gut, the developmental fate of the mesothelial-derived mesenchyme and their importance for visceral morphogenesis has also been demonstrated (reviewed in Ariza et al., Dev Dyn, 2016, 245:307-22). Hepatic stellate cells (HSC) are located in the perisinusoidal space of the liver. It has been described that cells derived from the liver mesothelium through an EMT contributes to the HSC population and also to the sinusoidal endothelium during development (IJpenberg et al. Dev Biol, 2007, 312: 157–170; Asahina et al., Hepatology, 2011, 53:983-95). Thus, we checked is a similar developmental origin accounts for pancreatic stellate cells (PSC), a population of pancreatic stromal cells that share many features with HSC. In normal adult pancreas, PSC are quiescent, star-shaped cells with a periacinar distribution. When activated by profibrogenic stimuli such as inflammatory cytokines or oxidative stress, PSC transform into myofibroblast-like cells. Thus, PSC are the major source of extracellular matrix in the adult pancreas, but their embryonic origin remains unknown. The Wilms’ tumor suppressor gene (Wt1) is highly expressed in the embryonic mesothelium. For this reason, we have used two lines of transgenic mice for lineage tracing of mesothelial-derived cells, systemic (Wt1Cre; R26REYFP), tamoxifen-inducible (Wt1ERT2; R26REYFP) and we have also used the inducible driver for conditional deletion of Wt1 (Wt1ERT2; Wt1 flox) in adult mice. Our results confirm that WT1 protein is only expressed in the mesothelium of the developing pancreas, allowing for reliable tracing of the mesothelial-derived cells. During the early stages of pancreas morphogenesis, its mesothelium shows the typical features of EMT. Mesothelial-derived cells, identified by constitutive YFP expression, differentiate into a major part of the PSCs and also contribute to other connective and vascular cell type, including endothelium. Thus, mesothelial-derived cells originated by EMT seem to constitute an important subpopulation of mesodermal cells during pancreas development, contributing to its morphogenesis. On the other hand, systemic deletion of Wt1 in adult mice causes a severe atrophy of the pancreas, although this factor is only expressed in the pancreatic mesothelium. In addition, we have observed that adult PSC express Wt1 in the caerulein-induced pancreatitis model. Our results suggest that: 1) normal pancreatic function is maintained by a Wt1-dependent signaling mechanism acting from the mesothelium and 2) Wt1 plays a role in PSC activation in adult mice. These observations point to a relevant function of the Wt1 gene in pancreatic development and function.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Incidencia de casos de salmonelosis y campilobacteriosis y su relación

Salmonella y Campylobacter son las dos principales causantes de toxiinfecciones a nivel mundial, siendo necesario comprender las múltiples interacciones que tienen estos patógenos con su entorno durante la trasmisión a lo largo de la cadena alimentaria a fin de desarrollar estrategias de prevención y control. Son muy versátiles y pueden adaptarse al entorno, asegurando así su supervivencia, crecimiento y la producción de toxinas. Se ha observado en los últimos años un descenso o estancamiento de los casos de salmonelosis a la par que un ascenso en los de campilobacteriosis. Por ello me ha parecido interesante analizar la variación en la incidencia de salmonelosis y campilobacteriosis a partir de la relación entre los casos de infecciones por Salmonella y Campylobacter. Este análisis lo he realizado a partir de la consulta en fuentes primarias y algunas secundarias, a fin de establecer una hipótesis sobre el agente o agentes causantes de esta variación. Tras la realización de este trabajo podríamos suponer que, la disminución en las toxiinfecciones por Salmonella puede ser debida a los programas de control llevados a cabo, y el aumento de casos de campilobacteriosis podría ser debido al vacío que ha dejado Salmonella. Podría darse el caso de que estas bacterias sufrieran modificaciones que las hicieran más resistentes en su principal vehículo, o que estos cambios estuvieran encaminados a la ocupación de nuevos nichos. Los sistemas de vigilancia y control sieguen siendo fundamentales, y la creación de equipos multidisciplinares a su cargo, que engloben a todo el sector alimentario

Understanding User Behavioral Intention to Adopt a Search Engine that Promotes Sustainable Water Management

An increase in users’ online searches, the social concern for an efficient management of resources such as water, and the appearance of more and more digital platforms for sustainable purposes to conduct online searches lead us to reflect more on the users’ behavioral intention with respect to search engines that support sustainable projects like water management projects. Another issue to consider is the factors that determine the adoption of such search engines. In the present study, we aim to identify the factors that determine the intention to adopt a search engine, such as Lilo, that favors sustainable water management. To this end, a model based on the Theory of Planned Behavior (TPB) is proposed. The methodology used is the Structural Equation Modeling (SEM) analysis with the Analysis of Moment Structures (AMOS). The results demonstrate that individuals who intend to use a search engine are influenced by hedonic motivations, which drive their feeling of contentment with the search. Similarly, the success of search engines is found to be closely related to the ability a search engine grants to its users to generate a social or environmental impact, rather than users’ trust in what they do or in their results. However, according to our results, habit is also an important factor that has both a direct and an indirect impact on users’ behavioral intention to adopt different search engines