STRATEGI BRANDING DESTINASI WISATA KAWASAN WISATA INTERNASIONAL BINTAN RESORTS PASCA PANDEMI COVID 19

This study aims to find out how the branding strategy for tourist destinations in the international tourist area of ​​Bintan Resorts after the COVID 19 pandemic was carried out by PT Bintan Resort Cakrawala as the master developer of the Bintan Resorts tourist area by looking at how positioning, differentiation and branding were carried out by PT Bintan Resort Cakrawala. This research is a qualitative research using the case study method. The paradigm used in this study is the constructivism paradigm. Data collection was obtained from interviews, observation and documentation. The results of this study indicate that the positioning strategy developed by PT Bintan Resort Cakrawala is to instill in the minds of tourists that the Bintan Resorts area is a safe area has also made Bintan Resorts the only tourist destination in Indonesia that has received two certifications from the Government of Indonesia and the Government of Singapore. The results showed that the master developer of the international tourist area of ​​Bintan Resorts, PT Bintan Resort Cakrawala has succeeded in carrying out a post-COVID-19 pandemic branding strategy through positioning, differentiation and branding strategies measured based on an increase in the number of tourists and has become a tourist destination trusted by tourists after the COVID-19 pandemic.Penelitian ini bertujuan untuk mengetahui bagaimana strategi branding destinasi wisata kawasan wisata internasional Bintan Resorts pasca pandemi COVID 19 yang dilakukan oleh PT Bintan Resort Cakrawala selaku pengelola kawasan wisata Bintan Resorts dengan melihat bagaimana positioning, differentiation dan branding yang dilakukan oleh PT Bintan Resort Cakrawala. Penelitian ini merupakan penelitian kualitatif dengan menggunakan metode studi kasus. Paradigma yang digunakan dalam penelitian ini adalah paradigma konstruktivisme. Data dikumpulkan melalui tahapan wawancara, observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa strategi positioning yang dibangun oleh PT Bintan Resort Cakrawala adalah dengan menanamkan di benak wisatawan bahwa kawasan Bintan Resorts merupakan kawasan yang aman dan membuat Bintan Resorts menjadi satu-satunya destinasi wisata di Indonesia yang memperoleh dua sertifikasi dari Pemerintah Indonesia dan Pemerintah Singapura. Hasil penelitian menunjukkan bahwa pengelola kawasan wisata internasional Bintan Resorts,  PT Bintan Resort Cakrawala berhasil melakukan strategi branding pasca pandemi COVID-19 melalui strategi positioning, differentiation dan branding diukur berdasarkan peningkatan jumlah wisatawan dan menjadi destinasi wisata kepercayaan wisatawan pasca pandemi COVID 19

Peran audit internal serta faktor-faktor pendukung terhadap pengendalian internal dan kinerja perusahaan

Penelitian ini bertujuan untuk mengetahui pengaruh peran audit internal dan faktor-faktor pendukung terhadap pengendalian dan kinerja perusahaan PT UBJOM Kaltim Teluk Balikpapan. Penelitian ini merupakan penelitian Kuantitatif, yang menggunakan data primer. Berupa kuesioner untuk menghimpun data. Populasi dalam penelitian ini adalah seluruh karyawan. Pengambilan sampel dilakukan dengan metode secara acak. Kuesioner yang disebarkan sebanyak 140. Teknik analisis data menggunakan analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa (1) peran audit internal, pengalaman kerja, profesionalisme secara signifikam berpengaruh terhadap pengendalian internal, (2) Pengendalian internal secara signifikan berpengaruh terhadap kinerja perusahaan, (3) Motivasi, profesionalisme, gaya kepemimpinan audit internal berpengaruh signifikan terhadap kinerja perusahaan. (4)Independensi, motivasi, gaya kepemimpinan audit internal tidak berpengaruh terhadap pengendalian internal, (5) peran audit internal, independensi pengalamaan kerja audit internal tidak berpengaruh terhadap kinerja perusahaa

Balance scorecard: pendekatan metode analytical hierarchy process usaha rintisan startup heksagonal trading di balikpapan

Penelitian ini bertujuan untuk mengetahui pengaruh setiap perspektif pada Balance Scorecard yaitu pengaruh perspektif keuangan, pengaruh perspektif pelanggan, pengaruh perspektif proses bisnis internal, pengaruh perspektif pertumbuhan dan pembelajaran serta pembobotan prioritas pada setiap perspektif diukur dengan metode Analytical Hierarchy Process. Uji yang digunakan dalam penelitian ini adalah uji konsistensi logis dengan menguji indeks konsistensi dan rasio konsistensi. Hasil Penelitian menunjukkan bahwa pembobotan dengan prioritas pertama dengan bobot 0,311 yaitu perspektif pertumbuhan dan pembelajaran, prioritas kedua bobot 0,272 yaitu perspektif keuangan, prioritas ketiga bobot 0,213 perspektif proses bisnis internal, dan prioritas keempat bobot 0,205 perspektif pelanggan. Hasil uji hipotesis dengan uji konsistensi logis diketahui bahwa semua variabel independent berpengaruh positif terhadap variabel dependent yaitu kinerja usaha rintisan startup Heksagonal Trading di Balikpapan dengan perspektif pertumbuhan dan pembelajaran  berpengaruh lebih dominan dan menjadi prioritas utama pada penelitian ini

Pinus roxburghii essential oil anticancer activity and chemical composition evaluation

The present study was conducted to appraise the anticancer activity of Pinus roxburghii essential oil along with chemical composition evaluation. MTT assay revealed cytotoxicity induction in colon, leukemia, multiple myeloma, pancreatic, head and neck and lung cancer cells exposed to essential oil. Cancer cell death was also observed through live/dead cell viability assay and FACS analysis. Apoptosis induced by essential oil was confirmed by cleavage of PARP and caspase-3 that suppressed the colony-forming ability of tumor cells and 50 % inhibition occurred at a dose of 25 μg/mL. Moreover, essential oil inhibited the activation of inflammatory transcription factor NF-κB and inhibited expression of NF-κB regulated gene products linked to cell survival (survivin, c-FLIP, Bcl-2, Bcl-xL, c-Myc, c-IAP2), proliferation (Cyclin D1) and metastasis (MMP-9). P. roxburghii essential oil has considerable anticancer activity and could be used as anticancer agent, which needs further investigation to identify and purify the bioactive compounds followed by in vivo studies

The effectiveness of the Inspiring Futures parenting programme in improving behavioural and emotional outcomes in primary school children with behavioural or emotional difficulties: study protocol for a randomised controlled trial.

textabstractBackground: There is a need to build the evidence base of early interventions promoting children's health and development in the UK. Malachi Specialist Family Support Services ('Malachi') is a voluntary sector organisation based in the UK that delivers a therapeutic parenting group programme called Inspiring Futures to parents of children identified as having behavioural and emotional difficulties. The programme comprises two parts, delivered sequentially: (1) a group-based programme for all parents for 10-12 weeks, and (2) one-to-one sessions with selected parents from the group-based element for up to 12 weeks. Methods/design: A randomised controlled trial will be conducted to evaluate Malachi's Inspiring Futures parenting programme. Participants will be allocated to one of two possible arms, with follow-up measures at 16 weeks (post-parent group programme) and at 32 weeks (post-one-to-one sessions with selected parents). The sample size is 248 participants with a randomisation allocation ratio of 1:1. The intervention arm will be offered the Inspiring Futures programme. The control group will receive services as usual. The aim is to determine the effectiveness of the Inspiring Futures programme on the primary outcome of behavioural and emotional difficulties of primary school children identified as having behavioural or emotional difficulties. Discussion: This study will further enhance the evidence for early intervention parenting programmes for child behavioural and emotional problems in the UK

The Role of Schools in Early Adolescents’ Mental Health: Findings from the MYRIAD Study

This is the author accepted manuscript. The final version is available on open access from Elsevier via the DOI in this recordData Sharing: The corresponding study protocol can be found at https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-017-1917-4. R code is available from the Open Science Framework (https://osf.io/s63fm/?view_only=5ae58f6c053c4a16b5ddfccd0e6e1ece). The baseline data and codebook from the MYRIAD trial is available from Prof. Kuyken ([email protected]) upon request (release of data is subject to an approved proposal and a signed data access agreement).Objective: Recent studies suggest deteriorating youth mental health. The current UK policy emphasises the role of schools for mental health promotion and prevention, but little data exist on what aspects of schools explain pupils’ mental health. We explored school-level influences on the mental health of young people in a large school-based sample from the UK. Methods: We analysed baseline data from a large cluster randomized controlled trial (ISRCTN 86619085) collected between 2016‒2018 from mainstream UK secondary schools selected to be representative in relation to their quality rating, size, deprivation, mixed or single-sex pupil population and country. Participants were pupils in their first or second year of secondary school. We assessed whether school-level factors were associated with pupil mental health. Results: 26,885 pupils (response rate=90%), aged 11‒14 years, 55% female, attending 85 UK schools, were included. Schools accounted for 2.4% (95% CI=2.0‒2.8; p<0.0001) of the variation in psychopathology, 1.6% (95% CI=1.2‒2.1; p<0.0001) of depression and 1.4% (95% CI=1.0‒1.7; p<0.0001) of well-being. Schools in urban locations, with a higher percentage of free school meals and of White British, were associated with poorer pupil mental health. A more positive school climate was associated with better mental health. Conclusion: School-level variables, primarily related to contextual factors, characteristics of their pupil population, and school climate explain a small but significant amount of variability in young people’s mental health. This might be used to identify schools that are in need of more resources to support young people’s mental health.Wellcome TrustNational Institute for Health Research (NIHR)Medical Research Council (MRC

Update to the effectiveness and cost-effectiveness of a mindfulness training programme in schools compared with normal school provision (MYRIAD): study protocol for a randomised controlled trial

Abstract: Background: MYRIAD (My Resilience in Adolescence) is a superiority, parallel group, cluster randomised controlled trial designed to examine the effectiveness and cost-effectiveness of a mindfulness training (MT) programme, compared with normal social and emotional learning (SEL) school provision to enhance mental health, social-emotional-behavioural functioning and well-being in adolescence. The original trial protocol was published in Trials (accessible at https://doi.org/10.1186/s13063-017-1917-4). This included recruitment in two cohorts, enabling the learning from the smaller first cohort to be incorporated in the second cohort. Here we describe final amendments to the study protocol and discuss their underlying rationale. Methods: Four major changes were introduced into the study protocol: (1) there were changes in eligibility criteria, including a clearer operational definition to assess the degree of SEL implementation in schools, and also new criteria to avoid experimental contamination; (2) the number of schools and pupils that had to be recruited was increased based on what we learned in the first cohort; (3) some changes were made to the secondary outcome measures to improve their validity and ability to measure constructs of interest and to reduce the burden on school staff; and (4) the current Coronavirus Disease 2019 (SARS-CoV-2 or COVID-19) pandemic both influences and makes it difficult to interpret the 2-year follow-up primary endpoint results, so we changed our primary endpoint to 1-year follow-up. Discussion: These changes to the study protocol were approved by the Trial Management Group, Trial Steering Committee and Data and Ethics Monitoring Committees and improved the enrolment of participants and quality of measures. Furthermore, the change in the primary endpoint will give a more reliable answer to our primary question because it was collected prior to the COVID-19 pandemic in both cohort 1 and cohort 2. Nevertheless, the longer 2-year follow-up data will still be acquired, although this time-point will be now framed as a second major investigation to answer some new important questions presented by the combination of the pandemic and our study design. Trial registration: International Standard Randomised Controlled Trials ISRCTN86619085. Registered on 3 June 2016

Maltoma veiled in the lung-a rare case of pulmonary and gastric maltoma

Mucosa associated lymphoid tissue (MALT) is a type of B-cell lymphoma that is commonly observed in the gastrointestinal site, most frequently occurring in the stomach. However, the incidence of this type of lymphoma in the respiratory tract is very uncommon. We report a case of this rare clinical entity in a patient who presented with non-symptomatology and was diagnosed with pulmonary MALT lymphoma (pMALToma)

A case of acquired immunodeficiency syndrome-related Kaposi sarcoma in a patient with COVID-19 - A brief review of HIV-COVID Co-infection and its Therapeutic challenges!

Barriers posed by the COVID-19 pandemic have led to reduced access to Human Immunodeficiency virus (HIV) care, leaving untreated patients at risk for various superimposed infections and malignancies such as Kaposi sarcoma (KS). We recently encountered a 37-year-old African-American male with a past medical history of HIV who tested positive for SARS-CoV-2 and was diagnosed with AIDS-related disseminated KS, representing the first reported case of COVID-19 infection with a newly diagnosed concomitant KS. The patient experienced multi-organ failure requiring tracheostomy, renal replacement therapy, and a prolonged intensive care unit (ICU) stay. Goals of care were changed to comfort measures and the patient passed away shortly afterwards. He was made comfort measures and passed away shortly afterwards. AIDS-related KS is a vascular tumor seen in association wit