Otimização de herbicidas utilizados em pré-emergência para o controle de Portulaca oleracea

Portulaca oleracea is found intervening in several crops mainly vegetables, besides crops like sugar cane and cotton. The study was developed with the objective of improving the recommendation of herbicides alternatives in pre emergency used on cotton crop, for controlling P. oleracea. The work was conducted in two stages in greenhouse conditions: the first to establishing, through dose-response curve, herbicides rates able to promote efficient control of P. oleracea; the second one, to verify the period of residual activity provided by herbicides rates considered efficient and selected in the first stage, and by recommended rates. In the first stage, increasing rates of alachlor, diuron, clomazone, oxyfluorfen, pendimethalin, prometryn, smetolachlor, trifluralin 600 and trifluralin 450 herbicides were used. In the second stage, an effective rate and a recommended one of each herbicide were applied in four periods preceding weeds sowing, evaluating control percentage at 0, 10, 20 and 30 days after treatments application (DAA). It was verified, in the first stage, that herbicides efficiently controlled P. oleracea species, with exception of two trifluralin formulations. However, the effective rates (C95) of alachlor and prometryn showed short residual activity, as observed in the second stage. Recommended rate of prometryn promoted the efficient control up to 30 DAA, unlike to alachlor. Diuron, pendimethalin, oxyfluorfen, s-metolachlor in both rates used, besides trifluralin 600 and clomazone in recommended rates, showed effective residual activity for periods up to 30 DAA, to sandy clay loam texture soil.      Portulaca oleracea é encontrada interferindo em diversas culturas principalmente em hortaliças, além de culturas como cana-de-açúcar e algodão. O trabalho foi desenvolvido com objetivo de aperfeiçoar a recomendação de alternativas de herbicidas utilizados em pré-emergência do algodoeiro, para o controle de P. oleracea. O trabalho foi realizado em duas etapas em casa-de-vegetação: a primeira para estabelecer, por meio da curva dose-resposta, as doses de herbicidas capazes de promover o controle eficiente de P. oleracea; a segunda, para verificar o período de atividade residual proporcionado pelas doses consideradas eficientes, selecionadas na primeira etapa e, por doses recomendadas. Na primeira etapa, foram utilizadas doses crescentes dos herbicidas alachlor, diuron, clomazone, oxyfluorfen, pendimethalin, prometryne, s-metolachlor, trifluralin 600 e trifluralin 450. Na segunda etapa, uma dose eficiente e uma dose recomendada de cada herbicida, foram aplicadas em quatro épocas antecedendo a semeadura da planta daninha, avaliando a porcentagem de controle aos 0, 10, 20 e 30 dias após aplicação dos tratamentos (DAA). Verificou-se na primeira etapa que os herbicidas controlaram eficientemente P. oleracea, com exceção das duas formulações de trifluralin. No entanto, as doses eficientes (C95) de alachlor e prometryne apresentam curta atividade residual, como observado na segunda etapa.A dose recomendada de prometryne promoveu o controle eficiente até aos 30 DAA, ao contrário de alachlor. Diuron, pendimethalin, oxyfluorfen, s-metolachlor, em ambas as doses utilizadas, além da trifluralin 600 e clomazone, em doses recomendadas, apresentaram atividade residual eficiente por períodos de até 30 DAA, para o solo de textura franco argilo-arenosa

Tolerância de duas variedades de algodoeiro a herbicidas aplicados em pré-emergência

This work aimed to evaluate the selectivity of herbicides applied pre-emergence, isolated or in tank-mixtures, for two cotton varieties, Delta-Opal and FMT-701. Treatments applied were: alachlor, S-metolachlor, diuron (two rates), prometryn (two rates), oxyfluorfen, alachlor + diuron, alachlor + prometryn (two rates of this mixture), S-metolachlor + diuron, S-metolachlor + prometryn (two rates of this mixture), oxyfluorfen + diuron, oxyfluorfen + prometryn. Evaluations performed were related to the visual plant intoxication, height of plants and crop yield. When rates of diuron and prometryn were increased, symptoms of crop injury were also more evident, in relation to lower rates of the same products. Oxyfluorfen, isolated or in tank mixture with diuron or prometryn propitiated intense symptoms of crop injury, but the only treatment which was considered as non-selective for both cotton varieties was the mixture of oxyfluorfen + prometryn (0.192 + 0.9 kg ha-1).Este trabalho teve por objetivo avaliar a seletividade de herbicidas aplicados em pré-emergência, isolados ou em misturas, para as variedades Delta-Opal e FMT-701. Os tratamentos avaliados foram: alachlor, S-metolachlor, diuron (em duas doses), prometryn (em duas doses), oxyfluorfen, alachlor + diuron, alachlor + prometryn (em duas doses da mistura), S-metolachlor + diuron, S-metolachlor + prometryn (em duas doses da mistura), oxyfluorfen + diuron, oxyfluorfen + prometryn. Foram realizadas avaliações relacionadas à fitointoxicação visual, altura de plantas e produtividade da cultura. Quando houve incremento na dose de diuron e prometryn, os sintomas de fitointoxicação foram intensificados em relação às menores doses. O herbicida oxyfluorfen quando aplicado isolado e em mistura com diuron ou prometryn proporcionou sintomas intensos de fitointoxicação à cultura do algodoeiro. No entanto, o único tratamento que não foi seletivo para ambas variedades de algodoeiro foi a mistura oxyfluorfen + prometryn (0,192 + 0,900 kg ha-1)

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

Períodos de controle e convivência das plantas daninhas na cultura do algodão em diferentes sistemas de cultivo no cerrado brasileiro

In search of economic support of the Brazilian cotton, the cotton cultivation system have been changing over the time when you compare what was traditionally made. Recently, dense crop has emerged as one option to increase the crop profitability, especially in spreading performed in "off season" due to the crop cycle reduction and the production costs reductions. Changing in spacing, plant density and sowing time induce a series of changes in growth and cotton development, besides interfering directly in cotton potential competitive with the weeds. Therefore, weed period control in the culture is variable according sowing system adopted. This research had as objective to determine the effects of different cropping systems, regard to spacing and sowing time on the weed interference in cotton yield (Gossypium hirsutum L.) under brazilian savannah conditions. For this, experiments were carried out, where the first (chapter 1) was installed in the summer crop (23/12/2009), with spacing between rows of 0,9 m and plant density of 95,000 ha-1. The second (chapter 2) was installed in 08/01/2010 in the second season after the bean harvest, with spacing between rows of 0,76 m and plant density of 165,000 ha-1. The third experiment (chapter 3) was seeded in the second crop season (04/02/2010), where the area was occupied with soybean, the spacing adopting between rows was of 0.45 m (high density) and the plant density was of 225,000 ha-1. The Bidens pilosa was the main weed in all the systems evaluated. The Period Prior to the interference was longer in the traditional seeding, discussed in experiment 1 (chapter 1). The reduction in spacing and sowing later in cotton resulted in greater initial weed competition. A dense planting of cotton in the off season resulted in lower Period Prior to the interference between the systems evaluated. The Total Period Interference Prevention and the Critical Period for Prevention of Interference was shorter when it took the dense planting of cotton in the off season. The Total Period Interference Prevention and the Critical Period for Prevention of interference were longer in the traditional sowing (chapter 1) in relation to other systems. The luminous flux incident on the culture was the variable that has suffered more similar effects on productivity, on the earliness of the damage suffered by cotton in the early periods of coexistence with the weeds. The dry weight of shoots was the variable related to weeds more important to indicate the periods of control and Weed in cotton. In the system of dense planting of cotton in the off season there is no tolerance for coexistence between the crop and weeds, since productivity was affected significantly in the first days after crop emergence.Em busca da sustentação econômica da cotonicultura brasileira, o sistema de cultivo do algodoeiro tem sofrido alterações importantes ao longo do tempo, em relação ao que tradicionalmente era conhecido. Recentemente, o cultivo adensado tem surgido como opção para incrementar a rentabilidade da cultura, principalmente em semeaduras realizadas na "Safrinha", em razão da redução no ciclo da cultura e dos custos de produção. Alterações no espaçamento, na densidade de plantas e na época de semeadura induzem modificações no crescimento e desenvolvimento do algodoeiro, além de interferirem no potencial competitivo da cultura frente às plantas daninhas. Sendo assim, os períodos de controle das plantas daninhas na cultura são variáveis de acordo com o sistema de semeadura adotado. O objetivo geral deste trabalho foi determinar os efeitos de diferentes sistemas de cultivo, no que se refere a espaçamento e época de semeadura, sobre os períodos de controle e de convivência das plantas daninhas no algodoeiro (Gossypium hirsutum), nas condições do Cerrado brasileiro. Para isso, foram realizados três experimentos cada qual representando um sistema de semeadura. O primeiro experimento (Capítulo 1) foi instalado na "safra de verão" (23/12/2009), utilizando espaçamento de 0,9 m entre linhas com densidade de 95 mil plantas ha-1. O segundo (Capítulo 2) foi instalado no dia 08/01/2010, após a colheita do feijão, portanto na "Segunda safra", em espaçamento de 0,76 m entre linhas e densidade de 165 mil plantas ha-1. No terceiro experimento (Capítulo 3), a semeadura foi realizada na "Safrinha", após a colheita da soja (07/02/2010), adotando o espaçamento de 0,45 m entre linhas (adensado) e estande final de 225 mil plantas ha-1. A espécie Bidens pilosa foi a principal planta daninha infestante nos experimentos realizados. O Período Anterior à Interferência foi mais longo no sistema tradicional de semeadura, onde a semeadura foi realizada na primeira safra adotando espaçamento de 0,9 m entre linhas. A redução no espaçamento e a semeadura mais tardia do algodoeiro resultaram em maior competição inicial das plantas daninhas. A semeadura adensada do algodoeiro na "Safrinha" resultou no menor Período Anterior à Interferência, entre os sistemas avaliados. O Período Total de Prevenção da Interferência e o Período Crítico de Prevenção da Interferência foram menores quando se realizou a semeadura adensada do algodoeiro na "Safrinha". O Período Total de Prevenção da Interferência e o Período Crítico de Prevenção da Interferência foram mais longos no sistema tradicional de vi semeadura (Capítulo 1) em relação aos demais sistemas. A transmissividade luminosa no dossel da cultura foi a característica que sofreu efeitos mais semelhantes à produtividade, quanto à precocidade dos danos sofridos pelo algodoeiro nos períodos iniciais de convivência com as plantas daninhas. A massa seca da parte aérea foi a característica relacionada às plantas daninhas mais importantes para indicar os períodos de controle e convivência das plantas daninhas no algodoeiro. No sistema de semeadura adensada do algodoeiro na "Safrinha" não houve tolerância de convivência entre a cultura e as plantas daninhas, uma vez que a produtividade foi afetada significativamente nos primeiros dias após a emergência da cultura.xiv, 153

Determinação da curva dose-resposta e atividade residual de herbicidas aplicados em pré-emergência utilizados na cultura do algodoeiro para o controle de Amaranthus e Portulaca oleracea

The low density of the plants in the stand, the growing in wide rows and the slow growth of the cotton crop cause the delay of soil cover, creating the necessity of weed control in different moments of the crop. In the Brazilian 'cerrado', which is a great cotton producer, farmers have observed an increase of weed infestation with Amaranthus spp. and Portulaca oleracea, and found difficulties controlling such weed species. The aim of this work was to improve the recommendation of the main herbicides alternatives used in preemergence to control P. oleracea and five different species of Amaranthus in cotton crop. The work was developed in two stages, both carried out in greenhouse: the first was aimed at establishing the herbicides rates which could promote efficient control of Portulaca oleracea, Amaranthus viridis, A. hybridus, A. spinosus, A. Lividus through the rate-response curve; the second was aimed at verifying the period of residual activity provided by the herbicides rates considered efficient and selected in the first stage, and by recommended rates. In the first stage, increasing herbicides rates of alachlor, diuron, clomazone, oxyfluorfen, pendimethalin, s-metolachlor, trifluralin 600, trifluralin 450 and prometryne were used. We verified that there were differences of susceptibility among species in relation to all herbicides through the calculus of sufficient rate for 80% (C80) or 95% (C95). A. lividus was the least sensitive species to herbicides and A. Spinosus was the most sensitive. We observed that efficient rates are much inferior to those used commercially, indicating the possibility of better adequacy of recommended rates. Trifluralin 600, trifluralin 450 and clomazone did not demonstrate the same efficiency of the other herbicides in the rate level used for these herbicides. In the second stage, herbicides were applied at four different periods prior to weed sowing (30, 20, 10 and 0 days before sowing - DAS) using C95 rate selected in the first stage, and the recommended rate with the exception of clomazone, trifluralin 600 and trifluralin 450, for which only the recommended rate was used. Residual activity of alachlor, oxyfluorfen and prometryne for C95 rate, clomazone, trifluralin 600 and trifluralin 450 at the only rate applied (recommended) was reduced as the period of time between application and weed sowing was increased. The application of the com ercial rate of oxyfluorfen prolonged the residual activity of control of the species A. hybridus and A. spinosus, which had not been efficiently controlled by the C95 rate, promoting then the effective control of the species until 30 DAS. For alachlor, the increase of the C95 rate to the recommended one did not reflect a considerable increase in residual activity for all species, except to A. viridis. The recommended rate of Prometryne did not promote efficient control only in relation to A. hybridus. Diuron, pendimethalin and s-metolachlor showed effective residual activity for all species until 30 DAS at both rates used, demonstrating consistent residual activity to the soil with sandy clay loam texture (21% clay and 13,68 g dm-³ carbon).A baixa densidade de plantas no estande, o cultivo em espaçamentos largos e o crescimento lento da cultura do algodoeiro fazem com que o fechamento das ruas demore a acontecer, gerando a necessidade do controle de plantas daninhas em diferentes momentos da cultura. No cerrado brasileiro, grande produtor de algodão, os agricultores têm observado aumento da infestação com Amaranthus spp. e Portulaca oleracea e encontrado dificuldade no controle dessas espécies de plantas daninhas. O objetivo do trabalho foi aperfeiçoar a recomendação das principais alternativas de herbicidas utilizados em pré-emergência para o controle de P. oleracea e cinco espécies de Amaranthus na cultura do algodoeiro. O trabalho foi desenvolvido em duas etapas, ambas realizadas em casa-de-vegetação: a primeira para estabelecer, por meio da curva dose-resposta, as doses de herbicidas capazes de promover o controle eficiente de Portulaca oleracea, Amaranthus viridis, A. hybridus, A. spinosus, A. lividus; a segunda, verificar o período de atividade residual, proporcionado pelas doses consideradas eficientes dos herbicidas selecionadas na primeira etapa, e de doses recomendadas. Na primeira etapa, foram utilizadas doses crescentes dos herbicidas alachlor, diuron, clomazone, oxyfluorfen, pendimethalin, smetolachlor, trifluralin 600, trifluralin 450 e prometryne. Verificou-se, por meio do cálculo da dose suficiente para 80% (C80) ou 95% (C95) de controle, que houve diferenças de suscetibilidade entre as espécies, em relação a todos os herbicidas. A. lividus foi à espécie menos sensível aos herbicidas e A. spinosus a mais sensível. Observou-se que as doses eficientes são muito inferiores àquelas utilizadas comercialmente, indicando a possibilidade de melhor adequação das doses recomendadas. Trifluralin 600, trifluralin 450 e clomazone não demonstraram a mesma eficiência dos demais herbicidas, dentro da faixa de dose utilizada para esses herbicidas. Na segunda etapa, os herbicidas foram aplicados em quatro épocas, antecedendo a semeadura das plantas daninhas (30, 20, 10 e 0 dias antes da semeadura - DAS), utilizando a dose C95, selecionada na primeira etapa, e a dose recomendada, com exceção do clomazone, trifluralin 600 e trifluralin 450, para os quais somente utilizou-se a dose recomendada. A atividade residual dos herbicidas alachlor, oxyfluorfen e prometryne, para a dose C95, clomazone, trifluralin 600 e trifluralin 450, na única dose empregada (recomendada) foi reduzida à medida que se aumentou o período de tempo entre a aplicação e a semeadura das plantas daninhas. A aplicação da dose comercial de oxyfluorfen prolongou a atividade residual de controle das espécies A. hybridus e A. spinosus, as quais não haviam sido eficientemente controladas pela dose C95 promovendo, assim, o controle efetivo dessas espécies até aos 30 DAS. Para alachlor, o aumento da dose de C95 para a dose recomendada não se refletiu em aumento considerável da atividade residual para as espécies, exceto para A. viridis. A dose recomendada de prometryne não promoveu o controle eficiente somente em relação à A. hybridus. Diuron, pendimethalin e s-metolachlor apresentaram atividade residual efetiva para todas as espécies até 30 DAS, em ambas as doses utilizadas, demonstrando atividade residual consistente para o solo de textura franco argilo-arenosa (21% de argila e 13,68 g dm-³ de carbono).viii, 101

WEED INTERFERENCE IN COTTON PLANTS GROWN WITH REDUCED SPACING IN THE SECOND HARVEST SEASON

Changes in row spacing may result in changes in crop and weed behavior and crop-weed competition. A study was performed to determine the periods of weed presence and weed control in cotton sown with 0.76 m spacing between planting rows. Cotton cultivar FM 993 was sown on 01/08/2010 with the aim of reaching a density of 190,000 seeds ha-1. Treatments with either weed presence or weed control during the first 0, 5, 10, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 190 days of cultivation were established to determine the period prior to weed interference (PPI), total period of interference prevention (TPIP) and critical period of weed control (CPWC). The weed species with high relative importance were Amaranthus retroflexus, Bidens pilosa, Eleusine indica, Digitaria horizontalis, Alternanthera tenella, and Commelina benghalensis. Considering a maximum yield loss of 5%, the PPI was established 11 days after cotton emergence (DAE), the TPWC at 46 DAE, and the CPWC between 11 and 46 DAE, for a total duration of 35 days. Considering a maximum acceptable yield loss equal to the standard deviation for the weed-free treatment, the PPI was established at 6 DAE, the TPWC at 55 DAE, and the CPWC between 6 and 55 DAE for a total duration of 49 days

Glyphosate associado a outros herbicidas no controle de Commelina benghalensis and Spermacoce latifolia

The widespread cultivation of Roundup Ready soybeans enabled the use of glyphosate for post-emergence weed control in, turning weed handling into an easier and less costly operation. Despite such improvements, controlling glyphosate tolerant species can still be improved by associations with other herbicides. The aimed at evaluating the effect of the association of different herbicides with glyphosate in relation to Commelina benghalensis and Spermacoce latifolia control, after spraying plants in two different growth stages (1-3 and 4-6 leaves). For that, four experiments were carried out under greenhouse conditions, where glyphosate was applies at rates of 480 and 960 g a.e. ha-1, isolated or combined in tank mixtures with cloransulam-methyl (30,24 g ha-1), chlorimuron-ethyl (12,5 g ha-1), imazethapyr (80 g ha-1), fomesafen (62,5 g ha-1), lactofen (72 g ha-1), flumiclorac-pentyl (30 g ha-1) and bentazon (480 g ha-1), besides a no-herbicide check. We evaluated the percentage of control at 3, 7, 14, 21, 28 and 35 days after application (DAA) and shoot dry mass (35 DAA). For C. benghalensis control, when herbicides were applied at 1-3 leaves stage, all treatments performed satisfactorily in weed control. For S. latifolia, the highest levels of weed control when applications were made at 4-6 leaves stage, when even glyphosate alone at lowest rate (480 g a.e. ha-1), provided excellent weed control. Overall, the use of tank mixtures improved weed control of both species when the rate of 480 g a.e. ha-1 of glyphosate was applied at earlier stages of weed development.A liberação da soja transgênica possibilitou o uso do glyphosate para o controle das plantas daninhas em pós-emergência, facilitando o manejo e diminuindo os custos. No entanto, o controle de algumas espécies tolerantes ao glyphosate pode ser otimizado com associações com outros herbicidas. O trabalho teve como objetivo verificar o efeito da associação de diferentes herbicidas com glyphosate para o controle de Commelina benghalensis e Spermacoce latifolia após aplicação dos herbicidas em dois estádios de desenvolvimento (1-3 e 4-6 folhas). Para isso, foram realizados quatro experimentos em casa de vegetação, aplicando-se glyphosate nas doses de 480 e 960 g ha-1, isolado ou combinado com os latifolicidas cloransulam-methyl (30,24 g ha-1), chlorimuron-ethyl (12,5 g ha-1), imazethapyr (80 g ha-1), fomesafen (62,5 g ha-1), lactofen (72 g ha-1), flumiclorac-pentyl (30 g ha-1) e bentazon (480 g ha-1), além de uma testemunha sem herbicida. Foram realizadas avaliações de porcentagem de controle aos 3, 7, 14, 21, 28 e 35 dias após aplicação (DAA) e massa seca da parte aérea (35 DAA). Para o controle de C. benghalensis, quando a aplicação é realizada no estádio de 1-3 folhas todos os tratamentos apresentaram controle satisfatório. Para S. latifolia, as maiores eficiências foram obtidas para as aplicações realizadas no estádio de 4-6 folhas, nas quais mesmo o glyphosate isolado na menor dose testada (480 g ha-1), proporcionou excelente controle. De modo geral, o uso de misturas melhorou o controle de ambas as espécies quando se usa glyphosate a 480 g ha-1 em estádios mais precoces do desenvolvimento das plantas daninhas

Control and weeds new fluxes with association to amonio-glufosinate and pyrithiobac-sodium in cotton Liberty Link®

O acompanhamento de áreas cultivadas com variedades de algodoeiro Liberty Link (LL®) no Cerrado brasileiro tem levado a se observar que o amonio-glufosinate isolado não tem proporcionado o controle adequado da comunidade infestante comumente encontrada nestas áreas, fazendo com que haja a necessidade de várias intervenções de controle até o fechamento da cultura. O objetivo deste trabalho foi verificar os benefícios de associar pyrithiobac-sodium a aplicações realizadas com amonio-glufosinate em algodoeiro LL®, para o controle e a redução da reinfestação das plantas daninhas. O experimento foi instalado no município de Chapadão do Sul – MS, empregando a variedade Fiber Max 966 LL®, em espaçamento de 0,90 m entre linhas. As aplicações dos tratamentos foram realizadas aos 15 dias após a emergência da cultura, utilizando a associação entre os herbicidas amonio-glufosinate e pyrithiobac-sodium em diferentes doses, além de um tratamento formado pela mistura entre pyrithiobac-sodium e trifloxysulfuron-sodium. A utilização de amonio-glufosinate isolado não foi eficiente para o controle das plantas daninhas presentes na área. A adição de pyrithiobac-sodium contribui para o controle de espécies como Commelina benghalensis, Amaranthus retroflexus, Ipomoea grandifolia e Euphorbia heterophylla. A atividade residual de pyrithiobac-sodium, principalmente em doses de 42 ou 56 g ha-1, mostrou ser uma excelente opção para o controle residual de Bidens pilosa e Euphorbia heterophylla, o que pode acarretar na redução do número aplicações em pós-emergência da cultura ao longo do seu ciclo.The accompaniment of cultivated areas with cotton Liberty Link genotype (LL®) in Brazilian Cerrado-like vegetation has conducted to the observation that amonio-glufosinate isolated does not have proportionate the adequate weeds control commonly found in these areas, becoming clear the necessity of several control interventions until crop closing. The objective of this work was to verify the benefits in associating pyrithiobac-sodium to applications carried with amonio-glufosinate in cotton Liberty Link genotype (LL®) for controlling and reducing weeds new infestation. The experiment was installed in Chapadão do Sul County, Mato Grosso do Sul State, using Fiber Max 966 LL® genotype spaced 0.90 m between lines. Treatments applications was carried out 15 days after crop emergency, by using the association between amonio-glufosinate and pyrithiobac-sodium herbicides in different doses, besides a treatment formed by the mixture between pyrithiobac-sodium and trifloxysulfuron-sodium. Amonio-glufosinate used alone was not efficient for controlling weeds presented in the area. The addition of pyrithiobac-sodium contributed for controlling weed specie as Commelina benghalensis, Amaranthus retroflexus, Ipomoea grandifolia and Euphorbia heterophylla. Residual activity of pyrithiobac-sodium, mainly in 42 or 56 g ha-1 doses represented to be an excellent option for Bidens pilosa and Euphorbia heterophylla residual control, what may cause the reduction of applications number in post emergency of the crop along its cycle