The information systems environment of time-based competitors

Time-based competitors create product development and manufacturing practices that reduce response-time and enhance customization capabilities. These practices require an information-rich, internal environment capable of flexible resource deployment and direct and continuous feedback. These firms should have enhanced information systems planning capabilities, cross-functional involvement in information systems related activities, responsiveness to organizational computing demands, high levels of end-user development, and high levels of information systems performance. Data were collected from 265 manufacturers to develop measures for these information systems variables and to determine if there are relationships between the use of time-based practices and the levels of these variables. Results indicate that firms with high levels of time-based product development practices and time-based manufacturing practices have significantly higher scores across these information systems variables than firms with low levels of these time-based practices

A modular approach to the antifungal sphingofungin family: concise total synthesis of sphingofungin A and C

Sphingofungins are fungal natural products known to inhibit the biosynthesis of sphingolipids which play pivotal roles in various cell functions. Here, we report a short and flexible synthetic approach towards the sphingofungin family. Key step of the synthesis was a decarboxylative cross-coupling reaction of chiral sulfinyl imines with a functionalized tartaric acid derivative, which yielded the core motive of sphingofungins carrying four consecutive stereocenters and a terminal double bond. Subsequent metathesis reaction allowed for the introduction of different side chains of choice resulting in a total of eight sphingofungins, including for the first time sphingofungin C (eight steps from commercially available protected tartaric acid with an overall yield of 6%) and sphingofungin A (ten steps). All newly synthesized derivatives were tested for their antifungal, cell proliferative and antiparasitic activity unraveling their structure-activity relations

Yeast thioredoxin reductase Trr1p controls TORC1-regulated processes

The thioredoxin system plays a predominant role in the control of cellular redox status. Thioredoxin reductase fuels the system with reducing power in the form of NADPH. The TORC1 complex promotes growth and protein synthesis when nutrients, particularly amino acids, are abundant. It also represses catabolic processes, like autophagy, which are activated during starvation. We analyzed the impact of yeast cytosolic thioredoxin reductase TRR1 deletion under different environmental conditions. It shortens chronological life span and reduces growth in grape juice fermentation. TRR1 deletion has a global impact on metabolism during fermentation. As expected, it reduces oxidative stress tolerance, but a compensatory response is triggered, with catalase and glutathione increasing. Unexpectedly, TRR1 deletion causes sensitivity to the inhibitors of the TORC1 pathway, such as rapamycin. This correlates with low Tor2p kinase levels and indicates a direct role of Trr1p in its stability. Markers of TORC1 activity, however, suggest increased TORC1 activity. The autophagy caused by nitrogen starvation is reduced in the trr1Δ mutant. Ribosomal protein Rsp6p is dephosphorylated in the presence of rapamycin. This dephosphorylation diminishes in the TRR1 deletion strain. These results show a complex network of interactions between thioredoxin reductase Trr1p and the processes controlled by TOR

The consequences of technostress for end users in organizations:conceptual development and empirical validation

The research reported in this paper studies the phenomenon of technostress, that is, stress experienced by end users of Information and Communication Technologies (ICTs), and examines its influence on their job satisfaction, commitment to the organization, and intention to stay. Drawing from the Transaction-Based Model of stress and prior research on the effects of ICTs on end users, we first conceptually build a nomological net for technostress to understand the influence of technostress on three variables relating to end users of ICTs: job satisfaction, and organizational and continuance commitment. Because there are no prior instruments to measure constructs related to technostress, we develop and empirically validate two second order constructs: technostress creators (i.e., factors that create stress from the use of ICTs) and technostress inhibitors (i.e., organizational mechanisms that reduce stress from the use of ICTs). We test our conceptual model using data from the responses of 608 end users of ICTs from multiple organizations to a survey questionnaire. Our results, based on structural equation modeling (SEM), show that technostress creators decrease job satisfaction, leading to decreased organizational and continuance commitment, while Technostress inhibitors increase job satisfaction and organizational and continuance commitment. We also find that age, gender, education, and computer confidence influence technostress. The implications of these results and future research directions are discussed

Metabolites in Safety Testing

This chapter summarizes the current thinking and practices in the pharmaceutical industry in support of metabolites in safety testing (MIST) related activities. It compares two of several options available for conducting absorption, distribution, metabolism, and excretion (ADME) studies using radiolabled materials. In the first option, radiolabeled studies are not scheduled until after the interpretation of human pharmacokinetics (PK) and metabolism in the first-in-human (FIH) studies, while in the second option, preclinical radiolabeled ADME studies are initiated before the completion of the FIH studies. The chapter discusses some of the liquid chromatography-mass spectrometry (LC-MS) methods available for detecting and characterizing metabolites. Bioanalytical assays, used for detection, characterization and exposure estimation of metabolites, are tiered into (i) metabolite profiling, (ii) standard free quantification/ response factor determination, (iii) qualified assays, and (vi) validated assays

Assessment of soil microbial diversity and soil enzyme activities under inorganic input sources on maize and rice ecosystems

Background: To increase crop productivity, modern agricultural practices comprises fertilizers, algaecides, herbicides and fungicides. Objective: The purpose of this study was to evaluate the effects of soil microbial population and soil enzyme activity by the use of fertilizer in maize and inorganic input in the rice ecosystem. Methods: A field experiment (2021 to 2023) was carried out using synthetic fertilizer doses with maize crops followed by rice crops using inorganic inputs. Soil microbial population and enzyme activities were examined. Results: Maize field experiment revealed that the plots treated with 75 % Standardized Dose of Fertilizer (SDF) of NPK had the highest populations of diazotrophs (124 × 105cfu / g), Phosphobacteria (66.33 × 105cfu / g), and Azospirillum (0.409 × 105 MPN / g) than 100 % and 150 % SDF of NPK. The soil enzyme activity was higher in the unfertilized control plot than fertilized plot. These experimental results revealed that a low amount of fertilizer and no fertilizers favour the growth of soil microorganisms and soil enzyme activities, respectively. Followed by the rice field experiment, revealed that the soil microbial population was decreased by the application of inorganic inputs viz., fertilizer, algaecide, herbicide and fungicide. However, the maximum soil microbial population was found in algaecide application followed by herbicide and fungicide. Conclusion: The field experiment concluded that soil microbial population and enzyme activity were affected by inorganic amendments. Less inorganic fertilizers and no fertilizers improve soil microbial activities and soil enzyme activities

Comparative Study on Mechanical Performances of Circular and Flat Geometry Welds in Friction Stir Welding of Aluminium Alloy

This study is to find the extent of variation in mechanical properties between plate and pipe welds fabricated out of the same FSW process parameters. Common thickness of 3 mm along with similar tool specifications is used to fabricate the weld. Process parameters of tool rotational speed 2000 rpm and weld speed 94 mm/min that was defined as optimal for pipe weld is used as common process parameters. Welds are analyzed for hardness and tensile properties. Yield strength and ultimate tensile strength varied about 8.1% and 11.2% respectively between plate and pipe welds. The hardness of the stir zones varied about 11.6% between plate and pipe welds

Survival analysis and visual outcome in a large series of corneal transplants in India

AIM/BACKGROUND—The public health significance of corneal transplantation in dealing with corneal blindness in the developing world would depend upon the survival rate of transplants. This study was done to analyse the survival rate of corneal transplants in a large series in India, and to evaluate the influence of various risk factors on transplant survival.
METHODS—The records of a series of 1725 cases of corneal transplants carried out during 1987-95 at a tertiary eye care institution in India were reviewed. The Kaplan-Meier method was used to determine 5 year survival rates of corneal transplants performed for the various categories of preoperative diagnosis. Multivariate Cox proportional hazards regression was used to assess how preoperative diagnosis, socioeconomic status, age, sex, vascularisation of host cornea, quality of donor cornea, and training status of surgeon influenced transplant survival. The effect of these variables on visual outcome was assessed using multiple logistic regression.
RESULTS—The survival rates at 1, 2, and 5 years for all corneal transplants performed for the first time in 1389 cases were 79.6% (95% confidence interval = 77.3-81.9%), 68.7% (65.7-71.7%) and 46.5% (41.7-51.3%). The 5 year survival rate was highest if the corneal transplant was done for keratoconus (95.1% (84.8-100%)) and lowest if carried out for previous transplant failure (21.2% (13.8-28.6%)). The relative risk of transplant failure was higher if the preoperative diagnosis was previous transplant failure (2.04 (1.62-2.55)), aphakic bullous keratopathy (1.78 (1.38-2.28)), corneal clouding due to miscellaneous causes including congenital conditions and glaucoma (1.63 (1.21-2.19)), or adherent leucoma (1.11 (0.81-1.51)) than for the other preoperative diagnoses. Patients with lower socioeconomic status had higher relative risk of transplant failure (1.28 (1.16-1.42)), as did patients <10 years of age (1.42 (1.23-1.64)). Higher relative risk of transplant failure was associated with vascularisation of the host cornea before transplantation (1.15 (1.04-1.27)), and with the use of fair quality donor cornea for transplantation compared with excellent, very good, or good quality donor cornea (1.26 (1.06-1.52)). Before corneal transplant 80.2% of the eyes were blind (visual acuity <3/60), whereas at last follow up 41.8% eyes were blind. The odds of having visual acuity >6/18 were higher if the transplant was done for keratoconus (9.99 (6.10-16.36)) or corneal dystrophies (1.77 (1.21-2.58)) than for the other preoperative diagnoses.
CONCLUSION—Reasonable success with corneal transplantation is possible in the developing world if data from this part of the world regarding the different survival rates for the various preoperative diagnoses and the influence of risk factors on transplant survival and visual outcome are taken into account while determining priority for transplant cases in the present situation of limited availability of donor corneas.


Variation in imperfections level due to winding of ring yarn

290-294The variation in imperfections level due to winding of carded and combed ring yarns and the effect of foreign matters, such as black specks of broken seeds, lead bits and trashes present in the ring cop yarn, on imperfections during winding process for carded cotton ring yarn has been studied. The results show that the thin places increase, and thick places and neps decrease due to the fall of foreign matters during winding in the carded yarn. In the combed yarn, the thin places, thick places and neps increase during windin